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1. 发明申请

WO2020201580A1 SYSTEM AND METHOD FOR DETERMINING LIGHT ATTENUATION AT OPTICAL MEMBERS INSERTED IN TISSUE 审中-公开
公开(公告)号：WO2020201580A1
公开(公告)日：2020-10-08
申请号：PCT/EP2020/059790
申请日：2020-04-06
申请人： SPECTRACURE AB
发明人： SWARTLING, Johannes , ARVIDSSON, Ida , AXELSSON, Johan
IPC分类号： A61N5/06 , A61B18/22
摘要： A system and method for determining or estimating the presence and effect of light-attenuating inhomogeneities in tissue when performing medical treatment or diagnostics using optical members in tissue. The system and method comprising inserting a plurality of optical members into the tissue, and then measuring by emitting light through a sub-set of optical members at a time, while measuring the light collected by another sub-set of optical members. Combining said measurement data with a model for light propagation in tissue, and setting up a system of equations. Solving the unknown attenuation values from said system of equations.

2. 发明申请

WO2004100761A3 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING IN COMBINATION NON-MECHANICAL AND MECHANICAL DISTRIBUTORS FOR DISTRIBUTION OF RADIATION 审中-公开
公开(公告)号：WO2004100761A3
公开(公告)日：2004-11-25
申请号：PCT/SE2004/000758
申请日：2004-05-14
申请人： SPECTRACURE AB , JOHANSSON, Ann , ANDERSSON ENGELS, Stefan , JOHANSSON, Thomas , PÅLSSON, Sara , SOTO THOMPSON, Marcelo , SVANBERG, Katarina , SVANBERG, Sune
发明人： JOHANSSON, Ann , ANDERSSON ENGELS, Stefan , JOHANSSON, Thomas , PÅLSSON, Sara , SOTO THOMPSON, Marcelo , SVANBERG, Katarina , SVANBERG, Sune
IPC分类号： A61B5/00
摘要： A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumour site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumour therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.

3. 发明申请

WO2008152076A3 SYSTEM AND METHOD FOR OPTICAL TOMOGRAPHY FEEDBACK CONTROL OF DOSIMETRY FOR PHOTODYNAMIC THERAPY (PDT) 审中-公开
公开(公告)号：WO2008152076A3
公开(公告)日：2008-12-18
申请号：PCT/EP2008/057333
申请日：2008-06-11
申请人： SPECTRACURE AB , SWARTLING, Johannes , AXELSSON, Johan
发明人： SWARTLING, Johannes , AXELSSON, Johan
IPC分类号： A61N5/06
摘要： Control of interstitial photodynamic therapy (PDT) by means of modulation control and/or optical tomography are disclosed. Accurate reconstruction of optical properties in tissue treated by the PDT is provided. Optical tomography is used as an input for controlling dosimetry in said PDT system.

4. 发明申请

WO2008152076A2 SYSTEM AND METHOD FOR OPTICAL TOMOGRAPHY FEEDBACK CONTROL OF DOSIMETRY FOR PHOTODYNAMIC THERAPY (PDT) 审中-公开
标题翻译：用于光化学疗法（PDT）的光学光谱反馈控制系统和方法
公开(公告)号：WO2008152076A2
公开(公告)日：2008-12-18
申请号：PCT/EP2008057333
申请日：2008-06-11
申请人： SPECTRACURE AB , SWARTLING JOHANNES , AXELSSON JOHAN
发明人： SWARTLING JOHANNES , AXELSSON JOHAN
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/20 , A61B5/417 , A61B5/4381 , A61N5/0601 , A61N2005/0612 , G06T7/0012 , G06T2207/10101 , G06T2207/30081
摘要： Control of interstitial photodynamic therapy (PDT) by means of modulation control and/or optical tomography are disclosed. Accurate reconstruction of optical properties in tissue treated by the PDT is provided. Optical tomography is used as an input for controlling dosimetry in said PDT system.
摘要翻译：公开了通过调制控制和/或光学层析成像技术控制间质光动力治疗（PDT）。提供了通过PDT处理的组织中光学性能的准确重建。光学层析成像被用作在PDT系统中控制剂量测定的输入。

