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1. 发明申请

WO2005072294A2 GLAUCOMA TREATMENT METHOD 审中-公开
标题翻译： GLAUCOMA治疗方法
公开(公告)号：WO2005072294A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002118
申请日：2005-01-24
申请人： SOLX, INC. , SIMON, Gabriel
发明人： SIMON, Gabriel
IPC分类号： A61B18/20 , A61F9/007 , A61F9/008
CPC分类号： A61F9/00781 , A61B18/20 , A61F9/008 , A61F9/00802 , A61F2009/00868 , A61F2009/00891
摘要： Embodiments of the present invention provide a method and system of treating intraocular pressure. Laser light is directed to the ciliary region of the target eye. The light stimulates the ciliary region and ablates debris lodged therein. An immune response may be triggered by the stimulation of the ciliary body. Intraocular pressure is reduced by the increase in aqueous flow from the anterior chamber in the eye permitted by the resultant removal of debris blocking the uveo-scleral outflow pathway.
摘要翻译：本发明的实施例提供了一种治疗眼内压的方法和系统。激光照射到目标眼睛的纤毛区域。光刺激睫状区，并消除其中的碎屑。免疫反应可能由刺激睫状体引起。眼睛压力由于眼睛前房的水流量的增加而减少，这是由于去除阻塞葡萄膜巩膜流出通道的碎屑所致。

2. 发明申请

WO1997017903A1 LASER BEAM OPHTHALMOLOGICAL SURGERY METHOD AND APPARATUS 审中-公开
标题翻译：激光光学手术方法和装置
公开(公告)号：WO1997017903A1
公开(公告)日：1997-05-22
申请号：PCT/US1996018009
申请日：1996-11-12
申请人： SIMON, Gabriel , HUANG, Cheng-Hao
IPC分类号： A61B17/36
CPC分类号： A61F9/008 , A61B2017/00199 , A61B2018/20351 , A61B2018/20359 , A61B2018/208 , A61F9/00804 , A61F2009/00844 , A61F2009/00872 , A61F2009/00897
摘要： A laser beam ophthalmological surgery method for ablating a cornea (16) of a patient's eye includes the steps of generating a laser beam (12) and directing the generated laser beam onto a scanner (13) and scanning the laser beam (12) in a random scanning pattern with a generated random scanning pattern signal on the surface of the cornea (16) of a patient to ablate the surface of the cornea of a patient's eye. A computer (17) generates the random pattern laser beam control signal which controls the scanner (13) to scan in the random scanning pattern over the cornea (16) and includes selecting a database of non-random scanning points to scan the laser beam onto the cornea (16) of a patient's eye and then randomly selects the non-random scanning points for the random scanning of predetermined scanning points. A laser ophthalmological surgery apparatus (10) is provided which includes a laser (11) for generating a laser beam (12) along with a scanner (13) positioned for receiving the laser beam (12) and producing a predetermined scanning pattern onto the cornea (16) of an eye. A computer (17) is used to generate a random scanning pattern signal and is connected to the scanner (13) for controlling the scanner in a random overlapping scanning beam pattern over a predetermined area.
摘要翻译：一种用于消除患者眼睛角膜（16）的激光束眼科手术方法包括以下步骤：产生激光束（12）并将所产生的激光束引导到扫描器（13）上并且将激光束（12）扫描在扫描仪随机扫描图案，其具有在患者的角膜（16）的表面上产生的随机扫描图案信号，以消除患者眼睛的角膜的表面。计算机（17）产生随机图案激光束控制信号，其控制扫描仪（13）以随机扫描图案扫描角膜（16），并且包括选择非随机扫描点的数据库以将激光束扫描到然后随机选择用于随机扫描预定扫描点的非随机扫描点的患者眼睛的角膜（16）。提供了一种激光眼科手术设备（10），其包括用于产生激光束（12）的激光器（11），以及定位成用于接收激光束（12）的扫描器（13）并且产生预定的扫描图案到角膜（16）眼睛。计算机（17）用于产生随机扫描图案信号，并连接到扫描仪（13），用于在预定区域上以随机重叠的扫描光束图案控制扫描仪。

