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1. 发明申请

WO2006071609A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：WO2006071609A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/045990
申请日：2005-12-16
申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , BETAGERI, Raj , DISALVO, Darren , THOMSON, David, S. , KUZMICH, Daniel , REGAN, John , KOWALSKI, Jennifer
发明人： DISALVO, Darren , THOMSON, David, S. , KUZMICH, Daniel , REGAN, John , KOWALSKI, Jennifer
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4，R 4，R 4， R 5，R 6和R 7如本文所定义，或其互变异构体，前药，溶剂化物或盐物; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。

2. 发明申请

WO2005030213A1 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO 审中-公开
标题翻译： 1,1,1-三氟-4-苯基-4-甲基-2-（1H-吡咯并
公开(公告)号：WO2005030213A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031009
申请日：2004-09-22
申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , BEKKALI, Younes , BETAGERI, Rajashehar , EMMANUEL, Michael, J. , HAMMACH, Abdelhakim , HARCKEN, Hanke, Justus, Joachim , KIRRANE, Thomas, Martin , KUZMICH, Daniel , LEE, Thomas, Wai-Ho , LIU, Pingrong , PATEL, Usha, R. , RAZAVI, Hossein , RIETHER, Doris , TAKAHASHI, Hidenori , THOMSON, David, S. , WANG, Ji , ZINDELL, Renee , PROUDFOOT, John, Robert
发明人： BEKKALI, Younes , BETAGERI, Rajashehar , EMMANUEL, Michael, J. , HAMMACH, Abdelhakim , HARCKEN, Hanke, Justus, Joachim , KIRRANE, Thomas, Martin , KUZMICH, Daniel , LEE, Thomas, Wai-Ho , LIU, Pingrong , PATEL, Usha, R. , RAZAVI, Hossein , RIETHER, Doris , TAKAHASHI, Hidenori , THOMSON, David, S. , WANG, Ji , ZINDELL, Renee , PROUDFOOT, John, Robert
IPC分类号： A61K31/475
CPC分类号： C07D213/75 , A61K31/4745 , A61K31/52 , C07D209/08 , C07D209/12 , C07D213/30 , C07D215/14 , C07D231/12 , C07D231/56 , C07D237/20 , C07D239/42 , C07D307/79 , C07D319/06 , C07D319/08 , C07D333/56 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (IA), IB), IC), and (ID) wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（IA），IB），IC）和（ID）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如（IA），（IB），（IC）和（ID），或其互变异构体，前药，溶剂合物或盐在本文中定义; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

3. 发明申请

WO2009017524A4 CURVED SENSOR ARRAY APPARATUS AND METHODS 审中-公开
标题翻译：弯曲传感器阵列装置和方法
公开(公告)号：WO2009017524A4
公开(公告)日：2009-06-18
申请号：PCT/US2008005129
申请日：2008-04-21
申请人： LUCID DIMENSIONS LLC , RIEL RYAN D , CALIHMAN ADAM E , THOMSON DAVID S
发明人： RIEL RYAN D , CALIHMAN ADAM E , THOMSON DAVID S
IPC分类号： G01S3/30
CPC分类号： G01C3/00 , G01S3/784
摘要： Curved sensor array configurations ( 702, Figures 1 A, 2A, 2B, 8A, 8B, 8C, 9, 10, 11) and methods (Figures 6A, 6B, 6C) of processing the data gathered by the sensors. A 2 dimensional embodiment (Figure 1 A) comprises singular ring of sensors that can monitor sources in a 2 dimensional plane. A sensor directly facing a target produces a maximum response (Figure 1 C). As the angle of a sensor relative to the target increases, the response decreases. Fitting the sensor response amplitudes.to a 2D Gaussian curve (Figure 1 B) and calculating the peak of the curve (606) allows a very accurate calculation of the angular direction (608) of the target. A 3D embodiment (Figures 2A, 8A, 8B, 8C) comprises sensors scattered over the surface of a sphere in order to monitor multiple targets in any spatial orientation. Again, the sensor amplitude data is fitted to a 3D curve or surface such as a Gaussian surface (Figure 2C). The present invention can resolve more than one target using deconvoluting techniques (622, Figures 4A, 4B, 4C, 5A, 5B, 5C, 5D).
摘要翻译：处理由传感器收集的数据的弯曲传感器阵列配置（702，图1A，2A，2B，8A，8B，8C，9,10,11）和方法（图6A，6B，6C）。二维实施例（图1A）包括能够监测二维平面中的源的传感器的单环。直接面向目标的传感器产生最大响应（图1C）。随着传感器相对于目标的角度增加，响应减小。将传感器响应振幅拟合成二维高斯曲线（图1B）并计算曲线（606）的峰值允许非常准确地计算目标的角度方向（608）。 3D实施例（图2A，图8A，图8B，图8C）包括散布在球表面上的传感器，以便监测任何空间定向中的多个目标。同样，传感器幅度数据适合3D曲线或表面，如高斯表面（图2C）。本发明可以使用去卷积技术（622，图4A，4B，4C，5A，5B，5C，5D）解决多于一个目标。

