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1. 发明申请

WO2004033461A1 5-SUBSTITUTED 7,9-DIFLUORO-5H-CHROMENO[3,4-f]QUINOLINE COMPOUNDS AS SELECTIVE PROGESTERONE RECEPTOR MODULATORS 审中-公开
标题翻译： 5-取代的7,9-二氟-5H-色胺[3,4-f]喹啉化合物作为选择性孕激素受体调节剂
公开(公告)号：WO2004033461A1
公开(公告)日：2004-04-22
申请号：PCT/US2003/024420
申请日：2003-08-04
申请人： LIGAND PHARMACEUTICALS INCORPORATED , ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , PEDRAM, Bijan , KARANEWSKY, Donald
发明人： ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , PEDRAM, Bijan , KARANEWSKY, Donald
IPC分类号： C07D491/04
CPC分类号： C07D491/04
摘要： The present invention is directed to compounds of formula (I) or (II), pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译：本发明涉及式（I）或（II）的化合物，药物组合物和调节由孕酮受体介导的过程的方法。还提供了制备这些化合物和药物组合物的方法。

2. 发明申请

WO2004033460A1 5-CYCLOALKENYL 5H-CHROMENO[3,4-F]QUINOLINE DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS 审中-公开
标题翻译：作为选择性前列腺素受体调节剂化合物的5-环烯基-5H-色胺[3,4-F]喹啉衍生物
公开(公告)号：WO2004033460A1
公开(公告)日：2004-04-22
申请号：PCT/US2003/024419
申请日：2003-08-04
申请人： LIGAND PHARMACEUTICALS INCORPORATED , ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , PEDRAM, Bijan , KARANEWSKY, Donald
发明人： ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , PEDRAM, Bijan , KARANEWSKY, Donald
IPC分类号： C07D491/04
CPC分类号： C07D491/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译：本发明涉及用于调节由孕酮受体介导的过程的化合物，药物组合物和方法。还提供了制备这些化合物和药物组合物的方法。

3. 发明申请

WO2007075884A3 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
标题翻译：雄激素受体调节剂化合物和方法
公开(公告)号：WO2007075884A3
公开(公告)日：2007-08-23
申请号：PCT/US2006048784
申请日：2006-12-21
申请人： LIGAND PHARM INC , VAN OEVEREN CORNELIS ARJAN , SHEN YIXING , ZHAO SHUO , ZHI LIN
发明人： VAN OEVEREN CORNELIS ARJAN , SHEN YIXING , ZHAO SHUO , ZHI LIN
IPC分类号： C07D498/04 , A61K31/5365 , A61P5/00
CPC分类号： C07D498/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions.
摘要翻译：本文提供了与雄激素受体结合和/或调节雄激素受体活性和/或调节雄激素受体量的化合物; 并涉及制备和使用这些化合物的方法。还提供了含有这些化合物的组合物以及制备和使用这些组合物的方法。

4. 发明申请

WO2007075884A2 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
标题翻译：雄激素受体调节剂化合物和方法
公开(公告)号：WO2007075884A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048784
申请日：2006-12-21
申请人： LIGAND PHARMACEUTICALS INCORPORATED , VAN OEVEREN, Cornelis, Arjan , SHEN, Yixing , ZHAO, Shuo , ZHI, Lin
发明人： VAN OEVEREN, Cornelis, Arjan , SHEN, Yixing , ZHAO, Shuo , ZHI, Lin
IPC分类号： C07D498/04 , A61K31/5365 , A61P5/00
CPC分类号： C07D498/04
摘要： Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions.
摘要翻译：本文提供了结合雄激素受体和/或调节雄激素受体活性和/或调节雄激素受体量的化合物; 以及制备和使用这些化合物的方法。还提供含有这些化合物的组合物和制备和使用这些组合物的方法。

