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1. 发明申请

WO2010022196A3 [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE 审中-公开
标题翻译： [4-（5-氨基甲基-2-氟 - 苯基） - 哌啶-1-基] - [7-氟-1-（2-甲氧基 - 乙基）-4-三氟甲氧基-1H-吲哚-3-基] - 甲烷作为细胞培养物的抑制剂
公开(公告)号：WO2010022196A3
公开(公告)日：2010-07-22
申请号：PCT/US2009054381
申请日：2009-08-20
申请人： SANOFI AVENTIS , CHOI-SLEDESKI YONG MI , CHOY NAKYEN , POLI GREGORY BERNARD , SHAY JOHN J JR , SHUM PATRICK WAI-KWOK , SLEDESKI ADAM W
发明人： CHOI-SLEDESKI YONG MI , CHOY NAKYEN , POLI GREGORY BERNARD , SHAY JOHN J JR , SHUM PATRICK WAI-KWOK , SLEDESKI ADAM W
IPC分类号： C07D401/06 , A61K31/404 , A61P29/00
CPC分类号： C07D401/06
摘要： The present invention is directed to an indole benzylamine compound useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient a therapeutically effective amount of the compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier. Formule (I).
摘要翻译：本发明涉及可用作类胰蛋白酶抑制剂的吲哚苄胺化合物。此外，本发明涉及该化合物用于治疗患有或受制于需要通过抑制类胰蛋白酶而改善的生理条件的患者，其包括向患者施用治疗有效量的该化合物。此外，本发明涉及包含药学有效量的式I化合物和药学上可接受的载体的药物组合物。 Formule（I）。

2. 发明申请

WO2011037947A1 SYNTHESIS OF (4-FLUORO-3-PIPERIDIN-4-YL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER AND INTERMEDIATES THEREOF 审中-公开
标题翻译：（4-氟-3-哌啶-4-基 - 苯甲酰基） - 氨基丁酸叔丁酯的合成及其中间体
公开(公告)号：WO2011037947A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049737
申请日：2010-09-22
申请人： SANOFI-AVENTIS U.S. LLC , CHOY, Nakyen , SHAY, John J., Jr. , SLEDESKI, Adam W.
发明人： CHOY, Nakyen , SHAY, John J., Jr. , SLEDESKI, Adam W.
IPC分类号： C07D211/18 , C07F5/02 , C07D213/16
CPC分类号： C07D211/18 , C07D213/16 , C07F5/025
摘要： The present invention is an improved method for the preparation of 4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester, compound of formula I. The invention is directed to a method of synthesis for the compound of formula I in three steps, comprising formation of 5-((tert-butoxycarbonyl)aminomethyl)-2-fluorobenzeneboronic acid (compound 11), reaction of compound 11 under Suzuki coupling conditions to yield (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester and selective hydrogenation of the aforementioned product under hydrogenation conditions yields compound I. The invention is also directed to the intermediates 5-((tert-Butoxycarbonyl)amino-methyl)-2-fluorobenzeneboronic acid (compound 11), and (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester (compound 13).
摘要翻译：本发明是制备4-氟-3-哌啶-4-基 - 苄基） - 氨基甲酸叔丁酯，式I化合物的改进方法。本发明涉及一种合成化合物的方法的式I化合物包括形成5 - （（叔丁氧基羰基）氨基甲基）-2-氟苯硼酸（化合物11），化合物11在Suzuki偶联条件下反应，得到（4-氟-2-吡啶-4-基 - 苄基） - 氨基甲酸叔丁酯，并在氢化条件下对上述产物进行选择性氢化，得到化合物I.本发明还涉及中间体5 - （（叔丁氧基羰基）氨基 - 甲基）-2-氟苯硼（化合物11）和（4-氟-2-吡啶-4-基 - 苄基） - 氨基甲酸叔丁酯（化合物13）。

