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1. 发明申请

WO2008104288A1 PDK4 AS A BIOMARKER FOR PPARA MODULATORS 审中-公开
标题翻译： PDK4作为PPARA调制器的生物标记
公开(公告)号：WO2008104288A1
公开(公告)日：2008-09-04
申请号：PCT/EP2008/001194
申请日：2008-02-16
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , WILMEN, Andreas , GRUSDAT, Gerda , BRÜGGEMEIER, Ulf
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , WILMEN, Andreas , GRUSDAT, Gerda , BRÜGGEMEIER, Ulf
IPC分类号： C12Q1/32 , C12Q1/68
CPC分类号： G01N33/6875 , C12Q1/485 , G01N2333/70567 , G01N2333/9121
摘要： The invention provides PDK4 as a biomarker for PPARa modulators. The invention relates to the identification of a biomarker or a set of biomarkers or a combination of molecular and clinical markers to monitor or identify or quantify a treatment with a PPARa modulator or a combination of one or more PPARa modulators with other pharmacological compounds.
摘要翻译：本发明提供PDK4作为PPARa调节剂的生物标志物。本发明涉及鉴定生物标志物或一组生物标志物或分子和临床标志物的组合，以监测或鉴定或定量用PPARa调节剂或一种或多种PPARα调节剂与其它药理化合物的组合的治疗。

2. 发明申请

WO2008046512A1 PRSS23 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： PRSS23作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046512A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008562
申请日：2007-10-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： G01N33/68 , G01N33/50
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/948
摘要： The invention provides PRSS23 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases.
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，呼吸系统疾病，肠胃病和泌尿系疾病有关的PRSS23。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，呼吸系统疾病，胃肠疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PRSS23的活性的化合物以及包含这些化合物的药物组合物。本发明还提供PRSS23作为心血管疾病，血液疾病，神经疾病，呼吸系统疾病，胃肠疾病和泌尿系疾病等疾病的生物标志物。

3. 发明申请

WO2008046510A1 FN1 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： FN1作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046510A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008559
申请日：2007-10-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT, Barbara , KLEIN, Martina
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides FN1 which is associated with the cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal diseases, inflammation, reproduction disorders, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal diseases, inflammation, reproduction disorders, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of FN1 as well as pharmaceutical compositions comprising such compounds. The invention also provides FN1 as a biomarker for diseases as cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal diseases, inflammation, reproduction disorders, neurological diseases and urological diseases.
摘要翻译：本发明提供了与心血管疾病，血液疾病，呼吸系统疾病，癌症，胃肠道疾病，炎症，繁殖障碍，神经系统疾病和泌尿系疾病有关的FN1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，呼吸系统疾病，癌症，胃肠疾病，炎症，繁殖障碍，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制FN1的活性的化合物以及包含这些化合物的药物组合物。本发明还提供FN1作为心血管疾病，血液疾病，呼吸系统疾病，癌症，胃肠道疾病，炎症，繁殖障碍，神经系统疾病和泌尿系疾病等疾病的生物标志物。

4. 发明申请

WO2007147496A1 USE OF N-ACYLAMINOACYLPEPTIDE HYDROLASE (APEH) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
标题翻译：作为治疗或诊断目标的N-乙酰氨基乙酸羟化酶（APEH）的使用
公开(公告)号：WO2007147496A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/005118
申请日：2007-06-11
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12Q1/37 , G01N33/574
CPC分类号： C12Q1/37 , G01N33/574 , G01N2500/00 , G01N2800/34
摘要： The invention provides a human APEH which is associated with the cardiovascular diseases, cancer, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of APEH as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，炎症，血液疾病，神经疾病和泌尿系疾病相关的人APEH。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，炎症，血液疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制APEH活性的化合物以及包含这些化合物的药物组合物。

5. 发明申请

WO2007140907A1 USE OF SERINE ENDOPEPTIDASES 22 (PRSS22) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
标题翻译：使用丝氨酸内切酶22（PRSS22）作为治疗或诊断目标
公开(公告)号：WO2007140907A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/004762
申请日：2007-05-30
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12Q1/37 , G01N33/574 , A61P35/00
CPC分类号： G01N33/574 , C12Q1/37 , G01N2333/96433 , G01N2500/00
摘要： The invention provides a human PRSS22 which is associated with the cardiovascular diseases, hematological diseases, cancer, urological diseases, neurological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, cancer, urological diseases, neurological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS22 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，血液疾病，癌症，泌尿系疾病，神经疾病有关的人类PRSS22。本发明还提供用于鉴定可用于治疗或预防心血管疾病，血液疾病，癌症，泌尿系统疾病，神经疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PRSS22活性的化合物以及包含这些化合物的药物组合物。

