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1. 发明申请

WO2007094663A1 ADENOVIRUS PARTICLES HAVING A CHIMERIC ADENOVIRUS SPIKE PROTEIN, USE THEREOF AND METHODS FOR PRODUCING SUCH PARTICLES 审中-公开
标题翻译：具有碱性腺病毒SPIKE蛋白的腺病毒颗粒及其生产方法及其制备方法
公开(公告)号：WO2007094663A1
公开(公告)日：2007-08-23
申请号：PCT/NL2007/050057
申请日：2007-02-13
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , VAN BEUSECHEM, Victor Willem , SCHAGEN, Frederik Hubertus Emanuel
发明人： VAN BEUSECHEM, Victor Willem , SCHAGEN, Frederik Hubertus Emanuel
IPC分类号： C12N15/861 , C12N5/10
CPC分类号： C07K14/005 , C07K2319/73 , C07K2319/74 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2720/12022 , C12N2720/12034 , C12N2810/6063
摘要： The present invention is concerned with means and methods for producing adenovirus particles comprising a chimeric adenovirus spike protein that essentially lacks a functional knob domain. One aspect of the invention is concerned with a method for producing adenovirus particles comprising providing cells that are permissive for adenovirus replication with an adenovirus vector, with nucleic acid encoding said chimeric adenovirus spike protein and with nucleic acid encoding at least one adenovirus E3 region protein or a functional part, derivative and/or analogue thereof, said method further comprising culturing said permissive cells to allow for at least one replication cycle of said adenovirus virus and harvesting said adenovirus particle.
摘要翻译：本发明涉及用于产生包含嵌合腺病毒尖峰蛋白质的腺病毒颗粒的方法和方法，其基本上缺乏功能性旋钮结构域。本发明的一个方面涉及用于产生腺病毒颗粒的方法，包括提供允许腺病毒复制的细胞与腺病毒载体，编码所述嵌合腺病毒尖峰蛋白的核酸和编码至少一种腺病毒E3区蛋白的核酸或其功能部分，衍生物和/或类似物，所述方法还包括培养所述允许细胞以允许所述腺病毒病毒的至少一个复制周期并收获所述腺病毒颗粒。

2. 发明申请

WO2005100576A3 REPLICATION COMPETENT VIRUSES CAPABLE OF SILENCING VIRUS INHIBITORY FACTOR EXPRESSION 审中-公开
标题翻译：复制阴道病毒抑制因子表达的能力较强的病毒
公开(公告)号：WO2005100576A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005004152
申请日：2005-04-15
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , CARETTE JAN EDUARD , VAN BEUSECHEM VICTOR WILLEM
发明人： CARETTE JAN EDUARD , VAN BEUSECHEM VICTOR WILLEM
IPC分类号： C12N15/861 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , A61K35/13 , A61K48/00 , C12N7/00 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/53 , C12N2320/10 , C12N2710/10343 , C12N2830/008 , C12N2830/205 , C12N2830/85
摘要： Described is a replication competent virus, being capable to replicate and having lytic capacity in tarjet cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, funcional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.
摘要翻译：描述了能够在焦油喷射细胞中复制并具有溶解能力的复制感染病毒，所述病毒在其基因组中包含编码在所述靶细胞中靶基因表达有功能的沉默因子的至少一个DNA序列与所述靶细胞中的一个或多个表达控制序列有效连接，以及其在制备药物中的用途及其在裂解表达病毒抑制因子的靶细胞的方法中的用途。

