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1. 发明申请

WO2007039752A1 ALKYL 4- [4- (5-OXO-2, 3, 5, 11A-TETRAHYD0-5H-PYRR0L0 [2, 1-C] [1, 4] BENZODIAZEPINE-8-YLOXY) -BUTYRYLAMINO]-1H-PYRROLE-2-CARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF A PROLIFERATIVE DISEASE 审中-公开
标题翻译：亚苄基4- [4-（5-氧代-2,3,5,11-四氢-2H-吲哚-5-基）[2,1-C] [1,4]苯并嗪-5-基） - 丁基]氨基] -1H-吡咯并[ 2-羧酸酯衍生物及相关化合物治疗增殖性疾病
公开(公告)号：WO2007039752A1
公开(公告)日：2007-04-12
申请号：PCT/GB2006/003718
申请日：2006-10-05
申请人： SPIROGEN LIMITED , HOWARD, Philip Wilson , THURSTON, David Edwin , WELLS, Geoffrey
发明人： HOWARD, Philip Wilson , THURSTON, David Edwin , WELLS, Geoffrey
IPC分类号： C07D487/04 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R 2 is selected from -H, -OH, =0, =CH 2 , -CN, -R, OR, halo, =CH-R, O-SO 2 -R, CO 2 R and COR; R 7 is selected from H, R, OH, OR, SH, SR, NH 2 , NHR, NRR', nitro, Me 3 Sn and halo, where R and R' are independently selected from optionally substituted C 1-7 alkyl, C 3-20 heterocyclyl and C 5-20 aryl groups; R 10 and R 11 either together form a double bond, or are selected from H and YR Y , where Y is selected from O, S and NH and R Y is H or C 1-7 alkyl or H and SO x M, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and R E is C 1-4 alkyl. The compound is useful for the treatment of proliferative diseases.
摘要翻译：式（I）化合物; 或其盐或溶剂合物，其中：虚线表示在C2和C3之间任选存在双键; R 2选自-H，-OH，= O，= CH 2，-CN，-R，OR，卤素，= CH-R，O-SO R 2和R 2，R 2和R C; R 7选自H，R，OH，OR，SH，SR，NH 2，NHR，NRR'，硝基，Me 3 Sn和卤素，其中R和R'独立地选自任选取代的C 1-7 - 烷基，C 3-20 - 杂环基和C 5-20 - SUB>芳基; R 10和R 11一起形成双键，或选自H和YR Y，其中Y选自O，S 和NH和R Y是H或C 1-7烷基或H和SO x M，其中x是2或3，M 是一价药学上可接受的阳离子; 每个X独立地是亚杂芳基; n为1至6; 并且R E是C 1-4烷基。该化合物可用于治疗增殖性疾病。

2. 发明申请

WO2009151677A2 FERTILIZER SUSPENSION AND METHOD OF PREPARATION 审中-公开
标题翻译：肥料悬浮液和制备方法
公开(公告)号：WO2009151677A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/036792
申请日：2009-03-11
申请人： LAWRENCE BROOKE ENGINEERING, LLC. , WELLS, Geoffrey Dylan
发明人： WELLS, Geoffrey Dylan
IPC分类号： C05C5/00 , C05C5/04 , C05B9/00 , C05G3/00
CPC分类号： C05B17/02 , C05B3/00 , C05G3/0064 , C05G3/007 , C05B7/00 , C05D9/02 , C05F11/00 , C05F5/006 , C05F9/04
摘要： A concentrated, homogenous, stable, water-soluble fertilizer suspension comprising: water-soluble mineral nutrients of at least nitrogen, phosphorous, potassium, calcium, and magnesium; and an organic stabilizing additive; and wherein the pourable, aqueous suspension has water-soluble mineral nutrients amounting to at least about 80 percent by weight (wt. %) of the suspension.
摘要翻译：一种浓缩，均匀，稳定的水溶性肥料悬浮液，其包含至少氮，磷，钾，钙和镁的水溶性矿物质营养物质; 和有机稳定添加剂; 并且其中所述可倾倒的水性悬浮液具有至少约80重量％（重量％）所述悬浮液的水溶性矿物营养物质。

3. 发明申请

WO2005085177A3 BIARYL AMINO ACIDS AND THEIR USE IN DNA BINDING OLIGOMERS 审中-公开
标题翻译： BIARYL氨基酸及其在DNA结合寡聚体中的用途
公开(公告)号：WO2005085177A3
公开(公告)日：2005-11-17
申请号：PCT/GB2005000752
申请日：2005-03-01
申请人： SPIROGEN LTD , HOWARD PHILIP WILSON , WELLS GEOFFREY
发明人： HOWARD PHILIP WILSON , WELLS GEOFFREY
IPC分类号： C07D207/34 , C07D213/73 , C07D233/90 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D27/56 , A61K31/4025 , A61K31/427
CPC分类号： C07D277/56 , C07D207/34 , C07D213/73 , C07D233/90 , C07D307/68 , C07D333/38 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D487/04 , Y02P20/55
摘要： Compounds of formula (I): Z' -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z' is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.
摘要翻译：式（I）化合物：Z'-CO-A-B-NH-Z（I）其中：Z为H或氨基保护基; Z'是OH，被保护或活化的羟基或C1; A是任选取代的C 5-6亚芳基; B是任选取代的C 5-6亚芳基。

