专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012138894A4 HSP90 INHIBITORS 审中-公开
标题翻译： HSP90抑制剂
公开(公告)号：WO2012138894A4
公开(公告)日：2012-12-06
申请号：PCT/US2012032371
申请日：2012-04-05
申请人： SLOAN KETTERING INST CANCER , SUN WEILIN , TALDONE TONY , PATEL PALLAV , CHIOSIS GABRIELA
发明人： SUN WEILIN , TALDONE TONY , PATEL PALLAV , CHIOSIS GABRIELA
IPC分类号： C07D473/34 , C07D473/40
CPC分类号： C07D473/34 , A61K31/52 , C07D473/40
摘要： The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Xd, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which X2 is a leaving for introducing a radiolabeled atom, such as 124I or 131I and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.
摘要翻译：本公开涉及其中Z 1，Z 2，Z 3，X a，X b，X c，X d，Y，X 2，和X 4如本文所定义的式（IA）和（IB）化合物及其药学上可接受的盐，式（IA）和/或（IB）的化合物的量以及治疗或预防过度表达Her-激酶的病症（例如癌症）的方法，所述方法包括向需要其的患者施用治疗有效量的式（IA）或（IB）。本公开还涉及其中X 2是用于引入放射性标记的原子例如124 I或131 I的离去的式（IA）和（IB）的化合物，并且涉及使用这些化合物制备放射性标记的化合物的方法，特别是用于成像。

2. 发明申请

WO2011022440A9 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：热休克蛋白结合化合物，组合物及其制备和使用方法
公开(公告)号：WO2011022440A9
公开(公告)日：2016-11-10
申请号：PCT/US2010045817
申请日：2010-08-17
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , CHIOSIS GABRIELA , TALDONE TONY , RODINA ANNA , PATEL PALLAV , KANG YANLONG
发明人： CHIOSIS GABRIELA , TALDONE TONY , RODINA ANNA , PATEL PALLAV , KANG YANLONG
IPC分类号： A61K31/54
CPC分类号： A61K31/513 , A61K31/496 , A61K31/506 , A61K2121/00 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60 , C07D403/12 , C07D495/04
摘要： The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).
摘要翻译：本发明涉及由通式（I）或（I'）表示的化合物或其药理学上可接受的盐; 含有这些化合物中的至少一种的药物组合物; 制备这些化合物中的至少一种的方法; 使用这些化合物中的至少一种治疗和/或预防各种癌症和/或增殖病症的方法; 使用这些化合物中的至少一种来监测针对各种癌症的抗癌疗法的有效性的方法。在一个实施方案中，主题涉及与热休克蛋白70（Hsp70）的特异性水平结合的化合物。在另一个实施方案中，主题涉及以特异性水平结合以抑制热休克蛋白70（Hsp70）和热休克同源蛋白70（Hsc70）的化合物。

3. 发明申请

WO2011022440A2 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：热休克蛋白结合化合物，组合物及其制备和使用方法
公开(公告)号：WO2011022440A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/045817
申请日：2010-08-17
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , CHIOSIS, Gabriela , TALDONE, Tony , RODINA, Anna , PATEL, Pallav , KANG, Yanlong
发明人： CHIOSIS, Gabriela , TALDONE, Tony , RODINA, Anna , PATEL, Pallav , KANG, Yanlong
IPC分类号： C07D403/02 , A61K31/513
CPC分类号： A61K31/513 , A61K31/496 , A61K31/506 , A61K2121/00 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60 , C07D403/12 , C07D495/04
摘要： The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).
摘要翻译：本发明涉及由通式（I）或（I'）表示的化合物或其药理学上可接受的盐; 含有这些化合物中的至少一种的药物组合物; 制备这些化合物中的至少一种的方法; 使用这些化合物中的至少一种治疗和/或预防各种癌症和/或增殖病症的方法; 使用这些化合物中的至少一种来监测针对各种癌症的抗癌疗法的有效性的方法。在一个实施方案中，主题涉及与热休克蛋白70（Hsp70）的特异性水平结合的化合物。在另一个实施方案中，主题涉及以特异性水平结合以抑制热休克蛋白70（Hsp70）和热休克同源蛋白70（Hsc70）的化合物。

4. 发明申请

WO2012138894A1 HSP90 INHIBITORS 审中-公开
标题翻译： HSP90抑制剂
公开(公告)号：WO2012138894A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032371
申请日：2012-04-05
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , SUN, Weilin , TALDONE, Tony , PATEL, Pallav , CHIOSIS, Gabriela
发明人： SUN, Weilin , TALDONE, Tony , PATEL, Pallav , CHIOSIS, Gabriela
IPC分类号： C07D473/34 , C07D473/40
CPC分类号： C07D473/34 , A61K31/52 , C07D473/40
摘要： The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z 1 , Z 2 , Z 3 , Xa, Xb, Xc, Xd, Y, X 2 , and X 4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which X 2 is a leaving for introducing a radiolabeled atom, such as 124 I or 131 I and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.
摘要翻译：本公开涉及式（IA）和（IB）化合物及其药学上可接受的盐，其中Z1，Z2，Z3，Xa，Xb，Xc，Xd，Y，X2和X4如本文所定义，式（IA）和/或（IB）的化合物的量，以及治疗或预防这种过度表达Her-激酶的这种癌症的方法的方法，包括向有需要的患者施用治疗有效量的式（IA）或（IB）。本公开还涉及式（IA）和（IB）的化合物，其中X 2是用于引入放射性标记的原子，例如124I或131I的离去，以及在制备放射性标记的化合物中使用这些化合物的方法，特别是用于成像。

5. 发明申请

WO2011022440A3 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：热激蛋白结合化合物，组合物和制备和使用相同的方法
公开(公告)号：WO2011022440A3
公开(公告)日：2011-08-11
申请号：PCT/US2010045817
申请日：2010-08-17
申请人： SLOAN KETTERING INST CANCER , CHIOSIS GABRIELA , TALDONE TONY , RODINA ANNA , PATEL PALLAV , KANG YANLONG
发明人： CHIOSIS GABRIELA , TALDONE TONY , RODINA ANNA , PATEL PALLAV , KANG YANLONG
IPC分类号： A61K31/54
CPC分类号： A61K31/513 , A61K31/496 , A61K31/506 , A61K2121/00 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60 , C07D403/12 , C07D495/04
摘要： The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).
摘要翻译：本发明涉及由通式（I）或（I'）表示的化合物或其药理学上可接受的盐; 含有至少一种这些化合物的药物组合物; 制造这些化合物中的至少一种的方法; 使用这些化合物中的至少一种用于治疗和/或预防各种癌症和/或增殖性疾病的方法; 使用这些化合物中的至少一种来监测针对各种癌症的抗癌疗法的有效性的方法。在一个实施方案中，主题涉及以对热休克蛋白70（Hsp70）的特异性水平结合的化合物。在另一个实施方案中，本主题涉及以特异性水平结合以抑制热休克蛋白70（Hsp70）和热休克同源蛋白70（Hsc70）两者的化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式