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1. 发明申请

WO2011079277A3 GENETIC MARKERS ASSOCIATED WITH DROUGHT TOLERANCE IN MAIZE 审中-公开
标题翻译：遗传标记与玉米耐旱性相关
公开(公告)号：WO2011079277A3
公开(公告)日：2011-10-06
申请号：PCT/US2010062028
申请日：2010-12-23
申请人： SYNGENTA PARTICIPATIONS AG , KISHORE VENKATA KRISHNA , ALTENDORF PAUL , PREST THOMAS JOSEPH , ZINSELMEIER CHRIS , WANG DAOLONG , BRIGGS WILLIAM , GANDHI SONALI , FOSTER DAVID , CHAULK-GRACE CHRISTINE , CLARKE JOSEPH DALLAS , SESSIONS ALLEN , KUST KARI DENISE , REINDERS JON AARON TUCKER , GUTIERREZ ROJAS LIBARDO ANDRES , LI MEIJUAN , WARNER TODD , MARTIN NICHOLAS , MILLER ROBERT LYNN , ARBUCKLE JOHN , SKALLA DALE WAYNE
发明人： KISHORE VENKATA KRISHNA , ALTENDORF PAUL , PREST THOMAS JOSEPH , ZINSELMEIER CHRIS , WANG DAOLONG , BRIGGS WILLIAM , GANDHI SONALI , FOSTER DAVID , CHAULK-GRACE CHRISTINE , CLARKE JOSEPH DALLAS , SESSIONS ALLEN , KUST KARI DENISE , REINDERS JON AARON TUCKER , GUTIERREZ ROJAS LIBARDO ANDRES , LI MEIJUAN , WARNER TODD , MARTIN NICHOLAS , MILLER ROBERT LYNN , ARBUCKLE JOHN , SKALLA DALE WAYNE
IPC分类号： A01H5/00 , C12Q1/68
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/8274 , C12N15/8275 , C12N15/8278 , C12N15/8282 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172 , Y02A40/132
摘要： The presently disclosed subject matter relates to methods and compositions for identifying, selecting, and/or producing drought tolerant maize plants or germplasm. Maize plants or germplasm that have been identified, selected, and/or produced by any of the methods of the presently disclosed subject matter are also provided.
摘要翻译：目前公开的主题涉及用于鉴定，选择和/或产生耐旱玉米植物或种质的方法和组合物。还提供已经通过本公开主题的任何方法鉴定，选择和/或生产的玉米植物或种质。

2. 发明申请

WO2011079277A2 GENETIC MARKERS ASSOCIATED WITH DROUGHT TOLERANCE IN MAIZE 审中-公开
标题翻译：与玉米干旱耐性相关的遗传标记
公开(公告)号：WO2011079277A2
公开(公告)日：2011-06-30
申请号：PCT/US2010/062028
申请日：2010-12-23
申请人： SYNGENTA PARTICIPATIONS AG , KISHORE, Venkata, Krishna , ALTENDORF, Paul , PREST, Thomas, Joseph , ZINSELMEIER, Chris , WANG, Daolong , BRIGGS, William , GANDHI, Sonali , FOSTER, David , CHAULK-GRACE, Christine , CLARKE, Joseph, Dallas , SESSIONS, Allen , KUST, Kari, Denise , REINDERS, Jon Aaron, Tucker , GUTIERREZ ROJAS, Libardo, Andres , LI, Meijuan , WARNER, Todd , MARTIN, Nicholas , MILLER, Robert, Lynn , ARBUCKLE, John , SKALLA, Dale, Wayne
发明人： KISHORE, Venkata, Krishna , ALTENDORF, Paul , PREST, Thomas, Joseph , ZINSELMEIER, Chris , WANG, Daolong , BRIGGS, William , GANDHI, Sonali , FOSTER, David , CHAULK-GRACE, Christine , CLARKE, Joseph, Dallas , SESSIONS, Allen , KUST, Kari, Denise , REINDERS, Jon Aaron, Tucker , GUTIERREZ ROJAS, Libardo, Andres , LI, Meijuan , WARNER, Todd , MARTIN, Nicholas , MILLER, Robert, Lynn , ARBUCKLE, John , SKALLA, Dale, Wayne
IPC分类号： A01H1/02 , A01H5/00 , C12N5/04 , C12Q1/68
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/8274 , C12N15/8275 , C12N15/8278 , C12N15/8282 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172 , Y02A40/132
摘要： The presently disclosed subject matter relates to methods and compositions for identifying, selecting, and/or producing drought tolerant maize plants or germplasm. Maize plants or germplasm that have been identified, selected, and/or produced by any of the methods of the presently disclosed subject matter are also provided.
摘要翻译：目前公开的主题涉及用于鉴定，选择和/或生产耐旱玉米植物或种质的方法和组合物。还提供了已经通过本公开主题的任何方法鉴定，选择和/或生产的玉米植物或种质。

