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    • 5. 发明申请
    • PHOSPHOSUCCINIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS
    • PHOSPHONOBERNSTEINSÄUREDERIVATE及其作为药物
    • WO1995000522A1
    • 1995-01-05
    • PCT/EP1994001980
    • 1994-06-17
    • BOEHRINGER MANNHEIM GMBHTSAKLAKIDIS, ChristosESSWEIN, AngelikaZIMMERMANN, GerdBAUSS, Frieder
    • BOEHRINGER MANNHEIM GMBH
    • C07F09/38
    • C07F9/655345C07F9/3808C07F9/3826C07F9/383C07F9/3882C07F9/572C07F9/59C07F9/6533C07F9/65515C07F9/6552
    • Compounds have formula (I), in which R , R may represent independently from each other hydrogen, lower alkyl, cycloalkyl or arylmethyl; R , R may represent independently from each other hydrogen, lower alkyl, or one of the groups -OR or -NR R , or they may form together with the atoms to which they are bound a five- to seven-membered carbocyclic ring or an heterocyclic ring containing one or two heteroatoms; R stands for lower alkenyl, cycloalkyl, cycloalkenyl, monocyclic arylalkyl, bicyclic aryl, biaryl or a group having formulae (a): R -X-alk- or (b), or forms together with R and the carbon atom to which it is bound a possibly substituted five- to seven-membered carbocyclic or heterocyclic ring; R stands for hydrogen, lower alkyl or arylmethyl; R , R represent independently from each other hydrogen or lower alkyl or form together with the nitrogen atom to which they are bound a five- or six-membered heterocyclic ring; R stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, mono- or bicyclic aryl, biaryl; R stands for a group having formula (a); X stands for a valence dash, oxygen or sulphur; Q stands for oxygen, sulphur or nitrogen; alk stands for a valence dash, a methylene chain, a saturated or unsaturated alkylene chain with 2-6 carbon atoms; n equals 0-3, m equals 0-2 and p equals 0-5. Also disclosed is a process for preparing said compounds and medicaments containing the same used for treating calcium metabolism disturbances.
    • 式(I)的化合物,其中R <1>,R <2>可以是氢,低级烷基,环烷基或彼此独立地芳甲基; [R <3>,R <4>各自独立地是氢,低级烷基,或以下基团之一-OR <6>,或-NR可以是<7> - [R <8>,或连同原子它们所连接 可形成五至七元碳环或含有一到两个杂原子的杂环; [R <5>低级链烯基,环烷基,环烯基,单环芳基烷基,二环芳基,联芳基或式的基团(一):R <9> -X-烷 - 或(b)指,或者与R一起<4> 和的碳原子其所连接形成任选经取代的五到形成七元碳环或杂环; [R <6>是氢,低级烷基或芳基甲基; [R <7> - [R <8>各自独立地表示氢或低级烷基,或一起与氮原子到它们所连接,形成五至六元杂环; [R <9>是氢,低级烷基,低级烯基,环烷基,环烯基,单环或双环芳基,联芳基,R <10>为式(a)的装置; X的化合价键,代表氧或硫; Q是氧,硫或氮; alk是价键,亚甲基,一个饱和或不饱和的亚烷基链与2 - 6个碳原子的装置; N = 0-3; M = 0-2且p = 0-5的装置,其制备方法和含有这些化合物,钙代谢紊乱的治疗的药物组合物的方法。