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1. 发明申请

WO2022150293A1 CORONAVIRUS REPLICON DELIVERY PARTICLES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2022150293A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011115
申请日：2022-01-04
申请人： THE ROCKEFELLER UNIVERSITY , NEW YORK UNIVERSITY , THE UNIVERSITY OF BERN
发明人： RICE, Charles , RICARDO-LAX, Inna , LUNA, Joseph, M. , EBERT, Nadine , JORES, Jörg , LABROUSSAA, Fabien , THIEL, Volker , TRAN, Thi, Nhu, Thao , POIRIER, John, T.
IPC分类号： C12N7/00 , C12N15/11 , C12N15/50
摘要： This disclosure provides RNA replicons (e.g., SARS-CoV-2 RNA replicons) that can be trans-packaged for single-cycle delivery into a wide array of cell types and recapitulate all major enzymatic activities of intracellular viral replication. As a low-containment platform, the disclosed RNA replicons are broadly amenable to molecular virology studies and drug development screening efforts.

2. 发明申请

WO2008025016A3 SYSTEMS AND METHODS FOR HIGH-THROUGHPUT, MINIMALLY-INVASIVE RADIATION BIODOSIMETRY 审中-公开
公开(公告)号：WO2008025016A3
公开(公告)日：2008-02-28
申请号：PCT/US2007/076825
申请日：2007-08-24
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , GEORGETOWN UNIVERSITY , NATIONAL CANCER INSTITUTE , UNIVERSITY OF BERN , SIONEX CORPORATION , FORNACE, Albert J. , IDLE, Jeff , NAZAROV, Erkinjon G. , GONZALEZ, Frank , COY, Stephen
发明人： FORNACE, Albert J. , IDLE, Jeff , NAZAROV, Erkinjon G. , GONZALEZ, Frank , COY, Stephen
IPC分类号： A61B5/00
摘要： A method for obtaining a sample, determining the sample's metabolomic signature, comparing that signature to at least one known metabolomic signature, and quantifying the radiation exposure of the sample Sample sources may include blood, blood plasma, sweat, urine, sebum, saliva, or cells, or a combination thereof The method may utilize samples obtained noninvasively The method may be capable of high throughput, 50, 100, 1000, 10,000, 100,000, or more samples per hour The method may utilize samples from mice, humans, or other mammals The method may utilize chromatography, mass spectroscopy, or radiofrequency differential ion mobility spectrometry analysis, or a combination thereof The method may employ software for comparing the metabolomic signature of the sample with at least one known radiation exposure metabolomics signature

3. 发明申请

WO2006067607A2 NOVEL POLYACETYLEN COMPOUNDS 审中-公开
标题翻译：新型聚乙烯化合物
公开(公告)号：WO2006067607A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/003903
申请日：2005-12-22
申请人： UNIVERSITY OF BASEL , UNIVERSITY OF BERN , SWISS TROPICAL INSTITUTE , SIMMEN, Urs , SIGEL, Erwin , BRUN, Reto , SEQUIN, Urs
发明人： SIMMEN, Urs , SIGEL, Erwin , BRUN, Reto , SEQUIN, Urs
IPC分类号： A61K31/22 , A61K36/25
CPC分类号： A61K31/22 , A61K36/25
摘要： The present invention relates to certain linear polyacetylene containing compounds which are indicated as having a positive allosteric modulating activity on the GABA A receptor. More specifically the invention relates to linear polyacetylene containing compounds having a β-subunit selective, positive allosteric modulating activity on the GABA A receptor and substantially lacking a binding capability at the benzodiazepine binding site, their use as agents for the treatment of diseases of the central nervous system (CNS) in mammals, such as humans, and in particular in the treatment of CNS diseases, such as anxiety and epilepsy.
摘要翻译：本发明涉及某些含有线性聚乙炔的化合物，其表示为对GABA A A受体具有正性变构调节活性。更具体地，本发明涉及具有对GABA A A受体具有β亚基选择性，正性变构调节活性的线性聚乙炔化合物，并且在苯并二氮杂结合位点上基本上不具有结合能力，它们作为治疗哺乳动物（例如人）中的中枢神经系统（CNS）的疾病，特别是治疗CNS疾病如焦虑和癫痫。

