专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1995031202A1 CAGE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTIVIRAL AGENTS 审中-公开
标题翻译：笼养化合物，其制备方法及其作为抗病毒剂的使用
公开(公告)号：WO1995031202A1
公开(公告)日：1995-11-23
申请号：PCT/AU1995000283
申请日：1995-05-17
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , MARCUCCIO, Sebastian, Mario , TURNER, Kathleen, Anne , HOLAN, George , OSVATH, Peter , SARGESON, Alan, McLeod , WEIGOLD, Helmut , GEUE, Rodney
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： A61K31/555
CPC分类号： A61K31/557 , C07D257/02
摘要： A method of treatment and/or prophylaxis of a viral infection which comprises administration of an effective amount of a compound of formula (I), wherein M is a metal capable of forming hexacoordinate complexes; Y is an integer between 1 and 6; n is 0 or 1; m is 0 or 1; A to A are NH, N, O and S; R to R and R to R have various values. Some of the compounds are novel.
摘要翻译：一种治疗和/或预防病毒感染的方法，其包括施用有效量的式（I）化合物，其中M是能够形成六配位络合物的金属; Y是1到6之间的整数; n为0或1; m为0或1; A 1至A 6是NH，N，O和S; R 1至R 14和R 3'至R 14'具有各种值。一些化合物是新的。

2. 发明申请

WO1995022330A1 ANTIVIRAL AGENTS 审中-公开
标题翻译：抗病毒剂
公开(公告)号：WO1995022330A1
公开(公告)日：1995-08-24
申请号：PCT/AU1995000076
申请日：1995-02-17
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , MARCUCCIO, Sebastian, Mario , HOLAN, George , COGHLAN, Phillip, Albert , JARVIS, Karen, Elizabeth , ROBERTSON, Alan, Duncan , TURNER, Kathleen, Anne , WEIGOLD, Helmut
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： A61K31/52
CPC分类号： C07D473/00 , A61K31/52 , C07F9/65616 , C07F9/65742
摘要： The invention relates to a method for the treatment and/or prophylaxis of a Hepadnaviridae associated infection which comprises administration of an effective amount of a compound of Formula (1), wherein R1 is hydrogen, halogen, hydroxy, azide, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryloxy, mercapto, optionally substituted alkylthio, optionally substituted amino, optionally substituted hydrazino or optionally substituted hydroxylamino; R2 is hydrogen, halogen, hydroxy, azide, optionally substituted alkoxy, optionally substituted aryloxy, mercapto, optionally substituted alkylthio or optionally substituted amino; R3 and R3' are the same or different and selected from hydrogen, optionally substituted alkyl, halogen, hydroxy, azide, optionally substituted alkoxy, optionally substituted aryloxy, mercapto, optionally substituted thio and optionally substituted amino; or R3 and R3' together form =O, =S, =NOH or =NOR, wherein R is optionally substituted alkyl; and R4, R5 and R6 are the same or different and selected from optionally substituted alkyl, optionally substituted aralkyl, halogen, hydroxy, azide, optionally substituted alkoxy, optionally substituted aryloxy, mercapto, optionally substituted alkylthio, optionally substituted amino, optionally substituted acyl, optionally substituted ester, cyano, carboxy and mono-, di- or tri- phosphate; two of R4, R5 and R6 are joined together to form a cyclic group; or R4, R5 and R6 are joined together to form a cyclic ortho ester group, salts thereof, pharmaceutically acceptable derivatives thereof, pro-drugs thereof, tautomers thereof and/or isomers thereof to a subject requiring said treatment and/or prophylaxis. The invention also relates to novel compounds of Formula (1), processes for their preparation and pharmaceutical or veterinary compositions containing them.
摘要翻译：本发明涉及一种治疗和/或预防肝炎病毒科相关感染的方法，其包括给予有效量的式（1）化合物，其中R 1是氢，卤素，羟基，叠氮化物，任选取代的烷基，任选地取代的烷氧基，任选取代的芳氧基，巯基，任选取代的烷硫基，任选取代的氨基，任选取代的肼基或任选取代的羟基氨基; R 2是氢，卤素，羟基，叠氮化物，任选取代的烷氧基，任选取代的芳氧基，巯基，任选取代的烷硫基或任选取代的氨基; R 3和R 3'相同或不同，选自氢，任选取代的烷基，卤素，羟基，叠氮化物，任选取代的烷氧基，任选取代的芳氧基，巯基，任选取代的硫代和任选取代的氨基; 或R3和R3'一起形成= O，= S，= NOH或= NOR，其中R是任选取代的烷基; 卤素，羟基，叠氮化物，任选取代的烷氧基，任选取代的芳氧基，巯基，任选取代的烷硫基，任选取代的氨基，任选取代的酰基，任选取代的烷基，任选取代的酯，氰基，羧基和一，二或三磷酸酯; R4，R5和R6中的两个连接在一起形成环状基团; 或R 4，R 5和R 6连接在一起以形成环状原酸酯基团，其盐，其药学上可接受的衍生物，其前药，其互变异构体和/或其异构体，用于需要所述治疗和/或预防的对象。本发明还涉及式（1）的新化合物，其制备方法和含有它们的药物或兽药组合物。

