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1. 发明申请

WO2014099870A1 ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：住院镜片
公开(公告)号：WO2014099870A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/075591
申请日：2013-12-17
申请人： NOVARTIS AG , SIMPSON, Michael, J.
发明人： SIMPSON, Michael, J.
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1682
摘要： A dynamic accommodative intraocular lens is provided in which a central lens portion of the intraocular lens undergoes dynamic change in curvature to adjust focus from distant objects to those nearby in response to natural accommodative actions of the patient's eye. The intraocular lens utilizes fluid movement from flexible fluid reservoirs defined along or adjacent haptic elements of the intraocular lens, which are engaged and compressed by the accommodating movements of the ciliary body of the patient's eye to cause expansion and flattening of the intraocular lens to adjust the optic power of the lens.
摘要翻译：提供了一种动态调节眼内透镜，其中眼内透镜的中心透镜部分经历曲率的动态变化，以响应于患者眼睛的自然调节作用将焦距从远处物体调整到附近的物体。眼内透镜利用由沿着或相邻的眼内透镜的触觉元件限定的柔性流体储存器的流体运动，其通过患者眼睛的睫状体的容纳运动而接合和压缩，以引起眼内透镜的扩张和变平，透镜的光学功率。

2. 发明申请

WO2013000967A9 SMOKING ARTICLE FILTER AND INSERTABLE FILTER UNIT THEREFOR 审中-公开
标题翻译：吸烟制品过滤器和插入式过滤器单元
公开(公告)号：WO2013000967A9
公开(公告)日：2013-02-21
申请号：PCT/EP2012062496
申请日：2012-06-27
申请人： BRITISH AMERICAN TOBACCO CO , PENROSE GRAHAM , MALTHOUSE MICHAEL , WAKE DAVID , FULCHER GARY , SIMPSON MICHAEL , BROOKBANK AARON , GRIERSON GORDON , HINDLEY JON , SAMPSON JOHN , KHAN-DAR RABYA , KALJURA KARL , ONG NELSON , RICHARDSON JOHN , MAJOR JOHN , YOUNG RICHARD
发明人： PENROSE GRAHAM , MALTHOUSE MICHAEL , WAKE DAVID , FULCHER GARY , SIMPSON MICHAEL , BROOKBANK AARON , GRIERSON GORDON , HINDLEY JON , SAMPSON JOHN , KHAN-DAR RABYA , KALJURA KARL , ONG NELSON , RICHARDSON JOHN , MAJOR JOHN , YOUNG RICHARD
IPC分类号： A24D3/04 , A24D3/06
CPC分类号： A24D3/04 , A24D3/048 , A24D3/061 , A24D3/14
摘要： A smoking article filter (20) comprises a recess (25) to receive a filter insert unit (30). The filter insert unit (30) is secured to the filter (20) once inserted. The filter (20) and the filter insert unit (30) may comprise additives such as flavourants, colourants or sorbents.
摘要翻译：吸烟制品过滤器（20）包括容纳过滤器插入单元（30）的凹部（25）。过滤器插入单元（30）一旦插入就被固定到过滤器（20）。过滤器（20）和过滤插件单元（30）可以包括添加剂，例如香料，着色剂或吸附剂。

