专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009067813A1 APURINIC/APYRIMIDINIC ENDONUCLEASE 1 (APE1) FOR USE IN THE TREATMENT OF DISORDERS ASSOCIATED WITH ABERRANT RNA TRANSCRIPTION, ABERRANT MICRORNA TRANSCRIPTION, VIRAL RNA TRANSCRIPTION, AND ABERRANT C-MYC RNA TRANSCRIPTION 审中-公开
标题翻译：用于治疗与ABERRANT RNA转录物，ABERRANT MICRORNA转录物，VIRAL RNA转录物和ABERRANT C-MYC RNA转录物相关的疾病的APURINIC / APYRIMIDINIC ENDNUCLEASE 1（APE1）
公开(公告)号：WO2009067813A1
公开(公告)日：2009-06-04
申请号：PCT/CA2008/002096
申请日：2008-11-28
申请人： THE UNIVERSITY OF NORTHERN BRITISH COLUMBIA , LEE, Chow , BARNES, Tavish , KIM, Wan, Cheol
发明人： LEE, Chow , BARNES, Tavish , KIM, Wan, Cheol
IPC分类号： A61K38/46 , A61K38/16 , C12P19/34 , C12N9/22
CPC分类号： C12Y402/99018 , A61K38/00 , C12N9/22
摘要： A method of treating or preventing a disorder selected from: aberrant RNA transcription; viral RNA transcription; aberrant microRNA transcription; and aberrant c-myc RNA transcription, the method including administering a pharmaceutically effective amount of apurinic/apyrimidic endonuclease (APE1), a fragment of APE1, variants of APE1 or a pharmaceutical composition thereof is provided. In other aspects uses of APE1 peptides or fragments or variants or pharmaceutical compositions thereof are provided for treatment, prevention, or for preparation of medicaments for treatment and prevention of a disorder selected from: aberrant RNA transcription; viral RNA transcription; aberrant microRNA transcription; and aberrant c-myc RNA transcription.
摘要翻译：一种治疗或预防选自以下的病症的方法：异常RNA转录; 病毒RNA转录; 异常microRNA转录; 和异常c-myc RNA转录物，该方法包括给药药物有效量的脱嘌呤/脱酰亚胺内切核酸酶（APE1），APE1的片段，APE1的变体或其药物组合物。在其它方面，提供APE1肽或其片段或变体或其药物组合物的用途用于治疗，预防或制备用于治疗和预防选自以下的病症的药物：异常RNA转录; 病毒RNA转录; 异常microRNA转录; 和异常c-myc RNA转录。

2. 发明申请

WO2005101169A1 METHODS AND SYSTEMS FOR INTERACTING WITH VIRTUAL OBJECTS 审中-公开
标题翻译：与虚拟对象交互的方法和系统
公开(公告)号：WO2005101169A1
公开(公告)日：2005-10-27
申请号：PCT/CA2005/000579
申请日：2005-04-15
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , CHEN, Liang , BROWN, Charles Grant
发明人： CHEN, Liang , BROWN, Charles Grant
IPC分类号： G06F3/00
CPC分类号： G06F3/011 , G06F3/016
摘要： The invention provides an apparatus for interacting with a computer system comprising a processor coupled to a display. The apparatus comprises a body configured to be moveable by a user. The body has a position sensor therein for producing a main position signal. A plurality of probe members are connected to the body. A plurality of transducers are coupled to the probe members for producing probe motion signals representative of positions of the probe members. A plurality of actuators are coupled to the probe members to selectively apply force to the probe members. A control system is coupled to the position sensor, the transducers and the actuators for receiving the main position signal and the probe position signals and interacting with the processor in order to produce control signals for controlling each of the probe members.
摘要翻译：本发明提供了一种用于与包括耦合到显示器的处理器的计算机系统交互的装置。该装置包括被配置为可由用户移动的主体。主体具有位置传感器，用于产生主位置信号。多个探针构件连接到主体。多个换能器耦合到探针构件，用于产生代表探针构件的位置的探针运动信号。多个致动器联接到探针构件以选择性地向探针构件施加力。控制系统耦合到位置传感器，换能器和致动器，用于接收主位置信号和探头位置信号并与处理器相互作用，以产生用于控制每个探针构件的控制信号。

3. 发明申请

WO2008106802A1 APPARATUS AND METHOD FOR OBJECTIVE PERIMETRY VISUAL FIELD TEST 审中-公开
标题翻译：用于目标视觉场景测试的装置和方法
公开(公告)号：WO2008106802A1
公开(公告)日：2008-09-12
申请号：PCT/CA2008/000472
申请日：2008-03-07
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , LO, Patrick , CHEN, Liang
发明人： LO, Patrick , CHEN, Liang
IPC分类号： A61B3/113
CPC分类号： A61B3/024 , A61B3/113 , G06K9/00604
摘要： Apparatus for testing a subject's visual field includes a data processor, which can be provided by a general purpose computer, coupled to a pupil tracking system. The data processor is programmed to cause targets to be displayed at different locations on a display screen and to determine from the pupil tracking system whether the subject's pupil has moved in response to display of each target. In some embodiments, the pupil tracking system comprises an infrared camera.
摘要翻译：用于测试受试者的视野的装置包括数据处理器，其可由通用计算机提供，耦合到瞳孔跟踪系统。数据处理器被编程为使得目标显示在显示屏幕上的不同位置，并且根据瞳孔跟踪系统确定对象的瞳孔是否响应于每个目标的显示而移动。在一些实施例中，瞳孔跟踪系统包括红外相机。