3. 发明申请

WO1992000078A1 ANTIVIRAL AGENTS CONTAINING HETEROPOLYTUNGSTATE 审中-公开
标题翻译：含有异黄酮的防腐剂
公开(公告)号：WO1992000078A1
公开(公告)日：1992-01-09
申请号：PCT/AU1991000280
申请日：1991-06-28
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , FAIRFIELD HOSPITAL BOARD , MACFARLANE BURNET CENTRE FOR MEDICAL RESEARCH ... , WEIGOLD, Helmut , HOLAN, George , MARCUCCIO, Sebastian, Mario , BIRCH, Christopher, John , GUST, Ian, David
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , FAIRFIELD HOSPITAL BOARD , MACFARLANE BURNET CENTRE FOR MEDICAL RESEARCH ...
IPC分类号： A61K31/66
CPC分类号： A61K33/24 , A61K31/28 , A61K31/295 , A61K31/315 , A61K31/66 , A61K33/26 , A61K33/30 , A61K33/42 , A61K45/06 , C01B25/45 , C01B25/451
摘要： Heteropolytungstate compounds of general formulae (I), wherein M is Co, Fe, Zn, FeOA, FeO1/2; Cp represents an optionally substituted cyclopentadienyl residue; A is a monovalent or divalent cation or mixture of such cations; m is the number of cations necessary for electrical neutrality of the molecule; or pharmaceutically acceptable derivatives thereof. Pharmaceutical compositions or methods for the treatment or prophylaxis of retrovirus-associated infection which involve the use of such compounds.
摘要翻译：通式（I）的异多钨酸盐化合物，其中M为Co，Fe，Zn，FeOA，FeO1 / 2; Cp表示任选取代的环戊二烯基残基; A是这种阳离子的一价或二价阳离子或混合物; m是分子电中性所必需的阳离子数; 或其药学上可接受的衍生物。用于治疗或预防涉及使用这些化合物的逆转录病毒相关感染的药物组合物或方法。

4. 发明申请

WO1995011033A1 POLYOXOMETALLATES IN THE TREATMENT OF FLAVIVIRUS INFECTIONS 审中-公开
标题翻译：治疗感染FLAVIVIRUS的多羟基化合物
公开(公告)号：WO1995011033A1
公开(公告)日：1995-04-27
申请号：PCT/AU1994000641
申请日：1994-10-21
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , WEIGOLD, Helmut
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , A61K33/26 , A61K33/42 , Y02A50/387 , Y02A50/389
摘要： Pharmaceutical compositions containing polyoxometallates and pharmaceutically acceptable derivatives thereof. The use of such compounds or compositions in therapy for the treatment or prophylaxis of infections by viruses which are confirmed or probable members of the family Flaviviridae including Hepatitis C.
摘要翻译：含有多金属氧酸盐及其药学上可接受的衍生物的药物组合物。这种化合物或组合物在治疗中用于治疗或预防病毒感染的用途，这些病毒是确认或可能的黄病毒科（包括丙型肝炎）家族的成员。

