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1. 发明申请

WO2004108755A3 CHIMERIC ADENOVIRUS CAPSID PROTEINS 审中-公开
标题翻译： CHIMERIC ADENOVIRUS CAPSID蛋白
公开(公告)号：WO2004108755A3
公开(公告)日：2005-05-19
申请号：PCT/IB2004002532
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
发明人： TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
CPC分类号： C07K14/005 , C07K2319/33 , C12N2710/10322 , C12N2810/405 , C12N2810/859
摘要： The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.
摘要翻译：本发明涉及包含哺乳动物肠道相关淋巴组织（GALT）中存在的细胞上的一部分或全部腺病毒衣壳蛋白和细胞表面结合位点的结合配偶体的嵌合腺病毒衣壳蛋白，其中嵌合腺病毒衣壳蛋白能够结合存在于肠道相关淋巴组织（GALT）中的细胞。在一些实例中，腺病毒衣壳蛋白位于腺病毒衣壳的表面上。本发明提供了包含嵌合衣壳蛋白的腺病毒衣壳。本发明还提供了包含与GALT中的细胞结合的嵌合腺病毒衣壳蛋白的复合物。本发明还提供能够表达包含在本发明内的嵌合腺病毒衣壳蛋白的包衣系统和载体，特别是腺病毒载体。本发明还提供病毒颗粒，宿主细胞和包含这种载体的组合物，特别是用于疫苗，引发免疫应答的方法和用于将异源蛋白质例如抗原靶向递送至靶细胞的方法。

2. 发明申请

WO2004108939A2 BAV PACKAGING REGIONS AND E1 TRANSCRIPTIONAL CONTROL REGIONS 审中-公开
标题翻译： BAV包装区和E1转录控制区
公开(公告)号：WO2004108939A2
公开(公告)日：2004-12-16
申请号：PCT/IB2004002409
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , XING LI
发明人： TIKOO SURESH K , XING LI
IPC分类号： A61K39/23 , A61K39/235 , A61K48/00 , C07K14/075 , C12N7/00 , C12N7/04 , C12N15/861 , C12Q1/70
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10323 , C12N2710/10343
摘要： The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and El transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising uBAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications BAV EI transcriptional control regions. The present inventionalso provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications BAV El transcriptional control regions.
摘要翻译：本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。本发明还提供了辅助载体，其包含在辅助病毒中用于繁殖重组腺病毒的用于壳化的uBAV序列。本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含修饰BAV EI转录控制区。本发明还提供了制备包含对于壳化所必需的BAV序列以及修饰BAV E1转录控制区的腺病毒载体的方法。

3. 发明申请

WO2002077210A2 METHODS TO CULTURE CIRCOVIRUS 审中-公开
标题翻译：培养CIRCOVIRUS的方法
公开(公告)号：WO2002077210A2
公开(公告)日：2002-10-03
申请号：PCT/CA2002/000413
申请日：2002-03-27
申请人： UNIVERSITY OF SASKATCHEWAN , LIU, Qiang , TIKOO, Suresh, K. , WILLSON, Philip , BABIUK, Lorne, A.
发明人： LIU, Qiang , TIKOO, Suresh, K. , WILLSON, Philip , BABIUK, Lorne, A.
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.
摘要翻译：本发明涉及培养圆环病毒，特别是猪圆环病毒的方法。本发明提供了在表达哺乳动物腺病毒E1功能的哺乳动物细胞中培养猪圆环病毒的组合物和方法。

4. 发明申请

WO0192547A2 MODIFIED BOVINE ADENOVIRUS HAVING ALTERED TROPISM 审中-公开
标题翻译：具有改良TROPISM的改良型牛血清病毒
公开(公告)号：WO0192547A2
公开(公告)日：2001-12-06
申请号：PCT/CA0100798
申请日：2001-05-31
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K
发明人： TIKOO SURESH K
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/861 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/6018
摘要： The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.
摘要翻译：本发明提供了修饰的牛腺病毒，其包含衣壳蛋白中的修饰，其中所述蛋白质与腺病毒向性相关，并且其中所述修饰与改变的嗜性相关。本发明提供了腺病毒载体和包含这种载体的宿主细胞。本发明还提供了制备和使用这种腺病毒的方法。

5. 发明申请

WO2004108939A8 BAV PACKAGING REGIONS AND E1 TRANSCRIPTIONAL CONTROL REGIONS 审中-公开
标题翻译： BAV包装区和E1转录控制区
公开(公告)号：WO2004108939A8
公开(公告)日：2005-09-29
申请号：PCT/IB2004002409
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , XING LI
发明人： TIKOO SURESH K , XING LI
IPC分类号： A61K39/23 , A61K39/235 , A61K48/00 , C07K14/075 , C12N7/00 , C12N7/04 , C12N15/861 , C12Q1/70 , C12N15/86 , C12N5/10 , C12N15/11
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10323 , C12N2710/10343
摘要： The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and El transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.
摘要翻译：本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，所述腺病毒载体包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。本发明还提供了辅助载体，其包含用于辅助病毒用于繁殖重组腺病毒的壳化所必需的BAV序列。本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含BAV E1转录控制区域中的修饰。本发明还提供了制备包含BAV序列的腺病毒载体的方法，所述BAV序列对于包囊是必需的，以及在BAV E1转录控制区中的修饰。

