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1. 发明申请

WO2004103389A3 MEANS FOR PREVENTING AND TREATING CELLULAR DEATH AND THEIR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：手段预防和治疗细胞死亡及其生物应用
公开(公告)号：WO2004103389A3
公开(公告)日：2005-10-20
申请号：PCT/EP2004006288
申请日：2004-05-24
申请人： THERAPTOSIS SA , CHAUVIER DAVID , BORGNE ANNIE , JACOTOT ETIENNE , LANGONNE ALAIN , LECOEUR HERVE , REBOUILLAT DOMINIQUE
发明人： CHAUVIER DAVID , BORGNE ANNIE , JACOTOT ETIENNE , LANGONNE ALAIN , LECOEUR HERVE , REBOUILLAT DOMINIQUE
IPC分类号： A61K31/713 , A61K38/00 , C07K5/103 , C07K14/47 , C12N15/113 , A61P9/10 , A61P25/16 , A61P25/28 , C12N15/11
CPC分类号： C12N15/1137 , A61K38/00 , C07K5/101 , C07K14/4747 , C07K14/8139 , C07K2319/10 , C12N2310/111 , C12N2310/14 , C12Y304/22055
摘要： Inhibitors for preventing, blacking/silencing caspase-2 activity in cell death.
摘要翻译：用于预防，阻断/沉默caspase-2活性的细胞死亡抑制剂。

2. 发明申请

WO2009001322A2 USE OF PEPTIDE DERIVATIVES FOR TREATING PATHOLOGIES RESULTING FROM ISCHEMIA 审中-公开
标题翻译：使用肽衍生物治疗ISCHEMIA的病理学
公开(公告)号：WO2009001322A2
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052591
申请日：2008-06-27
申请人： THERAPTOSIS SA , Institut National de la Santé et de la Recherche Médicale (INSERM) , CASIMIR, Richard , CHAUVIER, David , JACOTOT, Etienne , LACAMPAGNE, Alain , FAUCONNIER, Jérémy
发明人： CASIMIR, Richard , CHAUVIER, David , JACOTOT, Etienne , LACAMPAGNE, Alain , FAUCONNIER, Jérémy
CPC分类号： C07K7/02 , A61K47/545 , A61K47/58 , A61K47/60 , A61K47/645
摘要： The invention relates to use the of a caspase-2 inhibitor for making a drug for treating cardiovascular pathologies resulting from ischemic situations.
摘要翻译：本发明涉及使用胱天蛋白酶-2抑制剂制备用于治疗由缺血情况引起的心血管病变的药物。

3. 发明申请

WO2009001322A3 CASPASE INHIBITORS FOR TREATING PATHOLOGIES RESULTING FROM ISCHEMIA 审中-公开
标题翻译：用于治疗ISCHEMIA病理学的CASPASE抑制剂
公开(公告)号：WO2009001322A3
公开(公告)日：2009-09-03
申请号：PCT/IB2008052591
申请日：2008-06-27
申请人： THERAPTOSIS SA , INST NAT SANTE RECH MED , CASIMIR RICHARD , CHAUVIER DAVID , JACOTOT ETIENNE , LACAMPAGNE ALAIN , FAUCONNIER JEREMY
发明人： CASIMIR RICHARD , CHAUVIER DAVID , JACOTOT ETIENNE , LACAMPAGNE ALAIN , FAUCONNIER JEREMY
IPC分类号： A61K47/48 , A61P9/10 , A61P39/00 , C07K7/06
CPC分类号： C07K7/02 , A61K47/545 , A61K47/58 , A61K47/60 , A61K47/645
摘要： The inventors have studied the kinetic and hierarchy of activation of apoptogenic caspases during myocardial ischemia and have found that caspase 2 plays a major role during the cardiac pathology by a very fast activation after an ischemic episode. Experiments were carried out on animal models of transitory or permanent myocardial ischemia. It was then observed that electrophysiological remodeling and post-ischemic fibrosis were prevented by using caspase-2 specific inhibitors. The invention is then based on the demonstration that caspase-2 and its activation represents an early and transitory step of the cardiac apoptotic mechanisms resulting from a myocardial ischemic and involved in the development of hypertrophy and cardiac insufficiency. The invention thus relates to a method of treatment of cardiovascular pathologies resulting from ischemia by using certain caspase-2 specific inhibitors.
摘要翻译：本发明人研究了心肌缺血期间凋亡性胱天蛋白酶激活的动力学和层次结构，并且发现半胱天冬酶2在心脏病理学中通过在缺血发作后非常快速的活化而起主要作用。对短暂或永久性心肌缺血的动物模型进行实验。然后观察到通过使用胱天蛋白酶-2特异性抑制剂来防止电生理重塑和缺血后纤维化。然后，本发明基于这样的证据，即胱天蛋白酶-2及其活化代表由心肌缺血引起的心脏凋亡机制的早期和暂时的步骤，并且涉及肥大和心脏功能不全的发展。因此，本发明涉及通过使用某些半胱天冬酶-2特异性抑制剂治疗由局部缺血引起的心血管病变的方法。

