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1. 发明申请

WO2012138894A1 HSP90 INHIBITORS 审中-公开
标题翻译： HSP90抑制剂
公开(公告)号：WO2012138894A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032371
申请日：2012-04-05
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , SUN, Weilin , TALDONE, Tony , PATEL, Pallav , CHIOSIS, Gabriela
发明人： SUN, Weilin , TALDONE, Tony , PATEL, Pallav , CHIOSIS, Gabriela
IPC分类号： C07D473/34 , C07D473/40
CPC分类号： C07D473/34 , A61K31/52 , C07D473/40
摘要： The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z 1 , Z 2 , Z 3 , Xa, Xb, Xc, Xd, Y, X 2 , and X 4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which X 2 is a leaving for introducing a radiolabeled atom, such as 124 I or 131 I and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.
摘要翻译：本公开涉及式（IA）和（IB）化合物及其药学上可接受的盐，其中Z1，Z2，Z3，Xa，Xb，Xc，Xd，Y，X2和X4如本文所定义，式（IA）和/或（IB）的化合物的量，以及治疗或预防这种过度表达Her-激酶的这种癌症的方法的方法，包括向有需要的患者施用治疗有效量的式（IA）或（IB）。本公开还涉及式（IA）和（IB）的化合物，其中X 2是用于引入放射性标记的原子，例如124I或131I的离去，以及在制备放射性标记的化合物中使用这些化合物的方法，特别是用于成像。

2. 发明申请

WO2012138894A4 HSP90 INHIBITORS 审中-公开
标题翻译： HSP90抑制剂
公开(公告)号：WO2012138894A4
公开(公告)日：2012-12-06
申请号：PCT/US2012032371
申请日：2012-04-05
申请人： SLOAN KETTERING INST CANCER , SUN WEILIN , TALDONE TONY , PATEL PALLAV , CHIOSIS GABRIELA
发明人： SUN WEILIN , TALDONE TONY , PATEL PALLAV , CHIOSIS GABRIELA
IPC分类号： C07D473/34 , C07D473/40
CPC分类号： C07D473/34 , A61K31/52 , C07D473/40
摘要： The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Xd, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which X2 is a leaving for introducing a radiolabeled atom, such as 124I or 131I and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.
摘要翻译：本公开涉及其中Z 1，Z 2，Z 3，X a，X b，X c，X d，Y，X 2，和X 4如本文所定义的式（IA）和（IB）化合物及其药学上可接受的盐，式（IA）和/或（IB）的化合物的量以及治疗或预防过度表达Her-激酶的病症（例如癌症）的方法，所述方法包括向需要其的患者施用治疗有效量的式（IA）或（IB）。本公开还涉及其中X 2是用于引入放射性标记的原子例如124 I或131 I的离去的式（IA）和（IB）的化合物，并且涉及使用这些化合物制备放射性标记的化合物的方法，特别是用于成像。

3. 发明申请

WO2011044394A1 PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS 审中-公开
标题翻译：使用嘌呤衍生物作为HSP90抑制剂
公开(公告)号：WO2011044394A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051872
申请日：2010-10-07
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHIOSIS, Gabriela , TALDONE, Tony , SUN, Weilin
发明人： CHIOSIS, Gabriela , TALDONE, Tony , SUN, Weilin
IPC分类号： C07D473/34 , A61K31/538 , A61P35/00 , A61K31/52 , A61P25/00
CPC分类号： A61K31/52 , A61K31/538 , C07D473/34
摘要： The present application provides substituted purine derivatives and related compounds of the formulas shown. These com ounds are useful as inhibitors of HSP90, and hence in the treatment of related diseases. (Formulae) Z 1 -Z 3 , X a -X c , X 2 , X 4 , Y and R are as defined in the specification.
摘要翻译：本申请提供了所示式的取代的嘌呤衍生物和相关化合物。这些化合物可用作HSP90的抑制剂，因此用于治疗相关疾病。（式）Z1-Z3，Xa-Xc，X2，X4，Y和R如说明书中所定义。

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