3. 发明申请

WO2013192298A1 APOPTOSIS BIOMARKERS 审中-公开
标题翻译：杀虫剂生物标志物
公开(公告)号：WO2013192298A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/046554
申请日：2013-06-19
申请人： THE SCRIPPS RESEARCH INSTITUTE , DIX, Melissa , SIMON, Gabriel, M. , CRAVATT, Benjamin, F.
发明人： DIX, Melissa , SIMON, Gabriel, M. , CRAVATT, Benjamin, F.
IPC分类号： C07K7/08 , G01N33/68
CPC分类号： G01N33/6848 , C07K14/4747 , G01N2333/96413 , G01N2510/00
摘要： The present invention provides novel biomarkers for apoptosis. The apoptosis biomarkers comprise a polypeptide with a caspase cleaved terminus and also a phosphotylaCed amino acid residue located close to the terminus (e.g., within about 15 residues). The invention also provides methods of using such biomarkers to monitor apoptotic activities and methods for identifying apoptosis biomarkers in various cellular systems.
摘要翻译：本发明提供新的凋亡生物标志物。凋亡生物标志物包含具有胱天蛋白酶切割末端的多肽，以及位于接近末端（例如，约15个残基）内的磷酸羟化Ced氨基酸残基。本发明还提供使用这样的生物标志物来监测凋亡活性的方法和用于鉴定各种细胞系统中的凋亡生物标志物的方法。

4. 发明申请

WO2006052669A3 SHUNT FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：交换治疗GLAUCOMA
公开(公告)号：WO2006052669A3
公开(公告)日：2007-09-07
申请号：PCT/US2005039820
申请日：2005-11-03
申请人： SOLX INC , SIMON GABRIEL
发明人： SIMON GABRIEL
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： A system is provided for reducing intraocular pressure, the system having: an implantable shunt, the implantable shunt with a planar member, at least one microchannel disposed within that planar member, and a laser whereby at least one fenestration may be introduced into the microchannel.
摘要翻译：提供了一种用于降低眼内压的系统，所述系统具有：可植入分流器，具有平面构件的可植入分流器，设置在该平面构件内的至少一个微通道和激光器，由此至少一个开窗可以被引入微通道。

5. 发明申请

WO2017223387A1 WIRELESS GLAUCOMA THERAPY 审中-公开
标题翻译：无线GLAUCOMA治疗
公开(公告)号：WO2017223387A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038879
申请日：2017-06-22
申请人： IRAZOQUI, Pedro , SIMON, Gabriel , ALBORS, Gabriel Omar , WILLIAMS, Jack , WANG, Zhi , YUAN, Quan , SLAUBAUGH, Curtis
发明人： IRAZOQUI, Pedro , SIMON, Gabriel , ALBORS, Gabriel Omar , WILLIAMS, Jack , WANG, Zhi , YUAN, Quan , SLAUBAUGH, Curtis
IPC分类号： A61N1/00 , A61N1/36 , A61N1/40 , A61N2/00 , A61N2/02 , A61N2/06
摘要： Systems and methods for wireless glaucoma therapy involving the administration of energy to an eye of a mammalian subject in a therapeutically effective amount sufficient to (1) decrease the inflow of aqueous humor into the anterior segment of the eye and/or (2) increase the outflow of aqueous humor from the anterior segment of the eye. Systems and methods involve the use of wireless power transfer (WPT) and optional stimulus coils adapted to be positioned on and/or within the eye. A Frensel lens is also disclosed for vision correction, which may be used alone or in combination with the system for wireless glaucoma therapy.
摘要翻译：用于无线青光眼治疗的系统和方法，涉及以足以（1）减少房水流入眼睛前部的治疗有效量向哺乳动物受试者的眼睛施用能量的系统和方法和/或（2）增加房水从眼前节流出。系统和方法涉及使用无线功率传输（WPT）和可选的刺激线圈，所述刺激线圈适于定位在眼睛上和/或眼内。 Frensel透镜也被公开用于视力矫正，其可以单独使用或与用于无线青光眼治疗的系统组合使用。

6. 发明申请

WO2004110391A3 SHUNT FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：交换治疗GLAUCOMA
公开(公告)号：WO2004110391A3
公开(公告)日：2006-12-28
申请号：PCT/US2004019836
申请日：2004-06-16
申请人： SOLX INC , SIMON GABRIEL
发明人： SIMON GABRIEL
IPC分类号： A61M5/00 , A61F9/007
CPC分类号： A61F9/00781
摘要： A system is provided for reducing intraocular hypertension, the system comprising an implantable shunt, comprising a planar member having at least one microchannel disposed within the planar member. There is an inflow port disposed proximate to a first end of the microchannel and an outflow port disposed proximate to a second end of the microchannel, wherein the inflow port is configured such that when the implantable shunt is implanted, the inflow port is located about approximately within the region of an angle of an anterior chamber.
摘要翻译：提供了一种用于减少眼内高血压的系统，所述系统包括可植入分流器，包括平面构件，其具有设置在平面构件内的至少一个微通道。存在靠近微通道的第一端设置的流入端口和靠近微通道的第二端设置的流出端口，其中流入端口被配置为使得当植入式分流器被植入时，流入端口位于约大约在前房角度的区域内。

