专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013027845A1 RADIOLABELED COMPOUNDS AND THEIR USE AS RADIOTRACERS FOR QUANTITATIVE IMAGING OF PHOSPHODIESTERASE (PDE10A) IN MAMMALS 审中-公开
标题翻译：无机化合物及其作为放射性分子的用途，用于定量成像磷脂酰胆碱（PDE10A）
公开(公告)号：WO2013027845A1
公开(公告)日：2013-02-28
申请号：PCT/JP2012/071523
申请日：2012-08-21
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TANIGUCHI, Takahiko , MIURA, Shotaro , HASUI, Tomoaki , HALLDIN, Christer , STEPANOV, Vladimir , TAKANO, Akihiro
发明人： TANIGUCHI, Takahiko , MIURA, Shotaro , HASUI, Tomoaki , HALLDIN, Christer , STEPANOV, Vladimir , TAKANO, Akihiro
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D498/08 , A61K31/501 , A61K51/04
CPC分类号： A61K51/0459 , A61K51/0463 , A61K51/0468 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D498/08
摘要： The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of PDE10A in mammals. The compound of the present invention is represented by the formula (I): wherein each symbols are as defined in the specification.
摘要翻译：本发明提供了用作放射性示踪剂的放射性标记化合物，用于哺乳动物中PDE10A的定量成像。本发明的化合物由式（I）表示：其中每个符号如说明书中所定义。

2. 发明申请

WO2010090737A1 PYRIDAZINONE COMPOUNDS 审中-公开
标题翻译：吡咯烷酮化合物
公开(公告)号：WO2010090737A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/000307
申请日：2010-02-04
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TANIGUCHI, Takahiko , KAWADA, Akira , KONDO, Mitsuyo , QUINN, John, F. , KUNITOMO, Jun , YOSHIKAWA, Masato , FUSHIMI, Makoto
发明人： TANIGUCHI, Takahiko , KAWADA, Akira , KONDO, Mitsuyo , QUINN, John, F. , KUNITOMO, Jun , YOSHIKAWA, Masato , FUSHIMI, Makoto
IPC分类号： A01N43/58 , A61K31/50
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted,or a salt thereof.
摘要翻译：本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。

3. 发明申请

WO2011163355A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS 审中-公开
标题翻译：熔融杂环化合物作为磷酸二氢钾（PDES）抑制剂
公开(公告)号：WO2011163355A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041443
申请日：2011-06-22
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , MIURA, Kasei , HASUI, Tomoaki , HONDA, Eiji , IMAMURA, Keisuke , KAMATA, Makoto , KAMISAKI, Haruhi , QUINN, John, F. , RAKER, Joseph , CAMARA, Fatoumata , WANG, Yi
发明人： TANIGUCHI, Takahiko , YOSHIKAWA, Masato , MIURA, Kasei , HASUI, Tomoaki , HONDA, Eiji , IMAMURA, Keisuke , KAMATA, Makoto , KAMISAKI, Haruhi , QUINN, John, F. , RAKER, Joseph , CAMARA, Fatoumata , WANG, Yi
IPC分类号： C07D471/04 , C07D473/28 , C07D487/04 , C07D498/04 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52 , A61P25/18
CPC分类号： A61K31/4353 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/551 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/28 , C07D487/04 , C07D495/04 , C07D498/04 , C07D498/08 , C07D519/00 , C07F7/10
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I) :
摘要翻译：本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗由式（I）表示的精神分裂症等的药剂：

4. 发明申请

WO2012018909A1 FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：熔融杂环化合物
公开(公告)号：WO2012018909A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046417
申请日：2011-08-03
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , RAKER, Joseph , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , HASUI, Tomoaki , KUNITOMO, Jun
发明人： RAKER, Joseph , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , HASUI, Tomoaki , KUNITOMO, Jun
IPC分类号： C07D471/04 , C07D471/14 , C07D519/00 , A61K31/437 , A61P25/18
CPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound represented by the formula (1'): wherein, Ring A' represents an optionally substituted pyridine ring, an optionally substituted pyridazine ring, a pyrimidine ring, or 10 a pyrazine ring, R1' represents (1) wherein, R 1a' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B2 represents a bond, -S-, -0-, -CO-, an optionally substituted methylene group, or -NR a' - (R a' represents a hydrogen atom, or an optionally substituted C 1-6 alkyl group), and Ring B 1' represents an optionally further substituted 6- to 10- membered aromatic hydrocarbon ring, or an optionally further substituted 5- to 10-membered aromatic heterocyclic ring, or alternatively, L' and R 1a' may be taken together to form an optionally substituted bicyclic or tricyclic fused heterocyclic group, or (2), wherein, R 1b' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B 2' represents an optionally substituted benzene ring, an optionally substituted pyridine ring, an optionally substituted pyrimidine ring, an optionally substituted pyrazine ring, or an optionally substituted pyridazine ring, Ring D' represents an optionally further substituted 5- or 6- membered ring, R 2' represents a hydrogen atom, or a substituent, X' represents =N- or =CR b' - (R b' represents a hydrogen atom, or a substituent), _ _ _ _ _ represents that R b' and R 2' may form, taken together with the carbon atom and the nitrogen atom to which they are each adjacent, an optionally substituted 5- to 7-membered ring when.X' is =CR b' -, or a salt thereof.
摘要翻译：本发明提供了具有PDE 10A抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。由式（1'）表示的化合物：其中环A'表示任选取代的吡啶环，任选取代的哒嗪环，嘧啶环或吡嗪环，R1'表示（1）其中R1a'表示任选取代的苯基或任选取代的5至10元杂环基，环B2表示键，-S - ， - O-，-CO-，任选取代的亚甲基或-NR a' “表示氢原子或任选取代的C 1-6烷基），并且环B1'表示任选进一步取代的6-至10-元芳族烃环，或任选进一步取代的5至10元芳族杂环，或者可选地，L'和R 1a'可以一起形成任选取代的双环或三环稠合杂环基，或（2），其中，R 1b'表示任选取代的苯基，或任选取代的5-至10- 环B2'代表任选取代的苯环，任选取代的吡啶环，任选取代的嘧啶环，任选取代的吡嗪环或任选取代的哒嗪环，环D'表示任选进一步取代的5-或6-元环，R 2' 表示氢原子或取代基，X'表示= N-或= CRb'-（Rb'表示氢原子或取代基），表示Rb'和R2'可以一起形成与它们各自相邻的碳原子和氮原子，当X'= CRb'-时，任选取代的5-至7-元环，或其盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式