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1. 发明申请

WO2011069031A3 MULTIPLANAR LATERAL FLOW ASSAY WITH SAMPLE COMPRESSOR 审中-公开
标题翻译：多采用压缩机进行多边测量
公开(公告)号：WO2011069031A3
公开(公告)日：2012-04-19
申请号：PCT/US2010058827
申请日：2010-12-03
申请人： RAPID PATHOGEN SCREENING INC , SAMBURSKY ROBERT P , BABU UMA MAHESH , VANDINE ROBERT W , KANAUJIA GANGA V , ORSINI THOMAS
发明人： SAMBURSKY ROBERT P , BABU UMA MAHESH , VANDINE ROBERT W , KANAUJIA GANGA V , ORSINI THOMAS
IPC分类号： G01N33/538 , G01N33/531
CPC分类号： G01N33/558 , C12Q1/6825 , G01N33/54386 , C12Q2565/625 , C12Q2565/629
摘要： A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
摘要翻译：样品压缩机向样品收集器和测试条的样品施加区域施加压力，以将样品从样品收集器和分析物的结合配对物转移到侧向流动装置中的样品施加区域。在使用侧流装置之前，分析物的至少一个结合配偶体不位于测试条上。测试条可以是通用测试条，没有特异性结合分析物位于测试条上的分子。样品压缩机可以是通用样品压缩机，也不具有特异性结合样品压缩机上的分析物的分子。侧向流动装置还可以包括一个或多个增强元件，其中增强元件结合到分析物夹心物以增加测试区域中的检测信号。

2. 发明申请

WO2011069029A3 LATERAL FLOW ASSAYS 审中-公开
标题翻译：横向流动测定
公开(公告)号：WO2011069029A3
公开(公告)日：2011-10-13
申请号：PCT/US2010058822
申请日：2010-12-03
申请人： RAPID PATHOGEN SCREENING INC , BABU UMA MAHESH , SAMBURSKY ROBERT P , VANDINE ROBERT W
发明人： BABU UMA MAHESH , SAMBURSKY ROBERT P , VANDINE ROBERT W
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/558 , C12Q1/6825 , G01N33/54386 , C12Q2565/625 , C12Q2565/629
摘要： Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent.
摘要翻译：包括预加载在分析装置上的移动标记的单链核酸试剂的测定和方法，所述试剂优选标记但不标记且与靶核酸的链（优选双链DNA靶标中的反义链）互补酸。该测定还包括运行缓冲液，其包含非特异性结合双链核酸的染料或其他可检测标记。此外，分析装置包括检测区域，该检测区域包括具有与移动核酸试剂上的标签结合的固定标签的一个或多个测试区域。

3. 发明申请

WO2011069029A2 LATERAL FLOW ASSAYS 审中-公开
标题翻译：侧流测定
公开(公告)号：WO2011069029A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/058822
申请日：2010-12-03
申请人： RAPID PATHOGEN SCREENING, INC. , BABU, Uma, Mahesh , SAMBURSKY, Robert, P , VANDINE, Robert, W.
发明人： BABU, Uma, Mahesh , SAMBURSKY, Robert, P , VANDINE, Robert, W.
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/558 , C12Q1/6825 , G01N33/54386 , Y02A50/51 , Y02A50/53 , Y02A50/54 , Y02A50/60 , C12Q2565/625 , C12Q2565/629
摘要： Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent.
摘要翻译：测定和方法，包括预先加载在分析装置上的移动标记单链核酸试剂，其优选地被标记但未标记并与靶核酸的链（优选双链DNA靶的反义链）互补酸。该测定还包括运行缓冲液，其包括仅与双链核酸非特异性结合的染料或其它可检测标记。此外，分析装置包括检测区域，该检测区域包括具有与移动核酸试剂上的标签结合的固定化标签的一个或多个测试区域。