4. 发明申请

WO2004106370A1 M11L DERIVED PEPTIDES AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译： M11L衍生的肽及其治疗用途
公开(公告)号：WO2004106370A1
公开(公告)日：2004-12-09
申请号：PCT/EP2004/006581
申请日：2004-05-28
申请人： THERAPTOSIS SA , ROBARTS RESEARCH INSTITUTE , JACOTOT, Etienne , MCFADDEN, Grant
发明人： JACOTOT, Etienne , MCFADDEN, Grant
IPC分类号： C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2710/24022
摘要： This invention relates to a novel chimeric peptide derived from M11L protein of myxoma poxvirus capable of inhibiting apoptosis and its use as a cytoprotective molecule, as well as to pharmaceutical compositions containing the M11L derived chimeric peptides. Also provided are nucleic acid molecules that encode the chimeric anti-apoptotic peptides, and methods for using the proteins and nucleic acid molecules as cytoprotective molecules. The present invention further relates to a M11L fusion peptide possessing an uptake action and/or a targeted moiety into and to a cell and its use as apoptosis inhibitor. The M11L derived peptides and fusions peptides are useful for treating AIDS, neurodegenerative diseases, osteomyelodysplasia, ischemic diseases, infectious multiple organ failure, hepatitis, ischemic reperfusion disorders, diabetes and the like.
摘要翻译：本发明涉及能够抑制凋亡的粘液瘤痘病毒的M11L蛋白的新型嵌合肽及其作为细胞保护分子的用途，以及含有M11L衍生的嵌合肽的药物组合物。还提供编码嵌合抗凋亡肽的核酸分子，以及使用蛋白质和核酸分子作为细胞保护分子的方法。本发明还涉及具有吸收作用和/或靶向部分进入细胞和细胞的M11L融合肽及其作为细胞凋亡抑制剂的用途。 M11L衍生肽和融合肽可用于治疗AIDS，神经变性疾病，骨髓发育不良，缺血性疾病，感染性多器官功能衰竭，肝炎，缺血再灌注障碍，糖尿病等。

5. 发明申请

WO2004103389A2 MEANS FOR PREVENTING AND TREATING CELLULAR DEATH AND THEIR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：手段预防和治疗细胞死亡及其生物应用
公开(公告)号：WO2004103389A2
公开(公告)日：2004-12-02
申请号：PCT/EP2004/006288
申请日：2004-05-24
申请人： THERAPTOSIS SA , CHAUVIER, David , BORGNE, Annie , JACOTOT, Etienne , LANGONNE, Alain , LECOEUR, Hervé , REBOUILLAT, Dominique
发明人： CHAUVIER, David , BORGNE, Annie , JACOTOT, Etienne , LANGONNE, Alain , LECOEUR, Hervé , REBOUILLAT, Dominique
IPC分类号： A61K38/00
CPC分类号： C12N15/1137 , A61K38/00 , C07K5/101 , C07K14/4747 , C07K14/8139 , C07K2319/10 , C12N2310/111 , C12N2310/14 , C12Y304/22055
摘要： Inhibitors for preventing, blacking/silencing caspase-2 activity in cell death.
摘要翻译：用于预防，阻断/沉默caspase-2活性的细胞死亡抑制剂。

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