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1. 发明申请

WO2012064968A1 MOTOR NERVE ROOT STIMULATION 审中-公开
标题翻译：电动神经根刺激
公开(公告)号：WO2012064968A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/060205
申请日：2011-11-10
申请人： IINN, INC. , SHAH, Jawad, A. , IQBAL, Amer , SMITH, Richard, H.
发明人： SHAH, Jawad, A. , IQBAL, Amer , SMITH, Richard, H.
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61H3/04 , A61N1/0553 , A61N1/0556 , A61N1/0558 , A61N1/36067 , A61N1/36103
摘要： A motor device for bypassing or bridging an area of neurological damage, including at least one electrode having an electric mechanism for generating electric current, and a programming mechanism for programming the electrode. A biofeedback system and an artificial spinal cord. A method of stimulating muscle in a person having neurological damage, by applying electric current to nerves, bypassing or bridging an area of neurological damage, and moving the muscle in a natural manner. Methods of moving muscles of a paraplegic, reducing or eliminating pain from an individual, and treating foot drop. A therapeutic method for exercising for an individual with neurological damage. A method of generating movement of muscle and sensing that movement in a person having neurological damage. A method of generating movement of muscle using information from the brain and sensing that movement in a person having neurological damage. A method of diagnosing neurological damage.
摘要翻译：用于绕过或桥接神经损伤区域的电动机装置，包括至少一个具有用于产生电流的电机构的电极，以及用于编程电极的编程机构。生物反馈系统和人造脊髓。通过对神经施加电流，绕过或桥接神经损伤区域，以自然的方式移动肌肉，刺激具有神经损伤的人的肌肉的方法。移动截瘫肌肉的方法，减少或消除个体疼痛，治疗脚痛。用于对具有神经损伤的个体进行锻炼的治疗方法。一种产生肌肉运动并感知有神经损伤的人的运动的方法。使用来自大脑的信息产生肌肉运动的方法，并感测到具有神经损伤的人的运动。诊断神经损伤的方法。

2. 发明申请

WO2003003063A2 FIBER-OPTIC SENSOR ARRAY 审中-公开
标题翻译：光纤传感器阵列
公开(公告)号：WO2003003063A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020596
申请日：2002-06-27
申请人： IA, INC. , PRIUSKA, Eric, M. , SMITH, Richard, H. , ERB, Judith, L. , DOWNWARD, James, G. , ULRICH, Otho, E.
发明人： PRIUSKA, Eric, M. , SMITH, Richard, H. , ERB, Judith, L. , DOWNWARD, James, G. , ULRICH, Otho, E.
IPC分类号： G02B
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/533 , G01N33/54306 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482
摘要： A method for performing a rapid, homogenous assays for monitoring the reactions of a binding target, by immobilizing a fluorescent-capable chelate complex that is derivatized so as to posses recognition binding ligands, labeling the complex with a labeled second chelator that is added to the assay thereby forming a fluorescent mixed chelate, and measuring the fluorescent mixed chelate, whereby the measurement of the label enable monitoring of the reaction of the binding target. A rapid assay for performing the above method including a first chelating molecule, a fluorescent-capable ion complexed with the first chelating molecule, a second chelating molecule for reacting with the fluorescent-capable ion complexed with the first chelating molecule, and a measuring device for measuring fluorescent resulting from the second chelating molecule reacting with the fluorescent-capable ion complexed with the first chelating molecule. A biosensor for monitoring molecular interactions between receptors, including a biosensor having attached thereto a fluorescent-capable ion complexed with a first chelating molecule, whereby upon exposure to a second chelating molecule said complex becomes fluorescent is also provided.
摘要翻译：通过固定衍生化的具有荧光能力的螯合复合物以便具有识别结合配体，进行用于监测结合靶标的反应的快速，均质测定的方法，用标记的第二螯合剂添加到测定中，由此形成荧光混合螯合物，并测量荧光混合螯合物，由此标记的测量能够监测结合目标的反应。用于进行上述方法的快速测定法包括第一螯合分子，与第一螯合分子复合的能够发荧光的离子，与能够与第一螯合分子复合的能够发荧光的离子反应的第二螯合分子，以及测量装置测量由第二螯合分子与与第一螯合分子络合的可荧光离子反应产生的荧光。一种用于监测受体之间的分子相互作用的生物传感器，包括生物传感器，其上附着有与第一螯合分子复合的可荧光离子，由此当暴露于第二螯合分子时，所述复合物变成荧光的也被提供。

