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1. 发明申请

WO2011091268A3 EARLY WARNING METHOD AND SYSTEM FOR CHRONIC DISEASE MANAGEMENT 审中-公开
公开(公告)号：WO2011091268A3
公开(公告)日：2011-07-28
申请号：PCT/US2011/022078
申请日：2011-01-21
申请人： ASTHMA SIGNALS, INC. , SCHMIDT, Steven, P. , ANANTHRAMAN, Santosh , SMITH, Thomas, H.
发明人： SCHMIDT, Steven, P. , ANANTHRAMAN, Santosh , SMITH, Thomas, H.
IPC分类号： G06Q50/00
摘要： A computer-implemented method and system are provided for assisting a plurality of patients manage chronic health conditions. The method, for each patient, comprises: (a) receiving information from the patient or a member of a patient care network on an expected patient activity at a given future time period; (b) determining expected transient local ambient conditions in the patient's surroundings during the expected patient activity at the given future time period; (c) predicting health exacerbations for the patient using a stored computer model of the patient based on a desired patient control set-point range, the expected patient activity, and the expected transient local ambient conditions; and (d) proactively sending a message to the patient or a member of the patient care network before the given future time period, the message alerting the patient or a member of the patient care network of the predicted health exacerbations for the patient and identifying one or more corrective actions for the patient to avoid or mitigate the predicted health exacerbations.

2. 发明申请

WO2011091268A2 EARLY WARNING METHOD AND SYSTEM FOR CHRONIC DISEASE MANAGEMENT 审中-公开
标题翻译：早期预警方法和慢性疾病管理系统
公开(公告)号：WO2011091268A2
公开(公告)日：2011-07-28
申请号：PCT/US2011022078
申请日：2011-01-21
申请人： ASTHMA SIGNALS INC , SCHMIDT STEVEN P , ANANTHRAMAN SANTOSH , SMITH THOMAS H
发明人： SCHMIDT STEVEN P , ANANTHRAMAN SANTOSH , SMITH THOMAS H
IPC分类号： G06Q50/00
CPC分类号： G06Q10/00 , G06F19/3456 , G06Q30/0201 , G06Q30/0202 , G06Q50/22 , G16H50/20 , G16H50/30 , G16H50/50
摘要： A computer-implemented method and system are provided for assisting a plurality of patients manage chronic health conditions. The method, for each patient, comprises: (a) receiving information from the patient or a member of a patient care network on an expected patient activity at a given future time period; (b) determining expected transient local ambient conditions in the patient's surroundings during the expected patient activity at the given future time period; (c) predicting health exacerbations for the patient using a stored computer model of the patient based on a desired patient control set-point range, the expected patient activity, and the expected transient local ambient conditions; and (d) proactively sending a message to the patient or a member of the patient care network before the given future time period, the message alerting the patient or a member of the patient care network of the predicted health exacerbations for the patient and identifying one or more corrective actions for the patient to avoid or mitigate the predicted health exacerbations.
摘要翻译：提供了一种计算机实现的方法和系统，用于帮助多个患者管理慢性健康状况。对于每个患者，所述方法包括：（a）在给定的未来时间段期间从患者或患者护理网络的成员接收关于预期患者活动的信息; （b）在预期的患者活动期间在给定的未来时间段确定患者周围环境中预期的瞬时局部环境条件; （c）基于期望的患者控制设定点范围，预期的患者活动和预期的瞬时局部环境条件，使用患者的存储的计算机模型来预测患者的健康恶化; 以及（d）在给定的未来时间段之前主动地向患者或患者护理网络的成员发送消息，所述消息提示患者或患者护理网络的成员对患者的预测的健康恶化，并且识别一个或更多的纠正措施，以使患者避免或减轻预测的健康恶化。

3. 发明申请

WO2003067286A2 NANOFILM AND MEMBRANE COMPOSITIONS 审中-公开
标题翻译：纳米和薄膜组合物
公开(公告)号：WO2003067286A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003829
申请日：2003-02-07
申请人： COVALENT PARTNERS, LLC , KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas , MICKLATCHER, Mark , JOSHI, Serena
发明人： KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas , MICKLATCHER, Mark , JOSHI, Serena
IPC分类号： G02B
CPC分类号： B82Y30/00 , C07D259/00
摘要： Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.
摘要翻译：用于过滤的纳米薄膜由取向的两亲分子和取向的大环模块制备。两亲物种可以在界面或表面上取向。可以通过将定向层沉积或附着到基底来制备纳米薄膜。还可以通过将定向的大环模块偶联以提供膜来制备纳米薄膜。

