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1. 发明申请

WO2014083327A1 ADENINE DERIVATIVES SUITABLE FOR THE TREATMENT OF (INTER ALIA) MUSCULAR DYSTROPHY 审中-公开
标题翻译：适用于治疗（INTER ALIA）MUSCULAR DYSTROPHY的ADENINE衍生物
公开(公告)号：WO2014083327A1
公开(公告)日：2014-06-05
申请号：PCT/GB2013/053121
申请日：2013-11-26
申请人： MD PHARMA AB , SMITH, Stephen Edward
发明人： LEHMANN, Fredrik , MALMSTRÖM, Jonas , EVENÄS, Lars Johan , BRIMERT, Lars Thomas , SVENSSON, Bo Roger , WALSE, Björn Ulrik
IPC分类号： C07D473/34 , A61K31/52 , A61P25/00
CPC分类号： C07D473/34
摘要： The invention provides a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , Ra and R b have the meanings given in the description, with the proviso that the compound is not a compound selected from the group given in the description. The invention also provides the defined compounds (with or without the proviso) for use in the treatment of muscular dystrophy.
摘要翻译：本发明提供式（I）化合物，其中R1，R2，R3，R4，R5，Ra和Rb具有说明书中给出的含义，条件是该化合物不是选自描述。本发明还提供了用于治疗肌营养不良症的限定化合物（有或没有附带条件）。

2. 发明申请

WO2013061083A2 THERAPEUTIC AGENTS AND USES THEREOF 审中-公开
标题翻译：治疗剂及其用途
公开(公告)号：WO2013061083A2
公开(公告)日：2013-05-02
申请号：PCT/GB2012/052675
申请日：2012-10-26
申请人： FREDAX AB , SMITH, Stephen Edward
发明人： STRAND, Sven-Erik , TRAN, Amanda Thuy , AXELSSON, Sven-Niklas Anders
IPC分类号： A61K51/10 , A61P35/00 , C07K16/30 , G01N33/574
CPC分类号： A61K51/1072 , A61K47/6803 , A61K49/16 , A61K49/221 , A61K51/1018 , A61K51/1075 , A61K51/1093 , A61K51/1096 , C07K16/18 , C07K16/3069 , C07K16/40 , C07K2317/565 , G01N33/57434 , G01N2333/96455
摘要： The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.
摘要翻译：本申请提供了用于治疗前列腺癌的包含对激肽释放酶蛋白（例如，PSA或hK2）具有特异性的结合部分或由其组成的药剂和用于治疗所述方法包括向患者施用治疗有效量的包含对激肽释放酶蛋白具有特异性的结合部分或由其组成的试剂的步骤。

