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1. 发明申请

WO2010022043A3 TARGETING OF HISTONE DEACETYLASE 2 AND PROTEIN KINASE CK2 FOR TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译：靶向DEACETYLASE 2和蛋白激酶CK2治疗炎性疾病
公开(公告)号：WO2010022043A3
公开(公告)日：2010-06-17
申请号：PCT/US2009054152
申请日：2009-08-18
申请人： UNIV ROCHESTER MEDICAL CT , RAHMAN IRFAN
发明人： RAHMAN IRFAN
IPC分类号： A61K31/122 , A61K31/352 , A61K31/7088 , A61P11/06 , A61P19/02 , A61P29/00
CPC分类号： A61K31/122 , A61K31/352 , A61K31/7088
摘要： Methods for the treatment or prevention of diseases which are caused by the degradation of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma. The invention provides methods for treating or preventing of diseases caused by the degradation of HDAC2 by providing to the subject in need of treatment or prevention a molecular compound capable of preventing the degradation of HDAC2. Such molecular compounds include protein kinase CK2 inhibitors, ubiquitination inhibitors, ubiquitin-proteosome inhibitors and MAPK phosphatase 1 activators. Methods are also provided for the treatment and prevention of diseases caused by the degredation of HDAC2 by interfering with the expression of protein kinase CK2. Methods are further provided for the treatment and prevention of COPD and asthma by providing to a subject in need of such treatment and prevention a nucleic acid which causes expression of HDAC2 in lung cells.
摘要翻译：描述了用于治疗或预防细胞中由组蛋白脱乙酰酶2（HDAC2）降解引起的疾病的方法。可以通过本发明的方法治疗的疾病包括慢性阻塞性肺病（COPD）和哮喘。本发明提供了通过向需要治疗或预防的对象提供能够防止HDAC2降解的分子化合物来治疗或预防由HDAC2降解引起的疾病的方法。这样的分子化合物包括蛋白激酶CK2抑制剂，泛素化抑制剂，遍在蛋白 - 蛋白体抑制剂和MAPK磷酸酶1激活剂。还提供了通过干扰蛋白激酶CK2的表达来治疗和预防由HDAC2降解引起的疾病的方法。通过向需要这种治疗和预防的受试者提供引起肺细胞中HDAC2表达的核酸，进一步提供了用于治疗和预防COPD和哮喘的方法。

2. 发明申请

WO2009132271A2 RISK STRATIFICATION OF GENETIC DISEASE USING SCORING OF AMINO ACID RESIDUE CONSERVATION IN PROTEIN FAMILIES 审中-公开
标题翻译：使用蛋白质家族中氨基酸残留保留评估遗传病的风险分析
公开(公告)号：WO2009132271A2
公开(公告)日：2009-10-29
申请号：PCT/US2009041663
申请日：2009-04-24
申请人： UNIV ROCHESTER MEDICAL CT , JONS CHRISTIAN , MOSS ARTHUR , LOPES COELI , MCNITT SCOTT
发明人： JONS CHRISTIAN , MOSS ARTHUR , LOPES COELI , MCNITT SCOTT
IPC分类号： C12Q1/68 , C40B20/04 , C40B30/02 , G01N33/48 , G06F17/40 , G06F19/22
CPC分类号： G01N33/68 , C12Q1/6883 , C12Q2600/156 , G06F19/22 , Y10T436/143333
摘要： Methods, databases and software for determining the risk of an adverse health event for patient by analysis of the protein sequence of the patient are described. The methods involve obtaining a protein sequence that is associated with a specific disorder from the patient. The protein sequence from the patient is compared to a database of sequences of the same protein and is analyzed to determine the conservation score of the amino acid residues in the protein. Those amino acid residues having high conservation scores will be further analyzed to determine if there are mutations present at those highly conserved positions. Patients having proteins with mutations in highly conserved positions are determined to have a higher risk of an adverse event due to the disorder.
摘要翻译：描述了通过分析患者的蛋白质序列来确定患者不良健康事件风险的方法，数据库和软件。所述方法包括获得与患者的特定病症相关的蛋白质序列。将来自患者的蛋白质序列与相同蛋白质的序列的数据库进行比较，并进行分析以确定蛋白质中氨基酸残基的保守性评分。将进一步分析具有高保守分数的那些氨基酸残基，以确定在那些高度保守的位置是否存在突变。具有高度保守位置突变的蛋白质的患者被确定为由于该疾病而具有较高的不良事件的风险。

