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1. 发明申请

WO2015006235A1 POWERED PROSTHETIC DEVICES USING EMG-BASED LOCOMOTION STATE CLASSIFIER 审中-公开
标题翻译：使用基于EMG的机车状态分类器的动力前置装置
公开(公告)号：WO2015006235A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/045608
申请日：2014-07-07
申请人： THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON
发明人： HAHN, Michael , JOSHI, Deepak
IPC分类号： A61F2/72
CPC分类号： A61F2/72 , A61B5/04888 , A61B5/1123 , A61B5/1126 , A61F2/60 , A61F2002/704
摘要： Real-time control of a prosthetic device using EMG-based locomotion state classification computes a histogram [208] of a time-frequency spectrogram [206] of the EMG data [200] sampled from muscles, classifies the histogram using if-else rules [212] as representing a locomotion steady state [216] or locomotion transition state [214] in the prosthetic device, and controls the prosthetic device using the computed transitions between locomotion modes. The classification may be based on a comparison of feature values [210] derived from the histogram and stored feature values derived from histograms of known locomotion states. Alternatively, the classification may be based on matching scores calculated from the histogram and stored histograms of known locomotion states. The classifying preferably is performed using hierarchical if-else fuzzy classification rules [212], and may further include using a prior locomotion state and a state diagram specifying constraints on locomotion states accessible from other locomotion states.
摘要翻译：使用基于EMG的运动状态分类的假体装置的实时控制计算从肌肉采样的EMG数据[200]的时间频谱图[206]的直方图[208]，使用if-else规则对直方图进行分类[ 212]表示假体装置中的运动稳定状态[216]或运动过渡状态[214]，并且使用所计算的运动模式之间的转换来控制假体装置。分类可以基于从直方图导出的特征值[210]与从已知运动状态的直方图导出的存储的特征值的比较。或者，分类可以基于从直方图计算的匹配分数和存储的已知运动状态的直方图。分类优选地使用分层的if-else模糊分类规则[212]来执行，并且还可以包括使用先前的运动状态和指定从其他运动状态可访问的运动状态的约束的状态图。

2. 发明申请

WO1998006668A1 SILVER HALIDES OF ALTERED CRYSTAL HABIT OR MORPHOLOGY AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：改变晶体栖息地或形态的银盐及其生产方法
公开(公告)号：WO1998006668A1
公开(公告)日：1998-02-19
申请号：PCT/US1997015290
申请日：1997-08-12
申请人： THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON
发明人： THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , DOXSEE, Kenneth, M.
IPC分类号： C01G05/02
CPC分类号： B01D9/00 , B82Y10/00 , B82Y30/00 , C01F11/183 , C01F11/184 , C01G5/02 , C30B7/00 , C30B29/10 , G03C1/015 , G03C1/035
摘要： Methods are disclosed in which first and second reactant salts and a complexing agent are added to a non-aqueous reaction solvent in which the complexing agent is soluble. The complexing agent is a crown ether or other cyclic or acyclic polydentate chelating agent that, in the reaction solvent, forms chelation complexes with at least one of the reactant salts. The reactant salts, which are substantially soluble and reactive with each other in water to form a first crystallite of silver halide, are present in the reaction solvent in relative amounts that are sufficient to form a desired amount of the silver halide in the reaction solvent. Reaction of the first and second reactant salts in the reaction solvent forms a second crystallite precipitate comprising crystals of silver halide having a different habit or morphology from silver halide crystals in the first crystallite that would otherwise be formable in water by reaction of similar amounts of the first and second reactant salts.
摘要翻译：公开了将第一和第二反应物盐和络合剂加入其中络合剂可溶的非水反应溶剂中的方法。络合剂是冠醚或其它环状或无环多齿螯合剂，其在反应溶剂中与至少一种反应物盐形成螯合配合物。基本上可溶于水的反应物盐形成卤化银的第一晶体的反应物盐以足以在反应溶剂中形成所需量的卤化银的相对量存在于反应溶剂中。第一和第二反应物盐在反应溶剂中的反应形成第二微晶沉淀物，其包含具有不同习惯或形态的卤化银晶体，所述卤化银具有与第一微晶中卤化银晶体不同的习惯或形态，否则在水中可通过相似量的第一和第二反应物盐。

