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1. 发明申请

WO2013060881A1 PYRIDOPYRIMIDINES AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：吡咯并嘧啶及其治疗用途
公开(公告)号：WO2013060881A1
公开(公告)日：2013-05-02
申请号：PCT/EP2012/071321
申请日：2012-10-26
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
发明人： SMITS, Rogier , LIM, Herman , VAN DER MEER, Tiffany , LEURS, Rob , DE ESCH, Iwan , ANDALOUSSI, Mounir
IPC分类号： C07D471/04 , A61K31/519 , A61P37/08
CPC分类号： C07D471/04
摘要： A compound of formula (I) Wherein at least one of X and Y is N and the other of X or Y is either N or CR 2 . Such compounds may be useful in the therapy of inflammatory disorders, allergic disorders, dermatological disorders, autoimmune disease, lymphatic disorders, and immunodeficiency disorders.
摘要翻译：式（I）的化合物，其中X和Y中的至少一个为N，X或Y中的另一个为N或CR 2。这些化合物可用于治疗炎性疾病，过敏性疾病，皮肤病，自身免疫性疾病，淋巴系疾病和免疫缺陷病症。

2. 发明申请

WO2011005080A1 THREE DIMENSIONAL TRACKING SYSTEM AND METHOD 审中-公开
标题翻译：三维跟踪系统和方法
公开(公告)号：WO2011005080A1
公开(公告)日：2011-01-13
申请号：PCT/NL2010/050327
申请日：2010-05-31
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , OTTE, Marco , HOORN, Johan F.
发明人： OTTE, Marco , HOORN, Johan F.
IPC分类号： G01S5/16
CPC分类号： G01S5/163 , G01S5/16
摘要： During object movement tracking, such as tracking movement of a human head, infrared sensors at different locations are used to detect view angles to one or more light sources on the object. A distance from the sensors is calculated from the view angles. The light sources each contain a plurality of infrared light emitters oriented to generate a disk of light. In the example wherein the light sources are attached to the head and plane of the disc is oriented horizontally, this means that the light sources will remain visible from horizontally directed sensors during most head movements. In an embodiment the light source or light sources are attached above the head, mounted on a rod that is attached to the head, preferably at different heights if more than one light source is used.
摘要翻译：在物体运动跟踪期间，诸如人的头部的跟踪运动，使用不同位置处的红外传感器来检测物体上的一个或多个光源的视角。从视角计算与传感器的距离。光源各自包含多个定向成产生光盘的红外光发射器。在其中光源附接到头部并且盘的平面被水平定向的示例中，这意味着在大多数头部移动期间光源将保持从水平定向的传感器可见。在一个实施例中，如果使用多于一个光源，则光源或光源被安装在头部上方，安装在附接到头部的杆上，优选地在不同的高度处。

3. 发明申请

WO2010124344A1 PLANT NUCLEIC ACIDS ASSOCIATED WITH CELLULAR PH AND USES THEREOF 审中-公开
标题翻译：与细胞PH相关的植物核酸及其用途
公开(公告)号：WO2010124344A1
公开(公告)日：2010-11-04
申请号：PCT/AU2010/000504
申请日：2010-04-30
申请人： INTERNATIONAL FLOWER DEVELOPMENTS PTY LTD , STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , QUATTROCCHIO, Francesca , KOES, Ronald , SPELT, Kees
发明人： QUATTROCCHIO, Francesca , KOES, Ronald , SPELT, Kees
IPC分类号： C12N15/05 , A01H1/00 , A01H5/00
CPC分类号： C12N15/825 , A01H5/02 , A01H5/08 , C07K14/415 , C12N9/14 , C12N15/8243 , C12N15/8249 , C12N15/827
摘要： The present invention relates generally to the field of plant molecular biology and agents useful in the manipulation of plant physiological and biochemical properties. More particularly, the present invention provides genetic and proteinaceous agents capable of modulating or altering the level of acidity or alkalinity in a cell, group of cells, organelle, part or reproductive portion of a plant. Genetically altered plants, plant parts, progeny, subsequent generations and reproductive material including flowers or flowering parts having cells exhibiting an altered cellular including vacuolar pH compared to a non-genetically altered plant are also provided.
摘要翻译：本发明一般涉及植物分子生物学领域和用于操作植物生理和生物化学性质的试剂。更具体地，本发明提供能够调节或改变植物的细胞，细胞组，细胞器，部分或生殖部分中的酸度或碱度水平的遗传和蛋白质剂。还提供遗传改变的植物，植物部分，子代，后代和繁殖材料，包括花或开花部分，其具有与非遗传改变的植物相比显示改变的细胞，包括液泡pH的细胞。

