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1. 发明申请

WO2004109289A1 METHOD OF DIAGNOSING SARS CORONA VIRUS INFECTION 审中-公开
标题翻译：诊断SARS CORONA病毒感染的方法
公开(公告)号：WO2004109289A1
公开(公告)日：2004-12-16
申请号：PCT/SG2004/000174
申请日：2004-06-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TAN, Yee-Joo , GOH, Phuay-Yee , FIELDING, Burtram, Clinton , SHEN, Shuo , LIM, Seng, Gee , HONG, Wan, Jin , RUAN, Yijun , WEI, Chia, Lin
发明人： TAN, Yee-Joo , GOH, Phuay-Yee , FIELDING, Burtram, Clinton , SHEN, Shuo , LIM, Seng, Gee , HONG, Wan, Jin , RUAN, Yijun , WEI, Chia, Lin
IPC分类号： G01N33/68
CPC分类号： G01N33/56983 , C07K16/10 , G01N2333/165
摘要： The present invention relates to methods of detecting the presence or absence of antibody to SARS coronavirus in a sample, based on the discovery that the S, M, E, N and U274 proteins of SARS coronavirus are antigenic. Such methods may be used to diagnose whether a patient has been infected by or exposed to SARS coronavirus. Antibodies directed against S, M, E, N and U274 proteins of SARS are also provided.
摘要翻译：基于SARS冠状病毒的S，M，E，N和U274蛋白质是抗原性的发现，本发明涉及检测样品中SARS冠状病毒抗体的存在或不存在的方法。这种方法可用于诊断患者是否已被SARS冠状病毒感染或暴露于SARS冠状病毒。还提供针对SARS的S，M，E，N和U274蛋白的抗体。

2. 发明申请

WO2007106047A8 NUCLEIC ACID INTERACTION ANALYSIS 审中-公开
标题翻译：核酸相互作用分析
公开(公告)号：WO2007106047A8
公开(公告)日：2009-07-23
申请号：PCT/SG2007000069
申请日：2007-03-09
申请人： AGENCY SCIENCE TECH & RES , RUAN YIJUN , FULLWOOD MELISSA JANE , WEI CHIA LIN
发明人： RUAN YIJUN , FULLWOOD MELISSA JANE , WEI CHIA LIN
IPC分类号： C12N15/00 , C12N15/66 , C12Q1/68
CPC分类号： C12N15/1065 , C12Q1/6804 , C12Q2525/197 , C12Q2525/131 , C12Q2521/313 , C12Q2531/113 , C12Q2525/191 , C12Q2523/101
摘要： The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two polynucleotides from a nucleic acid-protein complex. The oligonucleotide comprises at least one first tag and at least one second tag, wherein the first and second tags are obtained from a nucleic acid-protein complex.
摘要翻译：本发明提供分离的寡核苷酸和使用分离的寡核苷酸从核酸 - 蛋白复合物检测和/或鉴定至少两种多核苷酸的方法。寡核苷酸包含至少一个第一标签和至少一个第二标签，其中第一个和第二个标签是从核酸 - 蛋白质复合物获得的。

3. 发明申请

WO2015130832A1 AGENTS FOR ENHANCEMENT OF PRODUCTION OF BIOFUEL PRECURSORS IN MICROALGAE 审中-公开
标题翻译：用于增强微生物中生物体前体的生物活性剂
公开(公告)号：WO2015130832A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017586
申请日：2015-02-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WEI, Chia-Lin , NGAN, Chew Yee , WONG, Chee Hong , CHOI, Cindy
发明人： WEI, Chia-Lin , NGAN, Chew Yee , WONG, Chee Hong , CHOI, Cindy
IPC分类号： C12P7/64 , C12N15/74 , C12N15/31 , C12N1/13
CPC分类号： C12N15/8247 , C07K14/405 , C12P7/64
摘要： We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.
摘要翻译：我们确定了调节生物体中脂质生成和活性的17个转录因子基因。我们随后详细描述了其中一个（psr1）。描述了用于增强或增加生物体中脂质生成的构建体，方法和系统。

4. 发明申请

WO2007106047A1 NUCLEIC ACID INTERACTION ANALYSIS 审中-公开
标题翻译：核酸相互作用分析
公开(公告)号：WO2007106047A1
公开(公告)日：2007-09-20
申请号：PCT/SG2007/000069
申请日：2007-03-09
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , RUAN, Yijun , FULLWOOD, Melissa Jane , WEI, Chia Lin
发明人： RUAN, Yijun , FULLWOOD, Melissa Jane , WEI, Chia Lin
IPC分类号： C12N15/00 , C12N15/66 , C12Q1/68
CPC分类号： C12N15/1065 , C12Q1/6804 , C12Q2525/197 , C12Q2525/131 , C12Q2521/313 , C12Q2531/113 , C12Q2525/191 , C12Q2523/101
摘要： The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two polynucleotides from a nucleic acid-protein complex. The oligonucleotide comprises at least one first tag and at least one second tag, wherein the first and second tags are obtained from a nucleic acid-protein complex.
摘要翻译：本发明提供分离的寡核苷酸和使用分离的寡核苷酸从核酸 - 蛋白复合物检测和/或鉴定至少两种多核苷酸的方法。所述寡核苷酸包含至少一个第一标签和至少一个第二标签，其中所述第一标签和第二标签是从核酸 - 蛋白质复合物获得的。