3. 发明申请

WO1998006667A1 CALCIUM CARBONATES OF ALTERED CRYSTAL HABIT OR MORPHOLOGY AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：改性晶体生物碳酸钙或其形态学及其生产方法
公开(公告)号：WO1998006667A1
公开(公告)日：1998-02-19
申请号：PCT/US1997015395
申请日：1997-08-12
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION, on behalf of THE UNIVERSITY OF OREGON
发明人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION, on behalf of THE UNIVERSITY OF OREGON , DOXSEE, Kenneth, M.
IPC分类号： C01F11/18
CPC分类号： C01F11/184 , B01D9/00 , B82Y10/00 , B82Y30/00 , C01F11/183 , C01G5/02 , C30B7/00 , C30B29/10 , G03C1/015 , G03C1/035
摘要： Methods are disclosed in which first and second reactant salts, and, optionally, a complexing agent are added to a non-aqueous reaction solvent to form a reaction system. The reactant salts, which are substantially soluble and reactive with each other in water to form a first crystallite of calcium carbonate, are present in the reaction solvent in relative amounts that are sufficient to form a desired amount of the calcium carbonate in the reaction system. The complexing agent, if present, is a crown ether or other cyclic or acyclic polydentate chelating agent that, in the reaction solvent, forms chelation complexes with at least one of the reactant salts. Reaction of the first and second reactant salts in the reaction solvent forms a second crystallite precipitate comprising crystals of calcium carbonate having a different habit or morphology from calcium carbonate crystals in the first crystallite that would otherwise be formable in water by reaction of similar amounts of the first and second reactant salts.
摘要翻译：公开了将第一反应物盐和第二反应物盐以及任选的配位剂加入非水反应溶剂以形成反应体系的方法。基本上可溶于水的反应物盐形成第一碳酸钙晶体的反应物盐以足以在反应体系中形成所需量的碳酸钙的相对量存在于反应溶剂中。络合剂（如果存在）是冠醚或其它环状或无环多齿螯合剂，其在反应溶剂中与至少一种反应物盐形成螯合配合物。第一和第二反应物盐在反应溶剂中的反应形成第二微晶沉淀物，其包含具有不同习惯或形态的碳酸钙晶体，所述晶体与第一微晶中的碳酸钙晶体不同，否则在水中可通过相似量的第一和第二反应物盐。

4. 发明申请

WO2014130818A1 INTERLOCKING EXTENSIBLE SHELVING SYSTEM 审中-公开
标题翻译：互锁可伸缩系统
公开(公告)号：WO2014130818A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017698
申请日：2014-02-21
申请人： THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON
发明人： FASTE, Trygve, A.
IPC分类号： A47B87/02
CPC分类号： A47B87/0246
摘要： A self-supporting, rigid, modular shelving system that is easily assembled and disassembled by hand without tools includes shelves [300, 302, 304] with pairs of slits at opposite ends, and pairs of vertical supports [306, 308, 310, 312, 314, 316] for each shelf. Each of the vertical supports has a top horizontal loop portion [202], two slanted vertical portions [204, 206] and two bottom horizontal portions [208, 21 0], and has a slanted L profile.
摘要翻译：自支撑，刚性，模块化的搁架系统，其易于由手工组装和拆卸而不用工具包括在相对端处具有成对狭缝的搁架（300,302,304）和成对的垂直支撑件[306,308,310,312 ，314,316]。每个垂直支撑件具有顶部水平环部分[202]，两个倾斜垂直部分[204,206]和两个底部水平部分[208,21 0]，并且具有倾斜的L剖面。

5. 发明申请

WO2006125570A1 METHOD AND DEVICE FOR IMAGING TOMOGAPHY 审中-公开
标题翻译：用于成像图像的方法和装置
公开(公告)号：WO2006125570A1
公开(公告)日：2006-11-30
申请号：PCT/EP2006/004781
申请日：2006-05-19
申请人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH , THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , TISCHENKO, Oleg , XU, Yuan , HOESCHEN, Christoph
发明人： TISCHENKO, Oleg , XU, Yuan , HOESCHEN, Christoph
IPC分类号： G06T11/00 , A61B6/03
CPC分类号： A61B6/06 , A61B6/027 , A61B6/032 , A61B6/482 , G06T11/003 , G06T11/005 , G06T2211/421
摘要： An imaging method for imaging a region of investigation (2) of an object (1), comprises the step of irradiating the region of investigation (2) with at least one energy input beam (3) along a plurality of projection directions, wherein the at least one energy input beam (3) comprises a plurality of individual energy input beam components, wherein the energy input beam (3) is shaped such that at least two of the energy input beam components have different cross-sections and groups (5) of parallel energy input beam components (5.1, 5.2, 5.3, ...) being parallel to one of the projection directions provide a continuous irradiation of the region of investigation (2). Furthermore, a device for imaging the object are described.
摘要翻译：用于对物体（1）的调查区域（2）进行成像的成像方法包括沿着多个投影方向将至少一个能量输入光束（3）照射到调查区域（2）的步骤，其中至少一个能量输入光束（3）包括多个单独的能量输入光束分量，其中所述能量输入光束（3）成形为使得所述能量输入光束分量中的至少两个具有不同的横截面和组（5）平行于投影方向之一的平行能量输入光束分量（5.1,5.2,5.3，...）提供对调查区域（2）的连续照射。此外，描述了用于对物体成像的装置。