3. 发明申请

WO2010091248A1 METHOD FOR SELECTING STATISTICALLY VALIDATED CANDIDATE GENES 审中-公开
标题翻译：选择统计证实候选基因的方法
公开(公告)号：WO2010091248A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023312
申请日：2010-02-05
申请人： SYNGENTA PARTICIPATIONS AG , KISHORE, Venkata, Krishna , GUO, Zhigang , LI, Min , WANG, Daolong , GUTIERREZ ROJAS, Libardo, Andres , CLARKE, Joseph, Dallas, V. , BYRUM, Joseph
发明人： KISHORE, Venkata, Krishna , GUO, Zhigang , LI, Min , WANG, Daolong , GUTIERREZ ROJAS, Libardo, Andres , CLARKE, Joseph, Dallas, V. , BYRUM, Joseph
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06F19/24
摘要： Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or both of nested association mapping (NAM), and expression QTL analysis (eQTL). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
摘要翻译：本文提供了评估候选基因与群体中感兴趣的性状之间的关联的方法。这些方法包括全基因组关联分析和嵌套关联定位（NAM）和表达QTL分析（eQTL）之一或两者的组合。如果使用GWA和NAM和eQTL中的一个或两个的组合显示与感兴趣的特征呈正相关的标记被选择或优先化。还提供了用于评估候选标记与嵌套生物群体中的性状之间的关联的模型。这些方法包括单标记回归和多标记回归模型。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，作为用于构建连锁图谱，用于基因发现，用于鉴定有助于感兴趣性状的基因以及产生具有所需性状的转基因生物的遗传标记。

4. 发明申请

WO2010065811A1 STATISTICAL VALIDATION OF CANDIATE GENES 审中-公开
标题翻译：糖尿病基因的统计学验证
公开(公告)号：WO2010065811A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066697
申请日：2009-12-04
申请人： SYNGENTA PARTICIPATIONS AG , KISHORE, Venkata, Krishna , WANG, Daolong , GUTIERREZ ROJAS, Libardo, Andres , MARTIN, Nicolas, Federico
发明人： KISHORE, Venkata, Krishna , WANG, Daolong , GUTIERREZ ROJAS, Libardo, Andres , MARTIN, Nicolas, Federico
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06F19/24
摘要： Provided herein are methods for evaluating associations between candidate markers and a trait of interest in a plant population. In various embodiments, the plant population is a breeding population, particularly early stage breeding populations. The methods include obtaining a genotypic value for candidate markers and correlating the marker with the trait. Various association models can be used to evaluate the association, and include statistical methods relevant to the structure of plant breeding populations. Population structure may be accounted for in the association models by using Principle Component Analysis. Further provided is a novel statistical approach for association mapping in early stage breeding materials using a transmission disequilibrium based methodology. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, for constructing genetic linkage maps, to identify genes contributing to a trait of interest, and for generating transgenic plants having a desired trait.
摘要翻译：本文提供了用于评估候选标记与植物群体中感兴趣的性状之间的关联的方法。在各种实施方案中，植物群体是育种群体，特别是早期育种群体。所述方法包括获得候选标记的基因型值并将标记与性状相关联。可以使用各种关联模型来评估关联，并且包括与植物育种种群结构相关的统计学方法。人口结构可以通过使用原则分量分析在关联模型中加以考虑。进一步提供了一种用于使用基于传输不平衡的方法的早期育种材料中的关联定位的新颖的统计方法。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，用于构建遗传连锁图谱，鉴定有助于感兴趣性状的基因以及产生具有期望性状的转基因植物。

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