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1. 发明申请

WO1998016527A1 BENZOXEPINE DERIVATIVES WHICH PROMOTE RELEASE OF GROWTH HORMONE 审中-公开
标题翻译：促生长激素释放的苯并吡喃衍生物
公开(公告)号：WO1998016527A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003704
申请日：1997-10-15
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TANIGUCHI, Kiyoshi , KURODA, Satoru , TSUBAKI, Kazunori , SHIMIZU, Yasuyo , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/10
CPC分类号： C07D405/06 , C07D471/10 , C07K5/0202 , C07K5/06139 , Y02P20/55
摘要： A pharmaceutically useful benzoxepine compound of formula (I), wherein R is 3-azetidinyl, 4-piperidyl or a group of the formula: -Y-NHR , in which R is hydrogen or amino protective group, and Y is lower alkylene or cyclo(lower) alkylene; R is cyano and R is aryl; R is esterified carboxy and R is ar(lower)alkyl: or R and R are linked together to form formula (a), in which R is acyl, A is -(CH2)n-, in which n is 2, 3 or 4, vinylene or butenylene, X is bond or lower alkylene, and formula (b) is piperidino, and pharmaceutically acceptable salts thereof. The compound or a pharmaceutically acceptable salt thereof of the present invention has excellent promotion activity of growth hormone release for animals and human bodies.
摘要翻译：其中R 1为3-氮杂环丁烷基，4-哌啶基或式-Y-NHR 4的基团，其中R 4为氢或氨基保护基并且Y是低级亚烷基或环（低级）亚烷基; R 2是氰基，R 3是芳基; R 2是酯化羧基，R 3是芳（低级）烷基：或R 2和R 3连接在一起形成式（a），其中R 5是酰基，A是 - （CH 2）n - ，其中n为2,3或4，亚乙烯基或亚丁烯基，X为键或低级亚烷基，式（b）为哌啶子基及其药学上可接受的盐。本发明的化合物或其药学上可接受的盐对于动物和人体具有优异的生长激素释放的促进活性。

2. 发明申请

WO1997041128A1 3-PYRAZOLIOMETHYLCEPHEM COMPOUNDS AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：作为抗微生物剂的3-吡唑啉酮化合物
公开(公告)号：WO1997041128A1
公开(公告)日：1997-11-06
申请号：PCT/JP1997001416
申请日：1997-04-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KAWABATA, Kohji , OKUDA, Shinya , KISHI, Kohei , EIKYU, Yoshiteru , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/46
CPC分类号： C07D501/00
摘要： The present invention relates to a cephem compound of formula (I) wherein R is amino, etc; R is halogen, etc; R is a group of formula (a) (wherein R is hydrogen, etc); R is a group of formula (b) (wherein R is hydroxy(lower)alkyl, etc; R is amino, etc; and R is hydrogen, etc), etc; R is -COO , etc; X is -S- etc; Y is an anion, and n is 0 or 1, and a salt thereof, which is useful as a medicament; the processes for the preparation of said cephem compound or a salt thereof; a pharmaceutical composition comprising said cephem compound or a pharmaceutically acceptable salt thereof; etc.
摘要翻译：本发明涉及其中R 1为氨基等的式（I）的头孢烯化合物; R 2是卤素等; R 3是式（a）的基团（其中R 6是氢等）; R 4是式（b）的基团（其中R 7是羟基（低级）烷基等; R 8是氨基等; R 9是氢等）等; R 5是-COOO等; X是-S-等; Y 0为阴离子，n为0或1，及其盐，可用作药物; 制备所述头孢烯化合物或其盐的方法; 包含所述头孢烯化合物或其药学上可接受的盐的药物组合物; 等等

3. 发明申请

WO1996017850A1 CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： CEPHEM化合物及其药物用途
公开(公告)号：WO1996017850A1
公开(公告)日：1996-06-13
申请号：PCT/JP1995002505
申请日：1995-12-06
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIDA, Yoshiki , SASAKI, Hiroshi , MATSUDA, Keiji , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/36
CPC分类号： C07D501/00
摘要： This invention relates to a new use of a cephem compound of formula (I), wherein R is aryl(lower)alkyl which may have one or more suitable substituent(s), arylthio(lower)alkyl, lower alkenylthio(lower)alkyl which may have one or more suitable substituent(s), or a group of the formula: R -A- or R -S-A- in which R is heterocyclic group which may have one or more suitable substituent(s), and A is lower alkylene which may have one or more suitable substituent(s) or lower alkenylene, R is heterocyclic group which may have one or more suitable substituent(s), or heterocyclic(lower)-alkyl and R is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof, which have antimicrobial activity against Helicobacter pylori, and are useful as anti-Helicobacter pylori agents, anti-gastritis agents, antiulcer agents and anticancer agents.
摘要翻译：本发明涉及式（I）的头孢烯化合物的新用途，其中R 1为可具有一个或多个合适取代基的芳基（低级）烷基，芳硫基（低级）烷基，低级链烯硫基（低级））烷基，其可以具有一个或多个合适的取代基，或下式的基团：R 4 -A或R 4 -SA-，其中R 4是杂环基，其可以具有一个或多个更合适的取代基，并且A是可以具有一个或多个合适的取代基或低级亚烯基的低级亚烷基，R 2是可以具有一个或多个合适的取代基的杂环基或杂环（低级） - 烷基和R 3是对幽门螺杆菌具有抗微生物活性的羧基或被保护的羧基及其药学上可接受的盐，并且可用作抗幽门螺杆菌药，抗胃炎剂，抗溃疡剂和抗癌剂。

