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1. 发明申请

WO2008070301A2 PREDICTING LUNG CANCER SURVIVAL USING GENE EXPRESSION 审中-公开
标题翻译：使用基因表达预测肺癌存活
公开(公告)号：WO2008070301A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/081938
申请日：2007-10-19
申请人： WASHINGTON UNIVERSITY IN ST. LOUIS , YOU, Ming , LU, Yan , GOVINDAN, Ramaswamy , WATSON, Mark A.
发明人： YOU, Ming , LU, Yan , GOVINDAN, Ramaswamy , WATSON, Mark A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： The present invention provides a plurality of biomarkers for predicting survival of a subject with a lung cancer. More specifically, the present invention relates to methods of predicting survival of a subject with a lung cancer, a kit for predicting survival of a subject with a lung cancer, and an array for predicting survival of a subject with lung cancer.
摘要翻译：本发明提供了用于预测患有肺癌的受试者的存活的多种生物标志物。更具体地，本发明涉及预测患有肺癌的受试者的存活的方法，用于预测患有肺癌的受试者的存活的试剂盒以及用于预测患有肺癌的受试者的存活的阵列。

2. 发明申请

WO2005111559A2 RAMAN SPECTROMETER 审中-公开
标题翻译：拉曼光谱仪
公开(公告)号：WO2005111559A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/015444
申请日：2005-05-04
申请人： DELTA NU , UNIVERSITY OF WYOMING , CARRON, Keith T. , WATSON, Mark A. , BULLER, Shane A.
发明人： CARRON, Keith T. , WATSON, Mark A. , BULLER, Shane A.
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/4424 , G01N21/65 , G01N2201/0221 , G01N2201/0612 , G01N2201/0813
摘要： A system, method and apparatus for taking a Raman spectrum of a sample is disclosed. In one embodiment, for example, an integrated Raman spectrometer (120) is provided. In another embodiment, a portable Raman spectrometer (320) is provided. In another embodiment, a Raman spectrometer (20) is provided comprising a collimated beam tube (32) for transmitting excitation radiation to an external optical system, such as a microscope (430), a telescope or a camera lens. In another embodiment, a method for correcting a Raman spectrum for background interference is provided. In yet another embodiment, a method for rejecting fluorescence in a Raman spectrometer is provided. A chemical reactor (930) comprising a built-in Raman detector for monitoring a chemical reaction in a reaction chamber of the reactor is also provided.
摘要翻译：公开了一种用于获取样品的拉曼光谱的系统，方法和装置。在一个实施例中，例如，提供了集成拉曼光谱仪（120）。在另一个实施例中，提供便携式拉曼光谱仪（320）。在另一个实施例中，提供了拉曼光谱仪（20），其包括用于将激发辐射传输到诸如显微镜（430），望远镜或相机透镜的外部光学系统的准直束管（32）。在另一实施例中，提供了用于校正背景干扰的拉曼光谱的方法。在另一个实施方案中，提供了一种用于在拉曼光谱仪中排除荧光的方法。还提供了包括用于监测反应器的反应室中的化学反应的内置拉曼检测器的化学反应器（930）。

3. 发明申请

WO0018783A9 MAMMAGLOBIN, A SECRETED MAMMARY-SPECIFIC BREAST CANCER PROTEIN 审中-公开
标题翻译： MAMMAGLOBIN，一种分泌乳腺特异性乳腺癌蛋白
公开(公告)号：WO0018783A9
公开(公告)日：2000-09-21
申请号：PCT/US9922616
申请日：1999-09-29
申请人： UNIV WASHINGTON , WATSON MARK A , FLEMING TIMOTHY P
发明人： WATSON MARK A , FLEMING TIMOTHY P
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , C07K14/47 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/577 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4721 , C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G01N2800/52
摘要： A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA enconding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
摘要翻译：公开了纯化和分离的DNA序列和编码的乳腺特异性分泌蛋白，乳腺球蛋白。还公开了基于乳腺癌细胞的乳腺球蛋白的过表达和分泌来检测乳腺癌的方法。该方法检测和/或定量乳腺球蛋白或包含乳腺球蛋白的mRNA的存在。还公开了用表达乳腺球蛋白的肿瘤治疗乳腺癌患者的基于免疫疗法的方法。该方法涉及使用乳腺球蛋白抗原诱导针对肿瘤的体液和/或细胞介导的免疫应答。