3. 发明申请

WO2008109786A3 REGIO-SELECTIVE ULLMANN SYNTHESIS OF 4-BROMO-3-METHYL-5-PROPOXY-THIOPHENE-2-CARBOXYLIC ACID 审中-公开
标题翻译：选择性雷蒙曼合成4-溴-3-甲基-5-丙氧基噻吩-2-羧酸
公开(公告)号：WO2008109786A3
公开(公告)日：2008-12-11
申请号：PCT/US2008056112
申请日：2008-03-07
申请人： SANOFI AVENTIS , AYERS TIMOTHY A , GELORMINI ANN MARIE , SHAY JOHN J JR , SLEDESKI ADAM W , YU YONG
发明人： AYERS TIMOTHY A , GELORMINI ANN MARIE , SHAY JOHN J JR , SLEDESKI ADAM W , YU YONG
IPC分类号： C07D333/38
CPC分类号： C07D333/38
摘要： This invention is directed to a two step regio-selective Ullmann synthesis of 4-bromo-3- methyl-5-propoxy-thiophene-2-carboxylic acid compound of formula 16 comprising the steps of brominating 3-methyl-thiophene-2-carboxylic acid to yield 4,5-dibromo-3-methyl- thiophene-2-carboxylic acid in appropriate bromination organic solvent, and then effecting the selective Ullmann coupling of the 4,5-dibromo-3-methyl-thiophene-2-carboxylic cid with alkali metal propoxide salt using copper catalyst in propanol to yield the compound of formula 16.
摘要翻译：本发明涉及式16的4-溴-3-甲基-5-丙氧基 - 噻吩-2-羧酸化合物的两步区域选择性乌尔曼合成，该方法包括溴化3-甲基 - 噻吩-2-羧酸在合适的溴化有机溶剂中生成4,5-二溴-3-甲基噻吩-2-羧酸，然后进行4,5-二溴-3-甲基噻吩-2-羧酸cid的选择性乌尔曼偶联与碱金属丙氧化物盐在丙醇中使用铜催化剂反应，得到式16化合物。

4. 发明申请

WO0040584A3 PROCESS FOR PREPARING N6-SUBSTITUTED DEAZA-ADENOSINE DERIVATIVES 审中-公开
标题翻译：制备N6-取代的哒嗪 - 腺苷衍生物的方法
公开(公告)号：WO0040584A3
公开(公告)日：2000-11-02
申请号：PCT/US9929841
申请日：1999-12-15
申请人： AVENTIS PHARM PROD INC , SLEDESKI ADAM W , GRONDARD LUC , POWERS MATTHEW R , POWNER TORY H , BRIEN MICHAEL K O , TSUEI CHING T , LEON PATRICK , KUBIAK GREGORY G , PAILLERES HUBERT LAURENCE , VIGUIER BENOIT
发明人： SLEDESKI ADAM W , GRONDARD LUC , POWERS MATTHEW R , POWNER TORY H , O'BRIEN MICHAEL K , TSUEI CHING T , LEON PATRICK , KUBIAK GREGORY G , PAILLERES-HUBERT LAURENCE , VIGUIER BENOIT
IPC分类号： A61K31/437 , A61P3/06 , A61P9/10 , A61P9/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07H19/23
CPC分类号： C07D409/12 , C07D471/04
摘要： This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
摘要翻译：本发明涉及一种制备N6-取代的腺苷衍生物的方法，涉及对其有用的中间体以及制备这些中间体的方法。

5. 发明申请

WO2007118010A1 IMPROVEMENTS IN THE PREPARATION OF INTERMEDIATES LEADING TO [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(4-BROMO-3-METHYL-5-PROPOXY-THIOPHEN-2YL)-METHANONE HYDROCHLORIDE 审中-公开
标题翻译：制备引入到[4-（5-氨基-2-氟 - 苯基） - 哌啶-1-基] - （4-溴-3-甲基-5-丙氧基 - 噻吩-2-基） - 甲基氢氯化物的中间体的改进
公开(公告)号：WO2007118010A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/065339
申请日：2007-03-28
申请人： SANOFI-AVENTIS , SLEDESKI, Adam W.
发明人： SLEDESKI, Adam W.
IPC分类号： C07C327/22 , C07C319/14 , C07C323/52
CPC分类号： C07C327/22 , C07C319/14 , C07C323/52
摘要： The present invention is directed (i) to a method for the preparation of a compound of formula (8) by condensing the compound of formula (7) with acetone and (ii) to a method for the preparation of a compound of formula (13) by alkylating the compound of formula (8) using methyl bromoacetate. The compounds of formula (7,8) and (13) useful intermediates for the preparation of the compound of formula (I).
摘要翻译：本发明涉及（i）通过将式（7）化合物与丙酮缩合制备式（8）化合物的方法，和（ii）制备式（13）化合物的方法）通过使用溴乙酸甲酯烷基化式（8）的化合物。式（7,8）和（13）的化合物可用于制备式（I）化合物的中间体。

