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1. 发明申请

WO2011140492A3 SYSTEM AND METHOD FOR EXTRACTING A SAMPLE FROM A SURFACE 审中-公开
标题翻译：从表面提取样品的系统和方法
公开(公告)号：WO2011140492A3
公开(公告)日：2012-01-26
申请号：PCT/US2011035604
申请日：2011-05-06
申请人： UT BATTELLE LLC , DH TECHNOLOGIES DEV PTE LTD , VAN BERKEL GARY J , COVEY THOMAS
发明人： VAN BERKEL GARY J , COVEY THOMAS
IPC分类号： H01J49/00
CPC分类号： G01N1/4055 , B01L3/502715 , G01N2001/028 , H01J49/00
摘要： A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.
摘要翻译：公开了从样品表面提取样品的系统和方法。提供样品并且样品表面接收沉积在样品表面上的样品。将疏水性材料施加到样品表面，并且一个或多个装置构造成分配样品上的液体，溶解样品的液体以形成溶解的样品材料，并且一个或多个装置被配置为提取溶解的样品材料从样品表面。

2. 发明申请

WO2012167259A1 ENHANCED SPOT PREPARATION FOR LIQUID EXTRACTIVE SAMPLING AND ANALYSIS 审中-公开
标题翻译：液体提取采样和分析的增强点准备
公开(公告)号：WO2012167259A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040757
申请日：2012-06-04
申请人： UT-BATTELLE, LLC , VAN BERKEL, Gary J. , KING, Richard C.
发明人： VAN BERKEL, Gary J. , KING, Richard C.
IPC分类号： G01N1/20
CPC分类号： G01N1/38 , G01N2001/383 , H01J49/0404 , H01J49/0468
摘要： A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.
摘要翻译：用于进行分析物的表面取样的方法包括将分析物放置在具有与分析物摩尔过量的材料的平台上的步骤，从而防止分析物 - 分析物的相互作用，并且分析物可以溶解以用于进一步分析。该材料可以是与分析物混合的基质材料。材料可以提供在样品支架上。然后可以将分析物与溶剂接触以提取分析物用于进一步处理，例如通过电喷雾质谱法。

3. 发明申请

WO2012040559A1 SPATIALLY RESOLVED THERMAL DESORPTION/IONIZATION COUPLED WITH MASS SPECTROMETRY 审中-公开
标题翻译：空间解析与大量光谱耦合的热解吸附
公开(公告)号：WO2012040559A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052925
申请日：2011-09-23
申请人： UT-BATTELLE, LLC , OVCHINNIKOVA, Olga, S. , VAN BERKEL, Gary, J. , JESSE, Stephen
发明人： OVCHINNIKOVA, Olga, S. , VAN BERKEL, Gary, J. , JESSE, Stephen
IPC分类号： G01N1/18
CPC分类号： H01J49/0004 , G01Q30/02 , G01Q60/38 , H01J49/0413 , H01J49/049
摘要： A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200°C, and positioning the target site and the thermally active tip such that the heating step forms the gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less.
摘要翻译：描述了用于样品的化学组成的亚微米分析的系统和方法。该方法包括提供用于评估的样本和热解吸探针，使用热活性尖端从所述样品的靶位点热解析分析物以形成气态分析物，电离气态分析物以形成离子化分析物，并分析化学物质电离分析物的组成。热解吸步骤可以包括将所述热活性尖端加热至高于200℃，并且定位靶部位和热活性末端，使得加热步骤形成气态分析物。热解吸探针可以包括从悬臂体延伸的热活性尖端，并且热活性尖端的顶点可以具有250nm或更小的半径。

4. 发明申请

WO2014179417A1 AFM FLUID DELIVERY/LIQUID EXTRACTION SURFACE SAMPLING/ELECTROSTATIC SPRAY CANTILEVER PROBE 审中-公开
标题翻译： AFM流体输送/液体萃取表面采样/静电喷雾CANTILEVER探头
公开(公告)号：WO2014179417A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/036086
申请日：2014-04-30
申请人： UT-BATTELLE, LLC , VAN BERKEL, Gary J.
发明人： VAN BERKEL, Gary J.
IPC分类号： G01N1/02
CPC分类号： H01J49/167 , G01Q30/14 , G01Q60/38 , G01Q70/08 , H01J49/0031 , H01J49/0459 , H01J49/26
摘要： An electrospray system comprises a liquid extraction surface sampling probe. The probe comprises a probe body having a liquid inlet and a liquid outlet, and having a liquid extraction tip. A solvent delivery conduit is provided for receiving solvent liquid from the liquid inlet and delivering the solvent liquid to the liquid extraction tip. An open liquid extraction channel extends across an exterior surface of the probe body from the liquid extraction tip to the liquid outlet. An electrospray emitter tip is in liquid communication with the liquid outlet of the liquid extraction surface sampling probe. A system for analyzing samples, a liquid junction surface sampling system, and a method of analyzing samples are also disclosed.
摘要翻译：电喷雾系统包括液体提取表面采样探针。探针包括具有液体入口和液体出口的探针体，并具有液体提取尖端。提供溶剂输送导管，用于从液体入口接收溶剂液体，并将溶剂液体输送到液体萃取尖端。开放的液体提取通道延伸穿过探针体的外表面从液体提取尖端延伸到液体出口。电喷射发射器尖端与液体提取面取样探针的液体出口液体连通。还公开了用于分析样品的系统，液体接合面采样系统和分析样品的方法。