7. 发明申请

WO2005072294A3 GLAUCOMA TREATMENT METHOD 审中-公开
标题翻译： GLAUCOMA治疗方法
公开(公告)号：WO2005072294A3
公开(公告)日：2006-08-31
申请号：PCT/US2005002118
申请日：2005-01-24
申请人： SOLX INC , SIMON GABRIEL
发明人： SIMON GABRIEL
IPC分类号： A61B18/18 , A61B18/20 , A61F9/007 , A61F9/008
CPC分类号： A61F9/00781 , A61B18/20 , A61F9/008 , A61F9/00802 , A61F2009/00868 , A61F2009/00891
摘要： Embodiments of the present invention provide a method and system of treating intraocular pressure. Laser light is directed to the ciliary region of the target eye. The light stimulates the ciliary region and ablates debris lodged therein. An immune response may be triggered by the stimulation of the ciliary body. Intraocular pressure is reduced by the increase in aqueous flow from the anterior chamber in the eye permitted by the resultant removal of debris blocking the uveo-scleral outflow pathway.
摘要翻译：本发明的实施例提供了一种治疗眼内压的方法和系统。激光照射到目标眼睛的纤毛区域。光刺激睫状区，并消除放在其中的碎屑。免疫反应可能是刺激睫状体引起的。眼睛压力通过从眼睛前房的水流量的增加而减少，允许通过去除堵塞葡萄膜巩膜流出道的碎屑。

8. 发明申请

WO2006052669A2 SHUNT FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：交流治疗GLAUCOMA
公开(公告)号：WO2006052669A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/039820
申请日：2005-11-03
申请人： SOLX, INC. , SIMON, Gabriel
发明人： SIMON, Gabriel
IPC分类号： A61M5/00 , A61F2/14
CPC分类号： A61F9/00781
摘要： A system is provided for reducing intraocular pressure, the system having: an implantable shunt, the implantable shunt with a planar member, at least one microchannel disposed within that planar member, and a laser whereby at least one fenestration may be introduced into the microchannel.
摘要翻译：提供了一种用于降低眼内压的系统，所述系统具有：可植入分流器，具有平面构件的可植入分路器，设置在该平面构件内的至少一个微通道和激光器，由此至少一个开窗可以被引入微通道。

9. 发明申请

WO2004110391A2 SHUNT FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：交换治疗GLAUCOMA
公开(公告)号：WO2004110391A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/019836
申请日：2004-06-16
申请人： SOLX, INC. , SIMON, Gabriel
发明人： SIMON, Gabriel
IPC分类号： A61K
CPC分类号： A61F9/00781
摘要： A system is provided for reducing intraocular hypertension, the system comprising an implantable shunt, comprising a planar member having at least one microchannel disposed within the planar member. There is an inflow port disposed proximate to a first end of the microchannel and an outflow port disposed proximate to a second end of the microchannel, wherein the inflow port is configured such that when the implantable shunt is implanted, the inflow port is located about approximately within the region of an angle of an anterior chamber.
摘要翻译：提供了一种用于减少眼内高血压的系统，所述系统包括可植入分流器，包括平面构件，其具有设置在平面构件内的至少一个微通道。存在靠近微通道的第一端设置的流入端口和靠近微通道的第二端设置的流出端口，其中流入端口被配置为使得当植入式分流器被植入时，流入端口位于约大约在前房角度的区域内。

10. 发明申请

WO2004075041B1 INTERACTIVE ELECTRONIC SCREEN FOR THE ACQUISITION AND RESTITUTION OF MANUALLY INPUTTED GRAPHIC INFORMATION 审中-公开
标题翻译：用于手动输入图形信息的获取和改进的交互式电子屏幕
公开(公告)号：WO2004075041B1
公开(公告)日：2004-10-28
申请号：PCT/FR2004000306
申请日：2004-02-11
申请人： SIMON GABRIEL , SIMON ADRIEN
发明人： SIMON GABRIEL , SIMON ADRIEN
IPC分类号： G06F3/033 , G06F3/041
CPC分类号： G06F3/0412
摘要： The interactive screen is the product of coupling by superposition or fusion of techniques of information acquisition and of graphic instructions by matrix mesh generation of two orthonormed layers of electrons sensitive to an electronic pointer with those of the iconographic restitution thereof by light-emitting diode doped nanometric polymer (conductive polymers). Said information acquisition and restitution peripheral is interactive in real time (and precise to the nanometre) according to manual graphic instructions. It represents an innovation in a graphic configuration computer from its digital slate versions to its interactive wall chart version.
摘要翻译：交互式屏幕是通过叠加或融合信息采集技术与图形指令进行耦合的产物，通过矩阵网格生成对电子指示器敏感的两个电子对称的电子层与通过发光二极管掺杂的纳米尺度的图像恢复聚合物（导电聚合物）。所述信息获取和恢复外围设备根据手动图形指令实时（和精确到纳米）交互。它代表了图形配置计算机从数字平板版本到其交互式壁纸版本的创新。

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