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1. 发明申请

WO2013048599A3 KETOL-ACID REDUCTOISOMERASES WITH IMPROVED PERFORMANCE PROPERTIES 审中-公开
标题翻译：具有改进的性能特征的酮酸 - 酸还原异构体
公开(公告)号：WO2013048599A3
公开(公告)日：2013-08-29
申请号：PCT/US2012042624
申请日：2012-06-15
申请人： GEVO INC , CALIFORNIA INST OF TECHN , BUELTER THOMAS , LIES DOUGLAS , PORTER-SCHEINMAN STEPHANIE , SMITH CHRISTOPHER , MEINHOLD PETER , BERRY RUTH , SNOW CHRISTOPHER , BASTIAN SABINE
发明人： BUELTER THOMAS , LIES DOUGLAS , PORTER-SCHEINMAN STEPHANIE , SMITH CHRISTOPHER , MEINHOLD PETER , BERRY RUTH , SNOW CHRISTOPHER
IPC分类号： C12N1/20 , C12N9/90 , C12P7/16
CPC分类号： C12P7/16 , C12N9/0006 , C12N15/52 , C12Y101/01086 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
摘要翻译：本发明涉及包含至少一个编码酮醇酸还原异构酶（KARI）或其修饰的NADH依赖性变体的核酸分子的重组微生物，其中所述KARI与SEQ ID NO：2至少约60％相同。在各种本发明的一些方面，重组微生物可以包含产生异丁醇的代谢途径并且可以用于制备异丁醇的方法中。

2. 发明申请

WO2012160373A3 VEHICLE NAVIGATION 审中-公开
标题翻译：车辆导航
公开(公告)号：WO2012160373A3
公开(公告)日：2013-05-10
申请号：PCT/GB2012051156
申请日：2012-05-22
申请人： BAE SYSTEMS PLC , SMITH CHRISTOPHER ANDREW , HESTER GEOFFREY JAMES
发明人： SMITH CHRISTOPHER ANDREW , HESTER GEOFFREY JAMES
IPC分类号： G05D1/02
CPC分类号： G05D1/0212 , B60W10/18 , B60W50/035 , B60W2050/0077 , B60W2550/20 , G01C21/165 , G01S13/726 , G01S13/931 , G01S19/44 , G05D1/024 , G05D1/0246 , G05D1/0261 , G05D1/027 , G05D1/0272 , G05D1/0274 , G05D1/0278 , G05D2201/0213
摘要： A method and apparatus for establishing a route for an autonomous vehicle (2), the method comprising: determining localisation information for the vehicle (2) with respect to a first frame of reference that is fixed with respect to a current 5 state of the vehicle (2); determining localisation information for the vehicle (2) with respect to a second frame of reference that is fixed with respect to an entity (e.g. Earth), the vehicle (2) being moveable with respect to the entity; establishing a route for the vehicle (2) with respect to the second frame using the localisation information for the vehicle (2) with respect to the second frame; transforming the route from the second frame to the first frame; and determining a route for the vehicle (2) with respect to the first frame using the localisation information for the vehicle (2) with respect to the first frame and the transformed route.
摘要翻译：一种用于建立自主车辆（2）的路线的方法和装置，所述方法包括：相对于相对于车辆的当前5状态固定的第一参考系，确定车辆（2）的定位信息（2）; 确定关于相对于实体（例如地球）固定的第二参考系的车辆（2）的定位信息，所述车辆（2）可相对于所述实体移动; 使用车辆（2）相对于第二帧的定位信息，相对于第二帧建立车辆（2）的路线; 将路由从第二帧转换到第一帧; 以及使用车辆（2）相对于第一帧和变换路线的定位信息，确定车辆（2）相对于第一帧的路线。