4. 发明申请

WO2005020820A1 METHOD AND SYSTEM FOR DETERMINING THE ABSOLUTE PERFUSION RATE OF A FLUID IN AN ANALYSIS REGION 审中-公开
标题翻译：用于确定分析区域中流体的绝对渗透速率的方法和系统
公开(公告)号：WO2005020820A1
公开(公告)日：2005-03-10
申请号：PCT/EP2004/009523
申请日：2004-08-26
申请人： UNIVERSITY OF BERN , VOGEL, Rolf , SEILER, Christian
发明人： VOGEL, Rolf , SEILER, Christian
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/06 , A61B8/13
摘要： An ultrasonic apparatus for performing perfusion measurements of a fluid carrying an ultrasound contrast agent into an analysis region comprises an ultrasound source means capable to provide a multitude of different ultrasound signals, an ultrasound detector means capable to detect backscatter of said multitude of different ultrasound signals, a processor operatively coupled with said ultrasound source means and said ultrasound detector means for controlling the emission of said multitude of different ultrasound signals and the detection of backscattered signals. The absolute perfusion II of an analysis region with the liquid is calculated by direct measurement of backscatter signals in an analysis region and an adjacent reference region.
摘要翻译：用于对携带超声造影剂的流体进行分析区域的灌注测量的超声波装置包括能够提供多种不同超声信号的超声源装置，能够检测所述多个不同超声信号的反向散射的超声波检测装置，可操作地与所述超声源装置和所述超声检测器装置耦合的处理器，用于控制所述多个不同超声信号的发射和反向散射信号的检测。通过在分析区域和相邻参考区域中直接测量反向散射信号来计算具有液体的分析区域的绝对灌注II。

5. 发明申请

WO2004017999A1 NON-GLYCOSYLATED POLYACRYLAMIDE CONJUGATES AND THEIR USE FOR CYTOPROTECTION 审中-公开
标题翻译：非糖化聚丙烯酰胺凝胶及其用于CYTOPROTECTION的用途
公开(公告)号：WO2004017999A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/008987
申请日：2003-08-12
申请人： UNIVERSITY OF BERN , SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY , RIEBEN, Robert , MOHACSI, Paul , BOVIN, Nicolai, Vladimirovich , KORCHAGINA, Elena, Yurievna
发明人： RIEBEN, Robert , MOHACSI, Paul , BOVIN, Nicolai, Vladimirovich , KORCHAGINA, Elena, Yurievna
IPC分类号： A61K47/48
CPC分类号： A61K47/646
摘要： The present invention relates to new non-glycosylated polyacrylamide conjugates, a method for protecting endothelial cells from complement-mediated cellular damage and the use of said non-glycosylated polyacrylamide conjugates as a medicament.
摘要翻译：本发明涉及新的非糖基化聚丙烯酰胺缀合物，一种保护内皮细胞免受补体介导的细胞损伤的方法，以及使用所述非糖基化的聚丙烯酰胺缀合物作为药物。

6. 发明申请

WO2022061236A1 HIGH AFFINITY ANTI-IGE ANTIBODIES 审中-公开
公开(公告)号：WO2022061236A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/051108
申请日：2021-09-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , UNIVERSITY OF BERN
发明人： JARDETZKY, Theodore S. , PENNINGTON, Luke , EGGEL, Alexander , GASSER, Pascal
IPC分类号： C07K16/42 , A61K39/395 , A61P37/08
摘要： Humanized or chimeric anti-IgE monoclonal antibodies are provided. The antibodies bind to human IgE, and find use in various therapeutic methods, including without limitation the reduction or prevention of allergic conditions.Humanized or chimeric anti-IgE monoclonal antibodies are provided. The antibodies bind to human IgE, and find use in various therapeutic methods, including without limitation the reduction or prevention of allergic conditions.

7. 发明申请

WO2021255687A1 MICROFLUIDIC DEVICE FOR CELL CULTURE AND SCREENING AND RELATED PRODUCTION METHOD 审中-公开
公开(公告)号：WO2021255687A1
公开(公告)日：2021-12-23
申请号：PCT/IB2021/055369
申请日：2021-06-17
申请人： UNIVERSITA' DEGLI STUDI MAGNA GRAECIA DI CATANZARO , UNIVERSITY OF BERN
发明人： PEROZZIELLO, Gerardo , GUZZI, Francesco , PARROTTA, Elvira , CUDA, Giovanni , COLUCCIO, Maria Laura , CANDELORO, Patrizio , VALENTINO, Gina , LUCIANI, Paola
IPC分类号： C12M3/06 , C12M1/00 , B01L3/00 , B01L2200/16 , B01L2300/0883 , B01L2300/0887 , B01L3/502715 , B01L3/502761 , C12M23/16 , C12M23/38
摘要： Microfluidic device (100, 200) for cell culture and screening, comprising: - a covering element (102,202) comprising a plurality of openings (102a,202a) configured for introducing and collecting fluids, and a central through hole (102b,202b); - an intermediate element (103,203) comprising a plurality of microchannels (103a,203a), a plurality of supply tanks (103d,203d) and at least one waste tank (103e), and a blind bottom cavity (103b); - a lower element (104,204), comprising a collecting tank and a recessed central portion; - a slide (105,205) housed in a housing pocket. The intermediate element (103,203) is interposed between the covering element (102,202) and the lower element (104,204) to form an upper optical window (106,206) and at least one culture chamber (103c,203c). The plurality of microchannels (103a,203a) puts in fluid communication the plurality of supply tanks (103a,203a), the at least one culture chamber (103c,203c) and the waste tank (103e).

