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    • 1. 发明申请
    • SOLUBLE ENDOGLIN AND USES THEREOF
    • 可溶性内酰胺酶及其用途
    • WO2011088047A1
    • 2011-07-21
    • PCT/US2011/020841
    • 2011-01-11
    • BETH ISRAEL DEACONESS MEDICAL CENTERTOPORSIAN, Mourad
    • TOPORSIAN, Mourad
    • A61K38/08A61K38/00C07K16/00
    • C12N15/1136A61K38/00C07K14/70596C07K16/2896C07K2317/34C12N15/1138Y02A50/411
    • The invention provides isolated soluble endoglin polypeptides, nucleic acids encoding soluble endoglin polypeptides, antibodies that specifically bind soluble endoglin polypeptides, and kits containing these materials. The invention also provides methods for treating or decreasing the likelihood of developing a soluble endoglin-mediated disorder in a subject requiring the administration of an agent capable of reducing the expression or biological activity of a soluble endoglin polypeptide and methods for treating or decreasing the likelihood of developing a soluble endoglin-preventive disorder in a subject requiring the administration of a soluble endoglin polypeptide or a nucleic acid encoding the soluble endoglin polypeptide. The invention further provides methods for the diagnosis of a soluble endoglin-mediated disorder or a soluble endoglin-preventive disorder and methods for identifying a compound to treat a soluble endoglin-mediated or a soluble endoglin- preventive disorder.
    • 本发明提供分离的可溶内皮糖蛋白多肽,编码可溶内皮糖蛋白多肽的核酸,特异性结合可溶内皮糖蛋白多肽的抗体,以及含有这些材料的试剂盒。 本发明还提供了治疗或降低在需要施用能够降低可溶内皮糖蛋白多肽的表达或生物学活性的试剂的受试者中发展可溶内皮糖蛋白介导的病症的可能性的方法,以及用于治疗或降低可溶内皮糖蛋白介导的病症的可能性的方法 在需要施用可溶内皮糖蛋白多肽或编码可溶内皮糖蛋白多肽的核酸的受试者中开发可溶内皮糖蛋白预防性疾病。 本发明还提供了用于诊断可溶内皮糖蛋白介导的病症或可溶内皮糖蛋白预防障碍的方法以及用于鉴定化合物以治疗可溶内皮糖蛋白介导的或可溶内皮抑素障碍的方法。