4. 发明申请

WO2009130320A3 MEASUREMENT OF PROTEIN KINASE ACTIVITY IN CEREBROSPINAL FLUID FOR DIAGNOSIS OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于诊断神经病学和心理疾病的尿液中蛋白激酶活性的测定
公开(公告)号：WO2009130320A3
公开(公告)日：2009-12-30
申请号：PCT/EP2009054994
申请日：2009-04-24
申请人： PAMGENE BV , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , HILHORST MARIA HELENA , DE WIJN RICHARD , HOOZEMANS JEROEN JOSEPH MARIA , VAN DER VIES SASKIA MARIA
发明人： HILHORST MARIA HELENA , DE WIJN RICHARD , HOOZEMANS JEROEN JOSEPH MARIA , VAN DER VIES SASKIA MARIA
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , G01N2333/91215 , G01N2800/2821
摘要： The present invention relates to the use of endogenous protein kinase activity in cerebrospinal fluid for the classification, diagnosis and prognosis of neurological and psychiatric disorders as well asfor predicting and monitoring treatment effects. An array of substrates for protein kinases, immobilized on a porous matrix, is used to monitor the protein kinase activity in cerebrospinal fluid. The method of the present invention enables the early diagnosis and discrimination between neurodegenerative disorders.
摘要翻译：本发明涉及内源性蛋白激酶活性在脑脊液中用于神经和精神疾病分类，诊断和预后以及预测和监测治疗效果的用途。用于固定在多孔基质上的蛋白激酶底物阵列用于监测脑脊髓液中的蛋白激酶活性。本发明的方法能够早期诊断和鉴别神经变性疾病。

5. 发明申请

WO2005100576A3 REPLICATION COMPETENT VIRUSES CAPABLE OF SILENCING VIRUS INHIBITORY FACTOR EXPRESSION 审中-公开
标题翻译：复制阴道病毒抑制因子表达的能力较强的病毒
公开(公告)号：WO2005100576A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005004152
申请日：2005-04-15
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , CARETTE JAN EDUARD , VAN BEUSECHEM VICTOR WILLEM
发明人： CARETTE JAN EDUARD , VAN BEUSECHEM VICTOR WILLEM
IPC分类号： C12N15/861 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , A61K35/13 , A61K48/00 , C12N7/00 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/53 , C12N2320/10 , C12N2710/10343 , C12N2830/008 , C12N2830/205 , C12N2830/85
摘要： Described is a replication competent virus, being capable to replicate and having lytic capacity in tarjet cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, funcional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.
摘要翻译：描述了能够在焦油喷射细胞中复制并具有溶解能力的复制感染病毒，所述病毒在其基因组中包含编码在所述靶细胞中靶基因表达有功能的沉默因子的至少一个DNA序列与所述靶细胞中的一个或多个表达控制序列有效连接，以及其在制备药物中的用途及其在裂解表达病毒抑制因子的靶细胞的方法中的用途。