4. 发明申请

WO2010009206A2 IN SITU LYSIS OF CELLS IN LATERAL FLOW IMMUNOASSAYS 审中-公开
标题翻译：在横向流免疫测定中细胞的原位裂解
公开(公告)号：WO2010009206A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050653
申请日：2009-07-15
申请人： RAPID PATHOGEN SCREENING, INC. , VANDINE, Robert, W. , BABU, Uma, Mahesh , SAMBURSKY, Robert, P.
发明人： VANDINE, Robert, W. , BABU, Uma, Mahesh , SAMBURSKY, Robert, P.
IPC分类号： G01N33/53 , G01N33/538
CPC分类号： G01N33/558 , C12Q1/6834 , C12Q2565/137
摘要： Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.
摘要翻译：装置和方法将裂解剂结合到护理点测试装置中。装载样本，然后样本移动直到遇到裂解剂。裂解剂优选预加载到收集装置上。在一个优选的实施方案中，最初的溶解剂位于样品施加区和缀合物区之间。裂解剂优选可溶于或可混溶于样品运输液体中，裂解剂在与样品运输液体接触时溶解并活化。样品输送液体然后包含溶液或悬浮液中的溶解剂和悬浮液中的样品组分。样品中任何溶解敏感组分，然后暴露于悬浮液中溶解试剂本身就地溶解。然后运行缓冲液将分析物（包括任何无溶解成分）携带到检测区。

5. 发明申请

WO2005075982A3 METHOD FOR THE RAPID DIAGNOSIS OF TARGETS IN HUMAN BODY FLUIDS 审中-公开
标题翻译：人体体液中靶标快速诊断的方法
公开(公告)号：WO2005075982A3
公开(公告)日：2006-02-09
申请号：PCT/EP2005001305
申请日：2005-02-09
申请人： RAPID PATHOGEN SCREENING INC , ABERL FRANZ , SCHEIBENZUBER MARCUS , SAMBURSKY ROBERT P , VANDINE ROBERT W , SAMBURSKY JOSE S
发明人： ABERL FRANZ , SCHEIBENZUBER MARCUS , SAMBURSKY ROBERT P , VANDINE ROBERT W , SAMBURSKY JOSE S
IPC分类号： G01N33/558 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/487 , G01N33/558 , G01N33/6893 , G01N2333/07 , Y10S436/811 , Y10T436/25375 , Y10T436/255
摘要： More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
摘要翻译：更具体地，本发明涉及用于检测靶的方法。人体液中的病原体，其中用拭子构件收集体液样品。

6. 发明申请

WO2005075982A2 METHOD FOR THE RAPID DIAGNOSIS OF TARGETS IN HUMAN BODY FLUIDS 审中-公开
标题翻译：人体体液中靶标快速诊断的方法
公开(公告)号：WO2005075982A2
公开(公告)日：2005-08-18
申请号：PCT/EP2005/001305
申请日：2005-02-09
申请人： RAPID PATHOGEN SCREENING INC. , ABERL, Franz , SCHEIBENZUBER, Marcus , SAMBURSKY, Robert, P. , VANDINE, Robert, W. , SAMBURSKY, Jose, S.
发明人： ABERL, Franz , SCHEIBENZUBER, Marcus , SAMBURSKY, Robert, P. , VANDINE, Robert, W. , SAMBURSKY, Jose, S.
IPC分类号： G01N33/48
CPC分类号： G01N33/56983 , G01N33/487 , G01N33/558 , G01N33/6893 , G01N2333/07 , Y10S436/811 , Y10T436/25375 , Y10T436/255
摘要： More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
摘要翻译：更具体地，本发明涉及用于检测靶的方法。人体液中的病原体，其中用拭子构件收集体液样品。

7. 发明申请

WO1998020719A1 MATERIALS FOR RADIO FREQUENCY/ELECTROMAGNETIC INTERFERENCE SHIELDING 审中-公开
标题翻译：无线电频率/电磁干扰屏蔽材料
公开(公告)号：WO1998020719A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020746
申请日：1997-11-07
申请人： THE JPM COMPANY, INC. , VANDINE, Robert, W. , JOHNSON, George, F. , LANGTON, Robert
发明人： THE JPM COMPANY, INC.
IPC分类号： H05K09/00
CPC分类号： H05K9/0083 , H01B1/22
摘要： The present invention provides an RFI and/or EMI shielding composition comprising a polymer, and an effective amount of metal particulates material in a size ranging from about 10 nm to about 100 mu m in length incorporated in said polymer. The figure exemplifies a cable connector which contains the shielding composition.
摘要翻译：本发明提供包含聚合物的RFI和/或EMI屏蔽组合物，以及有效量的长度为约10nm至约100μm的金属微粒材料，其掺入所述聚合物中。该图示出了包含屏蔽组合物的电缆连接器。