3. 发明申请

WO2008137425A3 IOL PERIPHERAL SURFACE DESIGNS TO REDUCE NEGATIVE DYSPHOTOPSIA 审中-公开
标题翻译： IOL外围表面设计减少负面的DYSPHOTOPSIA
公开(公告)号：WO2008137425A3
公开(公告)日：2009-03-19
申请号：PCT/US2008061905
申请日：2008-04-29
申请人： ALCON RES LTD , SIMPSON MICHAEL J , STANLEY DAN , ZHANG XIAOXIAO , ELLIS K SCOTT
发明人： SIMPSON MICHAEL J , STANLEY DAN , ZHANG XIAOXIAO , ELLIS K SCOTT
IPC分类号： A61F2/16
CPC分类号： A61F2/1656 , A61F2/1613 , A61F2/1654 , A61F2002/1699 , G02C7/044 , G02C2202/20
摘要： An IOL (10) is disclosed that includes an anterior surface (14) and a posterior surface (16) disposed about an optical axis (OA), where the posterior surface includes a central region (20) extending to a peripheral region (22). Once the IOL is implanted in a patient's eye, the anterior surface and the central region of the posterior surface cooperatively form an image of a field of view on the retina and the peripheral region of the posterior surface directs at least some light rays 'incident thereon (e.g., via refraction by the anterior surface) to at least one retinal location offset from the image so as to inhibit dysphotopsia.
摘要翻译：公开了一种IOL（10），其包括围绕光轴（OA）设置的前表面（14）和后表面（16），其中后表面包括延伸到周边区域（22）的中心区域（20）。一旦将IOL植入患者的眼睛中，后表面的前表面和中心区域协同地形成视网膜上的视野的图像，并且后表面的周边区域引导至少一些入射到其上的光线（例如，通过前表面的折射）到偏离图像的至少一个视网膜位置，以便抑制失调。

4. 发明申请

WO2008137419A2 INTRAOCULAR LENS WITH PERIPHERAL REGION DESIGNED TO REDUCE NEGATIVE DYSPHOTOPSIA 审中-公开
标题翻译：具有外围区域的内窥镜被设计为减少负面的皮肤病
公开(公告)号：WO2008137419A2
公开(公告)日：2008-11-13
申请号：PCT/US2008061896
申请日：2008-04-29
申请人： ALCON RES LTD , SIMPSON MICHAEL J , ZHANG XIAOXIAO
发明人： SIMPSON MICHAEL J , ZHANG XIAOXIAO
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1654
摘要： In one aspect, the invention provides an intraocular lens (IOL) that includes an optic and a peripheral optical flange that surrounds the optic. The optic can form an image of a field of view on the IOL user's retina and the peripheral flange can inhibit dysphotopsia. By way of example, the peripheral flange can include at least one textured surface that is adapted to receive peripheral light rays entering the eye at large visual angles so as to cause their scattering in order to inhibit dysphotopsia, e.g., by preventing the formation of a secondary peripheral image or scattering some light to a shadow region between such a secondary image and an image formed by the IOL.
摘要翻译：一方面，本发明提供了一种眼内透镜（IOL），其包括光学元件和围绕光学元件的外围光学法兰。光学元件可以在IOL用户的视网膜上形成视场图像，并且外围法兰可以抑制异位斑。作为示例，周边凸缘可以包括至少一个纹理表面，其适于以大的视角接收进入眼睛的周边光线，以便使其散射以便抑制异常斑，例如通过防止形成二次周边图像或将一些光散射到这种二次图像与由IOL形成的图像之间的阴影区域。

5. 发明申请

WO2006108004A2 OPTIMAL IOL SHAPE FACTORS FOR HUMAN EYES 审中-公开
标题翻译：人眼的最佳形状因子
公开(公告)号：WO2006108004A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/012571
申请日：2006-04-04
申请人： ALCON, INC. , HONG, Xin , VAN, Stephen, J., Noy , XIE, Jihong , STANLEY, Dan , KARAKELLE, Mutlu , SIMPSON, Michael, J. , ZHANG, Xiaoxiao
发明人： HONG, Xin , VAN, Stephen, J., Noy , XIE, Jihong , STANLEY, Dan , KARAKELLE, Mutlu , SIMPSON, Michael, J. , ZHANG, Xiaoxiao
IPC分类号： A61F2/16 , G02C7/02
CPC分类号： A61F2/1613 , A61F2/1637 , G02C7/02
摘要： The present invention provides an ophthalmic lens (e.g., an intraocular lens) having an optic with an anterior surface and a posterior surface, which exhibits a shape factor (defined as a ratio of the sum of the anterior and posterior curvatures to the difference of such curvatures) in a range of about -0.5 to about 4. In a related aspect, the shape factor of the optic lies in a range of about 0 to about 2. The above shape factors give rise to a plurality of different lens shapes, such as concave-convex, plano-convex and plano-concave.
摘要翻译：本发明提供了具有前表面和后表面的光学元件的眼用透镜（例如，眼内透镜），其呈现形状因子（定义为前曲率和后曲率之和与其之间的差的比值曲率）在约-0.5至约4的范围内。在相关方面，光学元件的形状因子在约0至约2的范围内。上述形状因子产生多个不同的透镜形状，例如作为凹凸，平凸和平凹。