4. 发明申请

WO2005111559A3 RAMAN SPECTROMETER 审中-公开
标题翻译：拉曼光谱仪
公开(公告)号：WO2005111559A3
公开(公告)日：2007-05-18
申请号：PCT/US2005015444
申请日：2005-05-04
申请人： DELTA NU , UNIV WYOMING , CARRON KEITH T , WATSON MARK A , BULLER SHANE A
发明人： CARRON KEITH T , WATSON MARK A , BULLER SHANE A
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/4424 , G01N21/65 , G01N2201/0221 , G01N2201/0612 , G01N2201/0813
摘要： A system, method and apparatus for taking a Raman spectrum of a sample is disclosed. In one embodiment, for example, an integrated Raman spectrometer (120) is provided. In another embodiment, a portable Raman spectrometer (320) is provided. In another embodiment, a Raman spectrometer (20) is provided comprising a collimated beam tube (32) for transmitting excitation radiation to an external optical system, such as a microscope (430), a telescope or a camera lens. In another embodiment, a method for correcting a Raman spectrum for background interference is provided. In yet another embodiment, a method for rejecting fluorescence in a Raman spectrometer is provided. A chemical reactor (930) comprising a built-in Raman detector for monitoring a chemical reaction in a reaction chamber of the reactor is also provided.
摘要翻译：公开了一种用于获取样品的拉曼光谱的系统，方法和装置。在一个实施例中，例如，提供了集成拉曼光谱仪（120）。在另一个实施例中，提供便携式拉曼光谱仪（320）。在另一个实施例中，提供了拉曼光谱仪（20），其包括用于将激发辐射传输到诸如显微镜（430），望远镜或相机透镜的外部光学系统的准直束管（32）。在另一实施例中，提供了用于校正背景干扰的拉曼光谱的方法。在另一个实施方案中，提供了一种用于在拉曼光谱仪中排除荧光的方法。还提供了包括用于监测反应器的反应室中的化学反应的内置拉曼检测器的化学反应器（930）。

5. 发明申请

WO1996038463A1 DNA SEQUENCE AND ENCODED MAMMARY-SPECIFIC BREAST CANCER PROTEIN 审中-公开
标题翻译： DNA序列和编码的特异性乳腺癌蛋白
公开(公告)号：WO1996038463A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008235
申请日：1996-05-31
申请人： WASHINGTON UNIVERSITY , WATSON, Mark, A. , FLEMING, Timothy, P.
发明人： WASHINGTON UNIVERSITY
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/112 , G01N33/57415
摘要： A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
摘要翻译：公开了纯化和分离的DNA序列和编码的乳腺特异性蛋白，乳腺球蛋白。还公开了基于乳腺癌细胞的乳腺球蛋白的过量表达和分泌来检测乳腺癌的方法。该方法检测和/或定量乳腺球蛋白或编码乳腺珠蛋白的mRNA的存在。

6. 发明申请

WO2013122991A1 INTEGRATED MOBILE APPLICATION DEVELOPMENT PLATFORM 审中-公开
标题翻译：综合移动应用开发平台
公开(公告)号：WO2013122991A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025850
申请日：2013-02-13
申请人： ANTENNA SOFTWARE, INC. , WATSON, Mark A. , WEIGHILL-SMITH, Philip C. , DUFFIN, Paul A. , VLK, Petr , KURCAB, Szymon W. , MALOTA, Slawomir P. , CORA, Jaroslaw K. , MISIOLEK, Maciej K. , DUDA, Pawel P. , KARPINSKI, Michal J. , GEORGE, Joseph , BURDA, Marcin W.
发明人： WATSON, Mark A. , WEIGHILL-SMITH, Philip C. , DUFFIN, Paul A. , VLK, Petr , KURCAB, Szymon W. , MALOTA, Slawomir P. , CORA, Jaroslaw K. , MISIOLEK, Maciej K. , DUDA, Pawel P. , KARPINSKI, Michal J. , GEORGE, Joseph , BURDA, Marcin W.
IPC分类号： G06F15/16
CPC分类号： H04W4/003 , G06F8/30 , G06F8/70 , H04W4/24 , H04W4/50 , H04W4/60
摘要： Provided herein is a method of and system for providing a software-as-a-service platform comprising implementing a mobile client application build phase to enable a developer-user to build a mobile client application; implementing, with a server computer, a mobile client application run phase to enable an end-user of the mobile client application to download and execute the mobile client application on a mobile device; and implementing a mobile client application manage phase to enable a manager-user to manage and analyze the usage of the mobile client application by the end-user.
摘要翻译：本文提供了一种用于提供软件即服务平台的方法和系统，包括实现移动客户端应用程序构建阶段，以使开发者用户构建移动客户端应用程序; 使用服务器计算机实现移动客户端应用程序运行阶段，以使得移动客户端应用的最终用户能够在移动设备上下载和执行移动客户端应用; 以及实施移动客户端应用程序管理阶段，以使管理者用户能够管理和分析最终用户对移动客户端应用的使用。

7. 发明申请

WO2008070301A3 PREDICTING LUNG CANCER SURVIVAL USING GENE EXPRESSION 审中-公开
公开(公告)号：WO2008070301A3
公开(公告)日：2008-12-24
申请号：PCT/US2007081938
申请日：2007-10-19
申请人： UNIV ST LOUIS , YOU MING , LU YAN , GOVINDAN RAMASWAMY , WATSON MARK A
发明人： YOU MING , LU YAN , GOVINDAN RAMASWAMY , WATSON MARK A
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： The present invention provides a plurality of biomarkers for predicting survival of a subject with a lung cancer. More specifically, the present invention relates to methods of predicting survival of a subject with a lung cancer, a kit for predicting survival of a subject with a lung cancer, and an array for predicting survival of a subject with lung cancer.