3. 发明申请

WO2007022420A3 COMBINED FLEXIBLE AND RIGID INTUBATING VIDEO LARYNGOSCOPE 审中-公开
标题翻译：组合灵活和刚性内嵌视频文件
公开(公告)号：WO2007022420A3
公开(公告)日：2007-11-01
申请号：PCT/US2006032337
申请日：2006-08-17
申请人： UNIV ROCHESTER MEDICAL CT , DUTCHER PAUL , TAGHIZADEH FARHAN
发明人： DUTCHER PAUL , TAGHIZADEH FARHAN
IPC分类号： A61B1/267
CPC分类号： A61B1/2673
摘要： A combined flexible and rigid intubating video laryngoscope. The laryngoscope has a handle, and a rigid blade, having a proximal end connectible to the handle and a distal end projecting therefrom. The laryngoscope also has a flexible video endoscope having a distal end connectible near the distal end of the blade, the distal end of the endoscope being movable relative to the distal end of the blade, so as to enable the endoscope to obtain a variable view including a more anterior anatomical view of a patient's vocal cords during direct laryngoscopy.
摘要翻译：组合柔性和刚性插管视频喉镜。喉镜具有手柄和刚性刀片，其具有可连接到手柄的近端和从其突出的远端。喉镜还具有柔性的视频内窥镜，其具有在刀片的远端附近可连接的远端，内窥镜的远端相对于刀片的远端可移动，以使得内窥镜能够获得可变视图，包括在直接喉镜检查期间患者的声带更前方的解剖视图。

4. 发明申请

WO2006031909A3 TEAR DYNAMICS MEASURED WITH OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：用光学相干层析成像测量的泪液动力学
公开(公告)号：WO2006031909A3
公开(公告)日：2006-09-08
申请号：PCT/US2005032781
申请日：2005-09-14
申请人： UNIV ROCHESTER MEDICAL CT , WANG M D PH D JIANHUA
发明人： WANG M D PH D JIANHUA
IPC分类号： A61B3/00 , A61B3/14
CPC分类号： A61B3/101
摘要： A system and method are provided for measuring the thickness of a tear film layer (208) and the heights of tear menisci (210, 212) around upper and lower eyelids of an eye. A plurality of images are acquired between consecutive blinks the eye using optical coherence tomography (OCT). The images depict the tear film layer (208) and tear menisci (210, 212) as distinct from the cornea of the eye. In an embodiment, a plurality of reflectivity profiles (602) from an OCT image are aligned and averaged. The difference between a first peak (608) and a second peak (610) of the average reflectivity profile is measured to determine the thickness of the tear film layer. The heights of the upper meniscus (210) and the lower meniscus (212) can also be measured from the same OCT image. In an embodiment, thickness measurements from the plurality of OCT images are combined. The measurements can be used to diagnose tear disorders, analyze treatments of dry eye and evaluate artificial tears.
摘要翻译：提供了一种用于测量泪膜层（208）的厚度和围绕眼睛的上眼睑和下眼睑的泪液膜（210,212）的高度的系统和方法。使用光学相干断层扫描（OCT）在连续的眨眼之间采集多个图像。这些图像描绘了与眼睛的角膜不同的泪膜层（208）和撕裂半月板（210,212）。在一个实施例中，来自OCT图像的多个反射率分布（602）被对准和平均。测量平均反射率分布的第一峰值（608）和第二峰值（610）之间的差值以确定泪膜层的厚度。也可以从相同的OCT图像测量上弯月面（210）和下弯月面（212）的高度。在一个实施例中，来自多个OCT图像的厚度测量被组合。测量结果可用于诊断眼泪疾病，分析干眼症的治疗并评估人造眼泪。

