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1. 发明申请

WO2021155612A ANTIMALARIAL AGENTS 审中-公开
公开(公告)号：WO2021155612A
公开(公告)日：2021-08-12
申请号：PCT/CN2020/074569
申请日：2020-02-09
申请人： MERCK SHARP & DOHME CORP. [US]/[US] , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU]/[AU] , MSD R&D (CHINA) CO., LTD. [CN]/[CN] , De Lera Ruiz, Manuel [US]/[US] (US) , FAVUZZA, Paola [IT]/[AU] (US) , GUO, Zhuyan [US]/[US] (US) , HU, Bin [CN]/[CN] (US) , LEI, Zhiyu [CN]/[CN] (US) , MCCAULEY, John A. [US]/[US] (US) , OLSEN, David B. [US]/[US] (US) , SLEEBS, Brad [AU]/[AU] (US) , TRIGLIA, Tony [AU]/[AU] (US) , ZHAN, Dongmei [CN]/[CN] (US) , ZHAO, Lianyun [US]/[CN] (US) , Kelly III, Michael J. (US)
发明人： De Lera Ruiz, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , LEI, Zhiyu , MCCAULEY, John A. , OLSEN, David B. , SLEEBS, Brad , TRIGLIA, Tony , ZHAN, Dongmei , ZHAO, Lianyun , Kelly III, Michael J.
IPC分类号： C07D401/10 , C07D403/10 , C07D417/10 , C07D471/04 , A61K31/513 , A61P33/06
摘要： Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Privided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

2. 发明申请

WO2021000013A1 COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2021000013A1
公开(公告)日：2021-01-07
申请号：PCT/AU2020/050685
申请日：2020-07-01
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , UNIVERSITY OF WASHINGTON
发明人： HERD GUSTAFSON, Heather Leigh , HWANG PUN, Suzie , MASTERS, Seth Lucien , VINCE, James Edmund
IPC分类号： A61K38/10 , A61K38/17 , A61P35/00 , A61P31/00 , A61P37/04
摘要： The disclosure relates to peptides that can interact with RIP homotypic interaction motif (RHIM) proteins/peptides. These peptides also contain a RHIM motif which has an evolutionary conserved core tetrad sequence (V/I)-Q-(V/I/L/C)-G found in RIPK1, RIPK3 and their orthologues, such as DAI and TRIP. The peptide-peptide RHIM motif interaction causes multimerisation, amyloid formation and activation of the NLRP3 inflammasome. This in turn causes an artificial or temporary induction of inflammatory cell death, enhances the level of inflammatory mediators, such as IL-Ιβ, and results in an increase of inflammatory cell infiltrate, such as CD8+ T cells, into the tissue space. The therapeutic application is for tumour suppression, pathogenic regression and enhancing the immune response to vaccination.

3. 发明申请

WO2020176921A1 IMMUNOSUPPRESSIVE GLYCOFORMS OF SOLUBLE CD52 审中-公开
公开(公告)号：WO2020176921A1
公开(公告)日：2020-09-10
申请号：PCT/AU2019/050197
申请日：2019-03-07
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MACQUARIE UNIVERSITY
发明人： HARRISON, Leonard Charles , BANDALA-SANCHEZ, Esther , GODDARD-BORGER, Ethan David , PACKER, Nicolle Hannah , MANSOUR, Shathili Abdulrahman
IPC分类号： C07K9/00 , C07K1/22 , C07K1/18 , A61P37/00 , A61K38/04
摘要： The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has α-2,3-sialylated N-glycans, O-glycosylation and a pI of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.

4. 发明申请

WO2020124136A1 METHODS OF TREATING INFLAMMATION 审中-公开
公开(公告)号：WO2020124136A1
公开(公告)日：2020-06-25
申请号：PCT/AU2019/051386
申请日：2019-12-17
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： ALLAN, Rhys , KEENAN, Christine , NUTT, Stephen
IPC分类号： A61K31/496 , A61P37/06 , A61P37/08 , A61P11/06
摘要： Methods for treating inflammation, including allergic inflammation, lymphocyte-driven inflammation, and inflammatory conditions such as allergic asthma and allergic lung inflammation, using inhibitors of the polycomb repressive complex 2 (PRC2) methyltransferase enhancer of zeste homolog 2 (Ezh2) are provided.