6. 发明申请

WO2005097780A1 [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(4-BROMO-3-METHYL-5-PROPOXY-THIOPHEN-2-YL)-METHANONE HYDROCHLORIDE AS AN INHIBITOR OF MAST CELL TRYPTASE 审中-公开
标题翻译： - （4-氨基-2-乙基-2-苯基） - 哌啶-1-基] - （4-溴-3-甲基-5-丙氧基 - 噻吩-2-基） - 甲醇氢氯化物作为细胞的抑制剂类胰蛋白酶
公开(公告)号：WO2005097780A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/009899
申请日：2005-03-24
申请人： AVENTIS PHARMACEUTICALS INC. , GAO, Zhongli , DAVIS, Larry , LEVELL, Julian , CZEKAJ, Mark , SLEDESKI, Adam, W. , HADDAD, El-Bdaoui
发明人： GAO, Zhongli , DAVIS, Larry , LEVELL, Julian , CZEKAJ, Mark , SLEDESKI, Adam, W. , HADDAD, El-Bdaoui
IPC分类号： C07D409/06
CPC分类号： C07D409/06
摘要： The present invention extends to the compound of formula I, or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed to the use of a compound of formula I as an inhibitor of tryptase, comprising introducing the compound into a composition comprising tryptase. In addition, the present invention is directed to the use of a compound of formula I for treating a patient suffering from, or subject to, a physiological condition in need of amelioration of an inhibitor of tryptase comprising administering to the patient a therapeutically effective amount of the compound of Claim 1. The present invention is directed also to the preparation of a compound of formula I.
摘要翻译：本发明延伸到式I化合物，或所述化合物的前药，药学上可接受的盐或溶剂合物。此外，本发明涉及包含药学有效量的式I化合物和药学上可接受的载体的药物组合物。此外，本发明涉及式I化合物作为类胰蛋白酶抑制剂的用途，其包括将化合物引入包含类胰蛋白酶的组合物中。此外，本发明涉及式I化合物用于治疗患有或受制于需要改善类胰蛋白酶抑制剂的生理条件的患者，包括向患者施用治疗有效量的权利要求1的化合物。本发明还涉及式I化合物的制备。

7. 发明申请

WO0037469A3 PROCESS FOR PREPARING N6-SUBSTITUTED DEAZA-ADENOSINE DERIVATIVES 审中-公开
标题翻译：制备N6取代的DEAZA-ADENOSINE衍生物的方法
公开(公告)号：WO0037469A3
公开(公告)日：2000-09-14
申请号：PCT/US9929643
申请日：1999-12-14
申请人： AVENTIS PHARM PROD INC , SALAZAR RICHARD EM , RODRIGUEZ WALTER , SHERBINE JAMES P , WOODWARD RICK G , SLEDESKI ADAM W , POWERS MATTHEW R , BRIEN MICHAEL K O
发明人： SALAZAR DIANE C , RODRIGUEZ WALTER , SHERBINE JAMES P , WOODWARD RICK G , SLEDESKI ADAM W , POWERS MATTHEW R , O'BRIEN MICHAEL K
IPC分类号： A61K31/437 , A61P3/06 , A61P9/10 , A61P9/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07H19/048
CPC分类号： C07D409/12 , C07D471/04
摘要： This invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
摘要翻译：本发明涉及用于制备N6取代的腺苷衍生物的改进方法，可用于其的中间体以及制备这些中间体的方法。

