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1. 发明申请

WO2008145384A1 INFLAMMATION AND OXIDATIVE STRESS LEVEL ASSAY 审中-公开
标题翻译：渗透和氧化应力水平测定
公开(公告)号：WO2008145384A1
公开(公告)日：2008-12-04
申请号：PCT/EP2008/004323
申请日：2008-05-30
申请人： BIOCRATES LIFE SCIENCES AG , SONNTAG, Denise , KOAL, Therese , RAMSAY, Steven, Lewis , DAMMEIER, Sascha , WEINBERGER, Klaus, Michael
发明人： SONNTAG, Denise , KOAL, Therese , RAMSAY, Steven, Lewis , DAMMEIER, Sascha , WEINBERGER, Klaus, Michael
IPC分类号： G01N33/50 , G01N33/74 , G01N33/88 , G01N33/92
CPC分类号： G01N33/5091 , G01N33/88
摘要： The present invention relates to a method for determining the systemic metabolic status of an organism in relation to inflammation and oxidative stress using a biological sample (Inflammation and Oxidative Stress Level Assay). This comprises detection and quantification of one or more derivatives of arachidonic acid (eicosanoids), linoleic acid and/ or docosahexaenoic acid, preferably together with one or more oxidative stress parameters and/or with one or more analytes from other metabolite classes in parallel, as well as a kit adapted for carrying out such a method. Moreover, the invention relates to the biomarkers as employed in the method.
摘要翻译：本发明涉及使用生物样品（炎症和氧化应激水平测定）来确定生物体与炎症和氧化应激相关的全身代谢状态的方法。这包括检测和定量花生四烯酸（类花生酸），亚油酸和/或二十二碳六烯酸的一种或多种衍生物，优选与一种或多种氧化应激参数一起和/或与来自其它代谢物类别的一种或多种分析物并行地检测和定量，如以及用于执行这种方法的试剂盒。此外，本发明涉及该方法中使用的生物标志物。

2. 发明申请

WO2007003344A3 DEVICE FOR QUANTITATIVE ANALYSIS OF A METABOLITE PROFILE 审中-公开
标题翻译：代数分布的定量分析装置
公开(公告)号：WO2007003344A3
公开(公告)日：2007-04-26
申请号：PCT/EP2006006328
申请日：2006-06-29
申请人： BIOCRATES LIFE SCIENCES GMBH , RAMSAY STEVEN LEWIS , GUGGENBICHLER WOLFGANG , WEINBERGER KLAUS MICHAEL , GRABER ARMIN , STOEGGL WOLFGANG MARKUS
发明人： RAMSAY STEVEN LEWIS , GUGGENBICHLER WOLFGANG , WEINBERGER KLAUS MICHAEL , GRABER ARMIN , STOEGGL WOLFGANG MARKUS
IPC分类号： C12Q1/68 , G01N33/68 , G06F19/00 , G06F19/28
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： The present invention relates to a device, in particular to a sample preparation device for the quantitative analysis of a drug and/ or metabolite profile in a biological sample. Moreover, the present invention relates to an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the present invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
摘要翻译：本发明涉及一种装置，特别涉及一种用于定量分析生物样品中药物和/或代谢物谱的样品制备装置。此外，本发明涉及一种用于这种装置的插入件，其具有至少一个内部标准，内部标准本身以及包括该装置的套件。此外，本发明还涉及含有该装置的装置以及使用该装置的生物样品中药物和/或代谢物分布的定量分析方法。

3. 发明申请

WO2008145385A1 BIOMARKER AND METHOD FOR DETERMINING AN OXIDATIVE STRESS LEVEL 审中-公开
标题翻译：生物标记和确定氧化应力水平的方法
公开(公告)号：WO2008145385A1
公开(公告)日：2008-12-04
申请号：PCT/EP2008/004324
申请日：2008-05-30
申请人： BIOCRATES LIFE SCIENCES AG , WEINBERGER, Klaus, Michael , GRABER, Armin , RAMSAY, Steven, Lewis
发明人： WEINBERGER, Klaus, Michael , GRABER, Armin , RAMSAY, Steven, Lewis
IPC分类号： C12Q1/26
CPC分类号： G01N33/5735 , C07C229/36 , C07C317/48 , C07D209/16 , C07D209/20 , C12Q1/26 , G01N2333/90245 , G01N2800/042 , G01N2800/7009
摘要： The present invention relates to a biomarker and a method for determining an oxidative stress level in a biological sample, which employs co- factor-dependent oxidative stress parameters, as well as a kit adapted for carrying out such a method. Preferably the co-factor is tetrahydrobiopterin.
摘要翻译：本发明涉及生物标志物和用于测定生物样品中的氧化应激水平的方法，所述生物标志物采用辅因子依赖性氧化应激参数，以及适用于进行这种方法的试剂盒。辅因子优选为四氢生物喋呤。