6. 发明申请

WO2013095132A1 MIRNA FOR TREATING HEAD AND NECK CANCER 审中-公开
标题翻译：用于治疗头部和颈部癌症的MIRNA
公开(公告)号：WO2013095132A1
公开(公告)日：2013-06-27
申请号：PCT/NL2012/050905
申请日：2012-12-20
申请人： INTERNA TECHNOLOGIES B.V. , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
发明人： BRAKENHOFF, Rudolf Henrikus , VAN DER PLAS, Marlon , DE KEMP, Sanne Rosaly , GOMMANS, Willemijn Maria , PREVOST, Grégoire Pierre André , SCHAAPVELD, Roeland Quirinus Jozef , CERISOLI, Francesco
IPC分类号： C12N15/113 , A61K31/713 , A61P35/00
CPC分类号： C12N15/113 , C12N2310/141 , C12N2320/31
摘要： The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
摘要翻译：本发明涉及miRNA-323，miRNA-342，miRNA-326，miRNA-371，miRNA-3157和/或miRNA-345分子的诊断和治疗用途，其在相关疾病和病症中的等同或来源具有鳞状细胞癌如头颈部癌症或癌前变粘膜变化。

7. 发明申请

WO2012093128A1 A METHOD FOR THE ADAPTIVE EVOLUTION OF A CELL AND SELECTION FOR A DESIRED PHENOTYPE BY SERIAL PROPAGATION IN AN EMULSION BASED SYSTEM AND USES THEREOF 审中-公开
标题翻译：一种用于通过基于乳液的系统中的串行传播的细胞的自适应演变和所选择的基因选择的方法及其用途
公开(公告)号：WO2012093128A1
公开(公告)日：2012-07-12
申请号：PCT/EP2012/050068
申请日：2012-01-04
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , TEUSINK, Bastiaan , BACHMANN, Herwig
发明人： TEUSINK, Bastiaan , BACHMANN, Herwig
IPC分类号： C12N1/28 , C12N1/36
CPC分类号： C12N15/01 , C12N1/28 , C12N1/36 , C12N15/1037
摘要： The invention provides a method for the selection of a cell metabolically efficient under conditions of high substrate concentration expressing a desired phenotype by serial propagation in a water in oil (w/o) emulsionbased systemwhereby said desired phenotype is optionally; a) selection for high yield/biomass production b) increased or decreased production of primary and/or secondary metabolites c)and/or increased or decreased levels of macromolecules and d) increased levels of (genetically engineered) biotechnologically relevant products, and/or two or more different organisms that interact with each other.
摘要翻译：本发明提供了一种用于在高底物浓度的条件下选择细胞代谢有效的方法，该条件是通过在油（w / o）乳液基的水中系统中连续繁殖来表达所需表型，其中所述期望的表型是任选的; a）选择高产量/生物质生产b）增加或减少初级和/或次级代谢物的产生c）和/或大分子水平的增加或降低; d）提高（遗传工程）生物技术相关产品的水平，和/或两种或更多种彼此相互作用的不同生物体。

