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1. 发明申请

WO2005112741A3 IMPLANTABLE ANALYTE SENSOR 审中-公开
公开(公告)号：WO2005112741A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/014708
申请日：2005-05-02
申请人： DEXCOM, INC. , BRAUKER, James, H. , TAPSAK, Mark, A. , SHULTS, Mark , CARR-BRENDEL, Victoria , FISHER, Jack, G. , SEARE, William, J., Jr. , NEALE, Paul, V.
发明人： BRAUKER, James, H. , TAPSAK, Mark, A. , SHULTS, Mark , CARR-BRENDEL, Victoria , FISHER, Jack, G. , SEARE, William, J., Jr. , NEALE, Paul, V.
IPC分类号： A61B5/00
摘要： An implantable analyte sensor (12) including a sensing region (16) for measuring the analyte and a non-sensing region (18) for immobilizing the sensor body in the host (10). The sensor (12) is implanted in a precisely dimensioned pocket to stabilize the analyte sensor (12) in vivo and enable measurement of the concentration of the analyte in the host (10) before and after formation of a foreign body capsule around the sensor (12). The sensor (12) further provides a transmitter (38) for RF transmission through the sensor body, electronic circuitry (22), and a power source (34) optimized for long-term use in the miniaturized sensor body.

2. 发明申请

WO1997015242A1 POROUS MATERIAL PRODUCT AND PROCESS 审中-公开
标题翻译：多孔材料产品和工艺
公开(公告)号：WO1997015242A1
公开(公告)日：1997-05-01
申请号：PCT/US1995013846
申请日：1995-10-25
申请人： SEARE, William, J., Jr.
IPC分类号： A61F02/02
CPC分类号： B29C67/202 , A61F2/0077 , A61F2210/0004 , A61F2240/001 , B29L2031/753
摘要： A porous implant and method of making such is disclosed. A mold form material (164) is created by adhering solid particles together to form a porous network. A liquid phase of a final product is forced through the interstices of the mold form (164), and then most of the liquid material is forced out of the interstices leaving a thin coat (162). Next, the thin coat is cured to produce a thin coat of a polymer such as silicone rubber (162). Next, the mold form material (164) is dissolved out creating a porous structure containing only the cured polymer.
摘要翻译：公开了一种多孔植入物及其制造方法。通过将固体颗粒粘附在一起以形成多孔网络来产生模具形成材料（164）。最终产品的液相被迫通过模具形式（164）的空隙，然后大部分液体材料被迫离开间隙，留下薄的涂层（162）。接下来，将薄涂层固化以产生诸如硅橡胶（162）的聚合物的薄涂层。接下来，将模具形成材料（164）溶解，形成仅含有固化的聚合物的多孔结构体。

3. 发明申请

WO2005112741A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析传感器
公开(公告)号：WO2005112741A2
公开(公告)日：2005-12-01
申请号：PCT/US2005014708
申请日：2005-05-02
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
发明人： BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要： An implantable analyte sensor (12) including a sensing region (16) for measuring the analyte and a non-sensing region (18) for immobilizing the sensor body in the host (10). The sensor (12) is implanted in a precisely dimensioned pocket to stabilize the analyte sensor (12) in vivo and enable measurement of the concentration of the analyte in the host (10) before and after formation of a foreign body capsule around the sensor (12). The sensor (12) further provides a transmitter (38) for RF transmission through the sensor body, electronic circuitry (22), and a power source (34) optimized for long-term use in the miniaturized sensor body.
摘要翻译：一种可植入分析物传感器（12），包括用于测量分析物的感测区域（16）和用于将传感器主体固定在主机（10）中的非感测区域（18）。将传感器（12）植入在精确尺寸的口袋中以在体内稳定分析物传感器（12），并且能够在传感器周围形成异物胶囊之前和之后测量主体（10）中分析物的浓度（ 12）。传感器（12）还提供用于通过传感器主体进行射频传输的发射器（38），电子电路（22）和为小型化传感器主体中长期使用而优化的电源（34）。