4. 发明申请

WO2009079769A1 METHODS AND SYSTEMS FOR ELECTORAL-COLLEGE-BASED IMAGE RECOGNITION 审中-公开
标题翻译：基于选择基于图像的图像识别的方法和系统
公开(公告)号：WO2009079769A1
公开(公告)日：2009-07-02
申请号：PCT/CA2008/002229
申请日：2008-12-19
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , CHEN, Liang , TOKUDA, Naoyuki
发明人： CHEN, Liang , TOKUDA, Naoyuki
IPC分类号： G06K9/68 , A61B5/117 , G06K9/42
CPC分类号： G06K9/00288 , G06K9/6292
摘要： An automated face-recognition system applies an electoral-college approach to face recognition. Windows correspond to portions of query and gallery images. Windows of a query image are compared to corresponding windows in the gallery. An identity corresponding to the best match for each window of the query image is identified. The identity best matching the overall query image is determined by a simple or weighted vote.
摘要翻译：一个自动化的面部认可系统将选举大学方法应用于面部识别。 Windows对应于查询和图库图像的部分。将查询图像的Windows与图库中的相应窗口进行比较。识别与查询图像的每个窗口的最佳匹配相对应的身份。与整体查询图像最匹配的身份通过简单或加权投票来确定。

5. 发明申请

WO2008022462A1 PARA-QUINOL DERIVATIVES AND METHODS OF STEREO SELECTIVELY SYNTHESIZING AND USING SAME 审中-公开
标题翻译： PARA-QUINOL衍生物和方法选择性合成和使用方法
公开(公告)号：WO2008022462A1
公开(公告)日：2008-02-28
申请号：PCT/CA2007/001494
申请日：2007-08-23
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , PLOURDE, Guy L. , SPAETZEL, Randy R.
发明人： PLOURDE, Guy L. , SPAETZEL, Randy R.
IPC分类号： C07D493/10 , A61K31/365 , A61P31/00 , A61P33/00 , C07D307/94 , C07D493/20
CPC分类号： C07D307/94 , C07D493/10 , C07D493/20 , Y02P20/55
摘要： This application relates to para -quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para -quinol derivatives. In one embodiment of the invention a compound having the chemical structure (I) is provided wherein X 1 and X 2 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring or a hydroxyethylene moiety; X 3 and X 4 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring; R 1 is selected from the group consisting of branched alkyl chains, unbranched alkyl chains, cycloalkyl groups, aromatic groups, alcohols, ethers, amines, and substituted or unsubstituted ureas, esters, aldehydes and carboxylic acids; and R 2 is selected from the group consisting of H, OH and NHR 3 wherein R 3 is a nitrogen protecting group. In a particular embodiment of the invention R 1 is a polyunsaturated carbon chain as found in biologically active manumycins. The applicant's synthetic method may involve diasteroselective formation of a spirolactone in an oxidative spiroannulation process using tyrosine or a tyrosine derivative having a chiral centre as a starting material.
摘要翻译：本申请涉及对 - 喹啉衍生物，例如manumycins，aranorosins和体坛运动员的类似物。本申请还涉及合成和使用对 - 喹啉衍生物的方法。在本发明的一个实施方案中，提供了具有化学结构（I）的化合物，其中X 1和X 2是通过双键连接或通过单键连接的碳原子键并且包含环氧化物环或羟基亚乙基部分的组分; X 3和X 4是通过双键连接或通过单键连接并且包含环氧化物环的组分的碳原子; R 1选自支链烷基链，无支链烷基链，环烷基，芳族基团，醇，醚，胺和取代或未取代的脲，酯，醛和羧酸; 和R 2选自H，OH和NHR 3，其中R 3为氮保护基。在本发明的一个具体实施方案中，R 1是在生物活性的马铃薯霉素中发现的多不饱和碳链。申请人的合成方法可以包括使用酪氨酸或具有手性中心作为起始原料的酪氨酸衍生物在氧化螺旋法处理中使用对映体选择性形成螺内酯。

