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1. 发明申请

WO2009149946A1 VERFAHREN ZUR SIMULATION VON IN EINEM DRUCKWASSERREAKTOR AUFTRETENDEN THERMOHYDRAULISCHEN PHÄNOMENEN 审中-公开
标题翻译：方法为在压力水反应堆发生THERMO液压现象模拟
公开(公告)号：WO2009149946A1
公开(公告)日：2009-12-17
申请号：PCT/EP2009/004242
申请日：2009-06-12
申请人： KSG KRAFTWERKS-SIMULATOR-GESELLSCHAFT MBH , SEEWALD, Michael
发明人： SEEWALD, Michael
IPC分类号： G09B9/00 , G09B23/20
CPC分类号： G09B25/025
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Simulation von in einem Druckwasserreaktor in Abhängigkeit des Betriebszustandes auftretenden thermohydraulischen Phänomenen. Zur Simulation von in einem Druckwasserreaktor in Abhängigkeit des Betriebszustandes auftretenden thermohydraulischen Phänomenen werden in einem Glasmodell Heizleistung, Dampfmenge und Hauptkühlmittelpumpe so eingestellt, dass mit in einem realen Reaktor auftretenden thermohydraulischen Phänomenen vergleichbare Phänomene auftreten, wobei die für die Heizleistung, Dampfmenge und Leistung der Hauptkühlmittelpumpe einzustellenden Parameter so gewählt sind, dass die in den einzelnen Teilen der Vorrichtung herrschenden Drücke und Temperaturen in einem nichtlinearen Verhältnis zu den in einem realen Druckwasserreaktor herrschenden Drücken und Temperaturen stehen.
摘要翻译：本发明涉及一种用于在发生热工水力现象操作模式依赖性的压水反应堆模拟的方法。为了模拟在压水反应堆中发生的上操作模式依赖热液压在玻璃模型的加热功率，蒸汽和主冷却剂泵的现象被调节，使得具有类似的现象发生在一个真正的反应器中发生热工水力现象，所述调整主冷却剂泵的加热功率，蒸汽和电力参数被选择成使得提供的压力以非线性的相对于压力在一个真正的压水反应堆的压力和温度普遍在装置的压力和温度的各个部分盛行。

2. 发明申请

WO2008046517A1 CTGF AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： CTGF作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046517A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008590
申请日：2007-10-04
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： G01N33/68 , C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/06 , G01N2800/12 , G01N2800/22 , G01N2800/28 , G01N2800/32 , G01N2800/34
摘要： The invention provides CTGF which is associated with the cardiovascular diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CTGF as well as pharmaceutical compositions comprising such compounds. The invention also provides CTGF as a biomarker for diseases as cardiovascular diseases and hematological diseases
摘要翻译：本发明提供了与心血管疾病和血液疾病相关的CTGF。本发明还提供了用于鉴定可用于治疗或预防心血管疾病和血液疾病的化合物的测定。本发明还涉及结合和/或活化或抑制CTGF活性的化合物以及包含这些化合物的药物组合物。本发明还提供CTGF作为心血管疾病和血液疾病疾病的生物标志物

3. 发明申请

WO2006108582A3 HUMAN MARKER GENES AND AGENTS FOR DIAGNOSIS, TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISORDERS AND ARTHEROSCLEROSIS 审中-公开
公开(公告)号：WO2006108582A3
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003217
申请日：2006-04-08
申请人： CENIX BIOSCIENCE GMBH , BETZ, Ulrich , D'URSO, Donatella , KOLKHOF, Peter , SEEWALD, Michael , STRAYLE, Jochen , GRABNER, Anne , HANNUS, Michael
发明人： BETZ, Ulrich , D'URSO, Donatella , KOLKHOF, Peter , SEEWALD, Michael , STRAYLE, Jochen , GRABNER, Anne , HANNUS, Michael
IPC分类号： G01N33/68 , C12N15/11 , A61K31/713 , C12Q1/68
摘要： The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis .

4. 发明申请

WO2008046512A1 PRSS23 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： PRSS23作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046512A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008562
申请日：2007-10-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： G01N33/68 , G01N33/50
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/948
摘要： The invention provides PRSS23 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases.
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，呼吸系统疾病，肠胃病和泌尿系疾病有关的PRSS23。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，呼吸系统疾病，胃肠疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PRSS23的活性的化合物以及包含这些化合物的药物组合物。本发明还提供PRSS23作为心血管疾病，血液疾病，神经疾病，呼吸系统疾病，胃肠疾病和泌尿系疾病等疾病的生物标志物。

