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1. 发明申请

WO2020193709A1 INHIBITOR OF MIR-129 AND USES THEREOF 审中-公开
公开(公告)号：WO2020193709A1
公开(公告)日：2020-10-01
申请号：PCT/EP2020/058571
申请日：2020-03-26
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO BICOCCA , FONDAZIONE IRCCS "CA' GRANDA - OSPEDALE MAGGIORE" POLICLINICO , UNIVERSITÀ DEGLI STUDI DI MILANO
发明人： CORTI, Stefania , BARABINO, Silvia Maria Luisa , NIZZARDO, Monica , LOFFREDA, Alessia
IPC分类号： C12N15/113 , C12Q1/6886 , A61K31/712
摘要： The present invention relates to an inhibitor of miR-129, relative compounds and pharmaceutical compositions for use in the treatment and/or prevention of amyotrophic lateral sclerosis and Alzheimer's disease. The invention also relates to a method for the diagnosis and/or prognosis of Alzheimer's disease in a subject or to identify a subject at risk to develop amyotrophic lateral sclerosis or Alzheimer's disease and to a method for the measuring the efficacy of a therapy for amyotrophic lateral sclerosis or for Alzheimer's disease and relative kits.

2. 发明申请

WO2020182635A1 CARBOCYCLIC DERIVATIVES AND CONJUGATED DERIVATIVES THEREOF, AND THEIR USE IN VACCINES 审中-公开
公开(公告)号：WO2020182635A1
公开(公告)日：2020-09-17
申请号：PCT/EP2020/055950
申请日：2020-03-06
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , UNIVERSITÀ DEGLI STUDI DI MILANO
发明人： ADAMO, Roberto , BERTI, Francesco , COSTANTINO, Paolo , LAY, Luigi
IPC分类号： A61K47/64 , A61K39/095 , C08B37/00 , A61P31/00
摘要： The invention is in the field of vaccines and relates to oligomers having a selected degree of polymerization, obtained by connecting together a number of carbocyclic repeating units, and to conjugated derivatives thereof. The oligomers and conjugated derivatives thereof of the invention also have a selected degree of acetylation. The derivatives of the invention are useful for the preparation of immunogenic compositions, e.g. in the form of a vaccine.

3. 发明申请

WO2019185731A1 POLYMERIC FILMS CONTAINING NANOPARTICLES ENDOWED WITH PHOTO-THERMAL EFFECT AND APPLICATION THEREOF AS THERMAL PATCHES 审中-公开
公开(公告)号：WO2019185731A1
公开(公告)日：2019-10-03
申请号：PCT/EP2019/057747
申请日：2019-03-27
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA
发明人： CHIRICO, Giuseppe , COLLINI, Maddalena , BORZENKOV, Mykola , PALLAVICINI, Piersandro
IPC分类号： A61N5/06 , A61F7/02
摘要： The present invention relates to thin polymeric films containing nanoparticles with tunable absorption in the visible and near infrared (NIR) region. When these films are irradiated with NIR sources, they show a pronounced photo-thermal effect. Said effect allows a localized temperature increase, which can be controlled both spatially and temporally. Once the irradiation source has been turned off, the temperature returns within a few seconds to the initial value and then raises again as soon as the film is irradiated again. These films can be used as reusable medical devices, with a controllable and reproducible heating profile, in particular thermal or heating patches.

4. 发明申请

WO2017191577A1 SUPERFICIALLY TREATED FLEXIBLE MATERIALS SUITABLE FOR FILTERING AND SEPARATING IMMISCIBLE LIQUIDS 审中-公开
标题翻译：经过超细处理的柔性材料，适合过滤和分离难溶液体
公开(公告)号：WO2017191577A1
公开(公告)日：2017-11-09
申请号：PCT/IB2017/052575
申请日：2017-05-03
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA
发明人： RICCARDI, Claudia , ZANINI, Stefano
IPC分类号： D06M10/06 , D06M11/83 , D21H25/04
CPC分类号： D06M11/83 , B01D2239/0421 , D06M10/06 , D06M23/16 , D06M2101/22 , D06M2101/32 , D06M2101/34 , D21H25/04 , D21H27/08
摘要： Process for the plasma surface treatment under vacuum of a fabric, nonwoven fabric or paper material for obtaining materials to be used for the filtration and separation of two immiscible liquids.
摘要翻译：用于获得用于过滤和分离两种不混溶液体的材料的织物，非织造织物或纸材料在真空下进行等离子体表面处理的方法