6. 发明申请

WO2005044500A1 MANUFACTURE OF HARDFACED PLATES 审中-公开
标题翻译：硬化板的制造
公开(公告)号：WO2005044500A1
公开(公告)日：2005-05-19
申请号：PCT/GB2003/004562
申请日：2003-10-21
申请人： WELDING ALLOYS LIMITED , SCANDELLA, Jean-Louis , SIMPSON, Michael, Paul , WHITMORE, Leslie
发明人： SCANDELLA, Jean-Louis , SIMPSON, Michael, Paul , WHITMORE, Leslie
IPC分类号： B23K9/04
CPC分类号： B23K9/048
摘要： A method of manufacturing a hardfaced plate (1) by applying a cladding (3) to a surface of a substrate (40) by arc welding, the method comprising moving the substrate (4) and a continuous arc welding wire feed (23) relative to each other, wherein the welding wire feed (23) is in a direction generally transverse to said given direction of relative movement. The welding wire can be fed by a welding gun (23) to the surface of the substrate (4) to be clad from one side of the given direction of relative movement at an acute angle to the surface of the substrate (40).
摘要翻译：一种通过电弧焊将涂层（3）施加到基板（40）的表面上来制造表面硬化板（1）的方法，所述方法包括使基板（4）和连续的电弧焊丝进给（23）相对移动彼此相对，其中焊丝进给（23）在大体上横向于所述给定的相对运动方向的方向上。焊丝可以通过焊枪（23）馈送到基板（4）的表面，以从基板（40）的表面的相对运动的给定方向的一侧以一个锐角的一侧包层。

7. 发明申请

WO2004000003A2 CONTROLLED ALIGNMENT OF CATALYTICALLY GROWN NANOSTRUCTURES IN A LARGE-SCALE SYNTHESIS PROCESS 审中-公开
标题翻译：大规模合成过程中催化还原纳米结构的控制对准
公开(公告)号：WO2004000003A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/003387
申请日：2003-02-05
申请人： UT-BATTELLE, LLC , MERKULOV , MELECHKO, Anatoli, V. , GUILLORN, Michael, A. , LOWNDES, Douglas, H. , SIMPSON, Michael, L.
发明人： MELECHKO, Anatoli, V. , GUILLORN, Michael, A. , LOWNDES, Douglas, H. , SIMPSON, Michael, L.
IPC分类号： A61K9/14 , B82B1/00 , C01B31/02 , C23C16/26 , D01F9/127 , G01N33/543 , H01J1/304 , H01J1/62 , H01J37/32 , H01L21/44 , H01L21/8234 , H01L21/8244 , H01L29/06 , H01L31/0328 , H01L31/0336 , H01L31/072 , H01L31/109
CPC分类号： G01N33/5438 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/08 , D01F9/127 , Y10S977/843 , Y10S977/891 , Y10S977/943 , Y10T428/24628
摘要： Systems and methods are described for controlled alignment of catalytically grown nanostructures in a large-scale synthesis process. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.
摘要翻译：描述了用于在大规模合成过程中催化生长的纳米结构的受控比对的系统和方法。一种方法包括：在电极的突出部分的边缘附近产生电场，所述电场限定矢量; 以及形成位于基底表面上的位置处的细长纳米结构，所述基底表面上靠近所述电极的突出部分的边缘的位置，至少一个细长纳米结构的切线i）基本上平行于所述载体由电场限定，ii）基本上不平行于由衬底的表面限定的法线。