3. 发明申请

WO2011154698A2 METHOD,ARRAY AND USE THEREOF 审中-公开
标题翻译：方法，阵列及其应用
公开(公告)号：WO2011154698A2
公开(公告)日：2011-12-15
申请号：PCT/GB2011/000865
申请日：2011-06-09
申请人： IMMUNOVIA AB , SMITH, Stephen Edward , BORREBAECK, Carl Ame Krister , WINGREN, Christer Lars Bertil
发明人： BORREBAECK, Carl Ame Krister , WINGREN, Christer Lars Bertil
IPC分类号： G01N33/543
CPC分类号： G01N33/6893 , G01N33/54366 , G01N33/57415
摘要： The present invention provides a method for the prognosis of breast cancer in a subject comprising the steps of: (a) providing a first proteome sample from the subject; (b) measuring in the first proteome sample the amount of one or more biomarkers selected from the group of biomarkers listed in Table 1; (c) providing an additional (e.g. a second) proteome sample from the subject; (d) measuring in the additional proteome sample the amount of the one or more biomarkers selected from the group of biomarkers listed in Table 1 measured in step (b); and (e) determining the difference between the amount of the one or more biomarkers in the first and additional proteome samples; wherein the first proteome sample and additional proteome sample are representative of the proteome composition of the subject on different days, and wherein the difference between the amount of the one or more biomarkers in the first and additional (e.g. second) proteome samples is indicative of the risk of recurrence and/or metastasis of the breast cancer in the subject. In further embodiments, step (b) comprises measuring the amount of each the biomarkers listed in Table 1 (A) or all of the biomarkers listed in Table 1. The present invention additionally provides an array for performing the method of the invention, the use in vitro of a biomarker selected from the group of biomarkers in Table 1 as a prognostic marker for determining risk of recurrence and/or metastasis of breast cancer in a subject, and a kit for performing the method of the invention comprising one or more binding agents capable of binding to a biomarker listed in Table 1.
摘要翻译：本发明提供了一种用于对象中乳腺癌预后的方法，包括以下步骤：（a）从受试者提供第一蛋白质组样品; （b）在第一蛋白质组样品中测量选自表1所列生物标志物组的一种或多种生物标志物的量; （c）从受试者提供另外的（例如第二）蛋白质组样品; （d）在另外的蛋白质组样品中测量选自在步骤（b）中测量的表1中列出的生物标志物组的一种或多种生物标志物的量; 和（e）确定第一和另外的蛋白质组样品中一种或多种生物标志物的量之间的差异; 其中所述第一蛋白质组样品和另外的蛋白质组样品在不同天数代表所述受试者的蛋白质组组成，并且其中所述第一和另外（例如第二）蛋白质组样品中所述一种或多种生物标志物的量之间的差异指示受试者乳腺癌复发和/或转移的风险。在另外的实施方案中，步骤（b）包括测量表1（A）中列出的每种生物标志物的量或表1中列出的所有生物标志物的量。本发明另外提供用于实施本发明方法的阵列，选自表1中的生物标志物组的生物标志物的体外作为用于确定受试者的乳腺癌复发和/或转移风险的预后标记物，以及用于进行本发明方法的试剂盒，其包含一种或多种结合剂能够结合表1中列出的生物标志物。

4. 发明申请

WO2011128642A1 COMPOISITONS COMPRISING POLYGLUTAMIC ACID NANOPARTICLES AND POLYPEPTIDES SUCH AS CD40 AGONISTS 审中-公开
标题翻译：包含聚氨基酸纳米颗粒和多肽的组合物如CD40激动剂
公开(公告)号：WO2011128642A1
公开(公告)日：2011-10-20
申请号：PCT/GB2011/000577
申请日：2011-04-13
申请人： ALLIGATOR BIOSCIENCE AB , SMITH, Stephen, Edward , BORREBAECK, Carl, Arne, Krister , BROOS, Sissela, Rachel, Linn , ELLMARK, Peter, Bo, Joakim , LINDSTEDT, Malin, Marie
发明人： BORREBAECK, Carl, Arne, Krister , BROOS, Sissela, Rachel, Linn , ELLMARK, Peter, Bo, Joakim , LINDSTEDT, Malin, Marie
IPC分类号： A61K9/14 , A61K39/39 , A61K39/395 , A61K47/34 , A61K9/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/146 , A61K9/5146 , A61K2039/55516 , A61K2039/55555
摘要： The present invention provides pharmaceutical compositions comprising an immunostimulatory polypeptide and polyglutamic acid (PGA) nanoparticles, formulated in a pharmaceutically acceptable diluent, carrier or excipient. Such compositions have utility in stimulating the immune system in subjects, with the components capable of interacting synergistically. The invention further provides uses of the compositions of the invention, for example in the treatment of cancer, and kit and components for use in the same.
摘要翻译：本发明提供包含免疫刺激多肽和聚谷氨酸（PGA）纳米颗粒的药物组合物，其配制在药学上可接受的稀释剂，载体或赋形剂中。这些组合物可有效地刺激受试者的免疫系统，其中组分能够协同相互作用。本发明进一步提供本发明组合物的用途，例如用于治疗癌症，以及用于其中的试剂盒和组分。