6. 发明申请

WO2004009824A3 PAV REGIONS FOR ENCAPSIDATION AND E1 TRANSCRIPTIOONAL CONTROL 审中-公开
标题翻译： PAV区域进行加密和E1码本控制
公开(公告)号：WO2004009824A3
公开(公告)日：2004-05-21
申请号：PCT/IB0303724
申请日：2003-07-18
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K
发明人： TIKOO SURESH K
IPC分类号： A61K48/00 , C12N15/861 , C12N15/86 , A61K39/235 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/11
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C12N2710/10343 , C12N2830/30 , C12N2830/32
摘要： The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus sequence essential for encapsidation as well as methods for making and using such adenovirus vectors. The present invention discloses porcine adenovirus sequence for E1 transcriptional control and provides porcine adenovirus vectors comprising a modificatin(s) in the E1 transcriptional control region.
摘要翻译：本发明提供了对于壳化所必需的猪腺病毒序列，并提供了包含这种序列的腺病毒载体。本发明提供宿主细胞和包含腺病毒载体的组合物，其包含对于壳化所必需的猪腺病毒序列以及制备和使用这种腺病毒载体的方法。本发明公开了用于E1转录控制的猪腺病毒序列，并提供了包含E1转录控制区中的修饰物的猪腺病毒载体。

7. 发明申请

WO02077210A3 METHODS TO CULTURE CIRCOVIRUS 审中-公开
标题翻译：培养CIRCOVIRUS的方法
公开(公告)号：WO02077210A3
公开(公告)日：2003-08-21
申请号：PCT/CA0200413
申请日：2002-03-27
申请人： UNIV SASKATCHEWAN , LIU QIANG , TIKOO SURESH K , WILLSON PHILIP , BABIUK LORNE A
发明人： LIU QIANG , TIKOO SURESH K , WILLSON PHILIP , BABIUK LORNE A
IPC分类号： C12N15/09 , C07K14/075 , C12N5/02 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/34 , C12N15/86 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.
摘要翻译：本发明涉及培养圆环病毒，特别是猪圆环病毒的方法。本发明提供了在表达哺乳动物腺病毒E1功能的哺乳动物细胞中培养猪圆环病毒的组合物和方法。

8. 发明申请

WO2003040305A2 PORCINE ADENOVIRUS E1 AND E4 REGIONS 审中-公开
标题翻译： PORCINE ADENOVIRUS E1和E4区域
公开(公告)号：WO2003040305A2
公开(公告)日：2003-05-15
申请号：PCT/IB2002/005829
申请日：2002-09-24
申请人： UNIVERSITY OF SASKATCHEWAN , TIKOO, Suresh, K.
发明人： TIKOO, Suresh, K.
IPC分类号： C12N
CPC分类号： C12N7/00 , A01K2227/108 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361
摘要： The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 and E4 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.
摘要翻译：本发明涉及猪腺病毒E1和E4区域的表征。本文描述了提供PAV3 E1和E4区域表征的猪腺病毒3型PAV-3基因组的完整核苷酸序列。提供了在原核细胞中通过同源重组构建感染性PAV基因组的方法。通过用重组PAV基因组转染哺乳动物细胞获得重组PAV病毒。 PAV-3基因组可用作异源核苷酸序列表达的载体，例如用于制备和施用猪或其他哺乳动物的亚单位疫苗。

9. 发明申请

WO0192547A9 MODIFIED BOVINE ADENOVIRUS HAVING ALTERED TROPISM 审中-公开
标题翻译：具有改良TROPISM的改良型牛血清病毒
公开(公告)号：WO0192547A9
公开(公告)日：2003-04-10
申请号：PCT/CA0100798
申请日：2001-05-31
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K
发明人： TIKOO SURESH K
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/861 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/6018
摘要： The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.
摘要翻译：本发明提供了修饰的牛腺病毒，其包含衣壳蛋白中的修饰，其中所述蛋白质与腺病毒向性相关，并且其中所述修饰与改变的嗜性相关。本发明提供了腺病毒载体和包含这种载体的宿主细胞。本发明还提供了制备和使用这种腺病毒的方法。

10. 发明申请

WO2004108939A3 BAV PACKAGING REGIONS AND E1 TRANSCRIPTIONAL CONTROL REGIONS 审中-公开
公开(公告)号：WO2004108939A3
公开(公告)日：2004-12-16
申请号：PCT/IB2004/002409
申请日：2004-06-10
申请人： UNIVERSITY OF SASKATCHEWAN , TIKOO, Suresh, K. , XING, Li
发明人： TIKOO, Suresh, K. , XING, Li
IPC分类号： C12N15/86
摘要： The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and El transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.

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