5. 发明申请

WO2017097865A1 COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR 审中-公开
标题翻译：热休克蛋白（CR）或IGF1 /胰岛素受体抑制剂与LSD1抑制剂的组合
公开(公告)号：WO2017097865A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080156
申请日：2016-12-07
申请人： ISTITUTO EUROPEO DI ONCOLOGIA , UNIVERSITÀ DEGLI STUDI DI MILANO
发明人： MAZZARELLA, Luca , MINUCCI, Saverio , PELICCI, Pier Giuseppe , PALLAVI, Rani , DURFORT, Tiphanie
IPC分类号： A61K31/4155 , A61K31/4465 , A61K31/4704 , A61K31/5375 , A61P35/00
CPC分类号： A61K31/5375 , A61K31/4155 , A61K31/4465 , A61K31/4704 , A61K2300/00
摘要： The present application relates to the use of an LSD1 inhibitor in combination with a caloric restricted diet, a calorie restriction mimetic and/or an IGF1/Insulin receptor inhibitor for the treatment of cancer, e.g., a leukemia, such as acute myeloid leukemia, acute promyelocytic leukemia.
摘要翻译：本申请涉及将LSD1抑制剂与卡路里限制饮食，卡路里限制模拟物和/或IGF1 /胰岛素受体抑制剂组合用于治疗癌症例如白血病，如急性粒细胞白血病，急性早幼粒细胞白血病。

6. 发明申请

WO2017072694A3 A PROCESS FOR COATING POLYMERIC SUBSTRATES AND PAPER 审中-公开
标题翻译：一种涂覆聚合物基材和纸的方法
公开(公告)号：WO2017072694A3
公开(公告)日：2017-05-04
申请号：PCT/IB2016/056473
申请日：2016-10-27
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA
发明人： RICCARDI, Claudia , ZANINI, Stefano , DELL`ORTO, Elisa Camilla
IPC分类号： B05D3/14 , B05D7/02 , B05D7/04 , B29C59/14 , C08J7/00 , D21H25/06 , D21H19/72 , D21H23/30
摘要： Method for coating on a polymeric substrate or on paper consisting of the following steps: a) Plasma pre-treatment at a pressure comprised between 0,5 and 3 atmospheres of the aforementioned polymeric substrate or paper b) Deposition and drying on said polymeric substrate or paper from step (a) of one of the following polymeric compositions: • Polymeric composition (A) comprising at least one polymer capable of adhering to said polymeric substrate or paper from step (a), • Polymerizable composition (B) comprising: (i) at least one polymer of the type of those of the polymeric composition (A) and polyvinylidene chloride or fluoride, and (ii) a polymerizable monomer selected from an epoxy monomer, or a monomer containing at least one ethylenic unsaturation; c) plasma treatment of the material coming from step (b).
摘要翻译：用于涂布在聚合物基底上或纸上的方法，其由以下步骤组成：a）在0.5至3个大气压的上述聚合物基底或纸的压力下的等离子体预处理b）在以下聚合物组合物之一的步骤（a）的所述聚合物基材或纸上沉积和干燥：·包含至少一种能够粘附到所述聚合物基材或来自步骤（a）的纸的聚合物的聚合物组合物（A），·可聚合组合物（B），其包含：（i）至少一种聚合物组合物（A）和聚偏二氯乙烯或氟化物类型的聚合物，和（ii）选自环氧单体的可聚合单体或至少含有一个烯属不饱和度; c）等离子体处理来自步骤（b）的材料。

7. 发明申请

WO2014016417A1 HMGB1 VARIANTS AND USES THEREOF 审中-公开
标题翻译： HMGB1变体及其用途
公开(公告)号：WO2014016417A1
公开(公告)日：2014-01-30
申请号：PCT/EP2013/065829
申请日：2013-07-26
申请人： OSPEDALE SAN RAFFAELE SRL , UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA
发明人： BIANCHI, Marco Emilio , CASALGRANDI, Maura , VENEREAU, Emilie Joelle , BRUNELLI, Silvia
IPC分类号： A61P21/00 , A61P19/00 , C07K14/47 , A61K38/17 , A61K38/19
CPC分类号： C07K14/47 , A61K38/005 , A61K38/1709
摘要： The present invention relates to HMGB1 variants that maintain HMGB1 wild type chemoattractant function while displaying abolished cytokine and/or chemokine stimulating properties. Such molecules are useful in therapy.
摘要翻译：本发明涉及在显示消除的细胞因子和/或趋化因子刺激性质的同时保持HMGB1野生型化学引诱物功能的HMGB1变体。这样的分子可用于治疗。