5. 发明申请

WO02086096A3 METHODS OF PRODUCING OR IDENTIFYING INTRABODIES IN EUKARYOTIC CELLS 审中-公开
标题翻译：在真核细胞中产生或鉴定入侵者的方法
公开(公告)号：WO02086096A3
公开(公告)日：2003-10-09
申请号：PCT/US0201677
申请日：2002-01-23
申请人： UNIV ROCHESTER MEDICAL CT , ZAUDERER MAURICE , WEI CHUNGWEN , SMITH ERNEST S
发明人： ZAUDERER MAURICE , WEI CHUNGWEN , SMITH ERNEST S
IPC分类号： C07K16/00 , C12P21/08 , C12Q1/70 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K16/00 , C07K2317/21 , C12N2799/021 , C12N2799/022
摘要： The present invention relates to a high efficiency method of expressing intracellular immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing intracellular immunoglobulin libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for intracellular immunoglobulin molecules and fragments thereof. The invention also provides kits for producing, screening and selecting intracellular immunoglobulin molecules. Finally, the invention provides intracellular immunoglobulin molecules and fragments thereof, produced by the methods provided herein.
摘要翻译：本发明涉及在真核细胞中表达细胞内免疫球蛋白分子的高效方法。本发明进一步涉及生产细胞内免疫球蛋白文库的方法，特别是使用三分子重组方法在真核细胞中表达。本发明还提供了选择和筛选细胞内免疫球蛋白分子及其片段的方法。本发明还提供用于产生，筛选和选择细胞内免疫球蛋白分子的试剂盒。最后，本发明提供了通过本文提供的方法产生的细胞内免疫球蛋白分子及其片段。

6. 发明申请

WO2010017396A2 ROBOTIC LOCALIZING AID FOR HIGH INTENSITY FOCUSED ULTRASOUND DELIVERY 审中-公开
标题翻译：高强度聚焦超声波输送的机器人定位辅助
公开(公告)号：WO2010017396A2
公开(公告)日：2010-02-11
申请号：PCT/US2009053011
申请日：2009-08-06
申请人： UNIV ROCHESTER MEDICAL CT , DOGRA VIKRAM , NG WAN
发明人： DOGRA VIKRAM , NG WAN
IPC分类号： A61N7/02 , A61B18/18 , A61N7/00 , B25J11/00
CPC分类号： A61B10/0233 , A61B8/0841 , A61B8/4218 , A61B34/30 , A61B2090/378 , A61N7/02
摘要： A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator structure performs the biopsy and HIFU through the percutaneous approach. In addition, the procedure is imaged by an imaging ultrasound probe. The imaging ultrasound probe can track the needle entry site even when needle has been removed. The HIFU transducer fires a short pulse of HIFU in the needle tract to cause coagulation and stop bleeding.
摘要翻译：保持结构容纳活检针和HIFU换能器，以允许HIFU束在会发生出血的肝脏界面处平稳且准确地输送HIFU束。该机械手结构通过经皮途径执行活检和HIFU。另外，该过程由成像超声探头成像。成像超声探头可以跟踪进针部位，即使针头已被移除。 HIFU传感器在针道中发射短暂的HIFU脉冲，导致凝血和止血。

7. 发明申请

WO2008022043A3 INTRAOPERATIVE IMAGING OF RENAL CORTICAL TUMORS AND CYSTS 审中-公开
标题翻译：肾癌合并肿瘤的临床与影像学表现
公开(公告)号：WO2008022043A3
公开(公告)日：2008-11-20
申请号：PCT/US2007075738
申请日：2007-08-10
申请人： UNIV ROCHESTER MEDICAL CT , GOLIJANIN DRAGAN , MESSING EDWARD M
发明人： GOLIJANIN DRAGAN , MESSING EDWARD M
IPC分类号： A61K49/00
CPC分类号： A61K49/0034 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/411 , A61B5/415 , A61B5/418
摘要： The invention provides methods for visualizing renal tumors and for staging cysts during an operation by use of a fluorescent dye.
摘要翻译：本发明提供了通过使用荧光染料在手术期间显现肾肿瘤和分期囊肿的方法。

