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1. 发明申请

WO2006020958A3 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：离散细胞中的有机体
公开(公告)号：WO2006020958A3
公开(公告)日：2006-06-01
申请号：PCT/US2005028933
申请日：2005-08-15
申请人： ADERANS RES INST INC , ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
发明人： ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
IPC分类号： A61K8/98 , A61K35/36 , A61Q7/00 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了用于从解离的上皮细胞和间充质细胞快速且可重复产生毛囊的方法测定法。该方法既可用作测量细胞毛发生成（即毛发生长诱导）特性的工具，也可用于研究分离细胞用于组装器官的机制。在本申请的方法中，将从新生小鼠皮肤分离的分离的细胞注射到成年小鼠躯干皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成簇，其通过细胞凋亡雕刻以产生“漏斗状囊肿”。从“漏斗状囊肿”形成毛发，然后形成毛囊芽，然后栓不对称生长以分化为成熟的毛囊皮脂结构。使用各种技术，通过穿刺，刺穿或刮擦皮肤暴露“漏斗囊肿”，并且在一种方法中，用产生毛囊的创伤敷料材料覆盖暴露的囊肿。

2. 发明申请

WO2006020958A2 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：离散细胞中的有机体
公开(公告)号：WO2006020958A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028933
申请日：2005-08-15
申请人： ADERANS RESEARCH INSTITUTE, INC. , ZHENG, Ying , DU, Xiaobing , WANG, Wei , BOUCHER, Marylene , PARIMOO, Satish , STENN, Kurt, Stricker
发明人： ZHENG, Ying , DU, Xiaobing , WANG, Wei , BOUCHER, Marylene , PARIMOO, Satish , STENN, Kurt, Stricker
IPC分类号： A61K35/12 , A61K35/36 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了用于从分离的上皮细胞和间充质细胞快速并可重复产生毛囊的方法测定。该方法既可用作测量细胞毛发生成（即毛发生长诱导）特性的工具，也可用于研究分离细胞用于组装器官的机制。在本申请的方法中，将从新生小鼠皮肤分离的分离的细胞注射到成年小鼠躯干皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过细胞凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗囊肿” 头发细菌形成，然后是毛囊芽，然后是不对称生长的毛球，以分化成为循环成熟的毛皮脂肪结构。使用各种技术，暴露“漏斗囊肿” 通过穿刺，刺穿或刮擦皮肤，并且在一种方法中，使用流出毛囊的伤口敷料材料覆盖暴露的囊肿。

3. 发明申请

WO2007092929A2 APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT 审中-公开
标题翻译：装置和方法将流体和材料输送到主体
公开(公告)号：WO2007092929A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061856
申请日：2007-02-08
申请人： ADERANS RESEARCH INSTITUTE, INC. , PRUITT, Terrell , COCHRAN, Stephen, A. , MARSHALL, Bryan , SU, Yandong , STENN, Kurt, Stricker , WASHENIK, Kenneth, Justin , DEPIANO, John , PROKOP, Gary, F. , RATHGEBER, Martin
发明人： PRUITT, Terrell , COCHRAN, Stephen, A. , MARSHALL, Bryan , SU, Yandong , STENN, Kurt, Stricker , WASHENIK, Kenneth, Justin , DEPIANO, John , PROKOP, Gary, F. , RATHGEBER, Martin
CPC分类号： A61M37/00 , A61M5/3148 , A61M5/31551 , A61M5/31573 , A61M5/31586 , A61M2005/2411 , A61M2005/2414 , A61M2005/341 , A61M2005/342
摘要： The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
摘要翻译：本发明提供了用于实施该方法的流体和材料输送方法和装置。本发明提供了递送细胞材料的方法，包括将细胞材料注射到受试者中，使得注射的细胞在注射时保持其固有的形态特征。该方法包括将多孔材料吸入包含注射器装置的流体递送装置中的步骤。将细胞材料吸入注射器的主体中，直到所需量的材料填充注射器体。然后将流体输送装置的针以与皮肤平行的角度插入受试者的皮肤中，直到达到所需的深度。然后将细胞材料注射到受试者中，直到注入了所需体积的材料。然后将装置的针旋转约45度至90度，并将针从注射部位移除。