4. 发明申请

WO2008064054A3 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的化合物
公开(公告)号：WO2008064054A3
公开(公告)日：2008-12-18
申请号：PCT/US2007084770
申请日：2007-11-15
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , CIRILLO PIER FRANCESCO , THOMSON DAVID S , RIETHER DORIS , BERRY ANGELA , WU LIFEN , HICKEY EUGENE RICHARD
发明人： CIRILLO PIER FRANCESCO , THOMSON DAVID S , RIETHER DORIS , BERRY ANGELA , WU LIFEN , HICKEY EUGENE RICHARD
IPC分类号： C07D295/195 , C07D413/12
CPC分类号： C07D295/195 , C07D413/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了式（I）的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

5. 发明申请

WO2009017524A3 CURVED SENSOR ARRAY APPARATUS AND METHODS 审中-公开
标题翻译：弯曲传感器阵列装置和方法
公开(公告)号：WO2009017524A3
公开(公告)日：2009-04-09
申请号：PCT/US2008005129
申请日：2008-04-21
申请人： LUCID DIMENSIONS LLC , RIEL RYAN D , CALIHMAN ADAM E , THOMSON DAVID S
发明人： RIEL RYAN D , CALIHMAN ADAM E , THOMSON DAVID S
IPC分类号： G01S3/30
CPC分类号： G01C3/00 , G01S3/784
摘要： Curved sensor array configurations ( 702, Figures 1 A, 2A, 2B, 8A, 8B, 8C, 9, 10, 11) and methods (Figures 6A, 6B, 6C) of processing the data gathered by the sensors. A 2 dimensional embodiment (Figure 1 A) comprises singular ring of sensors that can monitor sources in a 2 dimensional plane. A sensor directly facing a target produces a maximum response (Figure 1 C). As the angle of a sensor relative to the target increases, the response decreases. Fitting the sensor response amplitudes.to a 2D Gaussian curve (Figure 1 B) and calculating the peak of the curve (606) allows a very accurate calculation of the angular direction (608) of the target. A 3D embodiment (Figures 2A, 8A, 8B, 8C) comprises sensors scattered over the surface of a sphere in order to monitor multiple targets in any spatial orientation. Again, the sensor amplitude data is fitted to a 3D curve or surface such as a Gaussian surface (Figure 2C). The present invention can resolve more than one target using deconvoluting techniques (622, Figures 4A, 4B, 4C, 5A, 5B, 5C, 5D).
摘要翻译：处理由传感器收集的数据的弯曲传感器阵列配置（702，图1A，2A，2B，8A，8B，8C，9,10,11）和方法（图6A，6B，6C）。二维实施例（图1A）包括可监测二维平面中的源的传感器的奇异环。直接面向目标的传感器产生最大响应（图1C）。当传感器相对于目标物的角度增加时，响应减小。将传感器响应幅度拟合到2D高斯曲线（图1B）并计算曲线的峰值（606）允许非常准确地计算目标的角度方向（608）。 3D实施例（图2A，8A，8B，8C）包括散布在球体表面上的传感器，以便以任何空间方向监视多个目标。再次，将传感器振幅数据拟合到诸如高斯表面的3D曲线或表面（图2C）。本发明可以使用解卷积技术（622，图4A，4B，4C，5A，5B，5C，5D）来解决多于一个的目标。

6. 发明申请

WO2008064054A2 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
公开(公告)号：WO2008064054A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084770
申请日：2007-11-15
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , CIRILLO, Pier Francesco , THOMSON, David S. , RIETHER, Doris , BERRY, Angela , WU, Lifen , HICKEY, Eugene Richard
发明人： CIRILLO, Pier Francesco , THOMSON, David S. , RIETHER, Doris , BERRY, Angela , WU, Lifen , HICKEY, Eugene Richard
CPC分类号： C07D295/195 , C07D413/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

7. 发明申请

WO2008014199A2 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
公开(公告)号：WO2008014199A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074076
申请日：2007-07-23
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David S. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
发明人： BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David S. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