5. 发明申请

WO2018130871A9 SYSTEM, METHOD, APPARATUS AND DIAGNOSTIC TEST FOR PLASMODIUM VIVAX 审中-公开
公开(公告)号：WO2018130871A9
公开(公告)日：2018-07-19
申请号：PCT/IB2017/001776
申请日：2017-12-21
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： MUELLER, Ivo , TSUBOI, Takafumi , WHITE, Michael , LONGLEY, Rhea
IPC分类号： G01N33/569 , C07K14/445 , C07K16/00
摘要： A system, method, apparatus and diagnostic test for Plasmodium vivax , to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites ("dormant" liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.

6. 发明申请

WO2016197190A1 STRUCTURE OF PLASMEPSIN V IN COMPLEX WITH AN INHIBITOR AND USES THEREOF 审中-公开
标题翻译：具有抑制剂的复合物中的PLASMEPSIN V的结构及其用途
公开(公告)号：WO2016197190A1
公开(公告)日：2016-12-15
申请号：PCT/AU2016/050459
申请日：2016-06-08
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： BODDEY, Justin , COWMAN, Alan , CZABOTAR, Peter , HODDER, Tony , SLEEBS, Brad
IPC分类号： C07K5/09 , C12N9/96 , G06F19/16 , A61K38/06 , A61P33/06
CPC分类号： G06F19/16 , A61K38/00 , C07K5/06095 , C07K14/445 , C12N9/50 , C12Y304/23038 , C12Y304/23039
摘要： In one aspect, the present invention relates to the crystal structure of Plasmodium vivax plasmepsin V in complex with an inhibitor, and to methods of using the crystal structure and related structural information to identify, design and/or screen for inhibitors or redesign known inhibitors that interact with and/or modulate plasmepsin V activity. In another aspect, the present invention relates to a class of compounds based on the inhibitor useful in the treatment of malaria.
摘要翻译：一方面，本发明涉及与抑制剂复合的间日疟原虫质膜蛋白酶V的晶体结构，以及使用晶体结构和相关结构信息来鉴定，设计和/或筛选抑制剂或重新设计已知的抑制剂的方法与血浆蛋白酶V活性相互作用和/或调节。另一方面，本发明涉及一类基于可用于治疗疟疾的抑制剂的化合物。

7. 发明申请

WO2015006811A2 DIAGNOSTIC METHODS 审中-公开
标题翻译：诊断方法
公开(公告)号：WO2015006811A2
公开(公告)日：2015-01-22
申请号：PCT/AU2014/000730
申请日：2014-07-18
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： BLEWITT, Marnie , HARRISON, Leonard Charles , MAKSIMOVIC, Jovana , NASELLI, Gaetano , OSHLACK, Alicia , ZHANG, YUXIA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881
摘要： A method for identifying the level of T-regulatory cell activity in a test biological sample comprising immune cells, the method comprising screening a test sample for the methylation profiles of a pre-selected genetic locus/loci selected from the list consisting of: (i) at least one genetic locus or at least two genetic Loci defined m one or more of Table 1 to Table 5; (ii) at least one genetic locus or at least two genetic loci defined in one or more of Table 6 to Table 10; and (iii) at least two genetic loci defined in one or more of Table 1 to Table 5, and one or more of Table 6 to Table 10; and determining the degree of concordance between the test methylation profiles and a reference methylation profile, wherein the degree of concordance identifies the level of T-regulatory cell activity in the sample.
摘要翻译：一种用于鉴定包含免疫细胞的测试生物样品中T调节细胞活性水平的方法，所述方法包括筛选预先选择的遗传基因座/位点的甲基化谱的测试样品，所述选择的遗传基因座/位点选自：（i ）至少一个遗传基因座或至少两个定义在表1至表5中的一个或多个的遗传基因座; （ii）在表6至表10中的一个或多个中定义的至少一个遗传基因座或至少两个遗传基因座; 和（iii）在表1至表5中的一个或多个中定义的至少两个遗传基因座，以及表6至表10中的一个或多个; 并确定测试甲基化谱与参考甲基化谱之间的一致程度，其中一致度确定样品中T调节细胞活性的水平。