6. 发明申请

WO2006069709A1 METHOD AND DEVICE FOR COLLIMATING AN ENERGY INPUT BEAM 审中-公开
标题翻译：用于聚合能量输入束的方法和装置
公开(公告)号：WO2006069709A1
公开(公告)日：2006-07-06
申请号：PCT/EP2005/013802
申请日：2005-12-21
申请人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH , THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , HOESCHEN, Christoph , TISCHENKO, Oleg , XU, Yuan
发明人： HOESCHEN, Christoph , TISCHENKO, Oleg , XU, Yuan
IPC分类号： G06T11/00 , A61B6/06
CPC分类号： A61B6/482 , A61B6/027 , A61B6/06 , A61B6/4035 , A61B8/13 , G06T11/005 , G06T2211/421
摘要： An irradiation method, in particular for imaging a region of investigation (2) of an object (1), comprises the steps of generating at least one energy input beam (3) with at least one energy input beam source (210), wherein the at least one energy input beam (3) comprises a plurality of individual energy input beam components (3.1, 3.2, 3.3, ...), and irradiating the region of investigation (2) with the at least one energy input beam (3) along a plurality of projection directions, wherein the energy input beam components (3.1, 3.2, 3.3, ...) are formed with at least one beam mask (211) made of an energy input shielding material with through holes. Furthermore, an imaging method and devices for irradiating or imaging the object are described.
摘要翻译：特别是用于成像对象（1）的调查区域（2）的照射方法包括以下步骤：利用至少一个能量输入光束源（210）产生至少一个能量输入光束（3），其中，至少一个能量输入光束（3）包括多个单独的能量输入光束分量（3.1,3.2,3.3，...），以及用所述至少一个能量输入光束（3）照射所述调查区域（2）沿着多个投影方向，其中所述能量输入光束分量（3.1,3.2,3.3，...）由至少一个由具有通孔的能量输入屏蔽材料制成的光束掩模（211）形成。此外，描述了用于照射或成像物体的成像方法和装置。

7. 发明申请

WO2003104421A3 IMMUNOCAPTURE AND FUNCTIONAL ASSAY FOR MITOCHONDRIAL F1/F0 ATPASE 审中-公开
公开(公告)号：WO2003104421A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018114
申请日：2003-06-06
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , CAPALDI, Roderick, A. , MARUSICH, Michael, F.
发明人： CAPALDI, Roderick, A. , MARUSICH, Michael, F.
IPC分类号： G01N33/53
摘要： Fl/F0 ATPase defects are one of the causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using an anti F1/F0 ATPase capture antibody and antibodies that react with subunits of F1 /F0 ATPase to aid in diagnosis of F1/F0 ATPase deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides immunological methods for screening agents, such as drugs, for their effect upon F1/F0 ATPase activity and for screening patients to detect those with impairment of F1/F0 ATPase activity and those suspected of having a late onset disease associated with posttranslational modification of one or more subunits of F1/F0 ATPase.