3. 发明申请

WO2013009818A3 HIGH-PERFORMANCE KETOL-ACID REDUCTOISOMERASES 审中-公开
标题翻译：高性能氯酸低聚糖
公开(公告)号：WO2013009818A3
公开(公告)日：2013-04-25
申请号：PCT/US2012046185
申请日：2012-07-11
申请人： GEVO INC , CALIFORNIA INST OF TECHN , MEINHOLD PETER , LIES DOUG , PORTER-SCHEINMAN STEPHANIE , SMITH CHRISTOPHER , SNOW CHRISTOPHER , BASTIAN SABINE , SCHOOF SEBASTIAN
发明人： MEINHOLD PETER , LIES DOUG , PORTER-SCHEINMAN STEPHANIE , SMITH CHRISTOPHER , SNOW CHRISTOPHER , BASTIAN SABINE , SCHOOF SEBASTIAN
IPC分类号： C12N1/21
CPC分类号： C12P7/16 , C12N9/0006 , C12N15/746 , C12Y101/01086 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 80% identical to SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 28, SEQ ID NO: 40, or SEQ ID NO: 58. The present invention also relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 99% identical to SEQ ID NO: 64. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
摘要翻译：本发明涉及包含编码酮酸酸还原异构酶（KARI）或修饰的NADH依赖性变体的至少一种核酸分子的重组微生物，其中所述KARI与SEQ ID NO：2，SEQ ID NO：2至少约80％ SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8，SEQ ID NO：10，SEQ ID NO：28，SEQ ID NO：40或SEQ ID NO：58.本发明还涉及重组微生物其包含至少一个编码酮酸酸还原异构酶（KARI）或其修饰的NADH依赖性变体的核酸分子，其中所述KARI与SEQ ID NO：64至少约99％相同。在本发明的各个方面，重组微生物可以包含产生异丁醇的代谢途径，并可用于制备异丁醇的方法。

4. 发明申请

WO2013041443A2 METHODS OF CONTROLLING A COMBINED PLANT INCLUDING AT LEAST ONE GENERATOR AND AN ENERGY STORE 审中-公开
标题翻译：至少包括一个发电机组和一个能源商店的组合电厂的控制方法
公开(公告)号：WO2013041443A2
公开(公告)日：2013-03-28
申请号：PCT/EP2012/067982
申请日：2012-09-13
申请人： GE ENERGY POWER CONVERSION TECHNOLOGY LTD , BANHAM-HALL, Dominic David , TAYLOR, Gareth Anthony , SMITH, Christopher Alan
发明人： BANHAM-HALL, Dominic David , TAYLOR, Gareth Anthony , SMITH, Christopher Alan
IPC分类号： H02J3/28
CPC分类号： H02J3/28 , H02J3/386 , Y02E10/763 , Y10T307/352
摘要： The present invention provides a method of controlling a combined plant to provide frequency support to a power grid operating at a variable grid frequency. The combined plant includes at least one generator (e.g. a plurality of wind turbine generators) and an energy store (12). The combined plant is adapted to supply power to the power grid. The method includes the steps of charging the energy store (12) at less than its rated power when frequency support is not needed. When frequency support is needed the combined plant is controlled to increase or decrease the overall power that it supplies to the power grid to provide frequency support. The control of the combined plant can be designed to maximise frequency support revenues.
摘要翻译：本发明提供了一种控制组合工厂以向在可变电网频率下运行的电力网提供频率支持的方法。组合设备包括至少一个发电机（例如多个风力涡轮发电机）和能量存储器（12）。组合设备适用于向电网供电。该方法包括当不需要频率支持时以低于其额定功率对储能器（12）进行充电的步骤。当需要频率支持时，组合设备被控制以增加或减少其提供给电网的总功率以提供频率支持。组合工厂的控制可以设计为最大化频率支持收入。

5. 发明申请

WO2012113027A1 BLOWER AND PAP SYSTEM 审中-公开
标题翻译：鼓风和PAP系统
公开(公告)号：WO2012113027A1
公开(公告)日：2012-08-30
申请号：PCT/AU2012/000175
申请日：2012-02-22
申请人： RESMED MOTOR TECHNOLOGIES INC. , MOIR, Michael Bruce , VINOKUR, Roman , MAY, Frederick Arlet , DOUDKINE, Dmitri Anatolievich , KENYON, Barton John , SMITH, Christopher James
发明人： MOIR, Michael Bruce , VINOKUR, Roman , MAY, Frederick Arlet , DOUDKINE, Dmitri Anatolievich , KENYON, Barton John , SMITH, Christopher James
IPC分类号： A61M16/00 , F04D29/28 , F04D29/66 , F04D25/06 , A61M16/06
CPC分类号： A61M16/0066 , A61M16/0666 , A61M16/0683 , A61M16/107 , A61M16/125 , A61M2202/0208 , A61M2205/3358 , A61M2205/42 , F04D17/08 , F04D17/16 , F04D29/048
摘要： A blower includes a housing including an inlet and an outlet, a stationary component provided to the housing, an impeller positioned between the inlet of the housing and the stationary component, and a motor adapted to drive the impeller. The stationary component includes a tube portion structured to retain and align a pair of bearings that rotatably support a rotor to which the impeller is coupled. The tube portion includes a diameter in a side closest to the impeller that is sufficient size to accommodate adhesive to retain one of the bearings.
摘要翻译：鼓风机包括壳体，其包括入口和出口，设置到壳体的固定部件，位于壳体的入口与固定部件之间的叶轮和适于驱动叶轮的马达。固定部件包括管部分，其被构造成保持和对准一对可旋转地支撑叶轮联接到的转子的轴承。管部分包括最靠近叶轮的一侧的直径，其尺寸足够容纳粘合剂以保持其中一个轴承。