4. 发明申请

WO2008151306A1 SYNTHESIS OF CYCLODEPSIPEPTIDE COMPOUNDS HAVING ANTINEOPLASTIC AND/OR ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：具有抗生素和/或抗微生物活性的环磷酰胺化合物的合成
公开(公告)号：WO2008151306A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065991
申请日：2008-06-05
申请人： ARIZONA BOARD OF REGENTS, a body corporate of the State of Arizona, acting for and on behalf of ARIZONA STATE UNIVERSITY , PETTIT, George, R. , SMITH, Thomas, H. , FENG, Song
发明人： PETTIT, George, R. , SMITH, Thomas, H. , FENG, Song
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00
CPC分类号： C07D273/01 , C07C69/68 , C07C271/22 , C07F7/1852 , C07F7/1856
摘要： The present invention is directed to effective methods of synthesizing cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity. Total syntheses of the eighteen-membered ring cyclodepsipeptides kitastatin (1a) and respirantin (1b) are taught. One important step in the synthesis is an intramolecular transesterification of the ?-ketoester alcohol 6 to afford the protected macrocycle 5. The synthetic products were shown to be identical to the natural products and the absolute stereochemistry of 6 of the 7 asymmetric centers of cyclodepsipeptide 1b was unequivocally established. Kitastatin (1a) and respirantin (1b) were found to be remarkable inhibitors of cancer cell growth and are related to the antimycin family of antibiotics.
摘要翻译：本发明涉及合成具有抗肿瘤和/或抗微生物活性的环糊肽化合物的有效方法。教导了十八元环环十二肽益母毒素（1a）和呼吸素（1b）的总合成。合成中的一个重要步骤是β-酮酯醇6的分子内酯交换反应，得到受保护的大环化合物5.合成产物显示与天然产物相同，并且7个不对称中心的环糊精1b的6个绝对立体化学是明确的。 Kitastatin（1a）和呼吸素（1b）被发现是癌细胞生长的显着抑制剂，与抗生素抗霉素家族有关。

5. 发明申请

WO2007040996A3 MULTIPLE COMPONENT FEED METHODS AND SYSTEMS 审中-公开
标题翻译：多种成分进料方法和系统
公开(公告)号：WO2007040996A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036651
申请日：2006-09-30
申请人： CHEVRON PHILLIPS CHEMICAL CO , BURNS DAVID H , VERSER DONALD W , BENHAM ELIZABETH A , MCDANIEL MAX P , HOTTOVY JOHN D , THURMAN CLAY K , LOCKMAN DAVID A , LAWMASTER JOHN O , HABERLY MATTHEW T , SMITH THOMAS H
发明人： BURNS DAVID H , VERSER DONALD W , BENHAM ELIZABETH A , MCDANIEL MAX P , HOTTOVY JOHN D , THURMAN CLAY K , LOCKMAN DAVID A , LAWMASTER JOHN O , HABERLY MATTHEW T , SMITH THOMAS H , ZELLERS DALE A
IPC分类号： B01J19/00 , B01J19/18 , B01J19/24
CPC分类号： G05B13/048 , B01J8/0015 , B01J19/0006 , B01J19/0033 , B01J19/1837 , B01J19/2435 , B01J2219/00038 , B01J2219/0004 , B01J2219/00164 , B01J2219/00184 , B01J2219/00186 , B01J2219/002 , B01J2219/00218 , B01J2219/00231 , C08F2/00 , C08F10/00 , G05B13/042 , Y10S526/943
摘要： Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.
摘要翻译：在聚合系统中选择，传送和测量多个组分。控制系统将系统变量调整到所需的值。在引入聚合反应器之前，可将部分成分送入预接触器。催化剂组分浓度和停留时间在预接触器中严格控制以影响产品性能。预接触器可以是CSTR或塞流预接触器的单个或多个组合。