3. 发明申请

WO1996039412A1 ADMINISTRATION OF VALIENAMINE-RELATED DISACCHARIDE COMPOUNDS IN REDUCING INFLAMMATION IN A SENSITIZED MAMMAL ARISING FROM EXPOSURE TO AN ANTIGEN 审中-公开
标题翻译：在减少暴露于抗原的敏感的哺乳动物中引起的与相关的胆碱酯化合物的联合
公开(公告)号：WO1996039412A1
公开(公告)日：1996-12-12
申请号：PCT/CA1996000388
申请日：1996-06-06
申请人： ALBERTA RESEARCH COUNCIL , SRIVASTAVA, Om, P. , SZWEDA, Roman , SMITH, Richard, H. , IPPOLITO, Robert, M. , SPOHR, Ulrike
发明人： ALBERTA RESEARCH COUNCIL
IPC分类号： C07H15/22
CPC分类号： A61K31/7008 , C07H15/18
摘要： The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.
摘要翻译：本发明涉及由于通过施用维甲胺相关的二糖化合物和该方法中使用的药物组合物而导致由于抗原暴露（攻击）而减少由哺乳动物的次级免疫应答引起的炎症程度的方法。

4. 发明申请

WO2012125534A1 INTRA SPINOUS PROCESS AND METHOD OF BONE GRAFT PLACEMENT 审中-公开
标题翻译：内耳旋转过程和骨髓放置方法
公开(公告)号：WO2012125534A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028727
申请日：2012-03-12
申请人： IINN, INC. , SHAH, Jawad, A. , SMITH, Richard, H. , IQBAL, Amer
发明人： SHAH, Jawad, A. , SMITH, Richard, H. , IQBAL, Amer
IPC分类号： A61B17/80
CPC分类号： A61B17/7062 , A61B17/7059 , A61B17/80 , A61B17/8085 , A61B17/88
摘要： A spinal fixation plate for posterior fixation, including a plate body having flattened flanges extending along sides of the plate body, the flanges being interconnected by a convex arcuate process. A method of fixing vertebrae, including the steps of disposing a spinal fixation plate upon dorsal surfaces of adjoining vertebrae, wherein flanges of the spinal fixation plate extend parallel to the spinal column and rest upon superior articular processes of the adjoining vertebrae, and anchoring the spinal fixation plate to the vertebrae with at least one fastener by disposing the fastener through at least one aperture of the spinal fixation plate into the vertebrae.
摘要翻译：一种用于后固定的脊椎固定板，包括具有沿着板体侧面延伸的扁平凸缘的板体，凸缘通过凸弧形过程相互连接。一种固定椎骨的方法，包括以下步骤：将脊椎固定板设置在相邻椎骨的背面上，其中脊柱固定板的凸缘平行于脊柱延伸并且在相邻的椎骨的上关节进程上搁置，并且将脊柱通过将所述紧固件通过所述脊柱固定板的至少一个孔设置到所述椎骨中而将至少一个紧固件固定到所述椎骨上。

