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1. 发明申请

WO2009079450A3 COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER 审中-公开
标题翻译：预测人乳腺癌转移能力的拷贝数改变
公开(公告)号：WO2009079450A3
公开(公告)日：2009-10-01
申请号：PCT/US2008086815
申请日：2008-12-15
申请人： VERIDEX LLC , ZHANG YI , YU JACK X , JIANG YUQIU , WANG YIXIN
发明人： ZHANG YI , YU JACK X , JIANG YUQIU , WANG YIXIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.
摘要翻译：本说明书中公开了通过总结染色体的预定部分中的所有SNP（单核苷酸多态性）的显着性以定义具有预后价值的染色体区域来定义具有预后价值的染色体区域的方法。基于特定基因中的SNP，可以提供更准确的乳腺癌预后。

2. 发明申请

WO2009079450A2 COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER 审中-公开
标题翻译：预测人乳腺癌的分类能力的复制编号
公开(公告)号：WO2009079450A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/086815
申请日：2008-12-15
申请人： VERIDEX, LLC , ZHANG, Yi , YU, Jack, X. , JIANG, Yuqiu , WANG, Yixin
发明人： ZHANG, Yi , YU, Jack, X. , JIANG, Yuqiu , WANG, Yixin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.
摘要翻译：在本说明书中公开的是通过总结染色体预定部分中所有SNP（单核苷酸多态性）的意义来定义预后价值的染色体区域来定义预后价值的染色体区域的方法。基于特定基因的SNP，可以提供更准确的乳腺癌预后。

3. 发明申请

WO2009064901A2 DIAGNOSTIC BIOMARKERS OF DIABETES 审中-公开
标题翻译：糖尿病诊断生物标志物
公开(公告)号：WO2009064901A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083424
申请日：2008-11-13
申请人： VERIDEX, LLC , PALMA, John, F. , BACKUS, John, W. , ZHANG, Yi , WANG, Yixin , YU, Jack, X. , VENER, Tatiana , DERECHO, Carlo , LEE, Dong, U.
发明人： PALMA, John, F. , BACKUS, John, W. , ZHANG, Yi , WANG, Yixin , YU, Jack, X. , VENER, Tatiana , DERECHO, Carlo , LEE, Dong, U.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.
摘要翻译：公开了用于鉴定在诊断患有糖尿病前状态和明显II型糖尿病的患者的PBMC中差异表达的基因组的方法，显示3个基因和10个基因特征以准确预测患者的糖尿病疾病状态。该应用还描述了在护理设施点的患者中快速诊断糖尿病疾病状态的试剂盒。

4. 发明申请

WO2008045133A3 MOLECULAR ASSAY TO PREDICT RECURRENCE OF DUKES' B COLON CANCER 审中-公开
标题翻译：分子生物学检测预测D癌B结肠癌的复发
公开(公告)号：WO2008045133A3
公开(公告)日：2008-09-12
申请号：PCT/US2007005823
申请日：2007-03-05
申请人： VERIDEX LLC , WANG YIXIN , MAZUMDER ABHIJIT , JIANG YUQIU , BRIGGS THOMAS
发明人： WANG YIXIN , MAZUMDER ABHIJIT , JIANG YUQIU , BRIGGS THOMAS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： Assessing colorectal cancer status by determining differential expression of a collection of genes. Specially used to distinguish between relapsing and non-relapsing Duke's B operated patients.
摘要翻译：通过确定基因集合的差异表达来评估结肠直肠癌状态。特别用于区分复发和非复发的公爵B手术患者。

5. 发明申请

WO2008095152A2 METHODS AND MATERIALS FOR IDENTIFYING THE ORIGIN OF A CARCINOMA OF UNKNOWN PRIMARY ORIGIN 审中-公开
标题翻译：鉴别原发未成年原发癌起源的方法和材料
公开(公告)号：WO2008095152A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052741
申请日：2008-02-01
申请人： VERIDEX, LLC , WANG, Yixin , MAZUMDER, Abhijit , TALANTOV, Dmitri , JATKOE, Timothy , BADEN, Jonathan F.
发明人： WANG, Yixin , MAZUMDER, Abhijit , TALANTOV, Dmitri , JATKOE, Timothy , BADEN, Jonathan F.
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
摘要翻译：本发明提供了通过获得含有转移性细胞的样品来鉴定未知来源的转移的起源的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成线性判别分析，其中线性判别分析将生物标志物与参照标准化; 并对每个生物标志物的灵敏度和特异性进行优化，对癌症的患病率进行权衡，并根据线性判别分析确定的最高可能性选择确定起源的组织，或确定癌症不是从特定组的癌症; 并任选地测量对一种或多种其他不同癌的特异性的生物标志物，并重复用于其他生物标志物的步骤。

6. 发明申请

WO2008030845A8 METHODS OF PREDICTING DISTANT METASTASIS OF LYMPH NODE-NEGATIVE PRIMARY BREAST CANCER USING BIOLOGICAL PATHWAY GENE EXPRESSION ANALYSIS 审中-公开
标题翻译：使用生物路径基因表达分析预测淋巴结阴性原发性乳腺癌的距离性分期的方法
公开(公告)号：WO2008030845A8
公开(公告)日：2009-11-05
申请号：PCT/US2007077593
申请日：2007-09-05
申请人： VERIDEX LLC , WANG YIXIN , YU JACK X , ZHANG YI
发明人： WANG YIXIN , YU JACK X , ZHANG YI
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method for predicting distant metastasis of lymph node negative primary breast cancer by obtaining breast cancer cells; isolating nucleic acid and/or protein from the cells; and analyzing the nucleic acid and/or protein to determine the presence, expression level or status of a Biomarker selected from the pathways in Table 2.
摘要翻译：本发明提供一种通过获得乳腺癌细胞预测淋巴结阴性原发性乳腺癌远处转移的方法; 从细胞分离核酸和/或蛋白质; 并分析核酸和/或蛋白质以确定选自表2中的途径的生物标志物的存在，表达水平或状态。