5. 发明申请

WO2011140492A2 SYSTEM AND METHOD FOR EXTRACTING A SAMPLE FROM A SURFACE 审中-公开
标题翻译：从表面提取样品的系统和方法
公开(公告)号：WO2011140492A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/035604
申请日：2011-05-06
申请人： UT-BATTELLE, LLC , DH TECHNOLOGIES DEVELOPMENT PTE.LTD , VAN BERKEL, Gary, J. , COVEY, Thomas
发明人： VAN BERKEL, Gary, J. , COVEY, Thomas
IPC分类号： H01J49/10 , B01L3/02 , H01J27/02
CPC分类号： G01N1/4055 , B01L3/502715 , G01N2001/028 , H01J49/00
摘要： A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.
摘要翻译：公开了从样品表面提取样品的系统和方法。提供样品并且样品表面接收沉积在样品表面上的样品。将疏水性材料施加到样品表面，并且一个或多个装置构造成分配样品上的液体，溶解样品的液体以形成溶解的样品材料，并且一个或多个装置被配置为提取溶解的样品材料从样品表面。

6. 发明申请

WO2006132708A3 AUTOMATED POSITION CONTROL OF A SURFACE ARRAY RELATIVE TO A LIQUID MICROJUNCTION SURFACE SAMPLER 审中-公开
标题翻译：相对于液体微观表面采样器的表面阵列的自动位置控制
公开(公告)号：WO2006132708A3
公开(公告)日：2007-11-29
申请号：PCT/US2006014383
申请日：2006-04-18
申请人： UT BATTELLE LLC , VAN BERKEL GARY J , KERTESZ VILMOS , FORD MICHAEL JAMES
发明人： VAN BERKEL GARY J , KERTESZ VILMOS , FORD MICHAEL JAMES
IPC分类号： H01J49/04
CPC分类号： H01J49/0413 , H01J49/0004
摘要： A system (20) and method utilizes an image analysis approach for controlling the probe-to-surface distance of a liquid junction-based surface sampling system for use with mass spectrometric detection. Such an approach enables a hands-free formation of the liquid micro junction used to sample solution composition from the surface and for re-optimization, as necessary, of the micro junction thickness during a surface scan to achieve a fully automated surface sampling system.
摘要翻译：系统（20）和方法利用图像分析方法来控制用于质谱检测的基于液面的表面采样系统的探针到表面距离。这样的方法使得能够免于形成用于从表面取样溶液组合物的液体微结，并根据需要在表面扫描期间重新优化微结厚度以实现全自动表面采样系统。

7. 发明申请

WO2004108299A3 POROUS ELECTROSPRAY EMITTER 审中-公开
标题翻译：多孔电喷发生器
公开(公告)号：WO2004108299A3
公开(公告)日：2005-06-02
申请号：PCT/US2004018008
申请日：2004-06-04
申请人： ESA INC , GRANGER MICHAEL C , VAN BERKEL GARY J
发明人： GRANGER MICHAEL C , VAN BERKEL GARY J
IPC分类号： B01D59/44 , B05B20060101 , H01J49/04 , H01J49/10
CPC分类号： H01J49/165 , H01J49/0436
摘要： Disclosed are systems and methods that include a flow-cell (102) that includes porous conductive material(s) (204) that provides a working electrode(s) (108), an inlet (106) connected to the flow-cell (102)to deliver a solution (140) containing an analyte(s), an outlet (110) connected to the flow-cell (102) to allow the solution (140) to exit the flow-cell (102), a counter electrode (122) positioned proximate to the outlet (110), and a voltage source(s) (130) coupled to the working electrode(s) (108) and the counter electrode (122). The methods can include delivering a solution (140) containing an analyte(s) through an inlet (106) to a flow-cell (102) that includes porous conductive material(s) (204) that provides a working electrode(s) (108), connecting the flow-cell (102) to an outlet (110) for allowing the solution (140) to exit the flow-cell (102), placing a counter-electrode proximate the outlet, and supplying a voltage from a voltage source(s) to the working electrode(s) (108) and/or the counter-electrode (122).
摘要翻译：公开了包括流动池（102）的系统和方法，该流动池包括提供工作电极（108）的多孔导电材料（204），连接到流通池（102）的入口（106））输送含有分析物的溶液（140），连接到流通池（102）以使溶液（140）离开流通池（102）的出口（110），对电极（定位成靠近出口（110），以及耦合到工作电极（108）和对电极（122）的电压源（130）。所述方法可以包括将含有分析物的溶液（140）通过入口（106）输送到包括提供工作电极（多个）的多孔导电材料（204）的流动池（102） 108），将流通池（102）连接到出口（110），用于允许溶液（140）离开流通池（102），将反电极放置在靠近出口处，并且将电压从电压源极与工作电极（108）和/或对电极（122）之间。

