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1. 发明申请

WO2018033579A1 AUTOMATED TRANSPORT UNIT AND SYSTEM 审中-公开
标题翻译：自动化运输装置和系统
公开(公告)号：WO2018033579A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/070783
申请日：2017-08-16
申请人： SARTORIUS STEDIM BIOTECH GMBH , THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： STACEY, Adrian , BARGH, Neil , TINDAL, Stuart
IPC分类号： G01N35/10 , G01N35/04 , C12M1/26 , C12M1/34
摘要： Described is an automated transport unit for use in a laboratory environment the automated transport unit comprising a drive mechanism for moving the automated transport unit, a control system for controlling operation of the automated transport unit, a power supply for powering the automated transport unit, and a storage compartment configured to hold a material obtained from a fluid storage vessel and/or to be delivered to a fluid storage vessel. Also described is a system comprising an automated transport unit and a fluid storage vessel.
摘要翻译：描述了一种用于实验室环境中的自动运输单元，该自动运输单元包括用于移动自动化运输单元的驱动机构，用于控制自动化运输单元的操作的控制系统，电源用于为自动化运输单元提供动力;以及储藏室，其被配置为容纳从流体储存容器获得的材料和/或将被输送到流体储存容器的材料。还描述了包括自动运输单元和流体储存容器的系统。

2. 发明申请

WO2018015386A1 REVERSIBLE LIQUID FILTRATION SYSTEM 审中-公开
标题翻译：可逆液体过滤系统
公开(公告)号：WO2018015386A1
公开(公告)日：2018-01-25
申请号：PCT/EP2017/068128
申请日：2017-07-18
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： WALES, Richard , TAIT, Andrew , PALEY, Matthew
IPC分类号： C12M1/00 , C12M1/36 , C12M1/34
CPC分类号： C12M29/10 , C12M21/00 , C12M29/00 , C12M29/04 , C12M29/12 , C12M29/18 , C12M41/40 , C12M41/48 , C12M47/10
摘要： A reversible liquid filtration system for cell culture perfusion comprises: a bioreactor vessel (B4), for storing the cell culture (L4); a perfusion pump (P7), comprising a reciprocable element (P71) which is movable in opposing first and second pumping directions (dF, dR); a filter (F4); and first and second bi- directional valves (BV1, BV2), each selectively controllable between open and closed positions. The perfusion pump (P7), the filter (F4), and the first and second bi-directional valves (BV1, BV2), together comprise a fluidic circuit in communication with the bioreactor vessel (B4). The bi-directional valves (BV1, BV2) are controllable to open and close in co-ordination with the reciprocating perfusion pump (P7), in order to enable both a two-way filtering flow around the fluidic circuit and also an alternating filtering flow between the bioreactor vessel (B4) and the perfusion pump (P7).
摘要翻译：用于细胞培养灌注的可逆液体过滤系统包括：用于储存细胞培养物（L4）的生物反应器容器（B4）; 灌注泵（P7），其包括可在相反的第一和第二泵送方向（dF，dR）上移动的往复运动元件（P71）; 一个过滤器（F4）; 和第一和第二双向阀（BV1，BV2），每个阀可选择性地在打开和关闭位置之间控制。灌注泵（P7），过滤器（F4）以及第一和第二双向阀（BV1，BV2）一起构成与生物反应器容器（B4）连通的流体回路。双向阀（BV1，BV2）可控制以与往复式灌注泵（P7）配合地打开和关闭，以便实现流体回路周围的双向过滤流动以及交替的过滤流动在生物反应器容器（B4）和灌注泵（P7）之间。