8. 发明申请

WO2008064365A9 MULTI-CHANNEL MAGNETIC RESONANCE COIL ARRAY ASSEMBLY 审中-公开
标题翻译：多通道磁共振线圈阵列
公开(公告)号：WO2008064365A9
公开(公告)日：2008-08-21
申请号：PCT/US2007085501
申请日：2007-11-26
申请人： MR INSTR INC , BRADSHAW KENNETH M , JONES MICHAEL S , HOLWELL JOSHUA J , SCHILLAK SCOTT M , WAKS MATTHEW T , WATSON MARK A , TRAMM BRANDON J , PETROPOULOS LABROS L
发明人： BRADSHAW KENNETH M , JONES MICHAEL S , HOLWELL JOSHUA J , SCHILLAK SCOTT M , WAKS MATTHEW T , WATSON MARK A , TRAMM BRANDON J , PETROPOULOS LABROS L
IPC分类号： G01R33/34 , G01R33/3415
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/34084 , G01R33/3415 , G01R33/345 , G01R33/3453 , G01R33/3642 , G01R33/365 , G01R33/422 , G01R33/5659
摘要： This document discusses, among other things, a system and method for a coil array having a plurality of resonant elements capable of radiof requency transmission, reception, or both transmission and reception. One example includes a receive-only coil disposed within a transmit-only coil. Adjacent resonant elements are decoupled from one another by both capacitive elements and by the geometric configuration of the elements. Cables are coupled to each resonant element and are gathered at a junction in a particular manner.
摘要翻译：本文件尤其涉及一种线圈阵列的系统和方法，该系统和方法具有能够进行无线电频率传输，接收或传输和接收两者的多个谐振元件。一个示例包括设置在仅发射线圈内的仅接收线圈。相邻的谐振元件通过电容元件和元件的几何构型彼此分离。电缆耦合到每个谐振元件并以特定的方式聚集在结点处。

9. 发明申请

WO2008064365A3 MULTI-CHANNEL MAGNETIC RESONANCE COIL ARRAY ASSEMBLY 审中-公开
标题翻译：多通道磁共振线圈阵列组件
公开(公告)号：WO2008064365A3
公开(公告)日：2008-07-10
申请号：PCT/US2007085501
申请日：2007-11-26
申请人： MR INSTR INC , BRADSHAW KENNETH M , JONES MICHAEL S , HOLWELL JOSHUA J , SCHILLAK SCOTT M , WAKS MATTHEW T , WATSON MARK A , TRAMM BRANDON J , PETROPOULOS LABROS L
发明人： BRADSHAW KENNETH M , JONES MICHAEL S , HOLWELL JOSHUA J , SCHILLAK SCOTT M , WAKS MATTHEW T , WATSON MARK A , TRAMM BRANDON J , PETROPOULOS LABROS L
IPC分类号： G01R33/34 , G01R33/3415
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/34084 , G01R33/3415 , G01R33/345 , G01R33/3453 , G01R33/3642 , G01R33/365 , G01R33/422 , G01R33/5659
摘要： This document discusses, among other things, a system and method for a coil array having a plurality of resonant elements capable of radiof requency transmission, reception, or both transmission and reception. One example includes a receive-only coil disposed within a transmit-only coil. Adjacent resonant elements are decoupled from one another by both capacitive elements and by the geometric configuration of the elements. Cables are coupled to each resonant element and are gathered at a junction in a particular manner.
摘要翻译：本文件尤其讨论了用于具有能够进行射频频率传输，接收或发射和接收两者的多个谐振元件的线圈阵列的系统和方法。一个示例包括设置在仅发射线圈内的只收线圈。相邻的谐振元件通过电容元件和元件的几何配置彼此解耦。电缆被耦合到每个谐振元件并且以特定方式聚集在接合点处。

10. 发明申请

WO0018783B1 MAMMAGLOBIN, A SECRETED MAMMARY-SPECIFIC BREAST CANCER PROTEIN 审中-公开
标题翻译： MAMMAGAGOBOBIN，一种秘密的乳腺癌特异性乳腺癌蛋白
公开(公告)号：WO0018783B1
公开(公告)日：2000-05-11
申请号：PCT/US9922616
申请日：1999-09-29
申请人： UNIV WASHINGTON , WATSON MARK A , FLEMING TIMOTHY P
发明人： WATSON MARK A , FLEMING TIMOTHY P
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , C07K14/47 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/577 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4721 , C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G01N2800/52
摘要： A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA enconding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
摘要翻译：公开了纯化和分离的DNA序列和编码的乳房特异性分泌蛋白乳房珠蛋白。还公开了基于乳腺癌细胞过度表达和分泌乳房珠蛋白来检测乳腺癌的方法。该方法检测和/或定量乳房珠蛋白或乳腺球蛋白mRNA的存在。还公开了用乳腺球蛋白表达肿瘤治疗乳腺癌患者的基于免疫疗法的方法。该方法涉及使用乳房珠蛋白抗原诱导针对肿瘤的体液和/或细胞介导的免疫应答。

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