5. 发明申请

WO1993024506A1 IMMUNOSUPPRESSIVE AND TOLEROGENIC MODIFIED LEWISC AND LacNAc COMPOUNDS 审中-公开
标题翻译：免疫抑制和耐受性改良的LEWIS C和LacNAc化合物
公开(公告)号：WO1993024506A1
公开(公告)日：1993-12-09
申请号：PCT/US1993004995
申请日：1993-05-26
申请人： ALBERTA RESEARCH COUNCIL , IPPOLITO, Robert, M. , HAQUE, Wasimul , JIANG, Cong , HANNA, H., Rizk , VENOT, Andre, P. , NIKRAD, Pandurang, V. , KASHEM, Mohammed, A. , SMITH, Richard, H. , SRIVASTAVA, Om, P.
发明人： ALBERTA RESEARCH COUNCIL
IPC分类号： C07H15/06
CPC分类号： C07H15/10 , C07H3/06 , C07H11/00 , C07H15/04 , C07H15/18 , C07H15/203 , C07H19/10 , C07H19/20
摘要： Disclosed are novel Lewis and LacNAc analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.
摘要翻译：公开了新型Lewis C和LacNAc类似物，含有这些类似物的药物组合物，其制备方法及其使用方法。

6. 发明申请

WO2014116366A1 SYSTEM AND METHOD FOR BIO-OPTICAL ENVIRONMENTAL RECONNAISSANCE 审中-公开
标题翻译：用于生物光环境重建的系统和方法
公开(公告)号：WO2014116366A1
公开(公告)日：2014-07-31
申请号：PCT/US2013/075267
申请日：2013-12-16
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY , GOULD, Richard, W. , BOOK, Jeffrey, W. , HULBERT, Mark, S. , QUAID, Andrew, J. , SMITH, Richard, H. , HUGHES, Emery, W. , MCCORMICK, Berry, L. , MCNEAL, David, N. , HARRINGTON, J., Carey
发明人： GOULD, Richard, W. , BOOK, Jeffrey, W. , HULBERT, Mark, S. , QUAID, Andrew, J. , SMITH, Richard, H. , HUGHES, Emery, W. , MCCORMICK, Berry, L. , MCNEAL, David, N. , HARRINGTON, J., Carey
IPC分类号： B63B21/24 , G01L5/00
CPC分类号： G06F17/00 , B63B21/29 , B63G8/001 , G01L19/0092 , G01V1/38 , Y10T29/49002
摘要： System for collecting ocean data includes a trawl-resistant bottom mooring having a base unit and profiler on board. Method for collecting ocean data includes steps for receiving and executing a configuration file in the base unit and the profiler, collecting data, transmitting the data to a receiving station, and transferring to and archiving the data in the base unit.
摘要翻译：用于收集海洋数据的系统包括一个具有拖缆的底部系泊系统，其具有基座单元和轮廓仪。用于收集海洋数据的方法包括在基本单元和分析器中接收和执行配置文件的步骤，收集数据，将数据发送到接收站，以及传送到基站单元中的数据并将其归档。

7. 发明申请

WO1993024505A1 REDUCING INFLAMMATION BY TIME DEPENDENT ADMINISTRATION OF OLIGOSACCHARIDES GLYCOSIDES RELATED TO BLOOD GROUP DETERMINANTS 审中-公开
标题翻译：通过时间依赖性地降低与血液组合决定因素相关的寡糖糖苷类化合物的炎症反应
公开(公告)号：WO1993024505A1
公开(公告)日：1993-12-09
申请号：PCT/US1993004909
申请日：1993-05-24
申请人： ALBERTA RESEARCH COUNCIL , IPPOLITO, Robert, M. , HAQUE, Wasimul , JIANG, Cong , HANNA, H., Rizk , VENOT, Andre, P. , NIKRAD, Pandurang, V. , KASHEM, Mohammed, A. , SMITH, Richard, H. , SRIVASTAVA, Om, P.
发明人： ALBERTA RESEARCH COUNCIL
IPC分类号： C07H15/00
CPC分类号： C07H15/04 , A61K31/70 , C07H19/10 , C07H19/20
摘要： Disclosed are methods for reducing the degree of antigen induced inflammation in a sensitized mammal. The disclosed methods employ oligosaccharide glycosides related to blood group determinants having a type I or type Ii core structure wherein the administration of such oligosaccharide glycosides is after initiation of the mammal's immune response but at or prior one-half the period of time required to effect maximal antigen-induced inflammation.
摘要翻译：公开了减少致敏哺乳动物中抗原诱导的炎症程度的方法。所公开的方法使用与具有I型或Ii型核心结构的血型决定簇相关的寡糖糖苷，其中这种寡糖糖苷的施用是在哺乳动物的免疫应答开始之后或之前或之前所需的一半时间来实现最大抗原诱导的炎症。