3. 发明申请

WO2005100576A2 REPLICATION COMPETENT VIRUSES CAPABLE OF SILENCING VIRUS INHIBITORY FACTOR EXPRESSION 审中-公开
标题翻译：复制阴道病毒抑制因子表达的能力较强的病毒
公开(公告)号：WO2005100576A2
公开(公告)日：2005-10-27
申请号：PCT/EP2005/004152
申请日：2005-04-15
申请人： VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG , CARETTE, Jan, Eduard , VAN BEUSECHEM, Victor, Willem
发明人： CARETTE, Jan, Eduard , VAN BEUSECHEM, Victor, Willem
IPC分类号： C12N15/861
CPC分类号： C12N15/111 , A61K35/13 , A61K48/00 , C12N7/00 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/53 , C12N2320/10 , C12N2710/10343 , C12N2830/008 , C12N2830/205 , C12N2830/85
摘要： Described is a replication competent virus, being capable to replicate and having lytic capacity in tarjet cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, funcional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.
摘要翻译：描述了能够在焦油喷射细胞中复制并具有溶解能力的复制感染病毒，所述病毒在其基因组中包含编码在所述靶细胞中靶基因表达有功能的沉默因子的至少一个DNA序列与所述靶细胞中的一个或多个表达控制序列有效连接，以及其在制备药物中的用途及其在裂解表达病毒抑制因子的靶细胞的方法中的用途。

4. 发明申请

WO1996035798A1 IMPROVED RETROVIRAL VECTORS, ESPECIALLY SUITABLE FOR GENE THERAPY 审中-公开
标题翻译：改进的退化载体，特别适用于基因治疗
公开(公告)号：WO1996035798A1
公开(公告)日：1996-11-14
申请号：PCT/NL1996000195
申请日：1996-05-07
申请人： INTROGENE B.V. , VOGELS, Ronald , BOESEN, Johannes, Jozephes, Bernardus , VAN ES, Helmuth, Hendrikus, Gerardus , VAN BEUSECHEM, Victor, Willem , VALERIO, Domenico
发明人： INTROGENE B.V.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N7/00 , C12N2740/13023 , C12N2740/13043 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the field of molecular biology, especially recombinant DNA technology, especially concerning retroviral vectors. Retroviral vectors are very suitable vehicles for transferring genetic material of interest into certain cells in so-called gene therapy strategies. However, the retroviral vectors described so far are not ideal. They may give rise to recombination events resulting in helper (pathogenic) virus, they may express viral proteinaceous materials leading to immune responses, etc. These and other drawbacks are overcome by the vectors, cells, kits and methods of the present invention by providing a vector derived from a retrovirus, comprising a sequence responsible for transcriptional control, including an enhancer, which vector further comprises a site for insertion of at least one gene of interest, a packaging signal, said vector having no superfluous retroviral sequences and no open reading frame encoding at least parts of viral proteins, characterized in that the enhancer is an enhancer that is active in undifferentiated cells.
摘要翻译：本发明涉及分子生物学领域，特别是涉及逆转录病毒载体的重组DNA技术领域。逆转录病毒载体是用于将遗传物质转移到所谓基因治疗策略中的某些细胞的非常合适的载体。然而，迄今描述的逆转录病毒载体并不理想。它们可能引起导致辅助（致病性）病毒的重组事件，它们可以表达导致免疫应答的病毒蛋白质物质等。这些和其它缺点通过本发明的载体，细胞，试剂盒和方法来克服，衍生自逆转录病毒的载体，包含负责转录控制的序列，包括增强子，所述载体还包含用于插入至少一种目标基因的位点，包装信号，所述载体不具有多余的逆转录病毒序列，并且没有开放阅读框编码至少部分病毒蛋白质，其特征在于增强子是在未分化细胞中有活性的增强子。