6. 发明申请

WO2020240499A1 AN APPARATUS AND A METHOD FOR ACQUIRING AND PROCESSING IMAGES TO DETERMINE A PHYSICAL PROPERTY OF A PRODUCT 审中-公开
公开(公告)号：WO2020240499A1
公开(公告)日：2020-12-03
申请号：PCT/IB2020/055120
申请日：2020-05-29
申请人： MUCCHI, Luca , UNIVERSITY OF NORTHERN BRITISH COLUMBIA
发明人： MUCCHI, Luca , HARTLEY, Ian , REID, Matthew
IPC分类号： G01N21/45 , G01N21/3581 , G01N33/46 , G01J9/02 , G01B9/02 , G01N21/898
摘要： An image acquisition and processing apparatus (1) to determine a physical property of a product (2) movable along an advancement direction (A) comprises: - a source of electromagnetic radiation (9) arranged to generate a beam of electromagnetic waves (10), each electromagnetic wave having a frequency in the range of 0.05 – 5 THz, the product (2) being made of a material at least partially transparent to said frequency range; - a beam splitter (11) arranged to divide the beam of electromagnetic waves (10) into at least one reference beam (5) having a predetermined intensity and arranged to travel along a path in air and into at least one measure beam (6) arranged to travel a path through a section (22) of said product (2), the at least one measure beam (6) hitting a first face (7) of the product (2) with a first intensity and emerging from a second face (8) of the product (2) with a second intensity different from the first intensity and dependent on a material of which the product (2) is made; - an image acquisition device (12) arranged to receive the at least one reference beam (5) and the at least one measure beam (6) and acquire an image of an interference pattern due to the recombination of said at least one reference beam (5) and the at least one measure beam (6) in the image acquisition device (12); - first optical means (14) arranged to direct the at least one reference beam (5) from the beam splitter (11) to the image acquisition device (12); - second optical means (15) arranged to direct the at least one measure beam (6) from the beam splitter (11) to the image acquisition device (12); - processing means arranged to process the image of an interference pattern and calculate a phase shift of the at least one measure beam (6) traversing the product (2) and recombined to the at least one reference beam (5) with respect to said at least one measure beam (6) recombined to said at least one reference beam (5) when said product (2) has been removed from the apparatus (1), the processing means being configured to correlate the phase shift with a precalculated calibration curve that associates known values of a physical property with phase shift values of a measure beam (6); the first optical means (14) and the second optical means (15) being configured to recombine the at least one reference beam (5) and the at least one measure beam (6) with a recombination angle (Ψ) chosen so that on the image acquisition device (12) it is possible 35 to display at least two fringe peaks of the interference pattern due to the recombination of the at least one reference beam (5) and the at least one measure beam (6).

7. 发明申请

WO2008110017A1 SYSTEMS AND METHODS FOR MONITORING WOOD PRODUCT CHARACTERISTICS 审中-公开
标题翻译：木制品特性监测系统及方法
公开(公告)号：WO2008110017A1
公开(公告)日：2008-09-18
申请号：PCT/CA2008/000509
申请日：2008-03-14
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , REID, Matthew E. , HARTLEY, Ian D.
发明人： REID, Matthew E. , HARTLEY, Ian D.
IPC分类号： G01N9/24 , G01N23/06 , B07C5/34
CPC分类号： B07C5/14 , G01J3/42 , G01N9/24 , G01N9/36 , G01N21/3563 , G01N21/3581 , G01N33/46
摘要： Characteristics of wood and similar materials such as the bulk average orientation of fibres in composite fibrous materials, moisture content, density, microfibril orientation, wood species, and strength, can be evaluated based on measurements made with terahertz (THz) electromagnetic signals.
摘要翻译：可以基于使用太赫兹（THz）电磁信号进行的测量来评估木材和类似材料的特性，例如复合纤维材料中的纤维的主体平均取向，水分含量，密度，微原纤取向，木材种类和强度。

8. 发明申请

WO2007082371A1 METHODS AND APPARATUS FOR DETERMINING FIBRE ORIENTATION 审中-公开
标题翻译：用于确定光纤定向的方法和装置
公开(公告)号：WO2007082371A1
公开(公告)日：2007-07-26
申请号：PCT/CA2007/000062
申请日：2007-01-17
申请人： UNIVERSITY OF NORTHERN BRITISH COLUMBIA , REID, Matthew E. , FEDOSEJEVS, Robert
发明人： REID, Matthew E. , FEDOSEJEVS, Robert
IPC分类号： G01N22/00 , G01N21/23 , G01N23/00 , B32B23/00 , B32B21/00 , B32B41/00 , B32B43/00
CPC分类号： G01N21/23 , G01N21/3563 , G01N21/3581 , G01N33/365 , G01N2021/8444 , G01N2021/8681
摘要： Fibre distribution characteristics such as the bulk average orientation of fibres in composite fibrous materials can be evaluated based on the variation in the speed with which polarized electromagnetic signals propagate through the material as a function of angle. The electromagnetic radiation may comprise terahertz radiation. The composite fibrous materials may be wood-containing materials such as oriented strand board or particle board.
摘要翻译：基于复合纤维材料中的纤维的体积平均取向的纤维分布特征可以基于偏振电磁信号通过材料作为角度传播的速度的变化来评估。电磁辐射可以包括太赫兹辐射。复合纤维材料可以是含木材料，例如定向刨花板或刨花板。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式