8. 发明申请

WO2012045077A1 SYSTEMS AND METHODS FOR LASER ASSISTED SAMPLE TRANSFER TO SOLUTION FOR CHEMICAL ANALYSIS 审中-公开
标题翻译：用于激光辅助样品转移到化学分析方法的系统和方法
公开(公告)号：WO2012045077A1
公开(公告)日：2012-04-05
申请号：PCT/US2011/054622
申请日：2011-10-03
申请人： UT-BATTELLE, LLC , VAN BERKEL, Gary, J. , KERTESZ, Vilmos , OVCHINNIKOVA, Olga, S.
发明人： VAN BERKEL, Gary, J. , KERTESZ, Vilmos , OVCHINNIKOVA, Olga, S.
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： G01N1/04 , G01N1/22 , G01N2001/045 , G01Q30/02 , H01J49/0463 , H01J49/165
摘要： Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.
摘要翻译：描述了用于从样品激光烧蚀分析物并在分配的溶剂中捕获分析物以形成测试溶液的系统和方法。溶剂分配和萃取系统可以与样品形成液体微结构。溶剂分配和提取系统可以包括表面取样探针。激光束可以通过表面取样探针引导。表面采样探头也可以用作原子力显微镜探针。表面采样探头可以与样品形成密封。然后可以使用分析仪器分析包括分析物的测试溶液或进行进一步处理。

9. 发明申请

WO2012044720A1 SURFACE SAMPLING CONCENTRATION AND REACTION PROBE 审中-公开
标题翻译：表面采样浓度和反应探针
公开(公告)号：WO2012044720A1
公开(公告)日：2012-04-05
申请号：PCT/US2011/053799
申请日：2011-09-29
申请人： UT-BATTELLE, LLC , VAN BERKEL, Gary, J. , ELNAGGAR, Mariam, S.
发明人： VAN BERKEL, Gary, J. , ELNAGGAR, Mariam, S.
IPC分类号： G01N1/32 , H01J49/04
CPC分类号： G01N1/02 , G01N1/32 , G01N2001/028 , G01N2001/383 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/2575
摘要： A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.
摘要翻译：对分析试样的化学成分的方法进行说明。该方法可以包括提供包括外毛细管和内毛细管的探针，所述毛细管同轴地设置在外毛细管内，其中内毛细管和外毛细管限定溶剂毛细管和在探针的远端; 使样品表面上的目标部位与探针流体连通的溶剂接触; 保持邻近溶剂 - 样品界面的塞体积，其中所述塞体积与所述探针流体连通; 通过采样毛细管从塞子体积中排出塞子取样流体; 并用分析仪器分析塞子采样流体的化学成分。还描述了用于执行该方法的系统。

10. 发明申请

WO2012030715A1 DEVICE FOR HIGH SPATIAL RESOLUTION CHEMICAL ANALYSIS OF A SAMPLE AND METHOD OF HIGH SPATIAL RESOLUTION CHEMICAL ANALYSIS 审中-公开
标题翻译：高空间分辨率化学分析方法的设备及高分辨率化学分析方法
公开(公告)号：WO2012030715A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/049537
申请日：2011-08-29
申请人： UT-BATTELLE, LLC , VAN BERKEL, Gary, J.
发明人： VAN BERKEL, Gary, J.
IPC分类号： H01H49/00
CPC分类号： H01J49/0431
摘要： A system and method for analyzing a chemical composition of a specimen are described. The system can include at least one pin; a sampling device configured to contact a liquid with a specimen on the at least one pin to form a testing solution; and a stepper mechanism configured to move the at least one pin and the sampling device relative to one another. The system can also include an analytical instrument for determining a chemical composition of the specimen from the testing solution. In particular, the systems and methods described herein enable chemical analysis of specimens, such as tissue, to be evaluated in a manner that the spatial-resolution is limited by the size of the pins used to obtain tissue samples, not the size of the sampling device used to solubilize the samples coupled to the pins.
摘要翻译：描述用于分析试样的化学成分的系统和方法。该系统可以包括至少一个销; 采样装置，被配置为使液体与所述至少一个销上的样品接触以形成测试溶液; 以及步进机构，其构造成使所述至少一个销和所述取样装置相对于彼此移动。该系统还可以包括用于从测试溶液中测定样品的化学成分的分析仪器。特别地，本文描述的系统和方法使得可以以空间分辨率受到用于获得组织样本的针的尺寸限制的方式来评估样品（例如组织）的化学分析，而不是采样的尺寸用于溶解耦合到引脚的样品的装置。

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