专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003069309A3 IMMUNOCAPTURE AND FUNCTIONAL ASSAY FOR MITOCHONDRIAL COMPLEX I 审中-公开
公开(公告)号：WO2003069309A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/004567
申请日：2003-02-14
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
发明人： MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
IPC分类号： G01N33/53
摘要： Complex I defects are one of the most frequent causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using monoclonal antibodies that react with 39-, 30-, 20-, 18-, 15-, and 8-kDa subunits of Complex I to aid in diagnosis of Complex I deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides methods for screening agents, such as drugs, for their effect upon Complex I activity and for screening patients to detect those with impairment of Complex I activity and those suspected of having a late onset disease associated with post-translational modification of one or more subunits of Complex I.

2. 发明申请

WO2003069309A2 IMMUNOCAPTURE AND FUNCTIONAL ASSAY FOR MITOCHONDRIAL COMPLEX I 审中-公开
标题翻译：麻醉复合物的免疫和功能测定I
公开(公告)号：WO2003069309A2
公开(公告)日：2003-08-21
申请号：PCT/US2003/004567
申请日：2003-02-14
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
发明人： MARUSICH, Michael, F. , CAPALDI, Roderick, A. , OGLESBEE, Devin
IPC分类号： G01N
CPC分类号： C12Q1/26 , G01N33/573 , G01N2500/00
摘要： Complex I defects are one of the most frequent causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using monoclonal antibodies that react with 39-, 30-, 20-, 18-, 15-, and 8-kDa subunits of Complex I to aid in diagnosis of Complex I deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides methods for screening agents, such as drugs, for their effect upon Complex I activity and for screening patients to detect those with impairment of Complex I activity and those suspected of having a late onset disease associated with post-translational modification of one or more subunits of Complex I.
摘要翻译：复杂I缺陷是与线粒体呼吸链障碍相关的疾病和病症的最常见原因之一，包括遗传相关疾病和迟发性神经退行性疾病。本发明提供了使用与复合物I的39-，30-，20-，18-，15-和8-kDa亚基反应的单克隆抗体有助于诊断复合物I缺陷并可用于快速筛选的方法以检测各种疾病的发病或阶段。本发明进一步提供了筛选试剂例如药物对复合物I活性的影响的方法，并且用于筛选患者以检测具有复合物I活性损伤的那些，以及涉及与翻译后修饰相关的晚发型疾病的那些或更多的复合物I的亚基。

3. 发明申请

WO2003104421A3 IMMUNOCAPTURE AND FUNCTIONAL ASSAY FOR MITOCHONDRIAL F1/F0 ATPASE 审中-公开
公开(公告)号：WO2003104421A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018114
申请日：2003-06-06
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , CAPALDI, Roderick, A. , MARUSICH, Michael, F.
发明人： CAPALDI, Roderick, A. , MARUSICH, Michael, F.
IPC分类号： G01N33/53
摘要： Fl/F0 ATPase defects are one of the causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using an anti F1/F0 ATPase capture antibody and antibodies that react with subunits of F1 /F0 ATPase to aid in diagnosis of F1/F0 ATPase deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides immunological methods for screening agents, such as drugs, for their effect upon F1/F0 ATPase activity and for screening patients to detect those with impairment of F1/F0 ATPase activity and those suspected of having a late onset disease associated with posttranslational modification of one or more subunits of F1/F0 ATPase.

4. 发明申请

WO2004021000A1 IMMUNOCAPTURE-BASED MEASUREMENTS OF MAMMALIAN PYRUVATE DEHYDROGENASE COMPLEX 审中-公开
标题翻译：甘露聚糖脱氢复合物的基于免疫测定的测定
公开(公告)号：WO2004021000A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/027306
申请日：2003-08-29
申请人： THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , CAPALDI, Roderick, A. , LIB, Margarita , MARUSICH, Michael, F.
发明人： CAPALDI, Roderick, A. , LIB, Margarita , MARUSICH, Michael, F.
IPC分类号： G01N33/53
CPC分类号： C12Q1/48 , C07K16/40 , C12Q1/32 , G01N33/573 , G01N33/6893 , G01N33/6896 , G01N2500/02
摘要： The present invention is based on the discovery that an antibody specific for PDH complex can be used to immunoprecitate PDH complex from a patient sample in an active state. Therefore the anti-PDH complex specific antibody can be used to determine the amount of and/or active state of PDH in a patient sample. The invention immunoassay methods for determining the amount and/or active state of PDH complex present in a patient sample are useful for screening to identify individuals having symptoms indicating malfunction of PDH complex. For example, the invention methods can be used to screen individuals for symptoms of onset of the diabetic state, such as insulitis, and for diagnosing late onset diseases, such as diabetes, Alzheimer's and the like.
摘要翻译：本发明基于以下发现：可以使用对PDH复合物特异性的抗体从活性状态的患者样品中免疫复制PDH复合物。因此，抗PDH复合物特异性抗体可用于确定患者样品中PDH的量和/或活性状态。用于确定存在于患者样品中的PDH复合物的量和/或活性状态的本发明免疫测定方法可用于筛选以鉴定具有指示PDH复合物功能异常的症状的个体。例如，本发明的方法可以用于筛选个体的糖尿病状态的发作症状，例如胰岛炎，以及用于诊断晚发型疾病如糖尿病，阿尔茨海默病等。

5. 发明申请

WO2002082079A1 ENHANCED PROTEIN SEPARATION AND ANALYSIS 审中-公开
标题翻译：增强蛋白质分离和分析
公开(公告)号：WO2002082079A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/008723
申请日：2002-03-22
申请人： THE STATE OF OREGON, acting by and THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON , MOLECULAR PROBES, INC. , CAPALDI, Roderick, A. , PATTON, Wayne, F.
发明人： CAPALDI, Roderick, A. , PATTON, Wayne, F.
IPC分类号： G01N33/48
CPC分类号： G01N27/44773
摘要： Methods for enhancing separation and analysis of biological molecules, particularly proteins, and for characterizing tissue, cell, and subcellular (e.g., organelle) expressed protein profiles (proteomes or protein fingerprints) are disclosed. Multi-dimensional diagrams that illustrate the characteristics of the proteins in a sample, based at least in part on interactions between proteins in the system can be produced. In certain embodiments, the diagrams are three-dimensional and incorporate information on protein-protein interactions, protein charge, and protein size for substantially all of the protein species in the sample. Also described are methods of using the provided multi-dimensional diagrams to detect changes in biological systems that are for instance due to disease, drug treatment, environmental condition, and so forth. Methods are provided for correlating changes in three-dimensional proteomic diagrams to disease diagnosis and prognosis, toxicology, therapeutic compound (e.g., drug or hormone) efficacy and mode of action, and drug design.
摘要翻译：公开了用于增强生物分子特别是蛋白质的分离和分析以及表征组织，细胞和亚细胞（例如细胞器）表达的蛋白质谱（蛋白质组或蛋白质指纹图谱）的方法。可以产生说明样品中蛋白质特征的多维图，至少部分地基于系统中蛋白质之间的相互作用。在某些实施方案中，图是三维的，并且包含关于样品中基本上所有蛋白质种类的蛋白质 - 蛋白质相互作用，蛋白质电荷和蛋白质大小的信息。还描述了使用所提供的多维图来检测例如由于疾病，药物治疗，环境状况等的生物系统的变化的方法。提供了用于将三维蛋白质组图的变化与疾病诊断和预后，毒理学，治疗化合物（例如药物或激素）功效和作用方式以及药物设计相关联的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式