4. 发明申请

WO1998008838A1 SUBSTITUTED AMINE DERIVATIVES 审中-公开
标题翻译：取代的胺衍生物
公开(公告)号：WO1998008838A1
公开(公告)日：1998-03-05
申请号：PCT/JP1997002876
申请日：1997-08-20
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OKUMURA, Hiroyuki , WASHIZUKA, Kenichi , FUJII, Naoaki , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D333/16
CPC分类号： C07C217/58 , C07D333/16 , C07D333/22 , C07D333/38
摘要： This invention relates to substituted amine derivatives of formula (I) wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating hypercholesterolaemic, hypertrigliceridaemic, hyperlipaemic and hyperlipoproteinaemic states in human being or animal.
摘要翻译：本发明涉及式（I）的取代胺衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐，其制备方法，含有该化合物的药物组合物及其用于治疗高胆固醇血症，高胰岛素血症，高脂血症和高脂蛋白血症状态。

5. 发明申请

WO1994026709A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS 审中-公开
标题翻译：作为细胞中Na + / H +交换的抑制剂的胍衍生物
公开(公告)号：WO1994026709A1
公开(公告)日：1994-11-24
申请号：PCT/JP1994000786
申请日：1994-05-12
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KUNO, Atsushi , INOUE, Yoshikazu , TAKASUGI, Hisashi , MIZUNO, Hiroaki , YAMASAKI, Kumi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/32
CPC分类号： C07D207/327 , C07C279/22 , C07D207/335 , C07D207/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D257/04 , C07D277/30 , C07D333/24 , C07D401/04 , C07D401/10 , C07D413/04
摘要： Guanidine derivatives of formula (I), wherein Y is N or C-R (in which R is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.), R is hydrogen, aryl which may have one suitable substituent, aryloxy, etc., R is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., Z is N or C-R (in which R is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.), and W is N or C-R (in which R is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy), and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译：式（I）的胍衍生物，其中Y是N或CR 1（其中R 1是氢，低级烷基，羟基，保护的羟基等），R 2是氢，可以具有一个合适的取代基，芳氧基等，R 3是氢，低级烷氧基，羟基，保护的羟基等，Z是N或CR 4（其中R 4是氢，羧基，被保护的羧基，硝基，卤素，羟基（低级）烷基等），W是N或CR 12（其中R 12是氢，低级烷氧基，硝基，羟基或被保护的羟基）及其药学上可接受的盐，其中可用作药物。

6. 发明申请

WO1992016526A1 THIAZOLE DERIVATIVES 审中-公开
标题翻译：噻唑衍生物
公开(公告)号：WO1992016526A1
公开(公告)日：1992-10-01
申请号：PCT/JP1992000279
申请日：1992-03-09
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKASUGI, Hisashi , KATSURA, Yousuke , INOUE, Yoshikazu , TOMISHI, Tetsuo
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D277/48 , C07D417/14
摘要： Thiazole derivatives of formula (I) or a salt thereof, which are useful as antiulcer agent, H2-receptor antagonist or antimicrobial agent.
摘要翻译：式（I）的噻唑衍生物或其盐，其可用作抗溃疡剂，H 2受体拮抗剂或抗微生物剂。

