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1. 发明申请

WO2022192701A1 METHODS OF ENHANCING DIVERSITY OF HLA HAPLOTYPE EXPRESSION IN TUMORS TO BROADEN TUMOR CELL SUSCEPTIBILITY TO TCR-T THERAPY 审中-公开
公开(公告)号：WO2022192701A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/019995
申请日：2022-03-11
申请人： T-CURE BIOSCIENCE, INC. , VON EUW, Erika , DAVIS, Nicholas , PARRY, Gordon , ZENG, Gang
发明人： VON EUW, Erika , DAVIS, Nicholas , PARRY, Gordon , ZENG, Gang
IPC分类号： A61K35/17 , C07K14/725 , C07K14/74 , C12Q1/6881
摘要： The present invention provides methods for increasing the sensitivity of tumor cells to a TCR-engineered T cells (TCR-T) therapy comprising genetically modifying the tumor cells to express an haplotype, for example an HLA haplotype, different from the haplotype endogenous to the tumor cells.

2. 发明申请

WO2019030503A1 CASTOR WHEEL COVER 审中-公开
公开(公告)号：WO2019030503A1
公开(公告)日：2019-02-14
申请号：PCT/GB2018/052206
申请日：2018-08-01
申请人： DAVIS, Nicholas
发明人： DAVIS, Nicholas
IPC分类号： B60B33/00
摘要： A castor wheel cover is described, the castor wheel cover comprising a resiliently deformable material formable to provide a housing with a first aperture, wherein the housing is suitable for housing for accommodating a castor wheel which both rotates around a single axis and protrudes through the first aperture.

3. 发明申请

WO2008103834A1 METHODS AND SYSTEMS FOR GRAPHICAL IMAGE AUTHENTICATION 审中-公开
标题翻译：用于图形图像认证的方法和系统
公开(公告)号：WO2008103834A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/054592
申请日：2008-02-21
申请人： VIDOOP LLC , OSBORN, Steven, L. , DAVIS, Nicholas, A. , SONTAG, James, L. , NORVELL, Joel
发明人： OSBORN, Steven, L. , DAVIS, Nicholas, A. , SONTAG, James, L. , NORVELL, Joel
IPC分类号： G06F21/20
CPC分类号： G06F21/36 , H04L9/3226
摘要： Systems and methods for providing authentication using an arrangement of dynamic graphical images, which may display a popup element while a pointing device indicator is over a graphical image. The graphical images can be arranged as a grid or matrix for presentation on a device display for authentication of a user. The kinds of graphical images can be derived from a designated authentication category and non-authenticating categories. A series of password elements corresponding to the graphical images can be displayed with the graphical images. The user may enter the series of one or more password elements corresponding to graphical images from the authentication category which combine to form a password entry. An authentication server can compare the password entry to an authentication password corresponding to the particular arrangement of dynamic graphical images. The selection of graphical images, their arrangement and their corresponding password elements, may dynamically change in between authentication processes.
摘要翻译：用于使用动态图形图像的布置提供认证的系统和方法，其可以在指示设备指示符在图形图像上方时显示弹出元素。图形图像可以被布置为网格或矩阵，用于在设备显示器上呈现用于用户的认证。可以从指定的认证类别和非认证类别导出图形图像的种类。可以使用图形图像显示与图形图像相对应的一系列密码元素。用户可以输入一系列一个或多个来自认证类别的图形图像相对应的密码元素，这些组合形成密码条目。认证服务器可以将密码条目与对应于动态图形图像的特定布置的认证密码进行比较。图形图像的选择，它们的排列及其对应的密码元素可以在认证过程之间动态地改变。

4. 发明申请

WO2010082021A1 INFLATABLE MATTRESS 审中-公开
标题翻译：充满活力的东西
公开(公告)号：WO2010082021A1
公开(公告)日：2010-07-22
申请号：PCT/GB2010/000046
申请日：2010-01-13
申请人： FRONTIER PLASTICS LIMITED , DAVIS, Nicholas, John, Stratton
发明人： DAVIS, Nicholas, John, Stratton
IPC分类号： A47C27/08
CPC分类号： A61G7/1026 , A61G7/05769
摘要： Disclosed is an inflatable mattress (10) for use when transferring a patient from one area to another. The mattress has a flexible lowermost layer (15) providing a smooth or plate finished low friction surface of a polymer, for example a polyurethane, PTFE, or a polyamide such as nylon, or a combination of said polymers, for sliding the mattress whilst a patient is lying thereon; and one or more inflatable elements (30) located or locatable above the lowermost layer, the or each element comprising a flexible water vapour permeable material such as extruded polyurethane film. Said elements (30) may be exposed (see Figure 4).
摘要翻译：公开了一种在将患者从一个区域转移到另一个区域时使用的充气床垫（10）。床垫具有柔性最下层（15），其提供聚合物（例如聚氨酯，PTFE或聚酰胺，例如尼龙）或所述聚合物的组合的光滑或平板成品的低摩擦表面，用于滑动床垫同时患者躺在其上以及位于或可定位在最下层之上的一个或多个可膨胀元件（30），所述或每个元件包括柔性水蒸气可渗透材料，例如挤压聚氨酯膜。可以暴露所述元件（30）（参见图4）。