7. 发明申请

WO2006108135A9 LASER MICRODISSECTION AND MICROARRAY ANALYSIS OF BREAST TUMORS REVEAL ESTROGEN RECEPTOR RELATED GENES AND PATHWAYS 审中-公开
标题翻译：乳腺肿瘤的激光微观分析和微观分析相关基因和途径
公开(公告)号：WO2006108135A9
公开(公告)日：2009-10-15
申请号：PCT/US2006013004
申请日：2006-04-03
申请人： VERIDEX LLC , WANG YIXIN , YU JACK , JIANG YUQIU , YANG FEI , LEHNHARDT SUSAN
发明人： WANG YIXIN , YU JACK , JIANG YUQIU , YANG FEI
IPC分类号： A61K38/00
CPC分类号： C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158

8. 发明申请

WO2009123572A1 REMOTE NODE FOR WAVELENGTH-DIVISION-MULTIPLEXED PASSIVE OPTICAL NETWORK 审中-公开
标题翻译：用于波长多路复用被动光网络的远程节点
公开(公告)号：WO2009123572A1
公开(公告)日：2009-10-08
申请号：PCT/SG2009/000117
申请日：2009-03-31
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WEN, Yang Jing , XU, Zhaowen , CHENG, Xiaofei , WANG, Yixin
发明人： WEN, Yang Jing , XU, Zhaowen , CHENG, Xiaofei , WANG, Yixin
IPC分类号： H04B10/13 , H04J14/02
CPC分类号： H04B10/27 , H04B10/272 , H04J14/0282
摘要： A remote node for a wavelength-division-multiplexed passive optical network (WDM PON). The remote node comprises means for receiving uplink optical signals from one or more optical network units of the WDM PON; a broadband reflector for reflecting a self-seeding portion of the respective uplink optical signals to the respective uplink light sources; and wherein the reflector comprises a gain medium and is configured for receiving a pump optical signal from a central office of the WDM PON for amplifying the self seeding portion of the respective uplink optical signal.
摘要翻译：用于波分复用无源光网络（WDM PON）的远程节点。远程节点包括用于从WDM PON的一个或多个光网络单元接收上行光信号的装置; 宽带反射器，用于将各个上行链路光信号的自播种部分反射到相应的上行链路光源; 并且其中所述反射器包括增益介质，并且被配置为从所述WDM PON的中心局接收泵浦光信号，用于放大所述相应上行链路光信号的自播种部分。

9. 发明申请

WO2009064901A3 DIAGNOSTIC BIOMARKERS OF DIABETES 审中-公开
标题翻译：糖尿病的诊断生物标志物
公开(公告)号：WO2009064901A3
公开(公告)日：2009-09-24
申请号：PCT/US2008083424
申请日：2008-11-13
申请人： VERIDEX LLC , PALMA JOHN F , BACKUS JOHN W , ZHANG YI , WANG YIXIN , YU JACK X , VENER TATIANA , DERECHO CARLO , LEE DONG U
发明人： PALMA JOHN F , BACKUS JOHN W , ZHANG YI , WANG YIXIN , YU JACK X , VENER TATIANA , DERECHO CARLO , LEE DONG U
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.
摘要翻译：公开了用于鉴定在诊断患有糖尿病前期疾病状态和明显II型糖尿病的患者的PBMC中差异表达的基因集的方法，显示3个基因和10个基因标记准确预测患者的糖尿病疾病状态。该应用还描述了用于在护理点处的患者中快速诊断糖尿病疾病状态的试剂盒。

10. 发明申请

WO2008100227A1 DEVICE, SYSTEM AND METHOD USING DUAL DECISION DECODERS FOR ERROR CORRECTION IN OPTICAL RECEIVERS 审中-公开
标题翻译：使用双重判决解码器对光接收器进行错误校正的设备，系统和方法
公开(公告)号：WO2008100227A1
公开(公告)日：2008-08-21
申请号：PCT/SG2008/000050
申请日：2008-02-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , CHEN, Jian , WANG, Yixin , LU, Chao
发明人： CHEN, Jian , WANG, Yixin , LU, Chao
IPC分类号： H04B10/158 , H04L1/20
CPC分类号： H04L1/0045 , H04B10/695 , H04L1/0052 , H04L1/0057 , H04L25/063
摘要： Embodiments of the present invention provide an error correction device providing dual decision levels with internal dynamic decision level adjustments in an optical receiver, the error correction device comprising: a first decision decoder capable of receiving an input signal and of providing a first decision output based on a first decision level; a second decision decoder capable of receiving the input signal and of providing a second decision output based on a second decision level; an XOR gate for receiving the first and second decision outputs, the XOR gate providing a first output of a plurality of ambiguous data bits; a counter for receiving and counting the plurality of ambiguous bits over a period of time; and a decision level adjuster for receiving a count of the plurality of ambiguous bits from the counter, and adjusting the first and second decision levels based on said count.
摘要翻译：本发明的实施例提供了一种纠错装置，其在光接收机中提供具有内部动态决策电平调整的双重判定级别，所述纠错装置包括：第一判决解码器，能够接收输入信号并提供基于第一决策级别; 第二判定解码器，其能够接收所述输入信号并且基于第二判定级别提供第二判定输出; 用于接收第一和第二判定输出的异或门，XOR门提供多个模糊数据位的第一输出; 用于在一段时间内接收和计数多个不明确位的计数器; 以及判定级别调整器，用于从计数器接收多个模糊位的计数，以及基于所述计数调整第一和第二判定级别。

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