8. 发明申请

WO2012005588A2 NOVEL BIOMARKERS FOR DETECTING NEURONAL LOSS 审中-公开
标题翻译：新型生物标志物用于检测神经损失
公开(公告)号：WO2012005588A2
公开(公告)日：2012-01-12
申请号：PCT/NL2011050496
申请日：2011-07-07
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , PETZOLD AXEL FRANZ SIEGFRIED
发明人： PETZOLD AXEL FRANZ SIEGFRIED
IPC分类号： G01N33/68 , C07K14/47
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/6896 , G01N2800/28
摘要： The present invention relates to a biomarker for the detection of brain damage or a disease associated with loss of neurons, said biomarker comprising a protein fragment of the neurofilament heavy chain (NfH) protein in a biological sample, wherein said protein fragment is a polypeptide selected from the group consisting of i) a polypeptide having the amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and polypeptides composed of amino acids 476-1026 and 476-986 of SEQ ID NO 6; ii) a protein fragment of the NfH protein having an amino acid sequence that is at least 60% identical to SEQ ID NO:1, at least 60% identical to SEQ ID NO:2, at least 60% identical to SEQ ID NO:3, at least 60% identical to SEQ ID NO:4, at least 60% identical to SEQ ID NO:5; or at least 60% identical to a polypeptide composed of amino acids 476-1026 and.or 476-986 of SEQ ID NO 6; iii) an Enterokinase cleavage product of the NfH protein; and iv) a polypeptide that is derived from a naturally occurring allelic variant of the nucleic acid coding for NfH protein.
摘要翻译：本发明涉及用于检测脑损伤或与神经元损失有关的疾病的生物标志物，所述生物标志物包含生物样品中神经丝重链（NfH）蛋白质的蛋白质片段，其中所述蛋白质片段是选择的多肽 i）具有选自由SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5组成的组的氨基酸序列的多肽，和由SEQ ID NO 6的氨基酸476-1026和476-986组成的多肽; ii）NfH蛋白的蛋白片段，其具有与SEQ ID NO：1至少60％相同的氨基酸序列，与SEQ ID NO：2至少60％相同，与SEQ ID NO： 3，与SEQ ID NO：4至少60％相同，与SEQ ID NO：5至少60％相同; 或至少60％与由SEQ ID NO 6的氨基酸476-1026和或476-986组成的多肽相同; iii）NfH蛋白的肠激酶切割产物; 和iv）衍生自编码NfH蛋白的核酸的天然存在的等位基因变体的多肽。

9. 发明申请

WO2010067307A3 IN VITRO METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND/OR TREATMENT OF ADENOCARCINOMA 审中-公开
公开(公告)号：WO2010067307A3
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055577
申请日：2009-12-08
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , HARDEBOL, Anna, H. , PINTO MORAIS DE CARVALHO, Beatriz , FIJNEMAN, Remondus, J.A. , MEIJER, Gerrit, A.
发明人： HARDEBOL, Anna, H. , PINTO MORAIS DE CARVALHO, Beatriz , FIJNEMAN, Remondus, J.A. , MEIJER, Gerrit, A.
IPC分类号： C12Q1/68 , C12N15/11
摘要： The present invention relates to in vitro methods and compositions for diagnosing, preventing and/or treating an adenocarcinoma associated with a chromosomal aberration on chromosome 2Oq and/or the predisposition for developing such an adenocarcinoma by determining the expression levels of a set of particular marker genes, wherein an elevated expression level of said marker genes in target cells as compared to control cells is indicative of such an adenocarcinoma and by specifically modifying the gene expression of said marker genes in such way that the elevated expression level(s) identified in the target cells are down-regulated.

10. 发明申请

WO2010032177A1 METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING A COLORECTAL ADENOCARCINOMA 审中-公开
标题翻译：用于诊断和治疗色素性腺癌的方法和组合物
公开(公告)号：WO2010032177A1
公开(公告)日：2010-03-25
申请号：PCT/IB2009/053972
申请日：2009-09-10
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , PINTO MORAIS DE CARVALHO, Beatriz , MEIJER, Gerrit, A.
发明人： PINTO MORAIS DE CARVALHO, Beatriz , MEIJER, Gerrit, A.
IPC分类号： C12Q1/68 , A61K31/713 , A61K39/395
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to in vitromethods and compositions for diagnosing and/or treating a colorectal adenocarcinoma associated with a chromosomal aberration on chromosome 20q and/or the predisposition for developing such an adenocarcinoma by determining the expression levels of a set of particular marker genes, wherein an elevated expression level of the marker genes in a test sample as compared to a control level is indicative of a colorectal adenocarcinoma.
摘要翻译：本发明涉及用于诊断和/或治疗与染色体20q上的染色体畸变相关的结肠直肠腺癌和/或通过测定一组特定标志物基因的表达水平来发展这种腺癌的易感性的组合物，其中与对照水平相比，测试样品中标记基因的表达水平升高表明结肠直肠腺癌。

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