5. 发明申请

WO2011144910A1 A SHIP DEFENCE DEVICE AND SYSTEM 审中-公开
标题翻译：船舶防御装置和系统
公开(公告)号：WO2011144910A1
公开(公告)日：2011-11-24
申请号：PCT/GB2011/000777
申请日：2011-05-20
申请人： MERCHANT MARITIME WARFARE CENTRE LTD , DAVIS, Nicholas
发明人： DAVIS, Nicholas
IPC分类号： B63G9/04
CPC分类号： B63G9/04
摘要： Disclosed are a ship defence system and method comprising a deployment device (18, 100, 200, 300, 400) which is use is attached to a ship (90) and a number of cables (150) capable of deployment using the deployment device (18, 100, 200, 300, 400), which may include a reel (100) associated with each cable (150) and/or a boom (200, 300, 400) from which the cables (150) are deployed. A boom (200, 300, 400) may have several reels (150) attached thereto, which may be movable along the length of the boom. The boom (200, 300, 400) is movable between two positions: a first position (300,450) where the boom is substantially parallel to the hull and a second or deployed position (200, 400) where the boom is substantially perpendicular to the ships' hull. The cable (150) may comprise a number of different sections including one of more of a main or floating section; a weak link; a lead line; and a drag float.
摘要翻译：公开了一种船舶防御系统和方法，其包括使用的部署装置（18,100,200,300,400），所述部署装置连接到船舶（90）和能够使用所述展开装置部署的多个缆线（150） 18，100,200,300,400），其可以包括与每个电缆（150）相关联的卷轴（100）和/或电缆（150）展开的吊杆（200,300,400）。悬臂（200,300,400）可以具有附接到其上的多个卷轴（150），其可以沿着悬臂的长度移动。动臂（200,300,400）可以在两个位置之间移动：第一位置（300,450），其中悬臂基本上平行于船体;第二或展开位置（200,400），其中吊臂基本上垂直于船 “船体电缆（150）可以包括多个不同的部分，包括主要部分或浮动部分中的一个以上的部分; 一个薄弱环节; 引导线和拖动浮动。

6. 发明申请

WO2011028898A1 DEVICES AND METHODS FOR MAINTAINING AN ASEPTIC CATHETER ENVIRONMENT 审中-公开
标题翻译：用于维护自由导管环境的装置和方法
公开(公告)号：WO2011028898A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047668
申请日：2010-09-02
申请人： DAVIS & SON DEVELOPMENTS LLC , DAVIS, Nicholas, B.
发明人： DAVIS, Nicholas, B.
IPC分类号： A61M39/16
CPC分类号： A61M39/165 , A61M39/18
摘要： Devices and methods for maintaining an aseptic catheter environment. In at least one exemplary embodiment of a device for maintaining an aseptic catheter environment of the present disclosure, the device comprises a first housing and a second housing, the first housing and the second housing coupled to one another by way of at least one coupler, the first housing and the second housing configured to engage one another when in a closed configuration and to define an interior space when in the closed configuration, and at least one aperture and/or notch defined within at least one of the first housing and the second housing, the at least one aperture and/or notch sized and shaped to allow at least part of a catheter to be positioned therethrough.
摘要翻译：用于维持无菌导管环境的装置和方法。在用于维持本公开的无菌导管环境的装置的至少一个示例性实施例中，该装置包括第一壳体和第二壳体，第一壳体和第二壳体通过至少一个耦合器彼此耦合，所述第一壳体和所述第二壳体构造成当处于闭合构型时彼此接合并且当处于所述关闭构造时限定内部空间，以及限定在所述第一壳体和所述第二壳体中的至少一个中的至少一个孔和/ 所述至少一个孔和/或凹口的尺寸和形状被设计成允许导管的至少一部分穿过其定位。

7. 发明申请

WO2006064231A1 IMPROVEMENTS RELATING TO INJECTION SYRINGES AND NEEDLES 审中-公开
标题翻译：与注射器和针头相关的改进
公开(公告)号：WO2006064231A1
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004828
申请日：2005-12-14
申请人： FRONTIER PLASTICS LIMITED , HARRIS, Nigel , DAVIS, Nicholas, John, Stratton
发明人： HARRIS, Nigel , DAVIS, Nicholas, John, Stratton
IPC分类号： A61M5/32 , A61M5/31
CPC分类号： A61M5/3145 , A61M5/002 , A61M5/1782 , A61M5/3202 , A61M2005/3118
摘要： A sheath (1) is disclosed which is suitable for covering the needle of a syringe (2). The sheath (1) includes a filter (3) which projects partially from the end of the sheath to aid the drawing of liquid into the syringe. It is intended that the needle and/or syringe are sold fitted with the sheath (1) so that there is no need to expose the needle until the user is ready for injection. The invention includes a blister pack (12 Figure 4) which includes a ready assembled syringe, a mixing pan and paraphernalia for the preparation of the solution to be injected.
摘要翻译：公开了适合于覆盖注射器（2）的针的护套（1）。护套（1）包括从护套的端部部分突出以帮助将液体拉入注射器的过滤器（3）。旨在将针和/或注射器出售装配护套（1），使得不需要露出针直到使用者准备好注射。本发明包括泡罩包装（12图4），其包括准备组装的注射器，用于制备待注射溶液的混合盘和用具。