5. 发明申请

WO2006108581A3 HUMAN MARKER GENES AND AGENTS FOR CARDIOVASCULAR DISORDERS AND ARTHEROSCLEROSIS 审中-公开
标题翻译：人类标记基因和心脏病和阿片样物质的代理
公开(公告)号：WO2006108581A3
公开(公告)日：2007-04-12
申请号：PCT/EP2006003216
申请日：2006-04-08
申请人： BAYER HEALTHCARE AG , BETZ ULRICH , D URSO DONATELLA , KOLKHOF PETER , SEEWALD MICHAEL , STRAYLE JOCHEN , GRABNER ANNE , HANNUS MICHAEL
发明人： BETZ ULRICH , D URSO DONATELLA , KOLKHOF PETER , SEEWALD MICHAEL , STRAYLE JOCHEN , GRABNER ANNE , HANNUS MICHAEL
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： G01N33/6893 , G01N2333/91215 , G01N2500/04 , G01N2800/32 , G01N2800/323
摘要： The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention especially relates to antagonists and expression-inhibitory compounds that target G-protein coupled receptors (GPCRs), kinases and proteases, and to methods for identifying such compounds. The invention further relates to methods for identifing these antagonists and expression-inhibitory compounds, and methods for diagnosing a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis or a susceptibility to such a condition.
摘要翻译：本发明涉及筛选用于治疗和/或预防选自包括心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病的疾病的化合物的新靶标。本发明涉及用作涉及选自包含心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病的疾病或病症的药物的新化合物。本发明特别涉及靶向G蛋白偶联受体（GPCR），激酶和蛋白酶的拮抗剂和表达抑制性化合物，以及用于鉴定这些化合物的方法。本发明还涉及用于鉴定这些拮抗剂和表达抑制化合物的方法，以及用于诊断选自包括心血管疾病，脂质代谢紊乱或动脉粥样硬化或对这种病症的易感性的疾病的方法。

6. 发明申请

WO2006108583A2 HUMAN MARKER GENES AND AGENTS FOR DIAGNOSIS, TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISORDERS AND ARTHEROSCLEROSIS 审中-公开
标题翻译：人类基因组和基因药物诊断，治疗和预防心血管疾病和心血管疾病
公开(公告)号：WO2006108583A2
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003218
申请日：2006-04-08
申请人： BAYER HEALTHCARE AG , BETZ, Ulrich , D'URSO, Donatella , KOLKHOF, Peter , SEEWALD, Michael , STRAYLE, Jochen , GRABNER, Anne , HANNUS, Michael
发明人： BETZ, Ulrich , D'URSO, Donatella , KOLKHOF, Peter , SEEWALD, Michael , STRAYLE, Jochen , GRABNER, Anne , HANNUS, Michael
CPC分类号： G01N33/6893 , G01N2333/91215 , G01N2500/04 , G01N2800/32 , G01N2800/323
摘要： The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention especially relates to antagonists and expression-inhibitory compounds that target G-protein coupled receptors (GPCRs), kinases and proteases, and to methods for identifying such compounds. The invention further relates to methods for identifing these antagonists and expression-inhibitory compounds, and methods for diagnosing a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis or a susceptibility to such a condition.
摘要翻译：本发明涉及筛选用于治疗和/或预防选自心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病的化合物的新靶标。本发明涉及用作涉及选自心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病或病症的药物的新型化合物。本发明尤其涉及靶向G-蛋白偶联受体（GPCR），激酶和蛋白酶的拮抗剂和抑制表达的化合物，并且涉及鉴定此类化合物的方法。本发明进一步涉及鉴定这些拮抗剂和表达抑制化合物的方法，以及用于诊断选自心血管疾病，脂质代谢或动脉粥样硬化疾病或对这种疾病的易感性的疾病的方法。

7. 发明申请

WO2006092209A1 NOVEL TARGETS AND COMPOUNDS USEFUL IN THE TREATMENT OF A CARDIOVASCULAR DISORDER, DYSLIPIDEMIA AND ATHEROSCLEROSIS, AND METHODS TO IDENTIFY SUCH COMPOUNDS 审中-公开
标题翻译：用于治疗心血管疾病，血友病和甲状腺功能亢进的新目标和化合物以及鉴别这些化合物的方法
公开(公告)号：WO2006092209A1
公开(公告)日：2006-09-08
申请号：PCT/EP2006/001451
申请日：2006-02-17
申请人： GALAPAGOS NV , BETZ, Ulrich , D'URSO, Donatella , GATSIOS, Petros , SEEWALD, Michael , STRAYLE, Jochen , VAN ES, Helmuth, Hendrikus, Geradus , VAN ZUTPHEN, Marlijn , MESIC, Emir
发明人： BETZ, Ulrich , D'URSO, Donatella , GATSIOS, Petros , SEEWALD, Michael , STRAYLE, Jochen , VAN ES, Helmuth, Hendrikus, Geradus , VAN ZUTPHEN, Marlijn , MESIC, Emir
IPC分类号： G01N33/68 , G01N33/50 , A61K31/70 , A61P1/00 , A61P3/00 , A61P9/00 , A61K47/46
CPC分类号： G01N33/502 , G01N33/6893 , G01N2800/044 , G01N2800/32 , G01N2800/323
摘要： The present invention provides targets and methods for the screening for compounds useful in the prevention, amelioration or treatment of a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis. The invention also relates to the targets that were identified. Inhibiting target genes of the invention, or their expression products, by using compounds identifiable by methods of the invention, is beneficial in the treatment of diseases involving a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis.
摘要翻译：本发明提供了筛选用于预防，改善或治疗心血管疾病，血脂异常和/或动脉粥样硬化的化合物的靶标和方法。本发明还涉及确定的靶标。通过使用通过本发明的方法可鉴定的化合物抑制本发明或其表达产物的靶基因有益于治疗涉及心血管疾病，血脂异常和/或动脉粥样硬化的疾病。