6. 发明申请

WO2007140896A1 USE OF LYSOSOMAL CARBOXYPEPTIDASE C (PRCP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
标题翻译：作为治疗或诊断性目标的骨质疏松性羧肽酶C（PRCP）的使用
公开(公告)号：WO2007140896A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/004696
申请日：2007-05-25
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/57438 , G01N2333/948
摘要： The invention provides a human PRCP which is associated with the cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of PRCP as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病和癌症有关的人类PRCP。本发明还提供用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病和癌症的化合物的测定。本发明还涉及结合和/或活化或抑制PRCP的活性的化合物以及包含这些化合物的药物组合物。

7. 发明申请

WO2007140895A1 USE OF LEUCYL AMINOPEPTIDASE 3 (LAP3) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
标题翻译：作为治疗或诊断性目标使用胆固醇氨基酸3（LAP3）
公开(公告)号：WO2007140895A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/004691
申请日：2007-05-25
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12Q1/37 , G01N33/68 , G01N33/574 , C12Q1/68
CPC分类号： C12Q1/37 , G01N33/57407 , G01N33/6893 , G01N2333/948 , G01N2800/00 , G01N2800/046 , G01N2800/085
摘要： The invention provides a human LAP3 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, inflammation, metabolic diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, inflammation, metabolic diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of LAP3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，炎症，代谢疾病和癌症有关的人LAP3。本发明还提供用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，炎症，代谢疾病和癌症的化合物的测定。本发明还涉及结合和/或活化或抑制LAP3活性的化合物以及包含这些化合物的药物组合物。

8. 发明申请

WO2006037513A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MATRIX METALLOPROTEINASE 9 (MMP9) 审中-公开
标题翻译：与基质金属蛋白酶9（MMP9）相关的疾病的诊断和治疗
公开(公告)号：WO2006037513A1
公开(公告)日：2006-04-13
申请号：PCT/EP2005/010405
申请日：2005-09-27
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/68 , C12Q1/68 , C07K14/705
CPC分类号： C12Q1/37 , G01N2333/96486 , G01N2500/04
摘要： The invention provides a human MMP9 which is associated with the infections, cardiovacular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases, reproduction diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovacular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases, reproduction diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MMP9 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与感染，心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系统疾病，繁殖疾病相关的人MMP9 。本发明还提供了用于鉴定可用于治疗或预防感染，心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病泌尿系疾病，繁殖疾病。本发明还涉及结合和/或活化或抑制MMP9的活性的化合物以及包含这些化合物的药物组合物。

9. 发明申请

WO2006013013A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE (PPGB) 审中-公开
标题翻译：与抗凝胶酶（PPGB）的保护性蛋白质相关的疾病的诊断和治疗
公开(公告)号：WO2006013013A2
公开(公告)日：2006-02-09
申请号：PCT/EP2005/007952
申请日：2005-07-21
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12Q1/37 , G01N33/68 , G01N33/574 , A61K39/00 , A61K48/00
CPC分类号： C12Q1/37 , A61K48/00 , C07K16/40 , G01N33/57415 , G01N33/57434 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N33/6893 , G01N33/6896
摘要： The invention provides a human PPGB which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PPGB as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类PPGB。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PPGB活性的化合物以及包含这些化合物的药物组合物。

10. 发明申请

WO2006010496A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH DIPEPTIDASE 1 (DPEP1) 审中-公开
标题翻译：与DIPEPTIDASE 1（DPEP1）相关的疾病的诊断和治疗
公开(公告)号：WO2006010496A1
公开(公告)日：2006-02-02
申请号：PCT/EP2005/007705
申请日：2005-07-15
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12N9/64 , G01N33/68 , A61K39/00 , A61K48/00
CPC分类号： C12N9/48 , A61K48/00 , C07K16/40 , C12Q1/37 , G01N2500/04
摘要： The invention provides a human DPEP1 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases, respiratory diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases, respiratory diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPEP1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病和泌尿系疾病有关的人类DPEP1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，肌肉骨骼疾病，神经疾病，呼吸系统疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制DPEP1的活性的化合物以及包含这些化合物的药物组合物。

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