5. 发明申请

WO2006135342A1 METHOD OF PROCESSING AND/OR GENOME MAPPING OF DITAG SEQUENCES 审中-公开
标题翻译： DITAG序列的处理和/或基因组映射的方法
公开(公告)号：WO2006135342A1
公开(公告)日：2006-12-21
申请号：PCT/SG2006/000151
申请日：2006-06-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , CHIU, Kuo Ping , RUAN, Yijun , WEI, Chia Lin
发明人： CHIU, Kuo Ping , RUAN, Yijun , WEI, Chia Lin
IPC分类号： G06F17/30 , C12Q1/68 , G06F19/00 , C12N15/00 , G01N33/48
CPC分类号： G06F19/28 , G06F19/22
摘要： There is provided a method and system for processing and/or mapping ditag nucleotide sequence(s) to a genome, the ditag sequence comprising the 5' terminal tag and the 3' terminal tag of a nucleic acid molecule or fragment thereof or genomic fragment. The method of processing comprises preparing a database or file comprising at least one ditag sequence. The method of mapping comprises preparing a database or file of ditag(s), and mapping the ditag sequence(s) to the genome, comprising matching the 5' and the 3' terminal tags of the ditag sequence to at least a portion of the genome.
摘要翻译：提供了用于处理和/或将基因组的核苷酸序列映射到基因组的方法和系统，包括核酸分子或其片段的5'末端标签和3'末端标签的基因组序列或基因组片段。所述处理方法包括准备包含至少一个ditag序列的数据库或文件。映射方法包括准备数据库或文件的一个或多个ditag序列，并将该ditag序列映射到基因组，包括将ditag序列的5'和3'末端标签与至少一部分基因组。

6. 发明申请

WO2002095072A1 COLONY ARRAY-BASED cDNA LIBRARY NORMALIZATION BY HYBRIDIZATIONS OF COMPLEX RNA PROBES AND GENE SPECIFIC PROBES 审中-公开
标题翻译：通过复合RNA探针和基因特异性探针杂交的基于阵列的cDNA文库正常化
公开(公告)号：WO2002095072A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/015113
申请日：2002-05-10
申请人： LARGE SCALE BIOLOGY CORPORATION , WEI, Chia-Lin , RUAN, Yijun , ZHENG, Wenjiin
发明人： WEI, Chia-Lin , RUAN, Yijun , ZHENG, Wenjiin
IPC分类号： C12Q1/68
CPC分类号： C12N15/1096
摘要： Each cell normally has a widely differing number of mRNA transcribed for each gene. Consequently, a fill-length cDNA library constructed from the mRNA would also have a widely differing number of cDNA for each gene. A normalized library of the full-length cDNA of a cell is usful for basic, applied, industrial, and medical research. This invention provides for a method for constructing a normalized full-length cDNA library by probing the members of a non-normalized cDNA library with a library of probes generated from mRNA in order to identigy the cDNA of genes that have low or high expression. A collection of the cDNA from the library of the genes that have low expression would constitute a normalized library of these genes. This invention also provided for a method to reduce the number cDNA of genes that have high expression represented by probing these cDNA with a library of probes generated from a small randomly selected number of these cDNA. cDNA that hybridize are represented within this small randomly selectes number of cDNA, while cDNA that do not hybridize are not represented. The latter cDNA can undergo further such probing to further reduce the number of cDNA represented. The cDNA from the library of the genes that have low expression and the randomly selected highly expressed cDNA would constitute a normalized library of these genes.
摘要翻译：每个细胞通常具有每个基因转录的mRNA数量差异很大。因此，由mRNA构建的填充长度cDNA文库对于每个基因也将具有大量不同数量的cDNA。细胞全长cDNA的归一化库对于基础，应用，工业和医学研究是有用的。本发明提供了通过用mRNA产生的探针文库探测非标准化cDNA文库的成员来构建归一化全长cDNA文库的方法，以便鉴定具有低表达或高表达的基因的cDNA。来自具有低表达的基因的文库的cDNA的集合将构成这些基因的归一化文库。本发明还提供了通过用随机选择数量小的这些cDNA产生的探针文库探索这些cDNA来减少具有高表达性的基因的cDNA数量的方法。在该小的随机选择数量的cDNA中表达杂交的cDNA，而不表示不杂交的cDNA。后一种cDNA可以进一步进行这种探测，以进一步减少所表达的cDNA的数量。来自低表达基因的文库和随机选择的高表达cDNA的cDNA将构成这些基因的归一化文库。

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