6. 发明申请

WO2012013585A1 CO-DELIVERY OF TWO MEDICAMENTS IN A SINGLE INJECTION 审中-公开
标题翻译：在单次注射中共同交付两种药物
公开(公告)号：WO2012013585A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062604
申请日：2011-07-22
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , CLARKE, Alastair, Robert , EKMAN, Matthew, John , HEALD, Michael, James, David , SMITH, Christopher, James
发明人： CLARKE, Alastair, Robert , EKMAN, Matthew, John , HEALD, Michael, James, David , SMITH, Christopher, James
IPC分类号： A61M5/24 , A61M5/00
CPC分类号： A61M5/2448 , A61M5/002 , A61M5/2466 , A61M5/3129 , A61M5/3137 , A61M5/3202 , A61M5/326 , A61M2005/2414 , A61M2005/3121 , A61M2005/31598
摘要： An injection system for co-delivery of two medicaments having an adaptor (1) that accepts a mini-syringe (20) containing a first medicament and that accepts an injection device (30) that contains a second medicament, where the mini-syringe (20) connects to the injection device (30) during injection to deliver both medicaments to a patient simultaneously in a single injection.
摘要翻译：一种用于共同递送两种药物的注射系统，其具有接受包含第一药物的微型注射器（20）的适配器（1），并且接受包含第二药剂的注射装置（30），其中所述微型注射器 20）在注射期间连接到注射装置（30），以在单次注射中同时向患者递送两种药物。

7. 发明申请

WO2011154481A1 MEDICATION DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2011154481A1
公开(公告)日：2011-12-15
申请号：PCT/EP2011/059565
申请日：2011-06-09
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , SMITH, Christopher, James , HEALD, Michael , BUTLER, Stephen, David , HORLOCK, Mark, Philip
发明人： SMITH, Christopher, James , HEALD, Michael , BUTLER, Stephen, David , HORLOCK, Mark, Philip
IPC分类号： A61M5/24 , A61M5/315
CPC分类号： A61M5/24 , A61M5/31543 , A61M5/31555 , A61M5/31585
摘要： A medication delivery device (1) is provided which is switchable between an operational state and a resetting state and which comprises a housing (13) having a proximal end (8) and a distal end (7), a piston rod (12) being moveable in a distal direction with respect to the housing (13) for medication delivery, a conversion element (38) adapted to at least partially convert a rotational movement of the piston rod (12) into an axial movement of the piston rod (12), coupling means (39) prevented from rotational movement with respect to the housing (13) and adapted to engage with the conversion element (38) in the operational state, a drive assembly (3) comprising at least two drive assembly members and adapted for moving the piston rod (12) in the distal direction, and a resilient member (31) adapted to provide a force on the drive assembly (3) for engagement of the drive assembly members. In the operational state of the device (1) the coupling means (39) is engaged with the conversion element (38), the conversion element (38) thereby being prevented from rotation with respect to the housing (13). In the resetting state of the device (1) the coupling means (39) is disengaged from the conversion element (38) under force of the resilient member (31), the conversion element (38) thereby being allowed to rotate with respect to the housing (13) and thereby allowing a resetting of the device (1).
摘要翻译：提供了一种药物输送装置（1），其可在操作状态和复位状态之间切换，并且包括具有近端（8）和远端（7）的壳体（13），活塞杆（12）相对于用于药物输送的壳体（13）在远端方向上可移动的转换元件（38）适于至少部分地将活塞杆（12）的旋转运动转换成活塞杆（12）的轴向运动，，联接装置（39）防止相对于壳体（13）旋转运动并且适于在操作状态下与转换元件（38）接合;驱动组件（3），其包括至少两个驱动组件，并适于沿远端方向移动活塞杆（12），以及适于在驱动组件（3）上提供力以用于驱动组件的接合的弹性构件（31）。在装置（1）的操作状态下，联接装置（39）与转换元件（38）接合，从而防止转换元件（38）相对于壳体（13）旋转。在装置（1）的复位状态下，联接装置（39）在弹性构件（31）的作用下与转换元件（38）脱离接合，转换元件（38）因此被允许相对于壳体（13），从而允许装置（1）的复位。