8. 发明申请

WO2009117454A3 METHODS AND SYSTEMS FOR GRAPHICAL SEURITY AUTHENTICATION AND ADVERTISING 审中-公开
标题翻译：图像精确认证和广告的方法和系统
公开(公告)号：WO2009117454A3
公开(公告)日：2010-01-21
申请号：PCT/US2009037447
申请日：2009-03-17
申请人： VIDOOP LLC , LEE CHRISTOPHER JAMES , BLOMQUIST SCOTT A , STOVER BENJAMIN JOEL , DAVIS NICHOLAS A , SONTAG JAMES LUKE , OSBORN STEVSEN L , NORVELL JOEL
发明人： LEE CHRISTOPHER JAMES , BLOMQUIST SCOTT A , STOVER BENJAMIN JOEL , DAVIS NICHOLAS A , SONTAG JAMES LUKE , OSBORN STEVSEN L , NORVELL JOEL
IPC分类号： H04L9/32 , G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0248
摘要： The present invention is directed to a graphical image identity authentication system. In particular, the invention is directed to methods and systems for graphical security authentication and advertising. A security authentication system may receive advertisements from an advertising service company, process the advertisements to integrate them into the graphical image identity authentication system, and transmit the processed advertisement information back to the advertisement service company. The security authentication system may also monitor user interaction with the advertisements and transmit the logged information to the advertising service company.
摘要翻译：本发明涉及图形图像身份认证系统。特别地，本发明涉及用于图形安全认证和广告的方法和系统。安全认证系统可以从广告服务公司接收广告，处理广告以将它们集成到图形图像身份认证系统中，并将处理的广告信息发送回广告服务公司。安全认证系统还可以监视用户与广告的交互，并将记录的信息发送到广告服务公司。

9. 发明申请

WO2007139644A3 GRAPHICAL IMAGE AUTHENTICATION AND SECURITY SYSTEM 审中-公开
公开(公告)号：WO2007139644A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/010099
申请日：2007-04-25
申请人： VIDOOP, L.L.C. , OSBORN, Steven, L. , DAVIS, Nicholas, A. , SONTAG, James, L. , NORVELL, Joel
发明人： OSBORN, Steven, L. , DAVIS, Nicholas, A. , SONTAG, James, L. , NORVELL, Joel
IPC分类号： H04L9/32
摘要： A method and system for protection of and secure access to a computer system or computer network. The method includes the steps of receiving a first login account identifier, such as a user name from a user in communication with the computer system or network. A determination is made if the user is recognized and enrolled from the first login account from the first login account identifier. If the user is recognized, a grid of randomly generated visual images is displayed including one visual image from an image category which has been preselected by the user upon enrollment. An image category identifier is randomly assigned to each visual image in the grid. An image category identifier, second login account identifier, such as a password, is entered and received. If the login account identifier and the image category is validated, access is permitted to the computer system or network.

10. 发明申请

WO2007139644A2 GRAPHICAL IMAGE AUTHENTICATION AND SECURITY SYSTEM 审中-公开
标题翻译：图形图像认证和安全系统
公开(公告)号：WO2007139644A2
公开(公告)日：2007-12-06
申请号：PCT/US2007010099
申请日：2007-04-25
申请人： VIDOOP L L C , OSBORN STEVEN L , DAVIS NICHOLAS A , SONTAG JAMES L , NORVELL JOEL
发明人： OSBORN STEVEN L , DAVIS NICHOLAS A , SONTAG JAMES L , NORVELL JOEL
IPC分类号： H04L9/32
CPC分类号： G06F21/36 , H04L9/3226
摘要： A method and system for protection of and secure access to a computer system or computer network. The method includes the steps of receiving a first login account identifier, such as a user name from a user in communication with the computer system or network. A determination is made if the user is recognized and enrolled from the first login account from the first login account identifier. If the user is recognized, a grid of randomly generated visual images is displayed including one visual image from an image category which has been preselected by the user upon enrollment. An image category identifier is randomly assigned to each visual image in the grid. An image category identifier, second login account identifier, such as a password, is entered and received. If the login account identifier and the image category is validated, access is permitted to the computer system or network.
摘要翻译：一种用于保护和安全访问计算机系统或计算机网络的方法和系统。该方法包括以下步骤：从与计算机系统或网络通信的用户接收第一登录帐户标识符，例如用户名。如果用户从第一登录帐户识别并从第一登录帐户标识符注册，则确定。如果用户被识别，则显示随机生成的视觉图像的网格，包括来自用户在注册时预先选择的图像类别的一个视觉图像。图像类别标识符被随机分配给网格中的每个视觉图像。输入并接收图像类别标识符，第二登录帐户标识符（例如密码）。如果登录帐户标识符和图像类别被验证，则允许访问计算机系统或网络。

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