5. 发明申请

WO02066475A2 TRICYCLIC ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
公开(公告)号：WO02066475A2
公开(公告)日：2002-08-29
申请号：PCT/IB0200537
申请日：2002-02-23
申请人： LIGAND PHARM INC , ZHI LIN , VAN OEVEREN CORNELIS ARJAN , CHEN JYUN-HUNG , HIGUCHI ROBERT I
发明人： ZHI LIN , VAN OEVEREN CORNELIS ARJAN , CHEN JYUN-HUNG , HIGUCHI ROBERT I
IPC分类号： C07D491/052 , A61K31/366 , A61K31/436 , A61K31/437 , A61K31/4375 , A61P1/14 , A61P5/24 , A61P5/26 , A61P7/00 , A61P13/08 , A61P15/00 , A61P15/10 , A61P17/10 , A61P17/14 , A61P19/10 , A61P35/00 , C07D471/04 , C07D491/04 , C07D493/04 , C07D471/00
CPC分类号： C07D471/04 , C07D491/04 , C07D493/04
摘要： This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
摘要翻译：本发明涉及作为雄激素受体调节剂的非甾体三环化合物以及制备和使用这些化合物的方法。

6. 发明申请

WO2007062078A3 THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS 审中-公开
公开(公告)号：WO2007062078A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045129
申请日：2006-11-21
申请人： LIGAND PHARMACEUTICALS INC. , ZHI, Lin , PHILLIPS, Dean P. , DALGARD, Jackline E. , PENULIAR, Richard J. , MCNEILL, Matthew H. , CHEN, Jyun-Hung , CUERVO, Catalina , HIGUCHI, Robert , LI, Yongkai , LONG, Oliver , VAN OEVEREN, Cornelis Arjan
发明人： ZHI, Lin , PHILLIPS, Dean P. , DALGARD, Jackline E. , PENULIAR, Richard J. , MCNEILL, Matthew H. , CHEN, Jyun-Hung , CUERVO, Catalina , HIGUCHI, Robert , LI, Yongkai , LONG, Oliver , VAN OEVEREN, Cornelis Arjan
IPC分类号： C07D207/44 , C07D209/34 , C07D209/40 , C07D231/20 , C07D231/26 , C07D231/38 , C07D277/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/4152
摘要： Disclosed herein are amide containing heterocyclic compounds, pharmaceutical compositions comprising the compounds, methods of modulating the activity a thrombopoietin receptor using the compounds, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering the compounds to a patient in need thereof.

7. 发明申请

WO2007062078A2 THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS 审中-公开
标题翻译：血小板活化调节化合物和方法
公开(公告)号：WO2007062078A2
公开(公告)日：2007-05-31
申请号：PCT/US2006045129
申请日：2006-11-21
申请人： LIGAND PHARM INC , ZHI LIN , PHILLIPS DEAN P , DALGARD JACKLINE E , PENULIAR RICHARD J , MCNEILL MATTHEW H , CHEN JYUN-HUNG , CUERVO CATALINA , HIGUCHI ROBERT , LI YONGKAI , LONG OLIVER , VAN OEVEREN CORNELIS ARJAN
发明人： ZHI LIN , PHILLIPS DEAN P , DALGARD JACKLINE E , PENULIAR RICHARD J , MCNEILL MATTHEW H , CHEN JYUN-HUNG , CUERVO CATALINA , HIGUCHI ROBERT , LI YONGKAI , LONG OLIVER , VAN OEVEREN CORNELIS ARJAN
CPC分类号： C07D209/34 , C07D207/448 , C07D207/452 , C07D209/40 , C07D231/20 , C07D231/26 , C07D231/38 , C07D277/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed herein are amide containing heterocyclic compounds, pharmaceutical compositions comprising the compounds, methods of modulating the activity a thrombopoietin receptor using the compounds, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering the compounds to a patient in need thereof.
摘要翻译：本文公开了含酰胺的杂环化合物，包含该化合物的药物组合物，使用该化合物调节血小板生成素受体活性的方法，鉴定化合物作为血小板生成素受体调节剂的方法，以及通过向有需要的患者施用化合物来治疗疾病的方法。