8. 发明申请

WO2007118041A1 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的化合物
公开(公告)号：WO2007118041A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/065749
申请日：2007-04-02
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , ZINDELL, Renee, M. , RIETHER, Doris , THOMSON, David, S. , WU, Lifen
发明人： ZINDELL, Renee, M. , RIETHER, Doris , THOMSON, David, S. , WU, Lifen
IPC分类号： C07C215/30 , C07C217/58 , C07C317/32 , C07D213/64 , C07D213/74 , C07D215/12 , A61K31/135 , A61K31/435 , A61K31/44 , A61P29/00
CPC分类号： C07C215/30 , C07C217/58 , C07C317/32 , C07D213/64 , C07D213/643 , C07D213/74 , C07D215/12
摘要： Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R 1 , R 2 , R 3 , X and Ar have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：提供了与CB2受体结合并且是激动剂，拮抗剂或反向激动剂的化合物，具有通式（I）的化合物，其中R 1，R 2，R 2， 3，X和Ar具有说明书中给出的含义及其制备和用途。这些化合物是有价值的CB2受体调节剂，可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

9. 发明申请

WO2006135826A1 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：葡萄糖酸化物质，其制备方法，药物组合物及其用途
公开(公告)号：WO2006135826A1
公开(公告)日：2006-12-21
申请号：PCT/US2006/022651
申请日：2006-06-08
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , MUGGE, Ingo, Andreas , BURKE, Michael, Jason , RALPH, Mark, Stephen , THOMSON, David, S. , HAMMACH, Abdelhakim , KOWALSKI, Jennifer, A. , BENTZIEN, Joerg, Martin
发明人： MUGGE, Ingo, Andreas , BURKE, Michael, Jason , RALPH, Mark, Stephen , THOMSON, David, S. , HAMMACH, Abdelhakim , KOWALSKI, Jennifer, A. , BENTZIEN, Joerg, Martin
IPC分类号： C07D249/18 , C07D231/56 , C07D235/12 , C07D209/10 , C07D405/06 , C07D401/06 , C07D409/06 , C07D403/06 , C07D413/06 , C07D471/04 , A61K31/416 , A61K31/4184 , A61K31/4192
CPC分类号： C07D471/04 , C07D209/08 , C07D209/10 , C07D231/56 , C07D235/06 , C07D235/12 , C07D249/18 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06
摘要： Compounds of Formula (IA) and (IB) wherein R¿1?, R¿2?, R¿3?, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（IA）和（IB）的化合物，其中R 1，R 2，R 3，A，B，C，D和E如本文所定义，或互变异构体，前药，溶剂化物或其盐含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

10. 发明申请

WO2009017524A2 CURVED SENSOR ARRAY APPARATUS AND METHODS 审中-公开
标题翻译：弯曲传感器阵列装置和方法
公开(公告)号：WO2009017524A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/005129
申请日：2008-04-21
申请人： LUCID DIMENSIONS, LLC , RIEL, Ryan, D. , CALIHMAN, Adam, E. , THOMSON, David, S.
发明人： RIEL, Ryan, D. , CALIHMAN, Adam, E. , THOMSON, David, S.
CPC分类号： G01C3/00 , G01S3/784
摘要： Curved sensor array configurations ( 702, Figures 1 A, 2A, 2B, 8A, 8B, 8C, 9, 10, 11) and methods (Figures 6A, 6B, 6C) of processing the data gathered by the sensors. A 2 dimensional embodiment (Figure 1 A) comprises singular ring of sensors that can monitor sources in a 2 dimensional plane. A sensor directly facing a target produces a maximum response (Figure 1 C). As the angle of a sensor relative to the target increases, the response decreases. Fitting the sensor response amplitudes.to a 2D Gaussian curve (Figure 1 B) and calculating the peak of the curve (606) allows a very accurate calculation of the angular direction (608) of the target. A 3D embodiment (Figures 2A, 8A, 8B, 8C) comprises sensors scattered over the surface of a sphere in order to monitor multiple targets in any spatial orientation. Again, the sensor amplitude data is fitted to a 3D curve or surface such as a Gaussian surface (Figure 2C). The present invention can resolve more than one target using deconvoluting techniques (622, Figures 4A, 4B, 4C, 5A, 5B, 5C, 5D).
摘要翻译：弯曲的传感器阵列配置（702，图1A，2A，2B，8A，8B，8C，9,10,11）和方法（图6A，6B，6C）处理收集的数据通过传感器。二维实施例（图1A）包括能够监测二维平面中的源的传感器的单环。直接面向目标的传感器产生最大响应（图1C）。随着传感器相对于目标的角度增加，响应减小。将传感器响应振幅拟合成二维高斯曲线（图1B）并计算曲线（606）的峰值允许非常准确地计算目标的角度方向（608）。 3D实施例（图2A，图8A，图8B，图8C）包括散布在球表面上的传感器，以便监测任何空间定向中的多个目标。同样，传感器幅度数据适合3D曲线或表面，如高斯表面（图2C）。本发明可以使用解卷积技术（622，图4A，4B，4C，5A，5B，5C，5D）解决多于一个目标。

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