5. 发明申请

WO03057892B1 VIRUSES WITH ENHANCED LYTIC POTENCY 审中-公开
标题翻译：具有增强的淋巴细胞毒性的病毒
公开(公告)号：WO03057892B1
公开(公告)日：2004-05-13
申请号：PCT/EP0300340
申请日：2003-01-14
申请人： VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS , VAN BEUSECHEM VICTOR WILLEM , GERRITSEN WILLEM-RONALD
发明人： VAN BEUSECHEM VICTOR WILLEM , GERRITSEN WILLEM-RONALD
IPC分类号： A61K35/76 , A61K48/00 , C07K14/47 , C12N15/86 , C12N15/861
CPC分类号： C12N7/00 , A61K35/761 , A61K38/00 , A61K48/00 , C07K14/4746 , C07K14/4747 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway, the virus comprising in the genome thereof, the coding sequence of at least one restoring factor functional in restoring the p53 apoptosis pathway in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells., as well as the use thereof in the preparation of a medicament, in particular for suppresing uncontrolled cell growth.
摘要翻译：描述了一种复制型重组病毒，其能够在靶细胞中复制并具有裂解能力，所述细胞在p53依赖性细胞凋亡途径中受到阻碍，病毒在其基因组中包含至少一种恢复因子功能的编码序列在所述靶细胞中恢复所述靶细胞中的p53细胞凋亡途径，其可操作地连接至在所述靶细胞中起作用的一种或多种表达控制序列，以及其在制备药物中的用途，特别是用于抑制不受控制的细胞生长。

6. 发明申请

WO2003057892A3 VIRUSES WITH ENHANCED LYTIC POTENCY 审中-公开
公开(公告)号：WO2003057892A3
公开(公告)日：2003-07-17
申请号：PCT/EP2003/000340
申请日：2003-01-14
申请人： VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS , VAN BEUSECHEM, Victor, Willem , GERRITSEN, Willem-Ronald
发明人： VAN BEUSECHEM, Victor, Willem , GERRITSEN, Willem-Ronald
IPC分类号： C12N15/86
摘要： Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway, the virus comprising in the genome thereof, the coding sequence of at least one restoring factor functional in restoring the p53 apoptosis pathway in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells., as well as the use thereof in the preparation of a medicament, in particular for suppresing uncontrolled cell growth.

7. 发明申请

WO2012047109A2 MIRNA AND MIRNA INHIBITORS THAT MODULATE ADENOVIRUS REPLICATION AND/OR ADENOVIRUS INDUCED CELL DEATH 审中-公开
标题翻译： MIRNA和MIRNA抑制剂调节腺病毒复制和/或腺病毒感染细胞死亡
公开(公告)号：WO2012047109A2
公开(公告)日：2012-04-12
申请号：PCT/NL2011/050688
申请日：2011-10-07
申请人： ORCA THERAPEUTICS B.V. , VAN BEUSECHEM, Victor Willem , VAN GINKEL, Jan Willem Hendrik
发明人： VAN BEUSECHEM, Victor Willem , VAN GINKEL, Jan Willem Hendrik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： The invention relates to means and methods for identifying a mi RNA, a mi RNA mimic or a mi RNA inhibitor that modulates adenovirus replication in, and/or adenovirus induced cell death of a cell. Identified mi RNAs, mi RNA mimics or mi RNA inhibitors are used as anti-cancer agents in the context of adenovirus gene therapy.
摘要翻译：本发明涉及用于鉴定调节腺病毒在腺病毒中的复制和/或腺病毒诱导的细胞死亡的mi RNA，mi RNA模拟物或mi RNA抑制剂的手段和方法。在腺病毒基因治疗的背景下，将鉴定的mi RNA，mi RNA模拟物或mi RNA抑制剂用作抗癌剂。