8. 发明申请

WO1998007696A1 STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL] COMPOUNDS 审中-公开
标题翻译： N- [N-N-（4-（哌啶-4-基）丁氧基）-N-乙基甲基]化合物的稳定的非水解结晶形式
公开(公告)号：WO1998007696A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014756
申请日：1997-08-21
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , CHRZAN, Zofia, J. , MENCEL, James, J. , TOLEDO-VELASQUEZ, David , WINDISCH, Vincent , WOODWARD, Rick, G. , SALAZAR, Diane, C. , VEMURI, Narasimha, M. , GARDETTO, Anthony, J. , POWERS, Matthew, R. , KUBIAK, Gregory, G. , LIU, Robert, C. , VANASSE, Benoit, J. , SHERBINE, James, P. , RODRIGUEZ, Walter , SLEDESKI, Adam, W.
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07D211/06
CPC分类号： C07K5/021 , C07D211/34 , C07K5/0806 , Y02P20/55
摘要： The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperidin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of formula (II) wherein: A, B, Z, E , E , G, R, m, n, and p are as defined herein.
摘要翻译：本发明涉及抗血栓形成化合物N- [N- [N-（4-哌啶-4-基）丁酰基）-N-乙基甘氨酰] - （L） - 天门冬酰基] - （L ） - β-环己基 - 丙氨酸酰胺，制备所述稳定结晶形式的方法，其制备方法及其中间体，本发明还涉及制备式（II）化合物的方法，其中：A，B ，Z，E 1，E 2，G，R，m，n和p如本文所定义。

9. 发明申请

WO2008121669A1 4-BROMO-3-METHYL-5-PROPOXYTHIOPHENE-2-CARBOXYLIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER, ITS REGIO-SPECIFIC SYNTHESIS AND INTERMEDIATE THERETO 审中-公开
标题翻译： 4-溴-3-甲基-5-丙氧基-2-羟基乙酸2,5-二氧代吡咯烷-1-酮，其特异性合成和中间体
公开(公告)号：WO2008121669A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058346
申请日：2008-03-27
申请人： SANOFI-AVENTIS , GELORMINI, Ann, Marie , SHAY, John, Josephe, Jr. , SLEDESKI, Adam, W.
发明人： GELORMINI, Ann, Marie , SHAY, John, Josephe, Jr. , SLEDESKI, Adam, W.
IPC分类号： C07D409/06 , C07D409/12
CPC分类号： C07D409/06 , C07D409/12
摘要： The present invention is directed to 4-bromo-3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester, and intermediate, 3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester, thereto. The present invention is also directed to the regio-specific synthesis of 4-bromo-3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester compound comprising the steps of iodinating 3-methyl-thiophene with an iodinating agent in the presence of a strong base in an non-protic polar or hydrocarbon solvent to yield 2-iodo-4-methylthiophene; Ullmann coupling the 2-iodo-4-methylthiophene with an alkali metal propoxide salt using a copper catalyst in propanol to yield 4-methyl-2-propoxythiophene; coupling the 4-methyl-2-propoxythiophene with CO2 using strong base in an non-protic polar or hydrocarbon solvent to yield 3 methyl-5-propoxy-thiophene-2-carboxylic acid; esterifying the 3 methyl-5-propoxy-thiophene-2-carboxylic acid with N hydroxysuccinimide in the presence of a coupling agent in an non-protic polar, hydrocarbon or halohydrocarbon solvent to yield 3-methyl-5-propoxythiophene-2-carboxylic acid 2,5 dioxo-pyrrolidin-1-yl ester; and brominating the 3-methyl-5-propoxythiophene-2-carboxylic acid 2,5 dioxo-pyrrolidin-1-yl ester with a brominating agent in an inert solvent to yield 4-bromo-3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester.
摘要翻译：本发明涉及4-溴-3-甲基-5-丙氧基噻吩-2-羧酸2,5-二氧代 - 吡咯烷-1-基酯和中间体3-甲基-5-丙氧基噻吩-2-甲酸 2,5-二氧代 - 吡咯烷-1-基酯。本发明还涉及4-溴-3-甲基-5-丙氧基噻吩-2-羧酸2,5-二氧代 - 吡咯烷-1-基酯化合物的区域特异性合成，包括以下步骤：将3-甲基 - 噻吩与碘化剂在非质子极性或烃溶剂中在强碱存在下反应，得到2-碘-4-甲基噻吩; Ullmann使用铜催化剂在丙醇中将2-碘-4-甲基噻吩与碱金属丙醇盐偶联，得到4-甲基-2-丙氧基噻吩; 在非质子极性或烃溶剂中使用强碱将4-甲基-2-丙氧基噻吩与CO 2偶联，得到3甲基-5-丙氧基 - 噻吩-2-羧酸; 在非质子极性，烃或卤代烃溶剂中，在偶联剂存在下，用N羟基琥珀酰亚胺酯化3-甲基-5-丙氧基 - 噻吩-2-羧酸，得到3-甲基-5-丙氧基噻吩-2-羧酸 2,5-二氧代 - 吡咯烷-1-基酯; 并用溴化剂在惰性溶剂中溴化3-甲基-5-丙氧基噻吩-2-羧酸2,5二氧代 - 吡咯烷-1-基酯，得到4-溴-3-甲基-5-丙氧基噻吩-2-基酯羧酸2,5-二氧代 - 吡咯烷-1-基酯。

