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1. 发明申请

WO2011094073A4 NEEDLE DESIGN FOR RECORDING MONOPHASIC ACTION POTENTIAL AND DELIVERY OF THERAPY 审中-公开
标题翻译：用于记录单因素行动的针头设计和治疗的递送
公开(公告)号：WO2011094073A4
公开(公告)日：2012-01-19
申请号：PCT/US2011021227
申请日：2011-01-14
申请人： MEDTRONIC INC , URBAN JON F , SHARMA VINOD , STEWART MARK T
发明人： URBAN JON F , SHARMA VINOD , STEWART MARK T
IPC分类号： A61N1/05 , A61B17/00 , A61M25/00
CPC分类号： A61N1/0575 , A61B5/042 , A61B5/6848 , A61B5/6852 , A61B2017/00053 , A61M25/0084 , A61M2025/0089 , A61M2025/0091
摘要： A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.
摘要翻译：系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

2. 发明申请

WO2011153253A1 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 审中-公开
标题翻译：电子与生物学系统
公开(公告)号：WO2011153253A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038779
申请日：2011-06-01
申请人： MEDTRONIC INC. , SHARMA, Vinod , QIU, Xiaohong
发明人： SHARMA, Vinod , QIU, Xiaohong
IPC分类号： C12N15/864 , A61K48/00 , C07K14/47
CPC分类号： C12N15/86 , A61K35/13 , A61K48/005 , A61K48/0075 , C07K14/4705 , C12N2750/14143
摘要： The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214- 723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA. The HCN polynucleotide may be present in a vector, such as a viral vector (including, for instance, a single strand adeno-associated virus or a self complementary adeno-associated virus), a transposon vector, or a plasmid vector.
摘要翻译： HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。 HCN多核苷酸可以存在于载体中，例如病毒载体（包括例如单链腺相关病毒或自身互补腺相关病毒），转座子载体或质粒载体。

3. 发明申请

WO2011094073A2 NEEDLE DESIGN FOR RECORDING MONOPHASIC ACTION POTENTIAL AND DELIVERY OF THERAPY 审中-公开
标题翻译：用于记录单因素行动的针头设计和治疗的递送
公开(公告)号：WO2011094073A2
公开(公告)日：2011-08-04
申请号：PCT/US2011/021227
申请日：2011-01-14
申请人： MEDTRONIC, INC. , URBAN, Jon F. , SHARMA, Vinod , STEWART, Mark T.
发明人： URBAN, Jon F. , SHARMA, Vinod , STEWART, Mark T.
IPC分类号： A61N1/05
CPC分类号： A61N1/0575 , A61B5/042 , A61B5/6848 , A61B5/6852 , A61B2017/00053 , A61M25/0084 , A61M2025/0089 , A61M2025/0091
摘要： A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.
摘要翻译：系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

4. 发明申请

WO2011053381A1 MEASURING T-WAVE ALTERNANS 审中-公开
标题翻译：测量T波形ALTERNANS
公开(公告)号：WO2011053381A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/033366
申请日：2010-05-03
申请人： MEDTRONIC, INC. , SHARMA, Vinod , ZHOU, Xiaohong
发明人： SHARMA, Vinod , ZHOU, Xiaohong
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452
摘要： Techniques for monitoring T-wave alternans (TWAs) in a patient are described. An implantable medical device (IMD) (16), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.
摘要翻译：描述了用于监测患者中的T波交替（TWAs）的技术。诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）（16）产生例如远场EGM信号的EGM信号，对EGM信号进行采样以获得单个T波振幅值在多个节拍中的每个T波，并将T波振幅值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算特定频率的功率谱密度，例如每个节拍0.5个循环，作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。

5. 发明申请

WO2007138435A2 A PROCESS FOR THE PREPARATION OF SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS 审中-公开
标题翻译：一种制备SPIRO和DISPIRO的方法1,2,4-三氯苯醚类抗生素
公开(公告)号：WO2007138435A2
公开(公告)日：2007-12-06
申请号：PCT/IB2007/001374
申请日：2007-05-24
申请人： RANBAXY LABORATORIES LIMITED , YADAV, Gyan Chand , DORWAL, Harish N. , VALAVALA, Srinivas , SHARMA, Vinod Kumar
发明人： YADAV, Gyan Chand , DORWAL, Harish N. , VALAVALA, Srinivas , SHARMA, Vinod Kumar
IPC分类号： C07D323/02
CPC分类号： C07D323/02
摘要： This invention relates to an improved process for the preparation of a compound of Formula (I), salts of the free base cis -adamantane-2-spiro-3'-8'-[[[(2'-amino-2'-methyl propyl) amino] carbonyl] methyl]-1',2',4'-trioxaspiro [4.5] decane wherein X can be an anion.
摘要翻译：本发明涉及制备式（I）化合物的改进方法，游离碱顺式 - 金刚烷-2-螺-3'-8' - [[[（2'-氨基-2'- 甲基丙基）氨基]羰基]甲基] -1'，2'，4'-三氧杂螺[4.5]癸烷，其中X可以是阴离子。