8. 发明申请

WO2003069309A2 IMMUNOCAPTURE AND FUNCTIONAL ASSAY FOR MITOCHONDRIAL COMPLEX I 审中-公开
标题翻译：麻醉复合物的免疫和功能测定I
公开(公告)号：WO2003069309A2
公开(公告)日：2003-08-21
申请号：PCT/US2003/004567
申请日：2003-02-14
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
发明人： MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
IPC分类号： G01N
CPC分类号： C12Q1/26 , G01N33/573 , G01N2500/00
摘要： Complex I defects are one of the most frequent causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using monoclonal antibodies that react with 39-, 30-, 20-, 18-, 15-, and 8-kDa subunits of Complex I to aid in diagnosis of Complex I deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides methods for screening agents, such as drugs, for their effect upon Complex I activity and for screening patients to detect those with impairment of Complex I activity and those suspected of having a late onset disease associated with post-translational modification of one or more subunits of Complex I.
摘要翻译：复杂I缺陷是与线粒体呼吸链障碍相关的疾病和病症的最常见原因之一，包括遗传相关疾病和迟发性神经退行性疾病。本发明提供了使用与复合物I的39-，30-，20-，18-，15-和8-kDa亚基反应的单克隆抗体有助于诊断复合物I缺陷并可用于快速筛选的方法以检测各种疾病的发病或阶段。本发明进一步提供了筛选试剂例如药物对复合物I活性的影响的方法，并且用于筛选患者以检测具有复合物I活性损伤的那些，以及涉及与翻译后修饰相关的晚发型疾病的那些或更多的复合物I的亚基。

9. 发明申请

WO2003020951A2 IDENTIFICATION OF A NOVEL GROUP II INTRON SPLICING FACTOR 审中-公开
标题翻译：确定一个新的第二组INTRON分离因子
公开(公告)号：WO2003020951A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027704
申请日：2002-08-30
申请人： THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , BARKAN, Alice , WILLIAMS-CARRIER, Rosalind , TILL, Bradley , OSTHEIMER, Gerald , WATKINS, Kenneth , SCHMITZ-LINNEWEBER, Christian
发明人： BARKAN, Alice , WILLIAMS-CARRIER, Rosalind , TILL, Bradley , OSTHEIMER, Gerald , WATKINS, Kenneth , SCHMITZ-LINNEWEBER, Christian
IPC分类号： C12Q
CPC分类号： C07K14/415 , C12N9/22 , C12N15/8216 , C12N15/8218 , C12N15/8269
摘要： The present disclosure relates to group II intron splicing factors, nucleic acids encoding group II intron splicing factors, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of inhibiting the in vivo functions of the disclosed group II intron splicing factors.
摘要翻译：本公开涉及II组内含子剪接因子，编码II组内含子剪接因子的核酸，以及使用由其编码的核酸和蛋白质的方法。特别地，本公开涉及抑制所公开的II组内含子剪接因子的体内功能的方法。

10. 发明申请

WO2002082079A1 ENHANCED PROTEIN SEPARATION AND ANALYSIS 审中-公开
标题翻译：增强蛋白质分离和分析
公开(公告)号：WO2002082079A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/008723
申请日：2002-03-22
申请人： THE STATE OF OREGON, acting by and THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , MOLECULAR PROBES, INC. , CAPALDI, Roderick, A. , PATTON, Wayne, F.
发明人： CAPALDI, Roderick, A. , PATTON, Wayne, F.
IPC分类号： G01N33/48
CPC分类号： G01N27/44773
摘要： Methods for enhancing separation and analysis of biological molecules, particularly proteins, and for characterizing tissue, cell, and subcellular (e.g., organelle) expressed protein profiles (proteomes or protein fingerprints) are disclosed. Multi-dimensional diagrams that illustrate the characteristics of the proteins in a sample, based at least in part on interactions between proteins in the system can be produced. In certain embodiments, the diagrams are three-dimensional and incorporate information on protein-protein interactions, protein charge, and protein size for substantially all of the protein species in the sample. Also described are methods of using the provided multi-dimensional diagrams to detect changes in biological systems that are for instance due to disease, drug treatment, environmental condition, and so forth. Methods are provided for correlating changes in three-dimensional proteomic diagrams to disease diagnosis and prognosis, toxicology, therapeutic compound (e.g., drug or hormone) efficacy and mode of action, and drug design.
摘要翻译：公开了用于增强生物分子特别是蛋白质的分离和分析以及表征组织，细胞和亚细胞（例如细胞器）表达的蛋白质谱（蛋白质组或蛋白质指纹图谱）的方法。可以产生说明样品中蛋白质特征的多维图，至少部分地基于系统中蛋白质之间的相互作用。在某些实施方案中，图是三维的，并且包含关于样品中基本上所有蛋白质种类的蛋白质 - 蛋白质相互作用，蛋白质电荷和蛋白质大小的信息。还描述了使用所提供的多维图来检测例如由于疾病，药物治疗，环境状况等的生物系统的变化的方法。提供了用于将三维蛋白质组图的变化与疾病诊断和预后，毒理学，治疗化合物（例如药物或激素）功效和作用方式以及药物设计相关联的方法。

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