8. 发明申请

WO2002068754A3 CARBON TIPS WITH EXPANDED BASES 审中-公开
公开(公告)号：WO2002068754A3
公开(公告)日：2002-09-06
申请号：PCT/US2002/005848
申请日：2002-02-27
申请人： UT BATTELLE, LLC , MERKULOV, Vladimir, I. , LOWNDES, Douglas, H. , GUILLORN, Michael, A. , SIMPSON, Michael, L.
发明人： MERKULOV, Vladimir, I. , LOWNDES, Douglas, H. , GUILLORN, Michael, A. , SIMPSON, Michael, L.
IPC分类号： H01L51/40
摘要： Systems and methods are described for carbon tips (VACNF) with expanded bases (CNC). A method includes producing an expanded base (CNC) carbon containing tip (VACNF) including: fabricating a carbon containing expanded base (CNC) on a substrate (110); and then fabricating a carbon containing fiber (VACNF) on the expanded base (CNC). An apparatus includes a carbon containing expanded base (CNC) coupled to a substrate (110); and a carbon containing fiber (VACNF) coupled to said carbon containing expanded base (CNC).

9. 发明申请

WO2021214718A1 FAST-ACTING TOGGLING ARMATURE USES CENTRING 审中-公开
公开(公告)号：WO2021214718A1
公开(公告)日：2021-10-28
申请号：PCT/IB2021/053349
申请日：2021-04-22
申请人： CHEESECAKE ENERGY LTD , WASTLING, Michael , GARVEY, Seamus , ROBERTS, Samuel , SIMPSON, Michael , CARDENAS, Bruno , GARVEY, James , COOKE, Henry , FRANKLIN, Henry , KANTHARAJ, Bharath
发明人： WASTLING, Michael , GARVEY, Seamus , ROBERTS, Samuel , SIMPSON, Michael , CARDENAS, Bruno , GARVEY, James , COOKE, Henry , FRANKLIN, Henry , KANTHARAJ, Bharath
IPC分类号： F01L9/21
摘要： A translating actuator acting between two extreme positions defined by mechanical stops is described. Said actuator comprises: an armature mass movable relative to the armature body, a stiff armature spring set such that the natural resting position of the armature mass is close to the centre of travel between the two extreme positions and pair of latches with sufficient holding force that the armature mass can be held at either extreme position against the restoring force of the spring and can be released quickly relative to the natural period of vibration determined by the armature mass on the armature spring.

10. 发明申请

WO2012107706A8 PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE 审中-公开
标题翻译：双酚钠金属盐及其使用
公开(公告)号：WO2012107706A8
公开(公告)日：2013-09-19
申请号：PCT/GB2011001221
申请日：2011-08-15
申请人： WISTA LAB LTD , MARSHALL COLIN , CLUNAS SCOTT , STOREY JOHN MERVYN DAVID , SINCLAIR JAMES PETER , BADDELEY THOMAS CRAVEN , ISHAQ AHTSHAM , SIMPSON MICHAEL , WILLIAMSON CRAIG , WOOD BARRY ALAN , WISCHIK CLAUDE MICHEL , HARRINGTON CHARLES ROBERT , RICKARD JANET ELIZABETH , HORSLEY DAVID , LOH YIN SZE , KHAN KARRAR AHMAD
发明人： MARSHALL COLIN , CLUNAS SCOTT , STOREY JOHN MERVYN DAVID , SINCLAIR JAMES PETER , BADDELEY THOMAS CRAVEN , ISHAQ AHTSHAM , SIMPSON MICHAEL , WILLIAMSON CRAIG , WOOD BARRY ALAN , WISCHIK CLAUDE MICHEL , HARRINGTON CHARLES ROBERT , RICKARD JANET ELIZABETH , HORSLEY DAVID , LOH YIN SZE , KHAN KARRAR AHMAD
IPC分类号： C07D279/20 , A61K31/5415 , A61P25/00
CPC分类号： A61K31/5415 , A61K9/0053 , A61K9/2095 , A61K9/2893 , A61L2/0052 , C07C303/32 , C07C309/04 , C07C309/05 , C07C309/30 , C07C309/35 , C07D279/20
摘要： The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.
摘要翻译：本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

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