4. 发明申请

WO2007003344A2 DEVICE FOR QUANTITATIVE ANALYSIS OF A METABOLITE PROFILE 审中-公开
标题翻译：用于定量分析代谢物特征的装置
公开(公告)号：WO2007003344A2
公开(公告)日：2007-01-11
申请号：PCT/EP2006/006328
申请日：2006-06-29
申请人： BIOCRATES LIFE SCIENCES GMBH , RAMSAY, Steven, Lewis , GUGGENBICHLER, Wolfgang , WEINBERGER, Klaus, Michael , GRABER, Armin , STÖGGL, Wolfgang, Markus
发明人： RAMSAY, Steven, Lewis , GUGGENBICHLER, Wolfgang , WEINBERGER, Klaus, Michael , GRABER, Armin , STÖGGL, Wolfgang, Markus
IPC分类号： G06F19/00 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： The present invention relates to a device, in particular to a sample preparation device for the quantitative analysis of a drug and/ or metabolite profile in a biological sample. Moreover, the present invention relates to an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the present invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
摘要翻译：本发明涉及一种用于定量分析生物样品中的药物和/或代谢物谱的样品制备装置，尤其涉及一种用于定量分析生物样品中的药物和/或代谢物谱的样品制备装置。此外，本发明涉及一种用于这种装置的插入物，其用至少一种内部标准浸渍到内部标准本身中，并涉及一种包括该装置的套件。此外，本发明还涉及包含该装置的装置，以及使用该装置定量分析生物样品中的药物和/或代谢物谱的方法。

5. 发明申请

WO2007003343A1 APPARATUS AND METHOD FOR ANALYZING A METABOLITE PROFILE 审中-公开
标题翻译：用于分析代谢特征的装置和方法
公开(公告)号：WO2007003343A1
公开(公告)日：2007-01-11
申请号：PCT/EP2006/006327
申请日：2006-06-29
申请人： BIOCRATES LIFE SCIENCES GMBH , RAMSAY, Steven, Lewis , STÖGGL, Wolfgang, Markus , WEINBERGER, Klaus, Michael , GRABER, Armin , GUGGENBICHLER, Wolfgang
发明人： RAMSAY, Steven, Lewis , STÖGGL, Wolfgang, Markus , WEINBERGER, Klaus, Michael , GRABER, Armin , GUGGENBICHLER, Wolfgang
IPC分类号： G06F19/00
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： The present invention relates to an apparatus for analyzing a metabolic profile in a biological sample. Further, it relates to a method for analysis of a metabolite profile in a biological sample. To provide such a method and an apparatus capable of identifying relevant information in biological samples to provide a metabolite profile of a biological sample in a reliable way within a manageable time an apparatus for analyzing a metabolite profile in a biological sample (17) containing at least one metabolite is proposed comprising:an input unit (16) for inputting the kind of metabolites to be screened; a controlling unit (12) for determining a parameter set (21) for metabolites preparation and for mass spectrometry analysis depending on the input of the kind of metabolites to be screened; a treatment unit (11) for preparing the metabolites to be screened depending on the determined parameter set (21); mass spectrometer (14) for performing mass spectrometry analysis on prepared metabolites depending on the parameter set (21); a database (13) for storing results of analyzing and parameter sets (21) for metabolite preparation and for mass spectrometry analyses; an evaluation unit (20) for evaluating the results of mass spectrometry by use of reference results stored in the database (13) to output an analysis of the metabolites profile.
摘要翻译：本发明涉及用于分析生物样品中的代谢特征的装置。此外，它涉及生物样品中代谢物分布的分析方法。为了提供这样的方法和装置，能够识别生物样品中的相关信息，以在可管理的时间内以可靠的方式提供生物样品的代谢物分布，用于分析生物样品（17）中的代谢物分布的装置，所述生物样品至少包含提出了一种代谢物，其包括：输入单元（16），用于输入待筛选的代谢物的种类; 控制单元（12），用于根据待筛选的代谢物的种类的输入来确定用于代谢物制备和质谱分析的参数组（21）; 用于根据确定的参数组（21）制备要筛选的代谢物的处理单元（11）; 质谱仪（14），用于根据参数集（21）对制备的代谢物进行质谱分析; 用于存储用于代谢物制备和质谱分析的分析结果和参数组（21）的数据库（13）; 用于通过使用存储在数据库（13）中的参考结果来评估质谱结果以输出代谢物分布的分析的评估单元（20）。

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