4. 发明申请

WO2003004479A1 4-ARYL QUINOLS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS 审中-公开
标题翻译： 4-ARYL QUINOLS及其类似物作为治疗剂
公开(公告)号：WO2003004479A1
公开(公告)日：2003-01-16
申请号：PCT/GB2002/003097
申请日：2002-07-05
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , STEVENS, Malcolm, Francis, Graham , WELLS, Geoffrey , WESTWELL, Andrew, David , POOLE, Tracey, Dawn
发明人： STEVENS, Malcolm, Francis, Graham , WELLS, Geoffrey , WESTWELL, Andrew, David , POOLE, Tracey, Dawn
IPC分类号： C07D277/64
CPC分类号： C07D263/56 , C07C45/30 , C07C45/511 , C07C45/513 , C07C49/747 , C07C49/753 , C07C323/22 , C07C323/59 , C07C2601/14 , C07D209/12 , C07D215/14 , C07D235/12 , C07D277/64 , C07D307/80 , C07D333/54
摘要： The present invention pertains to compounds of the formula (1), which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitors: wherein: Q is =O or =N-S(=O) 2 -R Q ;R Q is -H or optionally substituted C 1-7 alkyl, C 3-20 heterocyclyl, or C 5-20 aryl; Ar is optionally substituted C 5-20 aryl; R o is an oxy substituent; the bond marked α is a single bond or a double bond; the bond marked ß is a single bond or a double bond; R 3 and R 5 are each independently ring substituents; R 2 and R 6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), mycobacterial infections (e.g., tuberculosis), and/or conditions mediated by thioredoxin/thioredoxin reductase.
摘要翻译：本发明涉及式（1）的化合物，其特别是抗增殖剂，抗癌剂，抗分枝杆菌药，抗结核药物和/或硫氧还蛋白/硫氧还蛋白还原酶抑制剂：其中：Q = = O）2-R Q; R Q是-H或任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基; Ar是任选取代的C 5-20芳基; R o是氧取代基; 标记为α的键是单键或双键; 标记为ss的键是单键或双键; R 3和R 5各自独立地为环取代基; R 2和R 6各自独立地为环取代基; 和其药学上可接受的盐，酯，酰胺，溶剂合物，水合物及其保护形式。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，例如用于治疗增殖性疾病（例如癌症），分枝杆菌感染（例如，结核病））和/或由硫氧还蛋白/硫氧还蛋白还原酶介导的条件。

5. 发明申请

WO2010109230A1 NOVEL PRODRUGS 审中-公开
标题翻译：新的PRODRUGS
公开(公告)号：WO2010109230A1
公开(公告)日：2010-09-30
申请号：PCT/GB2010/050490
申请日：2010-03-24
申请人： PHARMINOX LIMITED , WELLS, Geoffrey , McCARROLL, Andrew James , STEVENS, Malcolm Francis Graham
发明人： WELLS, Geoffrey , McCARROLL, Andrew James , STEVENS, Malcolm Francis Graham
IPC分类号： C07D209/12 , A61K31/404 , A61P35/00
CPC分类号： C07D209/12
摘要： The present invention relates to novel prodrug compounds, or pharmaceutically acceptable salts thereof, which convert in vivo to the active species 4-(1-benzenesulfonyl-6-fluoro-1H-indol-2-yl)-4-hydroxy-cyclohexa-2,5-dienone. The prodrug compounds of the invention have dramatically improved solubility relative to 4-(1-benzenesulfonyl-6-fluoro-1H- indol-2-yl)-4-hydroxy-cyclohexa-2,5-dienone and, accordingly, can be easily formulated for administration to a patient. The prodrugs of the invention are therefore useful for the treatment cellular proliferation disorders, such as cancer.
摘要翻译：本发明涉及在体内转化成活性物质4-（1-苯磺酰基-6-氟-1H-吲哚-2-基）-4-羟基 - 环己二烯-2的新型前药化合物或其药学上可接受的盐，5-二烯酮。本发明的前药化合物相对于4-（1-苯磺酰基-6-氟-1H-吲哚-2-基）-4-羟基 - 环己二-2,5-二烯酮具有显着改善的溶解度，因此可以容易地为患者配制。因此，本发明的前药可用于治疗细胞增殖紊乱，例如癌症。