5. 发明申请

WO2007099337A1 EXPANSION AND DIFFERENTIATION OF MESENCHYMAL STEM CELLS 审中-公开
标题翻译：骨髓间充质干细胞的扩增和分化
公开(公告)号：WO2007099337A1
公开(公告)日：2007-09-07
申请号：PCT/GB2007/000731
申请日：2007-03-01
申请人： CARTELA AB , SMITH, Stephen, Edward , LUNDGREN-AKERLUND, Evy , KJELLMAN, Christian
发明人： LUNDGREN-AKERLUND, Evy , KJELLMAN, Christian
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0655 , C12N2501/115 , C12N2501/15
摘要： A cell culture system for expanding and differentiating mammalian mesenchymal stem cells to chondrocytes is provided. Said cell culture system comprises a subpopulation of isolated MSC selected for their expression of integrin alpha 10, as well as additives promoting expansion and differentiation to chondrocytes. Methods and uses of said expanded and differentiated cells with a chondrogen phenotype are also provided, as well as compositions comprising said expanded and differentiated chondrocyte cells.
摘要翻译：提供了一种用于将哺乳动物间充质干细胞扩增和分化成软骨细胞的细胞培养系统。所述细胞培养系统包括选择用于表达整联蛋白α10的分离的MSC的亚群，以及促进软骨细胞扩增和分化的添加剂。还提供了所述扩增和分化的细胞与软骨素表型的方法和用途，以及包含所述扩增和分化的软骨细胞的组合物。

6. 发明申请

WO2007020405A2 NOVEL PEPTIDES AND USES THEREOF 审中-公开
标题翻译：新型肽及其用途
公开(公告)号：WO2007020405A2
公开(公告)日：2007-02-22
申请号：PCT/GB2006/003015
申请日：2006-08-11
申请人： CARTELA AB , SMITH, Stephen, Edward , LUNDGREN-ÅKERLUND, Evy , KJELLMAN, Christian
发明人： LUNDGREN-ÅKERLUND, Evy , KJELLMAN, Christian
IPC分类号： C07K7/64 , C07K7/06 , G01N33/53 , A61K38/08 , A61K38/12
CPC分类号： C12Q1/37 , A61K38/00 , A61K49/0002 , C07K14/70546 , G01N33/566 , G01N2333/70546
摘要： The present invention provides novel polypeptide comprising the amino acid sequence of SEQ ID NOS: 1, 2, 3, 4 or 5, variants, fusions or derivatives thereof, and pharmaceutical formulations of the same. The peptides and formulations of the invention are useful for treating diseases or conditions capable of being treated by an agent which modulates the function of an integrin and/or a metzincin, such as arthritic diseases, inflammatory diseases and conditions and cancer. Also provided are diagnostic methods for such diseases and conditions, and methods of screening for candidate compounds with efficacy in the treatment of such diseases and conditions.
摘要翻译：本发明提供了包含SEQ ID NO：1,2,3,4或5的氨基酸序列的变体，融合物或衍生物及其药物制剂的新型多肽。本发明的肽和制剂可用于治疗能够通过调节整联蛋白和/或美金辛（例如关节炎疾病，炎性疾病和病症和癌症）的功能的药物治疗的疾病或病症。还提供了用于这些疾病和病症的诊断方法，以及筛选在治疗这些疾病和病症方面具有疗效的候选化合物的方法。

7. 发明申请

WO2006120439A3 CELLULAR VACCINE AND USE THEREOF 审中-公开
公开(公告)号：WO2006120439A3
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001709
申请日：2006-05-10
申请人： AVARIS AB , SMITH, Stephen, Edward , SPETZ-HOLMGREN, Anna-Lena , JOHANSSON, Ulrika , ANDERSON, Jan , WALTHER-JALLOW, Lilian
发明人： SPETZ-HOLMGREN, Anna-Lena , JOHANSSON, Ulrika , ANDERSON, Jan , WALTHER-JALLOW, Lilian
IPC分类号： C12N5/06
摘要： The present invention provides a cellular vaccine for therapeutic or prophylactic treatment of a pathological condition, the vaccine comprising or consisting of a population of CD 4 + T cells modified such that they contain an antigenic component, and/or a nucleic acid molecule encoding an antigenic component thereof, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. The invention further provides an adjuvant composition for use in a method of vaccination, the composition comprising or consisting of a population of T cells, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. In addition, the invention provides a composition having microbicide activity, or capable thereof upon exposure to antigen-presenting cells, the composition comprising or consisting of a population of T cells, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. Also provided by the present invention are methods for making and using the vaccines and compositions described herein.