8. 发明申请

WO2011069031A2 MULTIPLANAR LATERAL FLOW ASSAY WITH SAMPLE COMPRESSOR 审中-公开
标题翻译：多采用压缩机进行多边测量
公开(公告)号：WO2011069031A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/058827
申请日：2010-12-03
申请人： RAPID PATHOGEN SCREENING, INC. , SAMBURSKY, Robert, P. , BABU, Uma, Mahesh , VANDINE, Robert, W. , KANAUJIA, Ganga, V. , ORSINI, Thomas
发明人： SAMBURSKY, Robert, P. , BABU, Uma, Mahesh , VANDINE, Robert, W. , KANAUJIA, Ganga, V. , ORSINI, Thomas
IPC分类号： G01N33/538 , G01N33/531
CPC分类号： G01N33/558 , C12Q1/6825 , G01N33/54386 , Y02A50/51 , Y02A50/53 , Y02A50/54 , Y02A50/60 , C12Q2565/625 , C12Q2565/629
摘要： A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
摘要翻译：样品压缩机向样品收集器和测试条的样品施加区域施加压力，以将样品从样品收集器和分析物的结合配对物转移到侧向流动装置中的样品施加区域。在使用侧流装置之前，分析物的至少一个结合配偶体不位于测试条上。测试条可以是通用测试条，没有特异性结合分析物位于测试条上的分子。样品压缩机可以是通用样品压缩机，也不具有特异性结合样品压缩机上的分析物的分子。侧向流动装置还可以包括一个或多个增强元件，其中增强元件结合到分析物夹心物以增加测试区域中的检测信号。

9. 发明申请

WO2010009206A3 IN SITU LYSIS OF CELLS IN LATERAL FLOW IMMUNOASSAYS 审中-公开
标题翻译：在流动免疫中的细胞的原位分析
公开(公告)号：WO2010009206A3
公开(公告)日：2010-05-14
申请号：PCT/US2009050653
申请日：2009-07-15
申请人： RAPID PATHOGEN SCREENING INC , VANDINE ROBERT W , BABU UMA MAHESH , SAMBURSKY ROBERT P
发明人： VANDINE ROBERT W , BABU UMA MAHESH , SAMBURSKY ROBERT P
IPC分类号： G01N33/53 , G01N33/538
CPC分类号： G01N33/558 , C12Q1/6834 , C12Q2565/137
摘要： Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.
摘要翻译：设备和方法将裂解剂并入护理点测试装置。加载样品，然后样品运行直到遇到裂解剂。裂解剂优选预加载到收集装置上。在优选的实施方案中，最初的裂解剂定位在样品施用区和缀合区之间。裂解剂优选在样品输送液体中可溶或可混溶，并且裂解剂在与样品输送液体接触时溶解和活化。样品输送液体随后含有溶液或悬浮液中的裂解剂和悬浮液中的样品组分。样品中任何裂解敏感的组分然后暴露于溶解剂的悬浮液中，它们本身就是裂解的。运行缓冲液然后将分析物（包括任何无裂解释放的组分）携带到检测区。

10. 发明申请

WO2010033963A2 METHOD AND DEVICE FOR COMBINED DETECTION OF VIRAL AND BACTERIAL INFECTIONS 审中-公开
标题翻译：用于组合检测病毒和细菌感染的方法和装置
公开(公告)号：WO2010033963A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057775
申请日：2009-09-22
申请人： RAPID PATHOGEN SCREENING, INC , SAMBURSKY, Robert P. , BABU, Uma Mahesh , VANDINE, Robert W.
发明人： SAMBURSKY, Robert P.
IPC分类号： G01N33/569 , C12Q1/04
CPC分类号： G01N33/558 , B01L3/5023 , B01L2300/0825
摘要： A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In one preferred embodiment, the bacterial marker is CRP. In another preferred embodiment, the viral marker is MxA. In some embodiments, it is unnecessary to lyse the cells in the sample prior to applying it to the device.
摘要翻译：侧流测定检测和区分病毒和细菌感染。护理诊断装置的综合点测试病毒感染的标记物和细菌感染的标记，以有效地帮助病毒和细菌感染的快速分化。在一个优选实施方案中，细菌标记物是CRP。在另一个优选的实施方案中，病毒标记是MxA。在一些实施方案中，在将样品中的细胞施加到装置之前，不必裂解细胞。

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