6. 发明申请

WO2009151677A3 FERTILIZER SUSPENSION AND METHOD OF PREPARATION 审中-公开
标题翻译：肥料悬浮液和制备方法
公开(公告)号：WO2009151677A3
公开(公告)日：2010-03-11
申请号：PCT/US2009036792
申请日：2009-03-11
申请人： LAWRENCE BROOKE ENGINEERING LL , WELLS GEOFFREY DYLAN
发明人： WELLS GEOFFREY DYLAN
IPC分类号： C05C5/00 , C05B9/00 , C05C5/04 , C05G3/00
CPC分类号： C05B17/02 , C05B3/00 , C05G3/0064 , C05G3/007 , C05B7/00 , C05D9/02 , C05F11/00 , C05F5/006 , C05F9/04
摘要： A concentrated, homogenous, stable, water-soluble fertilizer suspension comprising: water-soluble mineral nutrients of at least nitrogen, phosphorous, potassium, calcium, and magnesium; and an organic stabilizing additive; and wherein the pourable, aqueous suspension has water-soluble mineral nutrients amounting to at least about 80 percent by weight (wt. %) of the suspension.
摘要翻译：一种浓缩，均匀，稳定的水溶性肥料悬浮液，其包含至少氮，磷，钾，钙和镁的水溶性矿物营养物质; 和有机稳定添加剂; 并且其中所述可倾倒的水性悬浮液具有至少约80重量％（重量％）所述悬浮液的水溶性矿物营养物质。

7. 发明申请

WO2005085177A2 AMINO ACIDS 审中-公开
标题翻译：氨基酸
公开(公告)号：WO2005085177A2
公开(公告)日：2005-09-15
申请号：PCT/GB2005/000752
申请日：2005-03-01
申请人： SPIROGEN LIMITED , HOWARD, Philip, Wilson , WELLS, Geoffrey
发明人： HOWARD, Philip, Wilson , WELLS, Geoffrey
IPC分类号： C07C229/00
CPC分类号： C07D277/56 , C07D207/34 , C07D213/73 , C07D233/90 , C07D307/68 , C07D333/38 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D487/04 , Y02P20/55
摘要： Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C 5-6 arylene group; and B is an optionally substituted C 5-6 arylene group.
摘要翻译：式（I）化合物：Z'-CO-A-B-NH-Z（I）其中：Z为H或氨基保护基; Z'是OH，被保护或活化的羟基或C1; A是任选取代的C 5-6亚芳基; B是任选取代的C 5-6亚芳基。

8. 发明申请

WO2004056361A1 4-(1-(SULFONYL)-1H-INDOL-2-YL)-4-(HYDROXY)-CYCLOHEXA-2,5-DIENONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS 审中-公开
标题翻译： 4-（1-（磺酰基）-1H-吲哚-2-基）-4-（羟基） - 环己基-2,5-二酮化合物及其作为治疗剂的模拟物
公开(公告)号：WO2004056361A1
公开(公告)日：2004-07-08
申请号：PCT/GB2002/005842
申请日：2002-12-20
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , STEVENS, Malcolm, Francis, Graham , WESTWELL, Andrew, David , POOLE, Tracey, Dawn , WELLS, Geoffrey , BERRY, Jane, Marie
发明人： STEVENS, Malcolm, Francis, Graham , WESTWELL, Andrew, David , POOLE, Tracey, Dawn , WELLS, Geoffrey , BERRY, Jane, Marie
IPC分类号： A61K31/404
CPC分类号： C07D209/12 , A61K31/404
摘要： This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/thioredoxin reductase inhibitors: formula (I) wherein: Ar is a 1-(sulfonyl)-1H-indol-2-yl group; the bond marked α is independently: (a) a single bond; or: (b) a double bond; the bond marked β is independently: (a) a single bond; or: (b) a double bond; the group -OR O is independently: (a) -OH; (b) an ether group (e.g., -OMe); or: (c) an acyloxy (i.e., reverse ester) group (e.g., -OC(=O)Me); each of R 2 , R 3 , R 5 , and R 6 , is independently a ring substituent and is: (a) H; (b) a monovalent monodentate substituent; or: (c) a ring substituent which, together with an adjacent ring substituent, and together with the ring atoms to which these ring substituents are attached, form a fused ring; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), and/or conditions mediated by thioredoxin/thioredoxin reductase.
摘要翻译：本发明涉及某些4-（1-（磺酰基）-1H-吲哚-2-基）-4-（羟基） - 环己-2,5-二烯酮化合物及其类似物，包括下式的化合物，其中尤其是抗增殖剂，抗癌剂和/或硫氧还蛋白/硫氧还蛋白还原酶抑制剂：式（I）其中：Ar是1-（磺酰基）-1H-吲哚-2-基; 标记为α的键独立：（a）单键; 或（b）双键; 标记为β的债券是独立的：（a）单一债券; 或（b）双键; 基团-OR 0独立地为：（a）-OH; （b）醚基（例如-OMe）; 或（c）酰氧基（即反酯）基团（例如-OC（= O）Me）; R 2，R 3，R 5和R 6各自独立地为环取代基，并且是：（a）H; （b）一价单齿取代基; 或者：（c）环取代基，与环相邻的取代基一起以及与这些环取代基连接的环原子一起形成稠环; 和其药学上可接受的盐，酯，酰胺，溶剂合物，水合物及其保护形式。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内例如用于治疗增殖性疾病（例如癌症）和/或由硫氧还蛋白/硫氧还蛋白还原酶。

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