6. 发明申请

WO2007040996A2 MULTIPLE COMPONENT FEED METHODS AND SYSTEMS 审中-公开
标题翻译：多组分进料方法和系统
公开(公告)号：WO2007040996A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/036651
申请日：2006-09-30
申请人： CHEVRON PHILLIPS CHEMICAL COMPANY LP , BURNS, David, H. , VERSER, Donald, W. , BENHAM, Elizabeth, A. , MCDANIEL, Max, P. , HOTTOVY, John, D. , THURMAN, Clay, K. , LOCKMAN, David, A. , LAWMASTER, John, O. , HABERLY, Matthew, T. , SMITH, Thomas, H.
发明人： BURNS, David, H. , VERSER, Donald, W. , BENHAM, Elizabeth, A. , MCDANIEL, Max, P. , HOTTOVY, John, D. , THURMAN, Clay, K. , LOCKMAN, David, A. , LAWMASTER, John, O. , HABERLY, Matthew, T. , SMITH, Thomas, H.
IPC分类号： B01J19/00 , B01J19/18 , B01J19/24
CPC分类号： G05B13/048 , B01J8/0015 , B01J19/0006 , B01J19/0033 , B01J19/1837 , B01J19/2435 , B01J2219/00038 , B01J2219/0004 , B01J2219/00164 , B01J2219/00184 , B01J2219/00186 , B01J2219/002 , B01J2219/00218 , B01J2219/00231 , C08F2/00 , C08F10/00 , G05B13/042 , Y10S526/943
摘要： Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.
摘要翻译：在聚合系统中选择，传送和测量多种组分。控制系统将系统变量调整为所需的值。部分组分可以在引入聚合反应器之前供给预接触器。催化剂成分浓度和停留时间在预接触器中严格控制，以影响产品性能。预接触器可以是单个或多个CSTR或活塞式预接触器组合。

7. 发明申请

WO2003066646A2 MACROCYCLIC MODULE COMPOSITIONS 审中-公开
标题翻译：大分子模块组成
公开(公告)号：WO2003066646A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003830
申请日：2003-02-07
申请人： COVALENT PARTNERS, LLC , KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas
发明人： KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas
IPC分类号： C07H
CPC分类号： C07D259/00
摘要： Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.
摘要翻译：大环组合物由环状合成物制成。大环模块结构通过将闭合环中的合成子耦合的逐步或一致的方案来制备。大环模块结构可以具有纳米尺寸的孔。

8. 发明申请

WO2003066646A3 MACROCYCLIC MODULE COMPOSITIONS 审中-公开
公开(公告)号：WO2003066646A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003830
申请日：2003-02-07
申请人： COVALENT PARTNERS, LLC , KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas
发明人： KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas
IPC分类号： A61K31/33
摘要： Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.

9. 发明申请

WO2012148943A1 CRYSTAL STRUCTURES OF DOLASTATIN 16, DOLAMETHYLLEUINE AND DOLAPHENVALINE, AND METHODS FOR PREPARING DOLAMETHYLLEUINE AND DOLAPHENVALINE 审中-公开
标题翻译： DOLASTATIN 16，DOLAMETHYLLEUINE AND DOLAPHENVALINE的晶体结构及其制备方法
公开(公告)号：WO2012148943A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/034859
申请日：2012-04-25
申请人： ARIZONA BOARD OF REGENTS, for and on behalf of, ARIZONA STATE UNIVERSITY , PETTIT, George R. , SMITH, Thomas H. , XU, Jun-Ping , HERALD, Delbert
发明人： PETTIT, George R. , SMITH, Thomas H. , XU, Jun-Ping , HERALD, Delbert
IPC分类号： A61K35/12 , A61K38/00 , A61K38/04
CPC分类号： C07K7/54 , A61K38/00 , C07C227/18 , C07K5/0205 , G06F19/701
摘要： The present invention relates to the crystal structures of dolastatin 16, dolamethylleuine and dolaphenvaline. The present invention also relates to processes for preparing dolamethylleuine and dolaphenvaline. The present invention further relates to computer readable medium with crystal structural data and/or information stored thereon.
摘要翻译：本发明涉及多拉司他汀16，多亚甲基兰和多萘普坦的晶体结构。本发明还涉及制备多巴胺丁胺和多芬戊醇的方法。本发明还涉及具有晶体结构数据和/或存储在其上的信息的计算机可读介质。

10. 发明申请

WO2003067286A3 NANOFILM AND MEMBRANE COMPOSITIONS 审中-公开
公开(公告)号：WO2003067286A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003829
申请日：2003-02-07
申请人： COVALENT PARTNERS, LLC , KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas , MICKLATCHER, Mark , JOSHI, Serena
发明人： KRIESEL, Josh , KARPISHIN, Timothy, B. , BIVIN, Donald, B. , MERRILL, Grant , EDELSTEIN, Martin, Stuart , SMITH, Thomas, H. , WHITEFORD, Jeffery, A. , JONAS, Robert, Thomas , MICKLATCHER, Mark , JOSHI, Serena
IPC分类号： C07D245/00
摘要： Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.

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