8. 发明申请

WO2005090282A1 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
标题翻译：雄激素受体调节剂化合物和方法
公开(公告)号：WO2005090282A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007867
申请日：2005-03-11
申请人： LIGAND PHARMACEUTICALS INCORPORATED , ZHI, Lin , HIGUCHI, Robert, I. , KALLEL, E., Adam , VAN OEVEREN, Cornelis, Arjan , CHEN, Jyun-Hung , RUPPAR, Daniel, A. , PEDRAM, Bijan , LAU, Thomas, Lot, Stevens , MILLER, Todd
发明人： ZHI, Lin , HIGUCHI, Robert, I. , KALLEL, E., Adam , VAN OEVEREN, Cornelis, Arjan , CHEN, Jyun-Hung , RUPPAR, Daniel, A. , PEDRAM, Bijan , LAU, Thomas, Lot, Stevens , MILLER, Todd
IPC分类号： C07C211/52
CPC分类号： C07C211/52 , C07C205/55 , C07C255/58 , C07C2601/08 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/46 , C07D209/04 , C07D209/08 , C07D209/12 , C07D211/22 , C07D211/56 , C07D211/60 , C07D215/04 , C07D215/18 , C07D265/36 , C07D295/073 , C07F7/1848 , G01N2333/723
摘要： Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
摘要翻译：本文提供具有选自式（I），式（II），式（III），式（IV），式（V）和式（VI））的结构的化合物，其是雄激素受体调节剂和/或雄激素受体结合代理商。还公开了制备和使用这些化合物的方法，包括但不限于使用这些化合物来处理各种条件。

9. 发明申请

WO2004033459A1 5-(1',1'-CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO-5H-CHROMENO[3,4-f]QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS 审中-公开
标题翻译：作为选择性孕激素受体调节剂化合物的5-（1'，1'-环烯基/亚苄基）甲基1,2-二氢-5H-氯苯并[3,4-f]喹啉
公开(公告)号：WO2004033459A1
公开(公告)日：2004-04-22
申请号：PCT/US2003/024416
申请日：2003-08-04
申请人： LIGAND PHARMACEUTICALS INCORPORATED , ZHI, Lin , VAN OEVEREN, Cornelis, Arjan
发明人： ZHI, Lin , VAN OEVEREN, Cornelis, Arjan
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , G01N33/743
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. A compound of the formula (I), wherein R 1 is selected from the group of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C l -C 4 heteroalkyl, COR 5 , C0 2 R 5 , S0 2 R 5 , and CONR 5 R 6 ; R 2 and R 3 each independently is selected from the group of hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; or R 2 and R 3 taken together form a cycloalkyl ring of from three to twelve carbons; R 7 through R 9 each independently is selected from the group of hydrogen, F, Cl, Br, I, NO 2 , CN, OR 5 , NR 5 R 6 , SR 5 , COR 5 , C0 2 R 5 , CONR 5 R 6 , C 1 -C 8 alkyl, C 1 -C s heteroalkyl, C 1 -C 8 haloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl; Y and Z each independently is selected from the group of O, S, NR 6 and CR 14 R 15 ; n is 0, 1, 2, or 3.
摘要翻译：本发明涉及用于调节由孕酮受体介导的过程的化合物，药物组合物和方法。还提供了制备这些化合物和药物组合物的方法。式（I）的化合物，其中R 1选自氢，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4杂烷基，COR 5，CO 2 R 5，SO 2 R 5 >和CONR 5 R 6; R 2和R 3各自独立地选自氢，C 1 -C 6烷基和C 1 -C 6卤代烷基; 或R 2和R 3一起形成3至12个碳的环烷基环; R 7至R 9各自独立地选自氢，F，Cl，Br，I，NO 2，CN，OR 5，NR 5 R 6，SR 5， COR 5，CO 2 R 5，CONR 5 R 6，C 1 -C 8烷基，C 1 -C 8杂烷基，C 1 -C 8卤代烷基，C 2 -C 8烯基，C 2 -C 8炔基; Y和Z各自独立地选自O，S，NR 6和CR 14 R 15; n为0,1,2或3。

10. 发明申请

WO2002066475A3 TRICYCLIC ANDROGEN RECEPTOR MODULATOR COMPOUNDS 审中-公开
公开(公告)号：WO2002066475A3
公开(公告)日：2002-08-29
申请号：PCT/IB2002/000537
申请日：2002-02-23
申请人： LIGAND PHARMACEUTICALS INCORPORATED , ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , CHEN, Jyun-Hung , HIGUCHI, Robert, I.
发明人： ZHI, Lin , VAN OEVEREN, Cornelis, Arjan , CHEN, Jyun-Hung , HIGUCHI, Robert, I.
IPC分类号： C07D471/06
摘要： This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.

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