5. 发明申请

WO2008020050A1 SYSTEM AND METHOD FOR CONTROLLING AND ADJUSTING INTERSTITIAL PHOTODYNAMIC LIGHT THERAPY PARAMETERS 审中-公开
标题翻译：用于控制和调整相互间光化学光照治疗参数的系统和方法
公开(公告)号：WO2008020050A1
公开(公告)日：2008-02-21
申请号：PCT/EP2007/058477
申请日：2007-08-15
申请人： SPECTRACURE AB , SVANBERG, Sune , AXELSSON, Johan , SWARTLING, Johannes , JOHANSSON, Ann , ANDERSSON-ENGELS, Stefan
发明人： SVANBERG, Sune , AXELSSON, Johan , SWARTLING, Johannes , JOHANSSON, Ann , ANDERSSON-ENGELS, Stefan
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B2017/00022 , A61B2018/00642 , A61B2034/105 , A61N5/0601 , A61N2005/0612 , A61N2005/063
摘要： A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.
摘要翻译：公开了一种用于控制和调节受试者中的间质性光动力光疗法（IPDT）中的光的方法和系统。更具体地，使用用于在PDT处理期间确定组织状态的计算方法来描述用于控制间质肿瘤光动力光疗法中的光的方法。该状态用于反馈回路以控制持续的PDT治疗。公开了构成用于IPDT在整个前列腺腺组织上的预处理和实时剂量测定模块的方法。该方法包括重建目标几何，在该几何中优化源光纤位置，监测处理过程中的光衰减，并更新单个光纤照射时间以考虑到组织光透射中的任何变化。一种控制装置，其被配置为根据光动力学治疗参数之一的至少一个属性至少临时地限制治疗性光处理的递送。与没有治疗反馈相比，避免对患者的重大治疗以及处于危险中的健康器官的损害。

6. 发明申请

WO2012076631A1 SYSTEM AND METHOD FOR INTERSTITIAL PHOTODYNAMIC LIGHT THERAPY IN COMBINATION WITH PHOTOSENSITIZERS 审中-公开
标题翻译：与光敏剂组合的间接光化学光疗法的系统和方法
公开(公告)号：WO2012076631A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/072142
申请日：2011-12-07
申请人： SPECTRACURE AB , NILSEN, Jens , GÖTH, Maria
发明人： NILSEN, Jens , GÖTH, Maria
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N2005/0612 , A61N2005/063
摘要： A method and system for interstitial photodynamic light therapy (IPDT) in combination with photosensitizers is described. A calculation method is used to determine a tissue status used in a feedback loop to control ongoing treatment. Pre-treatment and realtime dosimetry modules for IPDT on whole prostate glandular tissue include target geometry reconstruction, optimization of fiber positions within the geometry, monitoring of light attenuation during treatment and updating individual fiber irradiation times taking variation in tissue light transmission into account. A control device is arranged to restrict delivery of therapeutic light treatment in dependence of at least one attribute of a photodynamic treatment parameter.
摘要翻译：描述了与光敏剂组合的间质光动力光疗法（IPDT）的方法和系统。使用计算方法来确定在反馈环路中使用的组织状态以控制正在进行的治疗。用于IPDT整个前列腺腺组织的预处理和实时剂量测定模块包括目标几何重建，几何中的纤维位置优化，监测治疗期间的光衰减和更新单个纤维照射时间，考虑到组织光透射的变化。控制装置被布置成根据光动力治疗参数的至少一个属性来限制治疗光治疗的递送。

7. 发明申请

WO2008062000A1 SYSTEM AND METHOD FOR PREDICTING AND/OR ADJUSTING CONTROL PARAMETERS OF INTERSTITIAL PHOTODYNAMIC LIGHT THERAPY 审中-公开
标题翻译：用于预测和/或调整相互间光化学光照治疗的控制参数的系统和方法
公开(公告)号：WO2008062000A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062602
申请日：2007-11-20
申请人： Spectracure AB , SWARTLING, Johannes , JOHANSSON, Ann , AXELSSON, Johan
发明人： SWARTLING, Johannes , JOHANSSON, Ann , AXELSSON, Johan
IPC分类号： A61N5/06 , A61B18/00 , A61B18/20
CPC分类号： A61N5/0601 , A61B18/20 , A61B2017/00066 , A61B2018/00636 , A61N5/062 , A61N2005/0612
摘要： A method and system for controlling and adjusting the treatment parameters in a photodynamic light therapy (PDT) in a subject are disclosed. More particularly, a method for controlling the treatment parameters in interstitial tumor photodynamic light therapy is described which uses a calibration procedure based on information from measured parameters and treatment outcome from prior treatments. Thus optimal treatment conditions are predicted and may be continuously updated during ongoing therapy.
摘要翻译：公开了一种用于控制和调整受试者中的光动力光疗法（PDT）中的治疗参数的方法和系统。更具体地，描述了一种用于控制间质肿瘤光动力光疗法中的治疗参数的方法，其基于来自测量参数的信息和来自先前治疗的治疗结果使用校准程序。因此预测最佳治疗条件，并且可以在持续治疗期间不断更新。

