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1. 发明申请

WO2020100024A1 METHOD AND SYSTEM 审中-公开
公开(公告)号：WO2020100024A1
公开(公告)日：2020-05-22
申请号：PCT/IB2019/059697
申请日：2019-11-12
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： TANG, Mimi Lai-Kuan , POIDINGER, Michael
IPC分类号： G01N33/68 , G01N33/53
摘要： The present disclosure relates generally to methods for determining whether a subject has, or is likely to have, desensitisation, sustained unresponsiveness or long-term sustained unresponsiveness (tolerance) to a food allergen following cessation of oral immunotherapy (OIT) for a food allergy, the method comprising measuring at least one food allergen specific immunoglobulin level from a sample of a subject at a time point relative to the start of OIT, and analysing the at least one allergen specific immunoglobulin level based on modelled subject OIT immunoglobulin levels to determine whether the subject has, or is likely to have, desensitisation, sustained unresponsiveness or long-term sustained unresponsiveness to the food allergen following cessation of OIT.

2. 发明申请

WO2018161121A1 METHODS FOR PRODUCING LYMPHOCYTE PROGENITORS 审中-公开
公开(公告)号：WO2018161121A1
公开(公告)日：2018-09-13
申请号：PCT/AU2018/050210
申请日：2018-03-08
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： STANLEY, Edouard , ELEFANTY, Andrew , MOTAZEDIAN, Ali
IPC分类号： C12N5/0781 , C12N5/0783
摘要： The invention relates to a method for producing a lymphocyte progenitor, the method comprising culturing a pluripotent stem cell (PSC)-derived CD34+ cell at an air-liquid interface (ALI). The invention also relates to a method for producing a B-cell progenitor, the method comprising co-culturing a PSC-derived CD34+ cell and a stromal cell in a medium comprising a CD117 activator and a NOTCH1 inhibitor. The invention further relates to a T-cell progenitor and a B-cell progenitor when produced by the methods of the invention and to use of the T-cell progenitor in the manufacture of T cell with defined antigen specificity, optionally a chimeric antigen receptor (CAR) T cell, and use of the B-cell progenitor in the manufacture of an antibody.

3. 发明申请

WO2018112553A1 METHODS AND COMPOSITIONS FOR DETERMINING, AND FOR MINIMIZING, THE LIKELIHOOD OF DEVELOPMENT OF ALLERGY IN INFANTS 审中-公开
公开(公告)号：WO2018112553A1
公开(公告)日：2018-06-28
申请号：PCT/AU2017/051453
申请日：2017-12-22
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： VUILLERMIN, Peter , PONSONBY, Anne-Louise , TANG, Mimi
IPC分类号： C12Q1/68 , A61K35/741
摘要： The invention relates to allergic disease, to the development of allergic disease in infants, to determining the likelihood of development of allergic disease in infants and to minimizing the likelihood of development of allergic disease in infants.

4. 发明申请

WO2016074016A1 VECTORS AND METHODS FOR TARGETED INTEGRATION IN LOCI COMPRISING CONSTITUTIVELY EXPRESSED GENES 审中-公开
标题翻译：在包含一般性表达基因的位点中的靶向整合的向量和方法
公开(公告)号：WO2016074016A1
公开(公告)日：2016-05-19
申请号：PCT/AU2015/000682
申请日：2015-11-10
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： STANLEY, Ed , ELEFANTY, Andrew , ELLIOTT, David , LABONNE, Tatiana
IPC分类号： C12N15/85 , C12N5/10
CPC分类号： C12N15/907 , A01K2217/072 , A01K2217/203 , A01K2267/0393 , C12N5/10 , C12N15/85 , C12N2800/24 , C12N2830/002 , C12N2840/107 , C12N2840/203
摘要： The invention relates to a vector comprising: a 5' nucleic acid that is homologous to a genomic sequence 5' of a stop codon of a constitutively expressed gene; an exogenous nucleic acid; a 3' nucleic acid that is homologous to a genomic sequence 3' of the stop codon of the constitutively expressed gene; a translation interruption-reinitiation signal operably linked to the 5' nucleic acid and the exogenous nucleic acid, wherein the translation interruption-reinitiation signal is capable of replacing the stop codon of the constitutively expressed gene.
摘要翻译：本发明涉及一种载体，其包含：与组成型表达基因的终止密码子的基因组序列5'同源的5'核酸; 外源核酸; 与组成型表达基因的终止密码子的基因组序列3'同源的3'核酸; 与5'核酸和外源核酸可操作地连接的翻译中断再启动信号，其中翻译中断再启动信号能够替代组成型表达的基因的终止密码子。

