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1. 发明申请

WO2006120473A2 PEPTIDE 审中-公开
标题翻译：肽
公开(公告)号：WO2006120473A2
公开(公告)日：2006-11-16
申请号：PCT/GB2006001769
申请日：2006-05-12
申请人： OXFORD BIOMEDICA LTD , HARROP RICHARD , SHINGLER WILLIAM , KINGSMAN SUSAN
发明人： HARROP RICHARD , SHINGLER WILLIAM , KINGSMAN SUSAN
IPC分类号： C07K14/705 , A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K14/4748 , C07K16/2833
摘要： The present invention relates to peptide epitopes of 5T4 antigen and their use in immunotherapy. In particular, the present invention relates to any one of the peptide epitopes as described herein as well as their use in diagnosis and therapy of cancer.
摘要翻译：本发明涉及5T4抗原的肽表位及其在免疫治疗中的用途。特别地，本发明涉及本文所述的任何肽表位以及它们在诊断和治疗癌症中的用途。

2. 发明申请

WO2008059252A3 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
公开(公告)号：WO2008059252A3
公开(公告)日：2008-12-04
申请号：PCT/GB2007004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA LTD , MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
发明人： MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
IPC分类号： C07K14/47
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.

3. 发明申请

WO2007034188A3 CHEMO-IMMUNOTHERAPY METHOD 审中-公开
标题翻译：化学免疫疗法
公开(公告)号：WO2007034188A3
公开(公告)日：2007-06-14
申请号：PCT/GB2006003507
申请日：2006-09-21
申请人： OXFORD BIOMEDICA LTD , HARROP RICHARD , KELLEHER MICHELLE , SHINGLER WILLIAM , KINGSMAN SUSAN
发明人： HARROP RICHARD , KELLEHER MICHELLE , SHINGLER WILLIAM , KINGSMAN SUSAN
IPC分类号： A61K39/00 , A61K31/00 , A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K39/0011 , A61K2039/545 , A61K2039/57 , A61K2300/00
摘要： A method of treating or preventing a disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.
摘要翻译：一种治疗或预防疾病的方法，所述方法包括同时，先后或分别给受试者施用抗原和化学治疗剂或试剂，所述方法包括以下步骤：施用化疗剂和施用抗原至多6 在化学治疗剂之后数周。

4. 发明申请

WO2010007365A1 IMMUNOTHERAPEUTIC METHOD 审中-公开
标题翻译：免疫学方法
公开(公告)号：WO2010007365A1
公开(公告)日：2010-01-21
申请号：PCT/GB2009/001748
申请日：2009-07-15
申请人： OXFORD BIOMEDICA (UK) LTD , HARROP, Richard , SHINGLER, William , MCDONALD, Michael , NAYLOR, Stuart
发明人： HARROP, Richard , SHINGLER, William , MCDONALD, Michael , NAYLOR, Stuart
IPC分类号： G01N33/68 , A61K39/00 , C12N15/863 , G01N33/574
CPC分类号： G01N33/6854 , A61K39/0011 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C12N2799/023 , G01N33/574 , G01N33/57419 , G01N33/57438 , G01N2800/52
摘要： The present invention provides a method of monitoring the efficacy of an immunotherapy in a mammalian subject, wherein the subject has been administered an immunotherapy, wherein the immunotherapy comprises a viral vector containing a polynucleotide encoding an antigen, wherein the viral vector is capable of transducing cells in the mammalian subject to cause the cells to express the antigen; the method comprising: (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the antigen and comparing the immune response of the subject to the antigen to a reference measurement of immune response to the antigen; (c) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to a reference measurement of immune response to the viral vector; and (d) determining efficacy based on the comparisons of (b) and (c), wherein an elevated immune response to the antigen and a reduced immune response to the viral vector are indicative of an effective immunotherapy.
摘要翻译：本发明提供了一种监测哺乳动物受试者的免疫治疗功效的方法，其中所述受试者已经进行免疫治疗，其中所述免疫治疗包含含有编码抗原的多核苷酸的病毒载体，其中所述病毒载体能够转导细胞在哺乳动物受试者中使细胞表达抗原; 该方法包括：（b）从分离自受试者的生物样品中测量受试者对抗原的免疫应答并将受试者与抗原的免疫应答与抗原的免疫应答的参考测量进行比较; （c）从分离自受试者的生物样品中测量受试者对病毒载体的免疫应答，并将受试者与病毒载体的免疫应答与对病毒载体的免疫应答的参考测量进行比较; 和（d）基于（b）和（c）的比较确定功效，其中对抗原的免疫应答升高和对病毒载体的免疫应答降低是指示有效的免疫治疗。