3. 发明申请

WO2003078066A1 LOW VOLUME DROPLET DISPENSING 审中-公开
标题翻译：低容量滴液分配
公开(公告)号：WO2003078066A1
公开(公告)日：2003-09-25
申请号：PCT/GB2003/000431
申请日：2003-01-31
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED , BARGH, Adrian, Neil
发明人： BARGH, Adrian, Neil
IPC分类号： B01L3/02
CPC分类号： G01N35/1016 , B01L3/0206 , B01L3/0217 , B01L3/0268 , B01L2200/025 , B01L2400/0424 , B01L2400/0478 , B05B1/02 , B05B9/03 , B05B17/0607 , B05B17/0676 , G01N2035/0491 , G01N2035/1041
摘要： A low volume dispensing apparatus has a droplet dispensing assembly (5) having a cylinder (51) for containing a fluid to be dispensed and having a nozzle (2) at one end. Extending through the other end is a piston (52, 54). A driving device (8) is connected to the piston and cylinder to move the piston relatively outwardly or inwardly along the cylinder to draw fluid into the cylinder through the nozzle or to provide fluid to the nozzle for dispensing therefrom. An impulse driver (7) connected to the droplet dispensing assembly or to the driving device to dispense fluid from the cylinder through the nozzle in a pulsed manner. A sensor (102) may be used to sense the position of the dispensing apparatus relative to the individual wells (100) in a sample plate (104) into which liquid is to be dispensed.
摘要翻译：低体积分配装置具有液滴分配组件（5），其具有用于容纳要分配的流体的圆筒（51），并且在一端具有喷嘴（2）。延伸通过另一端是活塞（52,54）。驱动装置（8）连接到活塞和气缸，以沿着气缸相对向外或向内移动活塞，以通过喷嘴将流体引入气缸，或者向喷嘴提供流体以从中分配。连接到液滴分配组件或驱动装置的脉冲驱动器（7），以脉冲方式通过喷嘴从气缸分配流体。可以使用传感器（102）来感测分配装置相对于要分配液体的样品板（104）中的各个孔（100）的位置。

4. 发明申请

WO2021214091A1 OPTIMISATION OF PROCESSES FOR THE PRODUCTION OF CHEMICAL, PHARMACEUTICAL AND/OR BIOTECHNOLOGICAL PRODUCTS 审中-公开
公开(公告)号：WO2021214091A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/060289
申请日：2021-04-21
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： STACEY, Adrian , SCHOLZ, Jochen , DANIELS, Charlie , GRIMM, Christian
IPC分类号： G05B13/02 , G05B17/02
摘要： Summarizing the invention, a computer-implemented method of determining at least one recipe for a production process to produce a chemical, pharmaceutical and/or biotechnological product is provided, wherein the production process is defined by a plurality of steps specified by recipe parameter(s) controlling an execution of the production process and a recipe comprises the plurality of steps defining the production process.

5. 发明申请

WO2019185860A1 COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR SPECTROSCOPIC ANALYSIS OF BIOLOGICAL MATERIAL 审中-公开
公开(公告)号：WO2019185860A1
公开(公告)日：2019-10-03
申请号：PCT/EP2019/057992
申请日：2019-03-29
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： STACEY, Adrian , GRIMM, Christian , HOEHSE, Marek , REGEN, Thomas
IPC分类号： G01N21/05 , G01N35/00 , G01N21/84 , C12M1/34 , B01L3/00 , G01N21/31 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65
摘要： Summarizing the invention, a computer-implemented method for spectroscopic analysis of biological material is provided. The method includes an analysis step comprising: taking, by a liquid router (10), a plurality of samples of biological material from a plurality of sources (20), wherein each sample of the plurality of samples is taken from a source of the plurality of sources (20); delivering, by the liquid router (10), the plurality of samples of biological material to at least one flow cell (30) for spectroscopy; performing, by at least one spectrometer connected to the at least one flow cell (30), the spectroscopic analysis of the plurality of samples of biological material; determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors; if the spectroscopic analysis for a given sample of the plurality of samples of biological material is or is predicted to be ambiguous, performing a disambiguating step comprising: routing, by the liquid router (10), the given sample of biological material from the at least one flow (30) cell to a manipulation station (40); manipulating, at the manipulation station (40), the given sample of biological material in order to impact the spectroscopic analysis; delivering, by the liquid router (10), the given manipulated sample of biological material from the manipulation station (40) to the at least one flow cell (30); performing, by the at least one spectrometer, the spectroscopic analysis of the given manipulated sample of biological material.

6. 发明申请

WO2019068868A1 MULTIVARIATE AUTOMATED CROSSFLOW FILTER CONTROL 审中-公开
公开(公告)号：WO2019068868A1
公开(公告)日：2019-04-11
申请号：PCT/EP2018/077137
申请日：2018-10-05
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： MAGAZOV, Salavat , LEUTHOLD, Martin
IPC分类号： B01D61/22
摘要： The present invention provide a control system and a control method for automated controlling of a crossflow filtration system as well as a corresponding crossflow filtration system. The control system comprises a measurement value processing unit configured to receive a plurality of sensor signals from a plurality of sensors of the crossflow filtration system; and to determine a plurality of process parameters defining an operation state of the crossflow filtration system based on the plurality of sensor signals; a control mode selection unit configured to determine based on a user input a subset of the process parameters as a set of control parameters; and to determine for each control parameter in the set of control parameters a corresponding set value; and a control unit comprising a plurality of control loop modules, each control loop module being configured to receive at least one control parameter from the set of control parameters; to determine a control deviation of the received control parameter from the corresponding set value; and to provide an actuating signal to a dedicated actuator of the crossflow filtration system suitable to change the operation state of the crossflow filtration system such as to reduce the determined control deviation.