8. 发明申请

WO2015159099A1 COMPOSITIONS COMPRISING OSTEOPONTIN DERIVATIVES FOR THE INHIBITION OF HAIR GROWTH 审中-公开
标题翻译：包含用于抑制头发生长的OSTEOPONTIN衍生物的组合物
公开(公告)号：WO2015159099A1
公开(公告)日：2015-10-22
申请号：PCT/GB2015/051165
申请日：2015-04-17
申请人： FOLLICUM AB , SMITH, Stephen Edward
发明人： ALENFALL, Jan , DUNÉR, Pontus , NILSSON, Anna Hultgårdh , PAUS, Ralf
IPC分类号： A61K8/64 , A61K38/04 , A61Q7/02 , A61P17/00
CPC分类号： A61K8/64 , A61K9/0014 , A61K38/19 , A61K2800/74 , A61Q7/02
摘要： The present invention provides a composition for inhibiting hair production in a mammal comprising an active polypeptide component and a pharmaceutically acceptable and/or cosmetically acceptable excipient, carrier or diluent. The invention further provides methods of inhibiting hair production in a mammal, e.g. human.
摘要翻译：本发明提供了用于抑制哺乳动物毛发生成的组合物，其包含活性多肽组分和药学上可接受的和/或化妆品可接受的赋形剂，载体或稀释剂。本发明进一步提供了抑制哺乳动物毛发产生的方法，例如，人类。

9. 发明申请

WO2015150799A1 NOVEL METHODS, POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：新方法，聚合物及其用途
公开(公告)号：WO2015150799A1
公开(公告)日：2015-10-08
申请号：PCT/GB2015/051006
申请日：2015-03-31
申请人： ENZYMATICA AB , SMITH, Stephen Edward
发明人： CLARSUND, Mats Peter , SVENSSON, Bo Roger , WALSE, Björn Ulrik , RASMUSSEN, Poul Baad , THORSTED, Peter Bjødstrup
IPC分类号： A61K38/48 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P11/00 , C12N9/76
CPC分类号： C12N9/6427 , A61K8/66 , A61K9/006 , A61K38/00 , A61K38/4826 , A61K2800/28 , A61Q7/00 , A61Q19/08 , C12N9/6408 , C12P21/02 , C12Y304/21004
摘要： The present invention provides methods for the production of recombinant polypeptides having serine protease activity, polypeptides obtainable by such methods and use of said polypeptides in medicine, cosmetics and industry. In particular, the invention provides recombinantly expressed mutants of trypsin I from Atlantic cod, which mutants exhibit improved stability and/or catalytic properties relative to the wildtype trypsin purified from cod.
摘要翻译：本发明提供了生产具有丝氨酸蛋白酶活性的重组多肽的方法，可通过这些方法获得的多肽和在医药，化妆品和工业中使用所述多肽。特别地，本发明提供了来自大西洋鳕鱼的重组表达的胰蛋白酶I突变体，该突变体相对于从鳕鱼纯化的野生型胰蛋白酶表现出改进的稳定性和/或催化性质。

10. 发明申请

WO2015075445A1 HUMANISED ANTI KALLIKREIN-2 ANTIBODY 审中-公开
标题翻译：人类抗原KALLIKREIN-2抗体
公开(公告)号：WO2015075445A1
公开(公告)日：2015-05-28
申请号：PCT/GB2014/053420
申请日：2014-11-19
申请人： FREDAX AB , SMITH, Stephen Edward
发明人： TIMMERMAND, Pär Oskar Vilhelmsson , TRAN, Amanda Thuy , STRAND, Sven-Erik , LAMMINMÄKI, Urpo Juhani
IPC分类号： C07K16/00 , A61K51/10 , C07K16/40 , A61K39/395 , A61P35/00
CPC分类号： C07K16/40 , A61K51/1045 , A61K51/1075 , A61K51/1096 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:l and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The disclosure further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer
摘要翻译：本公开提供对人激肽释放酶-2（hK2）具有结合特异性的抗体多肽，其中所述抗体多肽包含（a）包含SEQ ID NO：1和SEQ ID NO：2的氨基酸序列的重链可变区和SEQ ID NO：2的SEQ ID NO：（SEQ ID NO：3）和/或（b）包含SEQ ID NO：4和SEQ ID NO：5和SEQ ID NO：6的氨基酸序列的轻链可变区，其中重链可变区和轻链可变区区域包含来自一个或多个人抗体的框架氨基酸序列。本公开进一步提供了所述抗体多肽在前列腺癌的诊断和治疗中的用途

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