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1. 发明申请

WO1985000970A1 PHARMACEUTICAL COMPOSITIONS HAVING APPETITE REDUCING ACTIVITY AND A PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：具有显着降低活性的药物组合物及其制备方法
公开(公告)号：WO1985000970A1
公开(公告)日：1985-03-14
申请号：PCT/HU1984000042
申请日：1984-08-24
申请人： BALKANYI, Iván , SZEBENI, Rudolf , HADI, Ferenc , MARSO, Miklós , KÉRI, Éva , KOSZEGI, Béla
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , Y10S514/91
摘要： Pharmaceutical compositions having appetite reducing activity. The compositions contain (5 alpha ,6 alpha )-7,8-didehydro-4,5-epoxy-17-(2-propanyl)-morphinane-3,6-diol.
摘要翻译：具有食欲降低活性的药物组合物。组合物含有（5α，6α）-7,8-二脱氢-4,5-环氧-17-（2-丙基） - 吗啡-3,6-二醇。

2. 发明申请

WO1988004554A1 PROCESS FOR PREPARING PASTRY PRODUCTS HAVING ANTACID ACTIVITY 审中-公开
标题翻译：制备具有防潮活性的食品的方法
公开(公告)号：WO1988004554A1
公开(公告)日：1988-06-30
申请号：PCT/HU1987000059
申请日：1987-12-21
申请人： STARCZ, Judit , SZEBENI, Rudolf , KOSZEGI, Béla , VÉGH, Miklós , KORO, József , MIHALYAI, Margit , RIESZ, Tamás
IPC分类号： A61K33/08
CPC分类号： A61K9/0056 , A21D2/02 , A61K33/08
摘要： Process for preparing pastry products having antacid activity wherein 24-50 % by weight of magnesium oxide and 24-50 % by weight of aluminium hydroxide calculated on the weight of the flour being in the product are added to the known raw materials of a pastry product in any phase of the making up of the dough, then the dough thus obtained is baked at a temperature between 130 and 160 DEG C.
摘要翻译：用于制备具有抗酸活性的糕点产品的方法，其中将24-50重量％的氧化镁和24-50重量％的氢氧化铝按产品中面粉的重量计算，加入到糕点产品的已知原料中在制成面团的任何阶段中，将由此获得的面团在130-160℃的温度下烘烤。

3. 发明申请

WO1984001502A1 CONTRACEPTIVE VAGINAL TABLETS AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：承压阴道片及其制造方法
公开(公告)号：WO1984001502A1
公开(公告)日：1984-04-26
申请号：PCT/HU1983000052
申请日：1983-10-07
申请人： KOVACS, András , SZEBENI, Rudolf , KÖSZEGI, Béla
IPC分类号： A61K31/12
CPC分类号： A61K9/0034 , Y10S514/843
摘要： The composition of the tablets is as follows: 0.2 to 3 parts by weight of boric acid, 10 to 20 parts by weight of tartaric acid, 1 to 2 parts by weight of derivatives of sodium bisulphite and of vitamin K3, 0.8 to 1.2 parts by weight of polyvinylpyrrolidone, 2 to 5 parts by weight of magnesium stearate, 8 to 12 parts by weight of carboxymethylcellulose, 15 to 65 parts by weight of microcrystalline cellulose. The vaginal tablets contain preferably from 5 to 10 mg of derivatives of sodium bisulphite and of vitamin K3, and their total weight is 500 mg. Preferably said tablets are produced by separately homogenizing the boric acid, the tartaric acid and the derivative of sodium bisulphite and of vitamin K3, as well as the polyvinylpyrrolidone, the magnesium stearate, the carboxymethylcellulose, the lactose and the microcrystalline cellulose so as to obtain pulverulent mixtures, and by mixing the pulverulent mixtures obtained and compressing them to form the tablets. Ten minutes before the sexual intercourse, the tablets should be introduced to the bottom of the fornix vaginae after having moistened the tablets with water.
摘要翻译：片剂的组成如下：0.2〜3重量份的硼酸，10〜20重量份的酒石酸，1〜2重量份的亚硫酸氢钠和维生素K 3的衍生物，0.8〜1.2重量份聚乙烯吡咯烷酮的重量，2〜5重量份的硬脂酸镁，8〜12重量份的羧甲基纤维素，15〜65重量份的微晶纤维素。阴道片剂优选含有5〜10mg的亚硫酸氢钠和维生素K 3的衍生物，其总重量为500mg。优选地，所述片剂通过分别均化硼酸，酒石酸和亚硫酸氢钠和维生素K 3的衍生物，以及聚乙烯吡咯烷酮，硬脂酸镁，羧甲基纤维素，乳糖和微晶纤维素，以获得粉末状混合物，并通过混合获得的粉状混合物并压缩它们以形成片剂。在性交前10分钟，将片剂浸入水中后，应将片剂引入穹窿阴道底部。

4. 发明申请

WO1982001821A1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：抗菌协同药物组合物及其制备方法
公开(公告)号：WO1982001821A1
公开(公告)日：1982-06-10
申请号：PCT/HU1980000005
申请日：1980-11-27
申请人： CHINOIN GYOGYSZER ES VEGYESZET , KOVACS ANDRAS , SZEBENI RUDOLF , NEMES JOZSEF , NGYKALDI ATTILA
发明人： CHINOIN GYOGYSZER ES VEGYESZET
IPC分类号： A61K31/71
CPC分类号： A61K31/70 , A61K31/12 , A61K2300/00
摘要： Antimycotic synergistic pharmaceutical compositions comprising nystatine and a 2-lower alkyl-l, 4-naphthoquinone or an addition product thereof in admixture with suitable inert pharmaceutical carriers. The invention also relates to a process for the above compositions by admixing the active ingredients with suitable inert carriers. It is preferred to use 2-methyl-1, -naphthoquinone or the sodium bisulfite adduct thereof. The ratio of the active ingredients is preferably 20.000 to 100.000 IU of nystatine for 1 mg of 2-methyl-1,4-naphthoquinone-sodium bisulfite adduct. The compositions show strong synergism in the treatment of infections caused by Candida albicans and Trichomonas vaginalis and are active against resistant strains too. The compositions may be finished in forms suitable for topical use, such as suppository, aerosol, jelly or vaginal tablets.
摘要翻译：抗微生物协同药物组合物，其包含与合适的惰性药物载体混合的营养素和2-低级烷基-1,4-萘醌或其加成产物。本发明还涉及通过将活性成分与合适的惰性载体混合而获得的上述组合物的方法。优选使用2-甲基-1'-萘醌或其亚硫酸氢钠加成物。对于1mg 2-甲基-1,4-萘醌 - 亚硫酸氢钠加合物，活性成分的比例优选为20.000〜100.000IU的营养元素。该组合物在治疗由白色念珠菌和阴道毛滴虫引起的感染中表现出强烈的协同作用，并且对抗性菌株也具有活性。组合物可以以适于局部使用的形式，例如栓剂，气雾剂，果冻或阴道片剂来完成。

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