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2. 发明申请

WO2011080259A1 LIPOPEPTIDE- AND LIPOPROTEIN-CONJUGATES AND ITS USE 审中-公开
标题翻译： LIPOPEPTIDE-和LIPOPROTEIN-CONJUGATES及其用途
公开(公告)号：WO2011080259A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070776
申请日：2010-12-28
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH , EBENSEN, Thomas , GUZMAN, Carlos , MORR, Michael , TEGGE, Werner
发明人： EBENSEN, Thomas , GUZMAN, Carlos , MORR, Michael , TEGGE, Werner
IPC分类号： A61K47/48 , A61P35/00 , A61P31/16 , A61P31/18 , A61P31/12 , A61P31/14 , A61P31/20
CPC分类号： A61K47/646 , A61K47/543 , A61K47/60
摘要： The present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates. In particular, the present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates comprising a lipid-containing moiety representing an adjuvant moiety, a peptide or protein moiety whereby said peptide or protein moiety represents at least one antigenic structure, the antigen-moiety, and, optionally, a conjugate moiety, preferably a monodisperse polyethyleneglycol unit. Said compounds are particularly useful for therapeutic or prophylactic vaccination by mucosal or systemic administration, preferably mucosal and systemic vaccination. That is, the present invention relates in another aspect to pharmaceutical compositions comprising the compounds according to the present invention, in particular, said pharmaceutical compositions are vaccines. In addition, said pharmaceutical compositions are useful for the prophylaxis or treatment of infectious diseases, inflammatory and autoimmune diseases, cancer, allergies or for the control of fertility in human or animal populations.
摘要翻译：本发明涉及新的脂肽和脂蛋白分子和脂肽和脂蛋白共轭物。特别地，本发明涉及新的脂肽和脂蛋白分子和脂肽和脂蛋白共轭物，其包含代表佐剂部分的脂质部分，肽或蛋白质部分，由此所述肽或蛋白质部分代表至少一种抗原结构，抗原部分和任选的缀合物部分，优选单分散聚乙二醇单元。所述化合物特别可用于通过粘膜或全身给药进行治疗或预防性接种，优选粘膜和全身性接种疫苗。也就是说，本发明在另一方面涉及包含根据本发明的化合物的药物组合物，特别是所述药物组合物是疫苗。此外，所述药物组合物可用于预防或治疗感染性疾病，炎性和自身免疫性疾病，癌症，过敏或用于控制人或动物群体的生育力。

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