7. 发明申请

WO2004039795A3 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA 审中-公开
标题翻译：用于治疗高磷脂酰胆碱的化合物
公开(公告)号：WO2004039795A3
公开(公告)日：2005-03-24
申请号：PCT/JP0313683
申请日：2003-10-27
申请人： FUJISAWA PHARMACEUTICAL CO , DAISO CO LTD , INOUE YOSHIKAZU , TERASAWA TAKESHI , TAKASUGI HISASHI , NAGAYOSHI AKIRA , UESHIMA KOJI , SAWADA MASAE , FURUKAWA YOSHIRO , MIKAMI MASAFUMI , HINOUE KAZUMASA , FUKUMOTO DAISUKE
发明人： INOUE YOSHIKAZU , TERASAWA TAKESHI , TAKASUGI HISASHI , NAGAYOSHI AKIRA , UESHIMA KOJI , SAWADA MASAE , FURUKAWA YOSHIRO , MIKAMI MASAFUMI , HINOUE KAZUMASA , FUKUMOTO DAISUKE
IPC分类号： A61P3/06 , C07D207/32 , C07D207/325 , C07D209/08 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/38 , C07D249/08 , C07D277/40 , C07D277/48 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： C07D207/325 , C07D209/08 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/38 , C07D249/08 , C07D277/40 , C07D277/48 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： A compound of the formula (I) Wherein R is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR R ; R is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A )n-(A )m-, wherein n and m are independently 0 or 1) ; (II) is bivalent residue derived from arene or heteroarene; and (III) is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
摘要翻译：式（I）的化合物，其中R 1是氢，低级烷基，低级烯基，卤代（低级）烷基，环（低级）烷基，低级烷氧基，低级烷硫基，酰基，任选取代的芳基或NR 3 [R <4>; R 2是氢; 或芳基或杂芳基，其各自可以被取代; X是衍生自哌嗪的直接键或二价残基; Y是 - （A 1）n - （A 2）m - ，其中n和m独立地为0或1）; （II）是衍生自芳烃或杂芳烃的二价残基; 和（III）是衍生自芳烃或杂芳烃的二价残基或其盐。本发明化合物及其盐抑制载脂蛋白B（Apo B）分泌，可用作预防和治疗由ApoB升高的循环水平引起的疾病或病症的药物。

8. 发明申请

WO1997032858A1 QUINOXALINE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：喹啉衍生物作为谷氨酸受体拮抗剂
公开(公告)号：WO1997032858A1
公开(公告)日：1997-09-12
申请号：PCT/JP1997000571
申请日：1997-02-27
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NAKAI, Kazuo , OGAWA, Yasuhiro , YAMADA, Akira , CHIBA, Toshiyuki , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D241/44
CPC分类号： C07D231/12 , C07D233/56 , C07D241/44 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The present invention relates to a novel condensed heterocyclic compound of formula (I) wherein R is alkyl, etc.; R is hydrogen, etc.; R and R are each independently hydrogen, etc.; a group of formula (a) is the group of formula (b), etc.; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said condensed heterocyclic compound or a salt thereof; a pharmaceutical composition comprising said condensed heterocyclic compound or a pharmaceutically acceptable salt thereof; etc.
摘要翻译：本发明涉及式（I）的新型稠合杂环化合物，其中R 1是烷基等; R 2是氢等; R 3和R 4各自独立地为氢等; 式（a）的一组是式（b）等的基团; 和其药学上可接受的盐，其可用作药物; 所述稠合杂环化合物或其盐的制备方法; 包含所述稠合杂环化合物或其药学上可接受的盐的药物组合物; 等等

9. 发明申请

WO1997029111A1 NEW CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：新CEPHEM化合物及其药物用途
公开(公告)号：WO1997029111A1
公开(公告)日：1997-08-14
申请号：PCT/JP1997000280
申请日：1997-02-05
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIDA, Yoshiki , OKUDA, Shinya , SASAKI, Hiroshi , MATSUDA, Keiji , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/00
CPC分类号： A61K31/546 , C07D501/00
摘要： This invention relates to new cephem compounds represented by general formula (I) wherein each symbol is as defined in the specification or a salt thereof, which has antimicrobial activity against Helicobacter pylori, and are useful as anti-Helicobacter pylori agents, anti-gastritis agents, anti-ulcer agents and anti-cancer agents.
摘要翻译：本发明涉及由通式（I）表示的新的头孢烯化合物，其中每个符号如说明书中所定义或其盐，其对幽门螺杆菌具有抗微生物活性，并且可用作抗幽门螺杆菌药物，抗胃炎药，抗溃疡剂和抗癌剂。

10. 发明申请

WO1995018126A1 FURYLTHIAZOLE AND THEIR USE AS H2-RECEPTOR ANTAGONISM AND ANTIMICROBIAL 审中-公开
标题翻译：呋喃唑啉及其作为H2受体拮抗剂和抗微生物剂
公开(公告)号：WO1995018126A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002278
申请日：1994-12-28
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KATSURA, Yousuke , OHNO, Mitsuko , NISHINO, Shigetaka , TOMISHI, Tetsuo , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： This invention relates to furylthiazole derivatives represented by formula (I), wherein each symbol is as defined in the specification and pharmaceutically acceptable salts thereof which have antiulcer activity, H2-receptor antagonism and antimicrobial activity, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of ulcer and infectious diseases in human being or animals.
摘要翻译：本发明涉及由式（I）表示的呋喃基噻唑衍生物，其中每个符号如本说明书中所定义及其药学上可接受的盐，其具有抗溃疡活性，H 2受体拮抗作用和抗微生物活性，其制备方法，包含其的组合物和用于治疗人或动物中的溃疡和感染性疾病的方法。

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