8. 发明申请

WO2008046509A1 LTBP2 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： LTBP2作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046509A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008558
申请日：2007-10-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。本发明还提供LTBP2作为心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病的疾病的生物标志物

9. 发明申请

WO2007000292A2 NOVEL TARGETS AND COMPOUNDS USEFUL IN THE TREATMENT AND/OR PROPHYLAXIS OF A CARDIOVASCULAR DISORDER, DYSLIPIDEMIA AND ATHEROSCLEROSIS, AND METHODS TO IDENTIFY SUCH COMPOUNDS 审中-公开
标题翻译：用于治疗和/或预防心血管疾病，脱脂血症和动脉粥样硬化的新目标和化合物，以及鉴定这些化合物的方法
公开(公告)号：WO2007000292A2
公开(公告)日：2007-01-04
申请号：PCT/EP2006/006117
申请日：2006-06-24
申请人： GALAPAGOS NV , BETZ, Ulrich , D'URSO, Donatella , GATSIOS, Petros , SEEWALD, Michael , STRAYLE, Jochen , VAN ES, Helmuth, Hendrikus, Gerardus , VAN ZUTPHEN, Marlijn , MESIC, Emir
发明人： BETZ, Ulrich , D'URSO, Donatella , GATSIOS, Petros , SEEWALD, Michael , STRAYLE, Jochen , VAN ES, Helmuth, Hendrikus, Gerardus , VAN ZUTPHEN, Marlijn , MESIC, Emir
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2800/044 , G01N2800/32 , G01N2800/323
摘要： The present invention provides targets and methods for the screening for compounds useful in the prevention, amelioration or treatment and/or prophylaxis of a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis. The invention also relates to the targets that were identified. Inhibiting or activating target genes of the invention, or their expression products, by using compounds identifiable by methods of the invention, is beneficial in the treatment and/or prophylaxis of diseases involving a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis.
摘要翻译：本发明提供筛选可用于预防，改善或治疗和/或预防心血管病症，血脂异常和/或动脉粥样硬化的化合物的靶点和方法。本发明还涉及确定的目标。通过使用可通过本发明方法鉴别的化合物来抑制或激活本发明的靶基因或其表达产物有益于治疗和/或预防涉及心血管病症，血脂异常和/或动脉粥样硬化的疾病。

10. 发明申请

WO2007000292A3 NOVEL TARGETS AND COMPOUNDS USEFUL IN THE TREATMENT AND/OR PROPHYLAXIS OF A CARDIOVASCULAR DISORDER, DYSLIPIDEMIA AND ATHEROSCLEROSIS, AND METHODS TO IDENTIFY SUCH COMPOUNDS 审中-公开
标题翻译：用于治疗和/或预防心血管疾病，血糖和脑血管病的新目标和化合物，以及鉴别这些化合物的方法
公开(公告)号：WO2007000292A3
公开(公告)日：2007-08-16
申请号：PCT/EP2006006117
申请日：2006-06-24
申请人： GALAPAGOS NV , BETZ ULRICH , D URSO DONATELLA , GATSIOS PETROS , SEEWALD MICHAEL , STRAYLE JOCHEN , VAN ES HELMUTH HENDRIKUS GERAR , VAN ZUTPHEN MARLIJN , MESIC EMIR
发明人： BETZ ULRICH , D URSO DONATELLA , GATSIOS PETROS , SEEWALD MICHAEL , STRAYLE JOCHEN , VAN ES HELMUTH HENDRIKUS GERAR , VAN ZUTPHEN MARLIJN , MESIC EMIR
IPC分类号： C12Q1/48 , A61K48/00 , A61P3/00 , A61P9/00
CPC分类号： G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2800/044 , G01N2800/32 , G01N2800/323
摘要： The present invention provides targets and methods for the screening for compounds useful in the prevention, amelioration or treatment and/or prophylaxis of a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis. The invention also relates to the targets that were identified. Inhibiting or activating target genes of the invention, or their expression products, by using compounds identifiable by methods of the invention, is beneficial in the treatment and/or prophylaxis of diseases involving a cardiovascular disorder, dyslipidemia, and/or Atherosclerosis.
摘要翻译：本发明提供筛选用于预防，改善或治疗和/或预防心血管疾病，血脂异常和/或动脉粥样硬化的化合物的靶标和方法。本发明还涉及确定的靶标。通过使用通过本发明的方法可鉴定的化合物抑制或激活本发明的靶基因或其表达产物在治疗和/或预防涉及心血管疾病，血脂异常和/或动脉粥样硬化的疾病中是有益的。

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