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1. 发明申请

WO2009010733A2 PEPTIDE GAP JUNCTION MODULATORS 审中-公开
标题翻译：肽阻塞调节器
公开(公告)号：WO2009010733A2
公开(公告)日：2009-01-22
申请号：PCT/GB2008/002405
申请日：2008-07-14
申请人： ZEALAND PHARMA A/S , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , KIDDLE, Simon J. , LARSEN, Bjarne Due , DELMAR, Mario , TAFFET, Steven M , COOMBS, Wanda , VERMA, Vandana
发明人： LARSEN, Bjarne Due , DELMAR, Mario , TAFFET, Steven M , COOMBS, Wanda , VERMA, Vandana
IPC分类号： C07K5/02 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16
CPC分类号： C07K14/705 , A61K38/00 , C07K5/0817 , C07K5/1019
摘要： Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).
摘要翻译：公开了促进由间隙连接介导的细胞间通讯的肽。本发明具有广泛的有用应用，包括用于治疗与间隙连接细胞内通讯（GJIC）相关的疾病。

2. 发明申请

WO2009010733A3 PEPTIDE GAP JUNCTION MODULATORS 审中-公开
标题翻译：肽间隙连接调节剂
公开(公告)号：WO2009010733A3
公开(公告)日：2009-06-25
申请号：PCT/GB2008002405
申请日：2008-07-14
申请人： ZEALAND PHARMA AS , UNIV NEW YORK STATE RES FOUND , KIDDLE SIMON J , LARSEN BJARNE DUE , DELMAR MARIO , TAFFET STEVEN M , COOMBS WANDA , VERMA VANDANA
发明人： LARSEN BJARNE DUE , DELMAR MARIO , TAFFET STEVEN M , COOMBS WANDA , VERMA VANDANA
IPC分类号： C07K5/02 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K5/0817 , C07K5/1019
摘要： Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).
摘要翻译：公开了促进由间隙连接介导的细胞间通讯的肽。本发明具有广泛的有用应用，包括用于治疗与间隙连接细胞间通讯障碍（GJIC）相关的疾病。

3. 发明申请

WO2009012224A3 PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
公开(公告)号：WO2009012224A3
公开(公告)日：2009-01-22
申请号：PCT/US2008/069980
申请日：2008-07-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , DELMAR, Mario , TAFFET, Steven, M. , LARSEN, Bjarne, Due
发明人： DELMAR, Mario , TAFFET, Steven, M. , LARSEN, Bjarne, Due
IPC分类号： C07K14/00
摘要： The present invention relates to proteins and polypeptides that (i) have the formula A - [Wm - A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula X n RXPX m where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A - A n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula X n RXPX m where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP -binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.

4. 发明申请

WO2009012224A2 PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
标题翻译：基于肽基的GAP结构调节
公开(公告)号：WO2009012224A2
公开(公告)日：2009-01-22
申请号：PCT/US2008069980
申请日：2008-07-14
申请人： UNIV NEW YORK STATE RES FOUND , DELMAR MARIO , TAFFET STEVEN M , LARSEN BJARNE DUE
发明人： DELMAR MARIO , TAFFET STEVEN M , LARSEN BJARNE DUE
IPC分类号： A61K38/10
CPC分类号： A61K38/10
摘要： The present invention relates to proteins and polypeptides that (i) have the formula A - [Wm - A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A - An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP -binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.
摘要翻译：本发明涉及（i）具有式A - [Wm-A] n的蛋白质和多肽，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸 ; 每个W独立地是一个连接体; m为1或2; n是从1到5的任何数字; （ii）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从零到十五的任何数，m是从零到十五的任何数，以及n和 m是从8到15的任何数字; （iii）具有式A-An，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸; n是从1到5的任何数字; 或（iv）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从0到7的任何数字，m是从0到7的任何数字，并且n的总和 m是从零到七的任何数字。使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物和测量与Cx43CT结合的化合物的Cx43CT结合亲和力，也是披露。

5. 发明申请

WO2007084895A3 PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
公开(公告)号：WO2007084895A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/060584
申请日：2007-01-16
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , DELMAR, Mario , TAFFET, Steven, M.
发明人： DELMAR, Mario , TAFFET, Steven, M.
IPC分类号： A61K38/10
摘要： The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A] n where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula X n RXPX 3n where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed.

6. 发明申请

WO2010142293A1 COMPOUNDS ACTING AS PEPTIDE GAP JUNCTION MODULATORS, AND USES THEREOF 审中-公开
标题翻译：作为肽桥接调制器的化合物及其用途
公开(公告)号：WO2010142293A1
公开(公告)日：2010-12-16
申请号：PCT/DK2010/000092
申请日：2010-06-11
申请人： ZEALAND PHARMA A/S , DELMAR, Mario , TAFFET, Steven M. , COOMBS, Wanda , VERMA, Vandana , LARSEN, Bjarne Due , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： DELMAR, Mario , TAFFET, Steven M. , COOMBS, Wanda , VERMA, Vandana , LARSEN, Bjarne Due
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： G01N33/5032 , A61K38/00 , C07K7/64
摘要： Compounds capable of modulating intracellular gap junctional communication, as well as their use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC)1 are disclosed.
摘要翻译：公开了能够调节细胞间隙连接通讯的化合物及其在治疗与间隙连接细胞内通讯（GJIC）1相关的疾病中的用途。

7. 发明申请

WO2007084895A2 PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
标题翻译：基于肽基的GAP结构调节
公开(公告)号：WO2007084895A2
公开(公告)日：2007-07-26
申请号：PCT/US2007060584
申请日：2007-01-16
申请人： UNIV NEW YORK STATE RES FOUND , DELMAR MARIO , TAFFET STEVEN M
发明人： DELMAR MARIO , TAFFET STEVEN M
IPC分类号： A61K38/10
CPC分类号： C07K14/001 , A61K38/00 , C07K7/08
摘要： The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A] n where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula X n RXPX 3n where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed.
摘要翻译：本发明涉及（i）具有式A- [WA] n N的氨基酸和多肽，其中A是式XXXXRXPXXXX的肽，其中X是任何氨基酸，R是精氨酸，P是脯氨酸; W是一个连接子; n是从1到5的任何数字; 或（ii）基本上由式X其中每个X为任何氨基酸，R为精氨酸，P为脯氨酸，n为0至十五，m是从零到十五的任何数字，n和m之和在十到十五之间。还公开了使用这些蛋白质和多肽来筛选调节Cx43CT的化合物，测量与Cx43CT结合的化合物的Cx43CT结合亲和力并鉴定Cx43CT的RXP结合结构域的位置的方法。

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