5. 发明申请

WO2008059252A2 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
标题翻译：识别5T4抗原的方法和组合FRO T细胞受体
公开(公告)号：WO2008059252A2
公开(公告)日：2008-05-22
申请号：PCT/GB2007/004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA (UK) LIMITED , MYERS, Kevin , REDCHENKO, Irina , SHINGLER, William , HARROP, Richard , NAYLOR, Stuart , KINGSMAN, Alan , KINGSMAN, Susan
发明人： MYERS, Kevin , REDCHENKO, Irina , SHINGLER, William , HARROP, Richard , NAYLOR, Stuart , KINGSMAN, Alan , KINGSMAN, Susan
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
摘要翻译：本发明涉及5T4抗原的肽表位在识别和分离识别5T4抗原的T细胞受体中的用途。

6. 发明申请

WO2007034188A2 CHEMO-IMMUNOTHERAPY METHOD 审中-公开
标题翻译：化疗免疫疗法
公开(公告)号：WO2007034188A2
公开(公告)日：2007-03-29
申请号：PCT/GB2006/003507
申请日：2006-09-21
申请人： OXFORD BIOMEDICA (UK) LIMITED , HARROP, Richard , KELLEHER, Michelle , SHINGLER, William , KINGSMAN, Susan
发明人： HARROP, Richard , KELLEHER, Michelle , SHINGLER, William , KINGSMAN, Susan
IPC分类号： A61K39/00 , A61K31/00
CPC分类号： A61K45/06 , A61K31/00 , A61K39/0011 , A61K2039/545 , A61K2039/57 , A61K2300/00
摘要： A method of treating or preventing a disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.
摘要翻译：一种治疗或预防疾病的方法，所述方法包括向受试者同时，依次或分别施用抗原和化学治疗剂或试剂，所述方法包括以下步骤：施用化学治疗剂或试剂，并施用最多6个化疗剂后数周。

7. 发明申请

WO2008059252A9 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
标题翻译：识别5T4抗原的方法和组合物FRO T细胞受体
公开(公告)号：WO2008059252A9
公开(公告)日：2008-09-18
申请号：PCT/GB2007004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA LTD , MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
发明人： MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
摘要翻译：本发明涉及5T4抗原的肽表位在识别和分离识别5T4抗原的T细胞受体中的用途。

8. 发明申请

WO2006120473A3 MHC CLASS I AND II PEPTIDE ANTIGENS DERIVED FROM TUMOUR ANTIGEN 5T4 审中-公开
公开(公告)号：WO2006120473A3
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001769
申请日：2006-05-12
申请人： OXFORD BIOMEDICA (UK) LIMITED , HARROP, Richard , SHINGLER, William , KINGSMAN, Susan
发明人： HARROP, Richard , SHINGLER, William , KINGSMAN, Susan
IPC分类号： C07K14/47 , C07K16/28 , A61K39/395
摘要： The present invention relates to peptide epitopes of 5T4 antigen and their use in immunotherapy. In particular, the present invention relates to any one of the peptide epitopes as described herein as well as their use in diagnosis and therapy of cancer.

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