8. 发明申请

WO2011133040A3 REPLICATION-COMPETENT ADENOVIRUSES 审中-公开
标题翻译：复发性艾滋病毒
公开(公告)号：WO2011133040A3
公开(公告)日：2012-02-02
申请号：PCT/NL2011050281
申请日：2011-04-26
申请人： ORCA THERAPEUTICS B V , VERMEULEN CHRISTIE , VAN BEUSECHEM VICTOR WILLEM , TOL NIKKI
发明人： VERMEULEN CHRISTIE , VAN BEUSECHEM VICTOR WILLEM , TOL NIKKI
IPC分类号： A61K35/76 , C12N15/113 , C12N15/861
CPC分类号： C12N7/00 , A61K35/761 , C12N15/111 , C12N15/113 , C12N15/86 , C12N2310/14 , C12N2310/531 , C12N2330/51 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/008
摘要： The invention provides a replication competent adenovirus, being capable of replicating and having lytic capacity in a host cell, the virus genome comprising at least one DNA sequence coding for a silencing factor functional in reducing expression and/or activity of a target gene in the host cell. The invention further provides a kit of parts comprising a silencing factor and a replication competent adenovirus and a cell comprising a silencing factor and a replication competent adenovirus. In addition, the invention provides use of the kit of parts and the cell according to the invention.
摘要翻译：本发明提供了能够在宿主细胞中复制并具有溶解能力的复制感受态腺病毒，所述病毒基因组包含编码宿主中靶基因的表达和/或活性的功能的沉默因子的至少一个DNA序列细胞。本发明还提供了一种包含沉默因子和复制感受态腺病毒的部分试剂盒和包含沉默因子和复制型腺病毒的细胞。此外，本发明提供了本发明的部件和电池的试剂盒的用途。

9. 发明申请

WO2003057892A2 VIRUSES WITH ENHANCED LYTIC POTENCY 审中-公开
标题翻译：病毒与增强的LYTIC POTENCY
公开(公告)号：WO2003057892A2
公开(公告)日：2003-07-17
申请号：PCT/EP2003/000340
申请日：2003-01-14
申请人： VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS , VAN BEUSECHEM, Victor, Willem , GERRITSEN, Willem-Ronald
发明人： VAN BEUSECHEM, Victor, Willem , GERRITSEN, Willem-Ronald
IPC分类号： C12N15/86
CPC分类号： C12N7/00 , A61K35/761 , A61K38/00 , A61K48/00 , C07K14/4746 , C07K14/4747 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway, the virus comprising in the genome thereof, the coding sequence of at least one restoring factor functional in restoring the p53 apoptosis pathway in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells., as well as the use thereof in the preparation of a medicament, in particular for suppresing uncontrolled cell growth.
摘要翻译：描述了能够在靶细胞中复制并具有裂解能力的复制型重组病毒，所述细胞在p53依赖性凋亡途径中受阻，所述病毒在其基因组中包含至少一个恢复因子功能的编码序列在恢复所述靶细胞中的p53凋亡途径，其可操作地连接到所述靶细胞中功能的一种或多种表达调控序列，以及其在制备药物中的用途，特别是用于抑制不受控制的细胞生长。

10. 发明申请

WO2012047109A3 MIRNA AND MIRNA INHIBITORS THAT MODULATE ADENOVIRUS REPLICATION AND/OR ADENOVIRUS INDUCED CELL DEATH 审中-公开
标题翻译：调节腺病毒复制和/或腺病毒诱导的细胞死亡的MIRNA和MIRNA抑制剂
公开(公告)号：WO2012047109A3
公开(公告)日：2012-05-31
申请号：PCT/NL2011050688
申请日：2011-10-07
申请人： ORCA THERAPEUTICS B V , VAN BEUSECHEM VICTOR WILLEM , VAN GINKEL JAN WILLEM HENDRIK
发明人： VAN BEUSECHEM VICTOR WILLEM , VAN GINKEL JAN WILLEM HENDRIK
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： The invention relates to means and methods for identifying a mi RNA, a mi RNA mimic or a mi RNA inhibitor that modulates adenovirus replication in, and/or adenovirus induced cell death of a cell. Identified mi RNAs, mi RNA mimics or mi RNA inhibitors are used as anti-cancer agents in the context of adenovirus gene therapy.
摘要翻译：本发明涉及用于鉴定调节细胞中腺病毒复制和/或腺病毒诱导的细胞死亡的mi RNA，mi RNA模拟物或miRNA抑制剂的方法和方法。在腺病毒基因治疗的上下文中使用识别的mi RNA，mi RNA模拟物或mi RNA抑制剂作为抗癌剂。

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