8. 发明申请

WO2011124921A1 FUEL ENRICHMENT METHOD AND SYSTEM 审中-公开
标题翻译：燃料充足方法和系统
公开(公告)号：WO2011124921A1
公开(公告)日：2011-10-13
申请号：PCT/GB2011/050693
申请日：2011-04-08
申请人： ADVANCED FUEL TECHNOLOGIES UK LTD , LEWIS, David Charles Colin , SMITH, Christopher Leonard , LISTER, John Richard
发明人： LEWIS, David Charles Colin , SMITH, Christopher Leonard , LISTER, John Richard
IPC分类号： F02M25/12 , B01F3/04 , F02D19/08
CPC分类号： B01F3/04439 , C10L1/1208 , F02M25/12 , F02M27/045 , F02M31/02 , Y02E60/364 , Y02E60/366 , Y02T10/121
摘要： The present invention relates, inter alia , to a process for enriching a hydrocarbon fuel for use in an internal combustion engine, the process comprising: (i) generating hydrogen gas and oxygen gas; (ii) contacting a liquid hydrocarbon fuel with the hydrogen gas and oxygen gas under a pressure greater than atmospheric pressure such that at least some of the hydrogen gas and at least some of the oxygen gas is dissolved into the hydrocarbon fuel to produce an enriched hydrocarbon fuel. The present invention further provides a system for use in the process, an internal combustion engine having such a system, and a vehicle having such an internal combustion engine.
摘要翻译：本发明尤其涉及一种用于富集用于内燃机的烃燃料的方法，该方法包括：（i）产生氢气和氧气; （ii）在大于大气压的压力下使液体烃燃料与氢气和氧气接触，使得至少一些氢气和至少一些氧气被溶解在烃燃料中以产生富集烃汽油。本发明还提供一种在该方法中使用的系统，具有这种系统的内燃机和具有这种内燃机的车辆。

9. 发明申请

WO2011124872A1 FUEL ENRICHMENT METHOD AND DEVICE 审中-公开
标题翻译：燃料润滑方法和装置
公开(公告)号：WO2011124872A1
公开(公告)日：2011-10-13
申请号：PCT/GB2010/051862
申请日：2010-11-09
申请人： ADVANCED FUEL TECHNOLOGIES UK LIMITED , LEWIS, David Charles Colin , SMITH, Christopher Leonard , LISTER, John Richard
发明人： LEWIS, David Charles Colin , SMITH, Christopher Leonard , LISTER, John Richard
IPC分类号： F02M25/12 , B01F3/04
CPC分类号： B01F3/04439 , C10L1/1208 , F02M25/12 , F02M27/045 , F02M31/02 , Y02E60/364 , Y02E60/366 , Y02T10/121
摘要： The present invention relates, inter alia , to a process for enriching a hydrocarbon fuel for use in an internal combustion engine, the process comprising: (i) contacting a hydrocarbon fuel with a gas stream containing hydrogen gas such that at least some of the hydrogen gas is introduced into the hydrocarbon fuel to produce an enriched hydrocarbon fuel; and optionally (ii) delivering the enriched hydrocarbon fuel to an internal combustion engine. The present invention further provides a device for use in the process.
摘要翻译：本发明尤其涉及一种用于富集用于内燃机的烃燃料的方法，该方法包括：（i）使烃燃料与含有氢气的气流接触，使得至少一些氢将气体引入烃燃料中以产生富集的烃燃料; 和（ii）将富集的烃燃料输送到内燃机。本发明还提供一种用于该方法的装置。

10. 发明申请

WO2011066356A1 METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开
标题翻译：增加二羟酸脱水酶活性的方法，以提高燃料，化学品和氨基酸的生产
公开(公告)号：WO2011066356A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057957
申请日：2010-11-24
申请人： GEVO, INC. , URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
发明人： URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
IPC分类号： C12N1/00
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y402/01009 , Y02E50/10
摘要： The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明涉及包含一种或多种二羟基酸脱水酶（DHAD） - 生物合成途径的重组微生物，以及使用所述重组微生物产生源自所述DHAD需要生物合成途径的有益代谢物的方法。在本发明的各个方面，重组微生物可被工程化以过表达一种或多种编码一种或多种Aft蛋白或其同系物的多核苷酸。在一些实施方案中，重组微生物可以包含细胞溶质定位的DHAD酶。在另外的实施方案中，重组微生物可以包含线粒体定位的DHAD酶。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物，和非发酵酵母微生物。

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