5. 发明申请

WO1993021934A1 HETEROPOLYTUNGSTATES IN THE TREATMENT OF FLAVIVIRUS INFECTIONS 审中-公开
标题翻译：黄疸病毒治疗感染病毒感染
公开(公告)号：WO1993021934A1
公开(公告)日：1993-11-11
申请号：PCT/AU1993000192
申请日：1993-04-30
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , WEIGOLD, Helmut , BARTHOLOMEUSZ, Angeline, Ingrid , HOLAN, George , MARCUCCIO, Sebastian, Mario , WRIGHT, Peter, James
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , Y02A50/385 , Y02A50/387
摘要： Pharmaceutical compositions containing heteropolytungstates and pharmaceutically acceptable derivatives thereof. The use of such compounds or compositions in therapy for the treatment or prophylaxis of infections by viruses which are confirmed or probable members of the family Flaviviridae.
摘要翻译：含有多钨酸盐及其药学上可接受的衍生物的药物组合物。这些化合物或组合物在治疗中用于治疗或预防病毒感染的用途，这些病毒是黄病毒科的证实或可能的成员。

6. 发明申请

WO1994012192A1 ANTIVIRAL AGENTS 审中-公开
标题翻译：抗病毒剂
公开(公告)号：WO1994012192A1
公开(公告)日：1994-06-09
申请号：PCT/AU1993000606
申请日：1993-11-29
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , WEIGOLD, Helmut , BARTHOLOMEUSZ, Angeline, Ingrid , MARCUCCIO, Sebastian, Mario , HOLAN, George
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , C01G41/006 , C01P2002/82 , C01P2006/80 , C01P2006/82 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： Heteropolytungstates having anti-flaviviral activity having the general formulae (I) to (VII): (I) An[XW12O40] wherein X is selected from P , Si , Ge , Co , Co , Zn , Cu , B , H 2, Al , Fe , V , Ga , Mn , C . (II) An[X2W18O62] wherein X is P ; (III) An[XW11O39] wherein X is selected from P , Si , Ge , B , Al , Ga , Fe , Co ; (IV) An[XW9O34] wherein X is selected from P , Si , Ge ; (V) An[X2W17-mMmO61] wherein X is P , M is Mo , and m is 0, 1, 2, 4, or 5; (VI) An[X2W15-mMmO56] wherein X is P , M is V or Mo , and m is 0 or 1; (VII) An[XM2W9O39] wherein X is P, and M is Zr; and wherein in each of the general formulae (I) to (VII), A is a cation, and n is the number of cations necessary for electrical neutrality of the molecule; or dimers, hydrates or pharmaceutically acceptable derivatives thereof. Pharmaceutical compositions and methods for the treatment or prophylaxis of a flaviviral-associated infection which involve the use of these compounds are also disclosed.
摘要翻译：具有通式（I）至（VII）的抗黄病毒活性的异多钨酸盐：（I）An [XW12O40]其中X选自P v，Si IV，Ge IV，Co II， Co III，Zn II，Cu II，B III，H 2，Al III，Fe III，V V，Ga III，Mn IV，，C 。（II）An [X2W18O62]其中X为P;; （III）An [XW11O39]其中X选自PⅤ，Ⅳ，Ⅵ，Ⅵ，Ⅳ，Ⅳ，Ⅵa，Ⅳ，Ⅲ，Ⅳ >; （IV）[XW9O34]其中X选自PⅤ，SiⅣ，ⅣⅣ; （Ⅴ）An [X2W17-mMmO61]其中X为PⅤ，M为MoⅥ，m为0,1,2,4或5; （Ⅵ）[X2W15-mMmO56]其中X为PⅤ，M为VⅤ或MoⅥ，m为0或1; （Ⅶ）[XM2W9O39]其中X为P，M为Zr; 并且其中在每个通式（I）至（VII）中，A是阳离子，n是分子的电中性所必需的阳离子数; 或二聚体，水合物或其药学上可接受的衍生物。还公开了用于治疗或预防涉及使用这些化合物的黄病毒相关感染的药物组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式