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1. 发明申请

WO2002075317A3 SCREENING FOR DRUGS AGAINST DISORDERS ASSOCIATED WITH SCHIZOPHRENIA 审中-公开
公开(公告)号：WO2002075317A3
公开(公告)日：2002-09-26
申请号：PCT/EP2002/002872
申请日：2002-03-14
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , UNIVERSITY OF MARYLAND , ROBERTS, Rosalinda, Cusido , VAN OOSTRUM, Jan , VOSHOL, Johannes , TAMMINGA, Carol, Ann
发明人： ROBERTS, Rosalinda, Cusido , VAN OOSTRUM, Jan , VOSHOL, Johannes , TAMMINGA, Carol, Ann
IPC分类号： G01N33/68
摘要： A method of sreening for compounds useful for the treatment of SSDs comprising contacting a test compound with a y-synuclein polypeptide and detecting interactions of the test compounds with said polypeptide or a nucleotide sequence encoding y-synuclein for the diagnosing of SSDs or susceptibility to SSDs, a kit useful for diagnosing SSDs or susceptibility to a SSDs, and a transgenic animal useful for the study of SSDs.

2. 发明申请

WO2002075317A2 DISEASE ASSOCIATED GENE 审中-公开
标题翻译：疾病相关基因
公开(公告)号：WO2002075317A2
公开(公告)日：2002-09-26
申请号：PCT/EP2002/002872
申请日：2002-03-14
申请人： NOVARTIS AG , NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , UNIVERSITY OF MARYLAND , ROBERTS, Rosalinda, Cusido , VAN OOSTRUM, Jan , VOSHOL, Johannes , TAMMINGA, Carol, Ann
发明人： ROBERTS, Rosalinda, Cusido , VAN OOSTRUM, Jan , VOSHOL, Johannes , TAMMINGA, Carol, Ann
IPC分类号： G01N33/68
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2267/03 , A01K2267/0306 , A01K2267/0356 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2800/302
摘要： A method of sreening for compounds useful for the treatment of SSDs comprising contacting a test compound with a y-synuclein polypeptide and detecting interactions of the test compounds with said polypeptide or a nucleotide sequence encoding y-synuclein for the diagnosing of SSDs or susceptibility to SSDs, a kit useful for diagnosing SSDs or susceptibility to a SSDs, and a transgenic animal useful for the study of SSDs.
摘要翻译：一种筛选用于治疗SSD的化合物的方法，包括使测试化合物与γ-突触核蛋白多肽接触并检测测试化合物与所述多肽的相互作用或编码γ-突触核蛋白的核苷酸序列，用于诊断SSD或对SSD的易感性，用于诊断SSD或易感性SSD的试剂盒，以及可用于研究SSD的转基因动物。

3. 发明申请

WO1996018734A1 PRODUCTION OF RECOMBINANT SECRETORY COMPONENT 审中-公开
标题翻译：生产重组分泌成分
公开(公告)号：WO1996018734A1
公开(公告)日：1996-06-20
申请号：PCT/EP1995004797
申请日：1995-12-06
申请人： CIBA-GEIGY AG , VAN OOSTRUM, Jan , ASSELBERGS, Fredericus, Alphonsus, Maria , LEIST, Christian , GRÜTTER, Markus
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , A61K38/00
摘要： The current invention relates to a recombinant secretory component (rSC) obtainable from a Chinese Hamster Ovary (CHO) cell that can be crystallized and, hence, is susceptible to systematic studies of its 3-dimensional structure. The crystallized form may be used directly or indirectly (e.g. via the derived structure) for lead finding, screening and binding studies.
摘要翻译：本发明涉及可从结构化的中国仓鼠卵巢（CHO）细胞获得的重组分泌成分（rSC），因此易于对其三维结构进行系统的研究。结晶形式可以直接或间接使用（例如通过衍生结构）用于铅测定，筛选和结合研究。

4. 发明申请

WO1995016033A1 C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY 审中-公开
标题翻译： C5a受体拮抗剂具有主要的无激素活性
公开(公告)号：WO1995016033A1
公开(公告)日：1995-06-15
申请号：PCT/IB1994000359
申请日：1994-11-16
申请人： CIBA-GEIGY AG , VAN OOSTRUM, Jan , BOYAR, William, C. , GALAKATOS, Nicholas, G. , PEPPARD, Jane, V.
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/12
CPC分类号： C07K14/472 , A61K38/00 , C07K16/18 , C07K2319/00
摘要： Disclosed are polypeptide analogues of human C5a which are C5a receptor antagonists that exhibit substantially no analphylatoxin or agonist activity, and derivatives of the analogues, and dimeric forms of the analogues or derivatives. DNA molecules encoding the polypeptides and methods of making the analogues are also provided. Pharmaceutical formulations containing a C5a analogue are used therapeutically in the treatment of C5a-mediated diseases and inflammatory conditions in mammals, and prophylactically to prevent or reduce inflammation caused by an event which causes inflammation or aggravates an existing inflammatory condition, respectively. Further disclosed are antibodies specific to the C5a analogues, derivatives thereof, and dimers of the analogues and derivatives which exhibit substantially no cross-reactivity with human C5a. The antibodies are used to detect or quantify circulating C5a analogue or derivative, as well as to modify, e.g., neutralize, the activity of the C5a receptor antagonist in vivo.
摘要翻译：公开了人C5a的多肽类似物，其是显示基本上没有分泌毒素或激动剂活性的C5a受体拮抗剂，以及类似物的衍生物和类似物或衍生物的二聚体形式。还提供了编码多肽的DNA分子和制备类似物的方法。含有C5a类似物的药物制剂治疗性地用于治疗哺乳动物中C5a介导的疾病和炎性病症，并预防性地预防或减少由引起炎症或加剧现有炎性病症的事件引起的炎症。进一步公开的是对C5a类似物，其衍生物和类似物和衍生物的二聚体特异的抗体，其表现出与人C5a基本上没有交叉反应性。所述抗体用于检测或定量循环C5a类似物或衍生物，以及修饰，例如中和体内C5a受体拮抗剂的活性。