4. 发明申请

WO1998015308A1 NODED CUFFS FOR TRANSCUTANEAOUS OR INTRABODY PROSTHETIC DEVICES 审中-公开
标题翻译：用于过渡性或预防性前置装置的NODED CUFFS
公开(公告)号：WO1998015308A1
公开(公告)日：1998-04-16
申请号：PCT/US1997018404
申请日：1997-10-08
申请人： SEARE, William, J., Jr.
IPC分类号： A61M05/32
CPC分类号： A61M25/04 , A61M2025/0233
摘要： This invention relates to methods and apparatus for making and using node cuffs (14) on transcutaneous or intra-body prosthetic devices (20) such as catheters, to effect improved stability of the prosthesis/tissue opening site interface. In particular, the node cuff apparatus of the present invention provides for positioning of the tissue opening site in a manner which facilitates more rapid establishment of a stably bio-integrated and well healed prosthesis/tissue opening site interface. In addition, in accord with the methods of the present invention, non bio-integrated portions of the node cuff can be simply and easily removed from the underlying prosthetic device to facilitate maintenance of the stably bio-integrated interface. Preferably, this removal takes place after a period of time during which the interface has become stably established. In accord with the methods and apparatus of the present invention, thus, infections or healing difficulties at the prosthesis/tissue opening site interface are greatly reduced, and a more comfortable and stable interface is more rapidly established and more easily maintained.
摘要翻译：本发明涉及用于在经皮或体内假体装置（20）如导管上制造和使用节点箍（14）的方法和装置，以改善假体/组织开口部位界面的稳定性。特别地，本发明的节点套管装置提供组织开口部位的定位，以便于更快速地建立稳定的生物整合且良好愈合的假体/组织开放位置界面。此外，根据本发明的方法，可以简单且容易地从下面的假体装置移除节点箍的非生物集成部分，以便维持稳定的生物整合界面。优选地，该去除在接口稳定建立的一段时间之后进行。根据本发明的方法和装置，因此，假体/组织开口位置界面处的感染或愈合困难大大降低，并且更快速地建立和更容易地保持更舒适和稳定的界面。

5. 发明申请

WO1996011647A1 METHODS AND APPARATUS FOR ESTABLISHING BODY POCKET 审中-公开
标题翻译：建立身体口袋的方法和装置
公开(公告)号：WO1996011647A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013368
申请日：1995-10-17
申请人： SEARE, William, J., Jr.
IPC分类号： A61F02/02
CPC分类号： A61M39/0247 , A61F2/0013 , A61F2/12
摘要： The methods and apparatus of the present invention permit a stable body pocket (3) to be formed utilizing multiple biocompatible sheets (10, 14) or using only a single biocompatible sheet (10) positioned to create either a potential space or actual space stable body pocket. The sheets (10, 14) have one surface (16, 12) which permits tissue ingrowth and thereby stably secures the sheet (10, 14) in the desired position. The other sheet surface (18, 20) is non-adhering such that adherence to a facing surface does not occur thereby creating a stable body pocket. In addition, a stable body pocket can be formed by using a biocompatible sheet or sheets (10, 14) having a surface (12, 16) that is selectively capable of permitting tissue ingrowth such that some portions of the surface grows into the surrounding tissue and other portions of the surface (18, 20) do not adhere to the surrounding tissue. In this manner, the stable body pocket apparatus has flexible surface portions. Stable body pocket access channels can also be formed. Such channels can provide stable means for communication between the exterior of the body and a natural or created internal body pocket. A method for forming a stable body pocket utilizing fluid pressure introduced into the space where a body pocket is desired is also in accord with the present invention.
摘要翻译：本发明的方法和装置允许使用多个生物相容性片（10,14）形成稳定的身体口袋（3），或仅使用一个生物相容性片材（10），该片材定位成产生潜在空间或实际空间稳定体口袋。片材（10,14）具有允许组织向内生长的一个表面（16,12），从而将片材（10,14）稳定地固定在期望的位置。另一个片材表面（18,20）不粘附，使得不会发生与面对表面的粘附，从而形成稳定的身体口袋。此外，可以通过使用具有表面（12,16）的生物相容性片材（10,14）形成稳定的身体口袋，所述表面（12,16）选择性地能够允许组织向内生长，使得表面的一些部分生长到周围组织并且表面（18,20）的其它部分不粘附到周围组织。以这种方式，稳定体袋装置具有柔性的表面部分。也可以形成稳定的身体口袋通道。这样的通道可以提供稳定的装置，用于在身体的外部和自然或创建的内部身体口袋之间进行通信。使用引入到需要身体口袋的空间中的流体压力形成稳定的身体口袋的方法也符合本发明。

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