7. 发明申请

WO2018138159A1 FILTRATION SYSTEM INCORPORATING VISCOMETER 审中-公开
公开(公告)号：WO2018138159A1
公开(公告)日：2018-08-02
申请号：PCT/EP2018/051742
申请日：2018-01-24
申请人： SARTORIUS STEDIM BIOTECH GMBH , THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： WALES, Richard , BARGH, Neil , LEUTHOLD, Martin
IPC分类号： B01D61/18 , B01D61/22
摘要： A filtration system (10), in particular for a low volume tangential flow filtration process, comprises a filter device (24) including at least one membrane (18), and at least one input (12) for supplying a feed stream to a retentate loop (14). The retentate loop (14) includes a pump (16) for circulating the feed stream along one side of the membrane (18). The filtration system (10) further comprises a retentate output (22) allowing retentate to exit the retentate loop (14), and a permeate output (20) allowing permeate to exit the feed stream at the other side of the membrane (18). The filtration system (10) is characterised by a viscometer (42) integrated in the retentate loop (14).

8. 发明申请

WO2019185445A1 AUTO-ALIGNING CABLE SENSOR 审中-公开
公开(公告)号：WO2019185445A1
公开(公告)日：2019-10-03
申请号：PCT/EP2019/057092
申请日：2019-03-21
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： STACEY, Adrian , HUTTLESTONE, Daren , GRACE, Edmund
IPC分类号： C12M1/34 , C12M1/00
摘要： An auto-aligning cable sensor for performing measurements on a medium contained in a vessel is provided. The cable sensor includes a cable which has an end sensor and which is adapted to be carried by a mounting fixture. The mounting fixture and the vessel are movable into a measurement position relative to each other such that a contact face of the end sensor is held in alignment against a surface of the vessel by a pressing force, thereby enabling the end sensor to sense a characteristic of the medium contained in the vessel. The cable sensor further includes an elastically deformable coupling member which is arranged to mediate transfer of the pressing force from the mounting fixture to the cable and thence to the end sensor when the mounting fixture and the vessel are moved into the measurement position. The coupling member deforms under the pressing force such that the cable can flex to tilt the end sensor relative to the surface of the vessel to accommodate misalignment of the contact face and the surface of the vessel.

9. 发明申请

WO2019068855A1 DEVICES AND METHODS FOR IMPROVING AND EVALUATING STABILITY OF PUMPED PROTEIN SOLUTIONS IN BIOPROCESSING SYSTEMS 审中-公开
公开(公告)号：WO2019068855A1
公开(公告)日：2019-04-11
申请号：PCT/EP2018/077111
申请日：2018-10-05
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： BARGH, Adrian Neil , BETTS, John Paul James
IPC分类号： F04B43/12
摘要： The present invention relates to devices and methods for improving and evaluating stability of pumped protein solutions in cross-flow filtration applications. Inter alia, the present invention provides a peristaltic pump for cross-flow filtration having a pump head (1), wherein the pump head (1) comprises a stepped occlusion plate (2) and at least one pump roller (3), wherein a tubing is to be arranged between the stepped occlusion plate (2) and the at least one pump roller (3), wherein the stepped occlusion plate (2) has a specific configuration.

10. 发明申请

WO2019068789A1 FILTRATION SYSTEM AND WEIGHING DEVICE THEREFOR 审中-公开
公开(公告)号：WO2019068789A1
公开(公告)日：2019-04-11
申请号：PCT/EP2018/076960
申请日：2018-10-04
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： BARGH, Adrian Neil
IPC分类号： B01D61/20 , G01G3/14 , B01D61/10 , B01D61/30 , B01D61/36
摘要： The present invention relates to a filtration system (200) comprising: a cabinet (210); a filtration device having a filtrate or retentate vessel (222) arranged outside the cabinet (210); and a weighing device that is configured to weigh the filtrate or retentate vessel (222), wherein the weighing device is arranged inside an enclosure (250) and wherein the enclosure (250) is arranged inside the cabinet (210). Moreover, the present invention relates to a weighing device therefor.

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