8. 发明申请

WO2013140229A8 APPARATUS FOR ASSISTED VENTILATION AND CORRESPONDING REGULATION METHOD 审中-公开
公开(公告)号：WO2013140229A8
公开(公告)日：2013-09-26
申请号：PCT/IB2013/000432
申请日：2013-03-19
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
发明人： BELLANI, Giacomo , PESENTI, Antonio , PATRONITI, Nicolò, Antonino , MAURI, Tommaso
IPC分类号： A61M16/00
摘要： An apparatus for assisted ventilation (1) comprises at least one ventilatory block (2) connected to and controlled by a drive block (3), and at least one sensor block (4) connected to the drive block (3) and adapted to provide it with a signal of electrical activity produced by the diaphragm. The apparatus further comprises at least one calculation block (5) connected to the drive block (3), to the sensor block (4) and to the ventilatory block (2), the calculation block (5) receiving from the sensor block (4) a signal of diaphragmatic activity (Eadi) and from the ventilatory block (2) a ventilatory pressure signal (Paw) and providing the drive block (30) with calibration parameters (Cal) calculated on the basis of a signal of diaphragmatic electrical activity (Eadi*) and a ventilatory pressure signal (Paw*) upon switching-off said ventilatory block (2) so as to cause an expiratory pause.

9. 发明申请

WO2011131576A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 审中-公开
标题翻译：作为HISTONE DEMETHYLASE LSD1和/或LSD2的抑制剂的TRANYLCYPROMINE衍生物
公开(公告)号：WO2011131576A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/055990
申请日：2011-04-15
申请人： UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" , FONDAZIONE IEO , UNIVERSITÀ DEGLI STUDI DI PAVIA , UNIVERSITÀ DEGLI STUDI DI MILANO , MINUCCI, Saverio , MAI, Antonello , MATTEVI, Andrea
发明人： MINUCCI, Saverio , MAI, Antonello , MATTEVI, Andrea
IPC分类号： C07C233/43 , C07C233/44 , C07C233/80 , C07C271/22 , C07C271/28 , C07C275/24 , C07D333/60 , A61K31/167 , A61K31/17 , A61K31/325 , A61K31/381 , A61P35/00 , A61P31/12
CPC分类号： C07C271/26 , C07C233/44 , C07C233/80 , C07C259/06 , C07C271/22 , C07C271/28 , C07C275/24 , C07C2601/02 , C07C2601/14 , C07D333/60
摘要： Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R 3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
摘要翻译：可用作治疗剂的特兰基嘧啶衍生物，特别是用于预防和/或治疗与组蛋白脱甲基酶LSD1和LSD2的活性相关的疾病和病症，例如以基因转录，细胞分化和增殖为特征的疾病，例如，肿瘤，病毒感染。这些化合物属于结构式（I），其中A和R3如说明书中所定义。本发明还涉及这些化合物的制备，以及含有它们的组合物及其治疗用途。

10. 发明申请

WO2010130364A1 METHOD OF MANUFACTURING ELECTRICAL CONTACTS ON ORGANIC SEMICONDUCTORS 审中-公开
标题翻译：有机半导体制造电气接触的方法
公开(公告)号：WO2010130364A1
公开(公告)日：2010-11-18
申请号：PCT/EP2010/002767
申请日：2010-05-06
申请人： UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA , FONDAZIONE CASSA DI RISPARMIO DELLE PROVINCE LOMBARDE , CAMPIONE, Marcello , SASSELLA, Adele , MORET, Massimo , BRAGA, Daniele
发明人： CAMPIONE, Marcello , SASSELLA, Adele , MORET, Massimo , BRAGA, Daniele
IPC分类号： H01L51/10
CPC分类号： H01L51/0021 , H01L51/102 , H01L51/5203
摘要： A method for producing electrical contacts on organic semiconductors is described. The method, which involves low energy impact and can be carried out under ambient conditions, comprises covering the relevant surface of the semiconductor with a layer of an appropriate solvent; a metal leaf having an appropriate thickness and work function containing metal oxide impurities is deposited onto the area treated in this manner. Electrical contacts with elevated conductivity are obtained by evaporating the solvent. One embodiment of the invention describes a family of crystalline semiconductors, preferably based on perylene or α- quaterthiophene, provided with the electrical contacts according to the method described herein and provided with particular structural characteristics. The use of metal leaf satisfying the above-stated requirements (for example imitation gold leaf, gold leaf etc.), in the above- described method is furthermore described.
摘要翻译：描述了在有机半导体上产生电触点的方法。涉及低能量冲击并且可以在环境条件下进行的方法包括用合适的溶剂层覆盖半导体的相关表面; 具有适当厚度的金属叶片和包含金属氧化物杂质的功函被沉积到以这种方式处理的区域上。通过蒸发溶剂获得电导率提高的电触点。本发明的一个实施方案描述了一种优选基于苝或十四元噻吩的晶体半导体族，其具有根据本文所述的方法并具有特定结构特征的电接触。进一步描述了在上述方法中使用满足上述要求的金属叶片（例如仿金叶，金叶等）。

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