8. 发明申请

WO2014075125A1 SOLUBLE MEDIATOR 审中-公开
标题翻译：可溶性介质
公开(公告)号：WO2014075125A1
公开(公告)日：2014-05-22
申请号：PCT/AU2013/000292
申请日：2013-03-25
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： HARRISON, Leonard Charles , RASHIDI, Maryam , ZHANG, Yuxia
IPC分类号： A61K38/10 , C12N15/12 , C12N15/86 , G01N33/15 , G01N33/50 , A61P37/06
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/70592 , C07K16/2803 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K2317/76 , C07K2319/30 , C12N5/0637 , G01N33/502 , G01N33/564 , G01N33/6872 , G01N33/6893 , G01N2333/70592 , G01N2800/26 , G01N2800/285 , G01N2800/50 , G01N2800/52
摘要： The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.
摘要翻译：本公开涉及可溶性CD52糖蛋白在治疗由效应T细胞调节的疾病中的用途，例如败血症或多发性硬化症。本公开还涉及基于检测受试者中CD52表达水平的诊断方法。

9. 发明申请

WO2014063193A1 SUBSTITUTED SULFONE-CONTAINING TRICYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：取代的含硫化合物的三环化合物及其用途
公开(公告)号：WO2014063193A1
公开(公告)日：2014-05-01
申请号：PCT/AU2013/001229
申请日：2013-10-23
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： KILE, Benjamin Thomas , LESSENE, Guillaume Laurent , HUANG, David Ching Siang , WATSON, Keith Geoffrey , BUI, Chinh Thien , NGUYEN, Thao Lien Thi , CHAPPAZ, Stephane Andre
IPC分类号： C07D495/04 , A61K31/382 , A61P43/00
CPC分类号： C07D495/04
摘要： The present invention relates to substituted sulfone-containing tricyclic compounds and analogues thereof which inhibit Bak-mediated apoptosis. The invention further relates to pharmaceutical compositions comprising a compound of the present invention and to methods of inhibiting a Bak-mediated apoptotic pathway and Bak-mediated apoptosis in a cell.
摘要翻译：本发明涉及抑制Bak介导的凋亡的含取代砜的三环化合物及其类似物。本发明还涉及包含本发明化合物的药物组合物和抑制Bak介导的凋亡途径和Bak介导的细胞凋亡的方法。

10. 发明申请

WO2013185165A1 CD-52 ANTIBODIES AND THEIR USE IN DETERMINING AND ENHANCING AN IMMUNE RESPONSE IN A SUBJECT 审中-公开
标题翻译： CD-52抗体及其在确定和增强受试者的免疫应答中的应用
公开(公告)号：WO2013185165A1
公开(公告)日：2013-12-19
申请号：PCT/AU2013/000483
申请日：2013-05-10
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： HARRISON, Leonard Charles
IPC分类号： A61K39/395 , A61P37/04 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2893 , C07K2317/76 , G01N33/5047 , G01N33/6878 , G01N2333/70592
摘要： The present disclosure generally relates to antibodies that are capable of enhancing an immune response to an antigen and to methods of using such antibodies. In one example, the present disclosure generally relates to antibodies that are capable of binding to the cell surface membrane-anchored glycoprotein CD52 or a soluble fragment thereof. Exemplary methods of using such antibodies include enhancing a subject's immune response to an antigen, determining the level of a subject's immune response to an antigen, and other methods disclosed herein.
摘要翻译：本公开内容通常涉及能够增强对抗原的免疫应答的抗体和使用这种抗体的方法。在一个实例中，本公开内容通常涉及能够结合细胞表面膜锚定的糖蛋白CD52或其可溶性片段的抗体。使用这种抗体的示例性方法包括增强受试者对抗原的免疫应答，确定受试者对抗原的免疫应答的水平，以及本文公开的其它方法。

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