10. 发明申请

WO2008121666A1 USE OF 4-BROMO-3-METHYL-5-PROPOXYTHIOPHENE-2-CARBOXYLIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER FOR PREPARING THE TRYPTASE INHIBITOR [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(4-BROMO-3-METHYL-5-PROPOXY-THIOPHEN-2-YL)-METHANONE 审中-公开
标题翻译： 4-溴-3-甲基-5-丙氧基-2-羧酸的制备用于制备TRYPTASE抑制剂[4-（5-氨基乙基-2-氟 - 苯基）] - 的二氧杂环戊烯-2-酮哌啶-1-基] - （4-溴-3-甲基-5-丙氧基 - 噻吩-2-基） - 甲
公开(公告)号：WO2008121666A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058341
申请日：2008-03-27
申请人： SANOFI-AVENTIS , GELORMINI, Ann, Marie , SLEDESKI, Adam, W. , SHAY, John, Joseph, Jr.
发明人： GELORMINI, Ann, Marie , SLEDESKI, Adam, W. , SHAY, John, Joseph, Jr.
IPC分类号： C07D409/06
CPC分类号： C07D409/06
摘要： This invention is directed to a five step regio-specific synthesis of 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid compound of formula 16 comprising the steps of acetalating 3-methyl-thiophene-2-carbaldehyde in an alcohol solvent; iodinating the acetalated 3-methyl-thiophene-2-carbaldehyde in an non-protic polar or hydrocarbon solvent to yield the corresponding iodinated and acetalated 3-methyl-thiophene-2-carbaldehyde product; treating the iodinated and acetalated product with water to yield the corresponding 5-iodo-3-methyl-thiophene-2-carbaldehyde; oxidizing the 5-iodo-3-methyl-thiophene-2-carbaldehyde to the corresponding 5-iodo-3-methyl-thiophene-2-carboxylic acid in ketone solvent; Ullmann coupling of the 5-iodo-3-methyl-thiophene-2-carboxylic acid with alkali metal propoxide salt using a copper catalyst in propanol to yield 3-methyl-5-propoxy-thiophene-2-carboxylic acid; esterifying 3-methyl-5-propoxy-thiophene-2-carboxylic acid to yield the corresponding alkyl 3-methyl-5-propoxy-thiophene-2-carboxylate; brominating the 3-methyl-5-propoxy-thiophene-2-carboxylic acid to yield the corresponding alkyl 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylate; and basic hydrolyzing the alkyl 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylate with base to yield 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid.
摘要翻译：本发明涉及式16的4-溴-3-甲基-5-丙氧基 - 噻吩-2-羧酸化合物的五步区域特异性合成，包括以下步骤：将3-甲基 - 噻吩-2-甲醛缩醛醇溶剂; 在非质子极性或烃溶剂中碘化缩醛化的3-甲基 - 噻吩-2-甲醛，得到相应的碘化和缩醛化的3-甲基 - 噻吩-2-甲醛产物; 用水处理碘化和缩醛产物，得到相应的5-碘-3-甲基 - 噻吩-2-甲醛; 在酮溶剂中将5-碘-3-甲基 - 噻吩-2-甲醛氧化成相应的5-碘-3-甲基 - 噻吩-2-羧酸; 使用铜催化剂在丙醇中的5-碘-3-甲基 - 噻吩-2-羧酸与碱金属丙醇盐的Ullmann偶联，得到3-甲基-5-丙氧基 - 噻吩-2-羧酸; 酯化3-甲基-5-丙氧基 - 噻吩-2-羧酸，得到相应的3-甲基-5-丙氧基 - 噻吩-2-甲酸烷基酯; 溴化3-甲基-5-丙氧基 - 噻吩-2-羧酸，得到相应的4-溴-3-甲基-5-丙氧基 - 噻吩-2-羧酸烷基酯; 并用碱碱性水解4-溴-3-甲基-5-丙氧基 - 噻吩-2-羧酸烷基酯，得到4-溴-3-甲基-5-丙氧基 - 噻吩-2-羧酸。

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