4. 发明申请

WO2007047707A1 METHOD OF DELIVERING HAIR FOLLICLE PROGENITOR CELLS TO THE SKIN 审中-公开
标题翻译：将头发毛发前体细胞递送到皮肤的方法
公开(公告)号：WO2007047707A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/040608
申请日：2006-10-17
申请人： ADERANS RESEARCH INSTITUTE, INC. , ZHENG, Ying , DU, Xiaobing , WASHENIK, Kenneth, Justin , STENN, Kurt, Stricker
发明人： ZHENG, Ying , DU, Xiaobing , WASHENIK, Kenneth, Justin , STENN, Kurt, Stricker
IPC分类号： C12N5/06
CPC分类号： A61K35/36 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L2430/18 , C12N5/0627 , C12N5/0629
摘要： The present invention is a method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed from the hair follicle progenitor cells. The present invention is also a method of forming new skin comprising making a wound in the skin and placing skin forming cells on the wound, wherein new skin is formed from the skin forming cells.
摘要翻译：本发明是一种形成流出毛茸的方法，包括在皮肤中制造伤口并将毛囊祖细胞置于伤口上，其中从毛囊祖细胞形成出血毛发。本发明还是一种形成新皮肤的方法，包括在皮肤中制造伤口并将皮肤形成细胞置于伤口上，其中由皮肤形成细胞形成新的皮肤。

5. 发明申请

WO2007092929A3 APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT 审中-公开
标题翻译：装置和方法将流体和材料输送到主体
公开(公告)号：WO2007092929A3
公开(公告)日：2008-11-27
申请号：PCT/US2007061856
申请日：2007-02-08
申请人： ADERANS RES INST INC , PRUITT TERRELL , COCHRAN STEPHEN A , MARSHALL BRYAN , SU YANDONG , STENN KURT STRICKER , WASHENIK KENNETH JUSTIN , DEPIANO JOHN , PROKOP GARY F , RATHGEBER MARTIN
发明人： PRUITT TERRELL , COCHRAN STEPHEN A , MARSHALL BRYAN , SU YANDONG , STENN KURT STRICKER , WASHENIK KENNETH JUSTIN , DEPIANO JOHN , PROKOP GARY F , RATHGEBER MARTIN
IPC分类号： A61M37/00
CPC分类号： A61M37/00 , A61M5/3148 , A61M5/31551 , A61M5/31573 , A61M5/31586 , A61M2005/2411 , A61M2005/2414 , A61M2005/341 , A61M2005/342
摘要： The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
摘要翻译：本发明提供了用于实施该方法的流体和材料输送方法和装置。本发明提供了递送细胞材料的方法，包括将细胞材料注射到受试者中，使得注射的细胞在注射时保持其固有的形态特征。该方法包括将多孔材料吸入包含注射器装置的流体递送装置中的步骤。将细胞材料吸入注射器的主体中，直到所需量的材料填充注射器体。然后将流体输送装置的针以与皮肤平行的角度插入受试者的皮肤中，直到达到所需的深度。然后将细胞材料注射到受试者中，直到注入了所需体积的材料。然后将装置的针旋转约45度至90度，并将针从注射部位移除。

6. 发明申请

WO2006020958B1 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：来自不同细胞的成骨细胞
公开(公告)号：WO2006020958B1
公开(公告)日：2006-07-27
申请号：PCT/US2005028933
申请日：2005-08-15
申请人： ADERANS RES INST INC , ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
发明人： ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
IPC分类号： A61K8/98 , A61K35/36 , A61Q7/00 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

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