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1. 发明申请

WO2020191344A1 CLAUDIN-6 BISPECIFIC ANTIBODIES 审中-公开
公开(公告)号：WO2020191344A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023986
申请日：2020-03-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CONKLIN, Dylan , MCDERMOTT, Martina, S. , O'BRIEN, Neil, A. , PALAZZOLO, Michael, J. , SLAMON, Dennis , VON EUW, Erika , BOWERS, Peter
发明人： CONKLIN, Dylan , MCDERMOTT, Martina, S. , O'BRIEN, Neil, A. , PALAZZOLO, Michael, J. , SLAMON, Dennis , VON EUW, Erika , BOWERS, Peter
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/46
摘要： The present disclosure provides bispecific antigen-binding proteins which bind to Claudin-6 (CLDN6) and a second antigen. In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

2. 发明申请

WO2008126039A2 CELL LINES, COMPOSITIONS COMPRISING THEM FOR THE TREATMENT OF MELANOMAS, PROCEDURES TO PREPARE THE COMPOSITIONS, AND TREATMENT METHODS 审中-公开
标题翻译：细胞系，包含它们的组合物用于治疗梅拉诺马斯，制备组合物的程序和治疗方法
公开(公告)号：WO2008126039A2
公开(公告)日：2008-10-23
申请号：PCT/IB2008/051385
申请日：2008-04-11
申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) , FUNDACION SALES , INIS BIOTECH LLC , MORDOH, José , BARRIO, María Marcela , VON EUW, Erika María
发明人： MORDOH, José , BARRIO, María Marcela , VON EUW, Erika María
IPC分类号： C12N15/11
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154
摘要： CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modif iers, and/or autologous dendritic cells.
摘要翻译：细胞系，包含它们的组合物用于治疗黑素瘤，制备组合物的方法和治疗方法。更具体地说，本发明涉及用于治疗恶性疾病的多种人黑素瘤细胞系，其中细胞系是：（a）MeI-XY1（以保藏号DSM ACC2830保藏在德国微生物和细胞培养物保藏中心DSMZ），（ b）Mel-XY2（保藏在Germ＆amp; aacute微生物和细胞培养物保藏中心DSMZ，保藏号DSM ACC2831），（c）Mel-XY3（保藏在Germ＆amp; aacute微生物和细胞培养物保藏中心DSMZ，保藏号DSM ACC2832），（d）Mel-XX4（以微生物和细胞培养物DSMZ保藏在获取号DSM ACC2829下），或（e）其亚群。可以照射细胞系，从而获得具有凋亡表型的群体，以及具有这些系的坏死表型的群体。组合物可以包含佐剂和/或免疫修饰剂，和/或自体树突细胞。

3. 发明申请

WO2020191342A1 CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES 审中-公开
公开(公告)号：WO2020191342A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023981
申请日：2020-03-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CONKLIN, Dylan , MCDERMOTT, Martina, S. , O'BRIEN, Neil, A. , PALAZZOLO, Michael, J. , SLAMON, Dennis , VON EUW, Erika , BOWERS, Peter
发明人： CONKLIN, Dylan , MCDERMOTT, Martina, S. , O'BRIEN, Neil, A. , PALAZZOLO, Michael, J. , SLAMON, Dennis , VON EUW, Erika , BOWERS, Peter
IPC分类号： C07K16/30 , A61K39/395 , C07K16/46 , C07K16/28 , A61P35/00
摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

4. 发明申请

WO2022192701A1 METHODS OF ENHANCING DIVERSITY OF HLA HAPLOTYPE EXPRESSION IN TUMORS TO BROADEN TUMOR CELL SUSCEPTIBILITY TO TCR-T THERAPY 审中-公开
公开(公告)号：WO2022192701A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/019995
申请日：2022-03-11
申请人： T-CURE BIOSCIENCE, INC. , VON EUW, Erika , DAVIS, Nicholas , PARRY, Gordon , ZENG, Gang
发明人： VON EUW, Erika , DAVIS, Nicholas , PARRY, Gordon , ZENG, Gang
IPC分类号： A61K35/17 , C07K14/725 , C07K14/74 , C12Q1/6881
摘要： The present invention provides methods for increasing the sensitivity of tumor cells to a TCR-engineered T cells (TCR-T) therapy comprising genetically modifying the tumor cells to express an haplotype, for example an HLA haplotype, different from the haplotype endogenous to the tumor cells.

5. 发明申请

WO2008126039A3 CELL LINES, COMPOSITIONS COMPRISING THEM FOR THE TREATMENT OF MELANOMAS, PROCEDURES TO PREPARE THE COMPOSITIONS, AND TREATMENT METHODS 审中-公开
标题翻译：细胞系，包含它们的组合物，用于治疗MELANOMAS，制备组合物的程序和治疗方法
公开(公告)号：WO2008126039A3
公开(公告)日：2008-12-11
申请号：PCT/IB2008051385
申请日：2008-04-11
申请人： CONSEJO NAC INVEST CIENT TEC , FUNDACION SALES , INIS BIOTECH LLC , MORDOH JOSE , BARRIO MARIA MARCELA , VON EUW ERIKA MARIA
发明人： MORDOH JOSE , BARRIO MARIA MARCELA , VON EUW ERIKA MARIA
IPC分类号： A61K39/00 , C12N5/06
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154
摘要： CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modif iers, and/or autologous dendritic cells.
摘要翻译： CeIl系列，包含它们用于治疗黑素瘤的组合物，制备组合物的程序和治疗方法。更具体地，本发明涉及用于治疗恶性疾病的多种人黑素瘤细胞系，其中细胞系是：（a）MeI-XY1（保藏于德国收藏的微生物和细胞培养物DSMZ，存取号DSM ACC2830），（ b）Mel-XY2（保藏于Germán收集的微生物和细胞培养物DSMZ，存取号码为DSM ACC2831），（c）Mel-XY3（保藏于GermánCollection of Microorganisms and Cell Cultures DSMZ，access number DSM ACC2832），（d） Mel-XX4（保藏于GermánCollection of Microorganisms and Cell Cultures DSMZ in access number DSM ACC2829），或（e）其亚群。可以照射细胞系，从而获得具有凋亡表型的群体以及具有坏死表型的群体。组合物可以包含佐剂和/或免疫修饰剂和/或自体树突状细胞。

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