6. 发明申请

WO2018222904A1 TENSOR-BASED COMPUTING SYSTEM FOR QUATERNION OPERATIONS 审中-公开
公开(公告)号：WO2018222904A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035446
申请日：2018-05-31
申请人： INTEL CORPORATION , MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
发明人： MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
IPC分类号： G06N99/00
摘要： A machine-learning system includes a quaternion (QT) computation engine. Input data to the QT computation engine includes quaternion values, each comprising a real component and three imaginary components, represented as a set of real-valued tensors. A single quaternion value is represented as a 1-dimensional real-valued tensor having four real-valued components, wherein a first real-valued component represents the real component of the single quaternion value, and wherein a second, a third, and a fourth real-valued component each respectively represents one of the imaginary components. A quaternion-valued vector having a size N is represented as a 2-dimensional real-valued tensor comprising N 1-dimensional real-valued tensors. A quaternion-valued matrix having N x M dimensions is represented as a 3-dimensional real-valued tensor comprising M 2-dimensional real-valued tensors comprising N 1-dimensional real-valued tensors.

7. 发明申请

WO2018222900A1 COMPUTATIONALLY-EFFICIENT QUATERNION-BASED MACHINE-LEARNING SYSTEM 审中-公开
公开(公告)号：WO2018222900A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035439
申请日：2018-05-31
申请人： INTEL CORPORATION , MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
发明人： MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
IPC分类号： G06N3/04 , G06N99/00
摘要： A quaternion deep neural network (QTDNN) includes a plurality of modular hidden layers, each comprising a set of QT computation sublayers, including a quaternion (QT) general matrix multiplication sublayer, a QT non-linear activations sublayer, and a QT sampling sublayer arranged along a forward signal propagation path. Each QT computation sublayer of the set has a plurality of QT computation engines. In each modular hidden layer, a steering sublayer precedes each of the QT computation sublayers along the forward signal propagation path. The steering sublayer directs a forward-propagating quaternion-valued signal to a selected at least one QT computation engine of a next QT computation subsequent sublayer.

8. 发明申请

WO2018222896A1 GRADIENT-BASED TRAINING ENGINE FOR QUATERNION-BASED MACHINE-LEARNING SYSTEMS 审中-公开
公开(公告)号：WO2018222896A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035431
申请日：2018-05-31
申请人： INTEL CORPORATION , MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
发明人： MARTINEZ-CANALES, Monica Lucia , SINGH, Sudhir K. , SHARMA, Vinod , BHANDARU, Malini Krishnan
IPC分类号： G06N99/00
摘要： A deep neural network (DNN) includes hidden layers arranged along a forward propagation path between an input layer and an output layer. The input layer accepts training data comprising quaternion values, outputs a quaternion-valued signal along the forward path to at least one of the hidden layers. At least some of the hidden layers include quaternion layers to execute consistent quaternion (QT) forward operations based on one or more variable parameters. A loss function engine produces a loss function representing an error between the DNN result and an expected result. QT backpropagation-based training operations include computing layer-wise QT partial derivatives, consistent with an orthogonal basis of quaternion space, of the loss function with respect to a QT conjugate of the one or more variable parameters and of respective inputs to the quaternion layers.

9. 发明申请

WO2008067279A2 BIOLOGICAL PACEMAKERS INCLUDING MUTATED HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS 审中-公开
标题翻译：生物制剂包括突变的高效催化循环核糖核酸（HCN）通道
公开(公告)号：WO2008067279A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085576
申请日：2007-11-27
申请人： MEDTRONIC INC , SIGG DANIEL C , SHARMA VINOD , XIAO YONG-FU
发明人： SIGG DANIEL C , SHARMA VINOD , XIAO YONG-FU
CPC分类号： A61K48/005 , A61K38/00 , C07K14/705
摘要： A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify I h when compared with wild-type HCN. Methods for implementing each of the biological pacemakers include implanting each of biological pacemakers into cardiac tissue.
摘要翻译：用于植入心脏组织的组合物包括生物起搏器，当植入时，与野生型相比，表达有效量的突变的超极化激活和环状核苷酸门控（HCN）同种型以修饰I H 型HCN。实施每个生物起搏器的方法包括将每个生物起搏器植入心脏组织。

10. 发明申请

WO2008039909A1 GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM 审中-公开
标题翻译：心脏导管系统目标区域的遗传修饰
公开(公告)号：WO2008039909A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/079679
申请日：2007-09-27
申请人： MEDTRONIC, INC. , SHARMA, Vinod , OLSON, Walter H.
发明人： SHARMA, Vinod , OLSON, Walter H.
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca 2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生有趣电流的通道或其亚基的表达，并且T型Ca 2 + 通道或其亚基，并表达一种或多种抑制野生型钾通道表达的分子。

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