5. 发明申请

WO2008034573A1 COMPOSITIONS AND DEVICES FOR ELECTRO-FILTRATION OF MOLECULES 审中-公开
标题翻译：用于电离过滤分子的组合物和装置
公开(公告)号：WO2008034573A1
公开(公告)日：2008-03-27
申请号：PCT/EP2007/008074
申请日：2007-09-17
申请人： NOVARTIS AG , FAUPEL, Michel, Daniel , VAN OOSTRUM, Jan VAN
发明人： FAUPEL, Michel, Daniel , VAN OOSTRUM, Jan VAN
IPC分类号： B01D71/82 , B01D67/00 , B01D57/02 , C07K1/28 , C12N15/10 , G01N27/447
CPC分类号： B01D61/425 , B01D67/0093 , B01D71/82 , C07K1/28 , G01N27/44747 , G01N27/44795
摘要： The present invention relates to means and devices for electro-filtration of molecules. The membranes comprise N-acryloyl-tris(hydroxymethyl)aminomethane (NAT) covalently linked to a support. The invention further encompasses compositions comprising an isoelectric buffer covalently bound to N-acryloyl-tris(hydroxymethyl)aminomethane (NAT). In particular, the present invention relates to membranes and devices allowing an isoelectric filtration of molecules in solution.
摘要翻译：本发明涉及分子电过滤的方法和装置。膜包含与载体共价连接的N-丙烯酰基 - 三（羟甲基）氨基甲烷（NAT）。本发明还包括包含与N-丙烯酰基 - 三（羟甲基）氨基甲烷（NAT）共价结合的等电子缓冲剂的组合物。特别地，本发明涉及允许溶液中分子的等电过滤的膜和装置。

6. 发明申请

WO1996039503A1 C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION 审中-公开
标题翻译： C5a受体拮抗剂具有大量无激素活性及其制备方法
公开(公告)号：WO1996039503A1
公开(公告)日：1996-12-12
申请号：PCT/EP1996002422
申请日：1996-06-04
申请人： CIBA-GEIGY AG , VAN OOSTRUM, Jan , VAN HEEKE, Gino , SCHMITZ, Albert
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/12
CPC分类号： C07K16/18 , A61K38/00 , C07K14/472 , C07K2319/00
摘要： Disclosed are polypeptide analogues or derivatives of human C5a which are C5a receptor antagonists that exhibit substantially no analphylatoxin or agonist activity, and derivatives of the analogues, and dimeric forms of the analogues or derivatives. DNA molecules encoding the polypeptides and methods of making the analogues are also provided. Pharmaceutical formulations containing a C5a analogue or derivative, are used therapeutically in the treatment of C5a-mediated diseases and inflammatory conditions in mammals, and prophylactically to prevent or reduce inflammation caused by an event which causes inflammation or aggravates an existing inflammatory condition, respectively. Further disclosed are antibodies specific to the C5a analogues, derivatives thereof, and dimers of the analogues and derivatives which exhibit substantially no cross-reactivity with human C5a. The antibodies are used to detect or quantify circulating C5a analogue or derivative, as well as to modify, e.g., neutralize, the activity of the C5a receptor antagonist in vivo.
摘要翻译：公开了人C5a的多肽类似物或衍生物，其是显示基本上没有分泌毒素或激动剂活性的C5a受体拮抗剂，以及类似物的衍生物和类似物或衍生物的二聚体形式。还提供了编码多肽的DNA分子和制备类似物的方法。含有C5a类似物或衍生物的药物制剂可用于治疗哺乳动物中C5a介导的疾病和炎性病症，并预防性地预防或减少由引起炎症或加重现有炎性疾病的事件引起的炎症。进一步公开的是对C5a类似物，其衍生物和类似物和衍生物的二聚体特异的抗体，其表现出与人C5a基本上没有交叉反应性。所述抗体用于检测或定量循环C5a类似物或衍生物，以及修饰，例如中和体内C5a受体拮抗剂的活性。

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