8. 发明申请

WO2006015315A3 INTRAOCULAR VIDEO SYSTEM 审中-公开
标题翻译：内窥镜视频系统
公开(公告)号：WO2006015315A3
公开(公告)日：2007-04-19
申请号：PCT/US2005027254
申请日：2005-08-01
申请人： UNIV ROCHESTER MEDICAL CT , FELDON STEVEN M D
发明人： FELDON STEVEN M D
IPC分类号： A61F2/14 , A61F2/16 , G02C7/04
CPC分类号： G02B27/017 , A61F9/08 , G02B2027/0138
摘要： According to one aspect of the present invention, an intraocular video system (100, 200) includes a contact lens (116, 302), a camera (104, 204, 308), and a display (106, 220). The contact lens (116, 302) is adapted to be carried on a surface of a user's eye. The camera (104, 204, 308) is coupled to the contact lens (116, 302), and is adapted to generate a signal indicative of an image received by the camera (104, 204, 308). The display (106, 220) is positioned within the user's eye and it provides a display image to the retina in the user's eye. The display image is at least in part based upon the signal.
摘要翻译：根据本发明的一个方面，眼内视频系统（100,200）包括隐形眼镜（116,302），相机（104,204,308）和显示器（106,220）。隐形眼镜（116,302）适于承载在使用者眼睛的表面上。相机（104,204,308）耦合到隐形眼镜（116,302），并且适于产生指示由照相机（104,204,308）接收的图像的信号。显示器（106,220）位于用户的眼睛内，并且在用户的眼睛中向视网膜提供显示图像。显示图像至少部分地基于信号。

9. 发明申请

WO2006047747A3 DEVICES AND METHODS FOR ANEURYSM TREATMENT 审中-公开
标题翻译：装置和方法进行治疗
公开(公告)号：WO2006047747A3
公开(公告)日：2006-08-31
申请号：PCT/US2005038984
申请日：2005-10-25
申请人： UNIV ROCHESTER MEDICAL CT , MED COLLEGE GEORGIA RES INST , ALLEYNE CARGILL H JR , STONE JEFFREY A
发明人： ALLEYNE CARGILL H JR , STONE JEFFREY A
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M2025/1054
摘要： A device for treating a fusiform aneurysm includes an elongate catheter and an expandable member detachably coupled with the elongate catheter at or near its distal end and adapted to assume a fusiform expanded shape. In its expanded shape the external surface of the expandable member will contact an inner wall of the aneurysm, thus preventing blood from passing between the external surface of the expandable member and the inner wall of the aneurysm. The expandable member includes an inflation lumen for expansion and a blood flow lumen to allow blood to flow from a portion of a blood vessel proximal to the aneurysm, through the blood flow lumen, to a portion of the blood vessel distal to the aneurysm. The expandable member is adapted to retain an expanded configuration and remain in place within the aneurysm when detached from the elongate catheter body.
摘要翻译：用于治疗梭形动脉瘤的装置包括细长的导管和可伸长的构件，该可扩张的构件在其远端处或附近与细长导管可拆卸地联接并且适于呈现梭形的扩张形状。在其膨胀形状中，可扩张构件的外表面将接触动脉瘤的内壁，从而防止血液在可扩张构件的外表面与动脉瘤的内壁之间通过。可扩张构件包括用于扩张的充气腔和血流腔，以允许血液从靠近动脉瘤的血管的一部分通过血流腔流动到远离动脉瘤的血管的一部分。可膨胀构件适于在从细长导管主体分离时保持膨胀构型并保持在动脉瘤内的适当位置。

10. 发明申请

WO2008011573A3 PRE- AND INTRA- OPERATIVE IMAGING OF TESTICULAR TORSION 审中-公开
标题翻译：特殊扭曲的前期和内部操作成像
公开(公告)号：WO2008011573A3
公开(公告)日：2008-11-06
申请号：PCT/US2007073993
申请日：2007-07-20
申请人： UNIV ROCHESTER MEDICAL CT , GOLIJANIN DRAGAN
发明人： GOLIJANIN DRAGAN
IPC分类号： A61B5/00
CPC分类号： A61B17/2812 , A61B5/0059 , A61B5/4387 , A61B17/282 , A61B90/04 , A61B2090/049
摘要： The invention provides methods for visualizing perfusion or lack thereof in the spermatic cord and testicle, as well as for detecting testicular trauma. A surgical forceps adapted to facilitate such visualization is also provided.
摘要翻译：本发明提供了在精索和睾丸中可视化灌注或缺乏的方法，以及用于检测睾丸损伤的方法。还提供了适于促进这种可视化的手术钳。

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