5. 发明申请

WO2013049892A1 DIAGNOSTIC ASSAY FOR TISSUE TRANSPLANTATION STATUS 审中-公开
标题翻译：用于组织移植状态的诊断测定
公开(公告)号：WO2013049892A1
公开(公告)日：2013-04-11
申请号：PCT/AU2012/001210
申请日：2012-10-05
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE , SLATER, Howard Robert , BRUNO, Damien Luis , GANESAMOORTHY, Devika
发明人： SLATER, Howard Robert , BRUNO, Damien Luis , GANESAMOORTHY, Devika
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/118 , C12Q2600/156
摘要： The present disclosure relates generally to tissue, including organ, transplantation. Taught herein is a genetic-based diagnostic assay to ascertain the status of a tissue transplantation procedure in a recipient based on a characterization of circulating or other cell free nucleic acid material. The instant disclosure enables kits, primers and protocols for ascertaining the status of a transplantation procedure.
摘要翻译：本公开一般涉及组织，包括器官移植。本文中的教导是基于遗传的诊断测定，以基于循环或其他无细胞核酸材料的表征来确定接受者中组织移植程序的状态。本公开使用用于确定移植程序状态的试剂盒，引物和方案。

6. 发明申请

WO2012139159A1 SYSTEM AND PROCESS FOR DETERMINING A POSITIVE END-EXPIRATORY PRESSURE FOR A MECHANICAL VENTILATION SYSTEM 审中-公开
标题翻译：用于确定机械通风系统的正向终端压力的系统和过程
公开(公告)号：WO2012139159A1
公开(公告)日：2012-10-18
申请号：PCT/AU2012/000370
申请日：2012-04-11
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE , TINGAY, David, Gerald
发明人： TINGAY, David, Gerald
IPC分类号： A61M16/00
CPC分类号： A61M16/205 , A61M16/024 , A61M2205/502 , A61M2230/005 , A61M2230/46
摘要： A process for determining a positive end-expiratory pressure for a mechanical ventilation system, including: determining values for compliance of a patient's respiratory system during mechanical ventilation of the patient using respective positive end-expiratory pressure (PEEP) values; and processing the compliance values and the PEEP values to determine a PEEP value as substantially being a lowest PEEP value that provides a highest compliance value.
摘要翻译：一种用于确定机械通气系统的正向呼气末压力的过程，包括：使用相应的呼气末正压（PEEP）值确定患者机械通气期间患者呼吸系统的顺应性值; 并且处理合规值和PEEP值以确定PEEP值基本上是提供最高顺应值的最低PEEP值。

7. 发明申请

WO2009039589A1 CELL DETECTION, MONITORING AND ISOLATION METHOD 审中-公开
标题翻译：细胞检测，监测和分离方法
公开(公告)号：WO2009039589A1
公开(公告)日：2009-04-02
申请号：PCT/AU2008/001440
申请日：2008-09-26
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE , BRUNO, Damien, Luis , SLATER, Howard, Robert
发明人： BRUNO, Damien, Luis , SLATER, Howard, Robert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q2600/156
摘要： The present invention relates generally to a method for identifying or distinguishing one type of cell from other cells within a population of cells. The present invention further provides the detection, monitoring and isolation of sub- populations cell types within a population of cells including a biological entity comprising such cell types. Kits, diagnostic agents and panels of nucleic acid probes for identifying and distinguishing cell types also form part of the present invention. The detection of particular cell types is based upon the use of a labelled probe that hybridizes to chromosomal DNA at the flanking sequences of a deletion. Alternatively two probes with distinguishable reporter molecules are used wherein only one probe is capable of hybridizing to chromosomal DNA in one cell type whereas both are capable of hybridizing to chromosomal DNA in another cell type. The methods are useful in the identification of cells with copy number variations, chromosomal deletions, additions or aberrations.
摘要翻译：本发明一般涉及用于鉴定或区分细胞群体中的其它细胞的一种类型的细胞的方法。本发明还提供了检测，监测和分离细胞群体内的亚群细胞类型，包括包含这种细胞类型的生物实体。用于识别和鉴别细胞类型的核酸探针的试剂盒，诊断试剂和试剂盒也构成本发明的一部分。特定细胞类型的检测基于使用与缺失侧翼序列上染色体DNA杂交的标记探针。或者，使用具有可区分的报道分子的两个探针，其中只有一个探针能够与一种细胞类型的染色体DNA杂交，而两种能够与另一种细胞类型的染色体DNA杂交。该方法可用于鉴定具有拷贝数变异，染色体缺失，添加或异常的细胞。