8. 发明申请

WO2004101069A1 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING TRANSLATORY DISTRIBUTOR FOR DISTRIBUTION OF RADIATION 审中-公开
标题翻译：包含用于分布辐射的翻译分发器的治疗和诊断的系统和方法
公开(公告)号：WO2004101069A1
公开(公告)日：2004-11-25
申请号：PCT/SE2004/000755
申请日：2004-05-14
申请人： SPECTRACURE AB , JOHANSSON, Thomas , EKER, Charlotta , MALMBORG, Jörgen , WESSELTOFT MOGENSEN, Lasse , SVANBERG, Sune , SOTO THOMPSON, Marcelo , ANDERSSON ENGELS, Stefan
发明人： JOHANSSON, Thomas , EKER, Charlotta , MALMBORG, Jörgen , WESSELTOFT MOGENSEN, Lasse , SVANBERG, Sune , SOTO THOMPSON, Marcelo , ANDERSSON ENGELS, Stefan
IPC分类号： A61N5/01
CPC分类号： A61N5/0601 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B2017/00057 , A61B2018/208 , A61N5/062 , A61N2005/0612 , A61N2005/0629
摘要： A system and method for interactive interstitial photo-dynamic tumour therapy and/or photothermal tumour therapy of a human or animal, said system comprising at least one radiation distributor, which is arranged for distribution of optical radiation from at least one radiation source to a reaction site, or from the reaction site to at least one radiation sensor. The radiation distributor comprises at least one translatory displacement element being translatory movable relatively to another element. First ends of first radiation conductors are fixed to the first translatory displacement element and first ends of second radiation conductors are fixed to the other element, wherein the first and the second radiation conductors are connectable to each other in different constellations through translatory movement of the translatory displacement element and the other element relative each other in order to obtain different operation modes of said system.
摘要翻译：一种用于人或动物的交互式间质光动力肿瘤治疗和/或光热肿瘤治疗的系统和方法，所述系统包括至少一个辐射分布器，其被布置用于将光辐射从至少一个辐射源分配到反应位置，或从反应位点到至少一个辐射传感器。辐射分配器包括至少一个相对于另一元件平移的平移位移元件。第一辐射导体的第一端被固定到第一平移位移元件，第二辐射导体的第一端固定到另一个元件，其中第一和第二辐射导体可通过平移的平移运动在不同的星座中彼此连接位移元件和另一个元件相对，以获得所述系统的不同操作模式。

9. 发明申请

WO2012048891A1 DEVICE, SYSTEM AND METHOD FOR EMISSION OF LIGHT AND DETECTION OF LIGHT IN A THERAPY SYSTEM 审中-公开
标题翻译：用于发射光的装置，系统和方法以及治疗系统中的光的检测
公开(公告)号：WO2012048891A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/005170
申请日：2011-10-14
申请人： Spectracure AB , SVANBERG, Sune
发明人： SVANBERG, Sune
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61N5/062 , A61N2005/0628 , A61N2005/0629 , A61N2005/0651 , A61N2005/0652
摘要： A medical device for emission of therapeutic light from a light emitting unit and wherein the light emitting unit is devised to be reversed for detection of light when no light is emitted.
摘要翻译：一种用于发射来自发光单元的治疗光的医疗装置，其中，当不发出光时，发光单元设计为反转以检测光。

10. 发明申请

WO2012048890A1 PROBE HEAD DEVICE AND METHOD FOR ENHANCED DIAGNOSTICS 审中-公开
标题翻译：探头设备和增强诊断方法
公开(公告)号：WO2012048890A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/005169
申请日：2011-10-14
申请人： SPECTRACURE AB , SVANBERG, Sune , BRYDEGAARD, Mikkel
发明人： SVANBERG, Sune , BRYDEGAARD, Mikkel
IPC分类号： A61B5/00
CPC分类号： A61B5/0059
摘要： A probe head for topical illumination of a tissue sample and collection of backscattered light therefrom. The probe head comprising, a body having a distal end and a proximal end, the distal end arranged for apposition to a surface of the sample for covering a surface area thereof, a light source mounted elevated and inclined in said body for seguentially illuminating a central portion of the surface area, a detector at the proximal end perpendicularly positioned to detect backscattered light from the central portion.
摘要翻译：用于组织样本的局部照射的探针头和从其中收集的后向散射光。所述探针头包括具有远端和近端的主体，所述远端被布置成与所述样品的表面相对配置以覆盖其表面区域;安装在所述主体中升高和倾斜的光源，用于逐渐地照亮中心表面区域的一部分，近端的检测器垂直定位以检测来自中心部分的反向散射光。

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