8. 发明申请

WO03003063A3 FIBER-OPTIC SENSOR ARRAY 审中-公开
标题翻译：光纤传感器阵列
公开(公告)号：WO03003063A3
公开(公告)日：2003-04-17
申请号：PCT/US0220596
申请日：2002-06-27
申请人： IA INC , PRIUSKA ERIC M , SMITH RICHARD H , ERB JUDITH L , DOWNWARD JAMES G , ULRICH OTHO E
发明人： PRIUSKA ERIC M , SMITH RICHARD H , ERB JUDITH L , DOWNWARD JAMES G , ULRICH OTHO E
IPC分类号： G01N21/25 , G01N21/64 , G01N33/533 , G01N33/543 , G01N33/53
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/533 , G01N33/54306 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482
摘要： A method for performing a rapid, homogenous assays for monitoring the reactions of a binding target, by immobilizing a fluorescent-capable chelate complex that is derivatized so as to posses recognition binding ligands, labeling the complex with a labeled second chelator that is added to the assay thereby forming a fluorescent mixed chelate, and measuring the fluorescent mixed chelate, whereby the measurement of the label enable monitoring of the reaction of the binding target. A rapid assay for performing the above method including a first chelating molecule, a fluorescent-capable ion complexed with the first chelating molecule, a second chelating molecule for reacting with the fluorescent-capable ion complexed with the first chelating molecule, and a measuring device for measuring fluorescent resulting from the second chelating molecule reacting with the fluorescent-capable ion complexed with the first chelating molecule. A biosensor for monitoring molecular interactions between receptors, including a biosensor having attached thereto a fluorescent-capable ion complexed with a first chelating molecule, whereby upon exposure to a second chelating molecule said complex becomes fluorescent is also provided.
摘要翻译：一种用于进行用于监测结合靶的反应的快速均质测定的方法，通过固定衍生化以具有识别结合配体的荧光能螯合物复合物，将标记的第二螯合剂标记在添加到测定荧光混合螯合物，测定荧光混合螯合物，由此标记物的测定能够监测结合靶的反应。一种用于执行上述方法的快速测定法，包括第一螯合分子，与第一螯合分子络合的荧光能离子，用于与与第一螯合分子络合的荧光能离子反应的第二螯合分子，以及用于测量由第二螯合分子产生的荧光与与第一螯合分子络合的具有荧光能力的离子反应。用于监测受体之间的分子相互作用的生物传感器，包括附着有与第一螯合分子络合的荧光能离子的生物传感器，由此当暴露于第二螯合分子时，还提供所述络合物变为荧光的生物传感器。

9. 发明申请

WO1991012819A1 IMPROVED IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：改进的免疫组化
公开(公告)号：WO1991012819A1
公开(公告)日：1991-09-05
申请号：PCT/CA1991000063
申请日：1991-03-04
申请人： CHEMBIOMED, LTD. , SLEYTR, Uwe, B. , MUNDT, Wolfgang , MESSNER, Paul , SMITH, Richard, H. , UNGER, Frank, M. , MALCOLM, Andrew
发明人： CHEMBIOMED, LTD.
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K2039/6068 , C07K14/32 , C07K14/33
摘要： Superior pharmaceutical compositions which comprise carriers coupled to epitope-bearing moieties are described. The carriers are crystalline two-dimensional arrays of proteins or glycoproteins, derived from cell envelopes. These conjugates are capable of eliciting the formation of antibodies as well as a T-lymphocyte-mediated immune response following either parenteral or oral administration.
摘要翻译：描述了包含与表位承担部分偶联的载体的优质药物组合物。载体是衍生自细胞包膜的蛋白质或糖蛋白的结晶二维阵列。这些缀合物能够在肠胃外或口服给药之后引发抗体的形成以及T淋巴细胞介导的免疫应答。

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