8. 发明申请

WO2005040391A1 COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS 审中-公开
标题翻译：用于分化干细胞的组合物和方法
公开(公告)号：WO2005040391A1
公开(公告)日：2005-05-06
申请号：PCT/AU2004/001469
申请日：2004-10-25
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE , CHOO, Kong-Hong, Andy , WONG, Lee, Hwa , SAFFERY, Richard, Eric
发明人： CHOO, Kong-Hong, Andy , WONG, Lee, Hwa , SAFFERY, Richard, Eric
IPC分类号： C12N15/90
CPC分类号： C12N15/90 , A61K48/00 , C12N15/85
摘要： The present invention relates generally to the field of tissue engineering and genetic manipulation of cells and to methods for generating tissue suitable for use in repair, replacement, rejuvenation or augmentation therapy. Even more particularly, the present invention contemplates a method for genetically manipulating a stem cell by introducing a nucleic acid molecule comprising a centromere or neocentromere into the stem cell or a parent of the stem cell, wherein the nucleic acid molecule conveys genetic information which is capable of introducing to or modifying a trait within the stem cell or progeny of the stem cell such as but not limited to modulating the level of stem cell proliferation, differentiation and/or self-renewal. The engineered stem cells are useful inter alia in tissue repair, replacement, rejuvenation and/or augmentation therapy. The engineered stem cells may also be re-programmed, for example, to direct the cells down a different cell lineage.
摘要翻译：本发明一般涉及细胞的组织工程和遗传操作领域以及用于产生适合用于修复，替代，恢复或增生治疗的组织的方法。甚至更具体地，本发明考虑了通过将包含着丝粒或新中性丝氨酸的核酸分子引入干细胞或干细胞的母体来遗传操作干细胞的方法，其中所述核酸分子传递能够产生的遗传信息在干细胞或干细胞的后代中引入或修饰性状，例如但不限于调节干细胞增殖，分化和/或自我更新的水平。工程干细胞尤其可用于组织修复，替代，恢复和/或增强治疗。工程干细胞也可以被重新编程，例如将细胞引导到不同的细胞谱系。

9. 发明申请

WO2019084612A1 COMPOSITION AND METHOD 审中-公开
公开(公告)号：WO2019084612A1
公开(公告)日：2019-05-09
申请号：PCT/AU2018/051178
申请日：2018-10-31
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： LITTLE, Melissa , KUMAR, Santhosh V.
IPC分类号： C12N5/071 , A61K35/22
摘要： The present disclosure relates to kidney organoids and methods of manufacturing the same. The organoids and methods may be used in a variety of applications such as disease modelling, drug screening, regenerative medicine and 5 scaling up production of kidney cells.

10. 发明申请

WO2018223188A1 ASSAY 审中-公开
公开(公告)号：WO2018223188A1
公开(公告)日：2018-12-13
申请号：PCT/AU2018/050563
申请日：2018-06-06
申请人： MURDOCH CHILDRENS RESEARCH INSTITUTE
发明人： GODLER, David
IPC分类号： C12Q1/6848 , C12Q1/6844 , C12Q1/6827 , C12Q1/68 , C12Q1/6876 , C12Q1/6858 , C12Q1/6809
CPC分类号： C12Q1/6844 , C12Q1/6827 , C12Q1/6851 , C12Q1/6886 , C12Q2600/156 , C12Q2527/143 , C12Q2537/143 , C12Q2531/113
摘要： The present disclosure relates to methods of amplifying a target sequence in a sample using competitive priming. Such methods may be suitable for detecting sequence variants and diagnosing various pathologies as well as quantifying the level of these rare events that may be missed on the more abundant wildtype sequence background.

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