8. 发明申请

WO2006017954A1 PREPARATION OF ANTIGEN-PRESENTING HUMAN γδ T CELLS AND USE IN IMMUNOTHERAPY 审中-公开
标题翻译：抗原呈递人类细胞的制备及其在免疫学中的应用
公开(公告)号：WO2006017954A1
公开(公告)日：2006-02-23
申请号：PCT/CH2005/000469
申请日：2005-08-11
申请人： UNIVERSITY OF BERN , MOSER, Bernhard , BRANDES, Marlène
发明人： MOSER, Bernhard , BRANDES, Marlène
IPC分类号： C12N5/08
CPC分类号： C12N5/0636 , A61K2039/5154 , A61K2039/5158 , C12N2501/05 , C12N2501/23 , C12N2501/999
摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire "maturation" status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.
摘要翻译：本发明涉及一种制备有效的抗原呈递人类β细胞的方法，涉及通过这种方法制备的γdT细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。类似于树突状细胞（DCs）的效力和功效，这些人类T细胞处理抗原并将抗原肽存在于β细胞中并诱导幼稚T细胞中的抗原特异性应答（增殖和分化）。 β细胞可以从外周血中轻松纯化，在刺激前1天内获得“成熟”状态（必需粘附，共刺激和主要组织相容性复合物分子的表达），诱导强的初级和辅助性T辅助细胞细胞毒性T细胞应答。 βT细胞可用于治疗肿瘤或慢性或复发性传染病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

9. 发明申请

WO2003035677A3 ANTIMICROBIAL PEPTIDES FROM THE VENOM OF THE SPIDER CUPIENNIUS SALEI 审中-公开
公开(公告)号：WO2003035677A3
公开(公告)日：2003-05-01
申请号：PCT/EP2002/009174
申请日：2002-08-16
申请人： UNIVERSITY OF BERN , SCHALLER, Johann , WALZ, Alfred , NENTWIG, Wolfgang , KUHN-NENTWIG, Lucia
发明人： SCHALLER, Johann , WALZ, Alfred , NENTWIG, Wolfgang , KUHN-NENTWIG, Lucia
IPC分类号： C07K14/435
摘要： The present invention relates to highly cationic peptides from a novel family of antimicrobial compounds designated cupiennins with an unique helical structure isolated from the venom of the hunting spider Cupiennius salei . Said peptides are characterized by having antimicrobial, cytotoxic and/or insecticidal activity. The invention further comprises nucleic acid molecules encoding the peptides, vectors and host cells containing said nucleic acid molecules; methods for producing the peptides; and pharmaceutical compositions comprising them.

10. 发明申请

WO2012170347A1 BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 审中-公开
标题翻译：双相核苷和其制备的低分子化合物
公开(公告)号：WO2012170347A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/040739
申请日：2012-06-04
申请人： ISIS PHARMACEUTICALS, INC. , UNIVERSITY OF BERN , LEUMANN, Christian, J. , DUGOVIC, Branislav , SETH, Punit, P. , SWAYZE, Eric, E.
发明人： LEUMANN, Christian, J. , DUGOVIC, Branislav , SETH, Punit, P. , SWAYZE, Eric, E.
IPC分类号： C07H21/00 , C07H19/04
CPC分类号： C07H21/00 , C07H19/04
摘要： The present invention provides novel bicyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the bicyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
摘要翻译：本发明提供由其制备的新型双环核苷和寡聚化合物。将一种或多种双环核苷掺入低聚化合物中预期会增强寡聚化合物的一种或多种性质。这种低聚化合物也可以包括在双链组合物中。在某些实施方案中，预期本文提供的寡聚化合物与靶RNA的一部分杂交，导致靶RNA的正常功能丧失。

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